{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:43:59Z","timestamp":1791549839844,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.clnu.2013.11.006","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T10:47:13Z","timestamp":1384512433000},"page":"1046-1053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Alteration of intestinal barrier function during activity-based anorexia in mice"],"prefix":"10.1016","volume":"33","author":[{"given":"Pierre","family":"J\u00e9sus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassila","family":"Ouelaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Riachy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moutaz","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Do Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"D\u00e9chelotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergue\u00ef O.","family":"Fetissov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo\u00efse","family":"Co\u00ebffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2013.11.006_bib1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1192\/bjp.186.2.132","article-title":"Time trends in eating disorder incidence","volume":"186","author":"Currin","year":"2005","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.clnu.2013.11.006_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0447.2010.01627.x","article-title":"Factors predictive of ten-year mortality in severe anorexia nervosa patients","volume":"123","author":"Huas","year":"2011","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.clnu.2013.11.006_bib3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MCO.0b013e3282fcec2e","article-title":"The putative role of neuropeptide autoantibodies in anorexia nervosa","volume":"11","author":"Fetissov","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clnu.2013.11.006_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.2009.04063.x","article-title":"Barrier effects of nutritional factors","volume":"1165","author":"Amasheh","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clnu.2013.11.006_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/MPG.0b013e318247240d","article-title":"Methotrexate modulates tight junctions through NF-kappaB, MEK, and JNK pathways","volume":"54","author":"Beutheu Youmba","year":"2012","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2013.11.006_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jss.2006.07.050","article-title":"Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis","volume":"140","author":"Poritz","year":"2007","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.clnu.2013.11.006_bib7","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/ajg.2011.257","article-title":"The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype","volume":"106","author":"Bertiaux-Vandaele","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.11.006_bib8","doi-asserted-by":"crossref","first-page":"G518","DOI":"10.1152\/ajpgi.00024.2006","article-title":"Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis","volume":"292","author":"Brun","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2013.11.006_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gut.42.3.396","article-title":"Gut barrier function in malnourished patients","volume":"42","author":"Welsh","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2013.11.006_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.mp.4001374","article-title":"Intestinal permeability is decreased in anorexia nervosa","volume":"9","author":"Monteleone","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.clnu.2013.11.006_bib11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.euroneuro.2010.04.002","article-title":"Activity-based anorexia in C57\/BL6 mice: effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2","volume":"20","author":"Lewis","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.clnu.2013.11.006_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.euroneuro.2010.06.005","article-title":"Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity","volume":"21","author":"Verhagen","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.clnu.2013.11.006_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.euroneuro.2010.11.006","article-title":"Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area","volume":"21","author":"Verhagen","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.clnu.2013.11.006_bib14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.physbeh.2010.05.010","article-title":"Adolescent activity-based anorexia increases anxiety-like behavior in adulthood","volume":"101","author":"Kinzig","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clnu.2013.11.006_bib15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.physbeh.2011.08.035","article-title":"Physiological and behavioral responses to intermittent starvation in C57BL\/6J mice","volume":"105","author":"Zhang","year":"2012","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clnu.2013.11.006_bib16","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/00365520510015836","article-title":"Psychological features are important predictors of functional gastrointestinal disorders in patients with eating disorders","volume":"40","author":"Boyd","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.11.006_bib17","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4065\/75.10.1015","article-title":"Anorectal dysfunction in constipated women with anorexia nervosa","volume":"75","author":"Chiarioni","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.clnu.2013.11.006_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/00042737-200411000-00009","article-title":"Anorexia nervosa in gastrointestinal practice","volume":"16","author":"Emmanuel","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2013.11.006_bib19","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/ajg.2009.700","article-title":"Increased proteasome-mediated degradation of occludin in irritable bowel syndrome","volume":"105","author":"Coeffier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.11.006_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gut.2009.181834","article-title":"MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome","volume":"59","author":"Zhou","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2013.11.006_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pain.2009.06.017","article-title":"Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome","volume":"146","author":"Zhou","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.clnu.2013.11.006_bib22","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1152\/jappl.2001.90.6.2075","article-title":"Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages","volume":"90","author":"Lambert","year":"2001","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clnu.2013.11.006_bib23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/jappl.1997.82.2.571","article-title":"Effect of running intensity on intestinal permeability","volume":"82","author":"Pals","year":"1997","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clnu.2013.11.006_bib24","first-page":"1879","article-title":"Colonic and anorectal function in constipated patients with anorexia nervosa","volume":"92","author":"Chun","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.11.006_bib25","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.clnu.2013.11.006_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1113\/jphysiol.2011.222133","article-title":"Gut microbiota, epithelial function and derangements in obesity","volume":"590","author":"Raybould","year":"2012","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.clnu.2013.11.006_bib27","doi-asserted-by":"crossref","first-page":"e7125","DOI":"10.1371\/journal.pone.0007125","article-title":"Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients","volume":"4","author":"Armougom","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2013.11.006_bib28","doi-asserted-by":"crossref","first-page":"17155","DOI":"10.1073\/pnas.222658699","article-title":"Autoantibodies against alpha -MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients","volume":"99","author":"Fetissov","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2013.11.006_bib29","doi-asserted-by":"crossref","first-page":"14865","DOI":"10.1073\/pnas.0507204102","article-title":"Autoantibodies against neuropeptides are associated with psychological traits in eating disorders","volume":"102","author":"Fetissov","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2013.11.006_bib30","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/ncomms3685","article-title":"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans","volume":"4","author":"Takagi","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.clnu.2013.11.006_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.nut.2007.12.006","article-title":"Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora","volume":"24","author":"Fetissov","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2013.11.006_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0197-0070(85)80016-4","article-title":"Metabolic abnormalities in adolescent patients with anorexia nervosa","volume":"6","author":"Milner","year":"1985","journal-title":"J\u00a0Adolesc Health Care"},{"key":"10.1016\/j.clnu.2013.11.006_bib33","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2008.05.055","article-title":"Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy","volume":"135","author":"Rautou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2013.11.006_bib34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/00042737-200410000-00011","article-title":"Failure of the gut barrier system enhances liver injury in rats: protection of hepatocytes by gut-derived hepatocyte growth factor","volume":"16","author":"Choda","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561413003105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561413003105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T23:45:25Z","timestamp":1564703125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561413003105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0261561413003105"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2013.11.006","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alteration of intestinal barrier function during activity-based anorexia in mice","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2013.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}