{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:15Z","timestamp":1790501235599,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Carlos III Health Institute","award":["FIS PI10\/1993"],"award-info":[{"award-number":["FIS PI10\/1993"]}]},{"name":"FEDER European Funds"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.clnu.2015.04.022","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T19:29:56Z","timestamp":1432150196000},"page":"706-712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pyridoxal-5\u2032-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients"],"prefix":"10.1016","volume":"35","author":[{"given":"Jorge","family":"Molina-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Florea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolom\u00e9","family":"Quintero-Osso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P\u00e9rez","family":"de la Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez-Elvira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Planells","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.clnu.2015.04.022_bib1","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1097\/CCM.0b013e31822d2a43","article-title":"Supplemental parenteral nutrition in the critically ill: \u00abdifferent strokes for different folks\u00bb","volume":"39","author":"Mizock","year":"2011","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.clnu.2015.04.022_bib2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/CCM.0b013e31822f0ad7","article-title":"Energy deficit and length of hospital stay can be reduced by a two-step quality improvement of nutrition therapy: the intensive care unit dietitian can make the difference","volume":"40","author":"Soguel","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnu.2015.04.022_bib3","first-page":"1","article-title":"Higher plasma pyridoxal phosphate is associated with increased antioxidant enzyme activities in critically ill surgical patients","volume":"2013","author":"Cheng","year":"2013","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.clnu.2015.04.022_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/0148607110372391","article-title":"Nutrition therapy for the critically ill surgical patient: we need to do better!","volume":"34","author":"Drover","year":"2010","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2015.04.022_bib5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/MCO.0b013e328350767e","article-title":"Nutrition risk assessment in the ICU","volume":"15","author":"Hiesmayr","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/00003246-199504000-00011","article-title":"Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction","volume":"23","author":"Goode","year":"1995","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/01.CCM.0000055371.27268.36","article-title":"Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome","volume":"31","author":"Motoyama","year":"2003","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib8","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/1755-5922.12014","article-title":"Updating the relationship between hyperhomocysteinemia lowering therapy and cardiovascular events","volume":"31","author":"Cheng","year":"2013","journal-title":"Cardiovasc Ther"},{"issue":"2","key":"10.1016\/j.clnu.2015.04.022_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1562\/0031-8655(2000)071<0129:SIPVBP>2.0.CO;2","article-title":"Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants","volume":"71","author":"Bilski","year":"2000","journal-title":"Photochem Photobiol"},{"issue":"5","key":"10.1016\/j.clnu.2015.04.022_bib10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/0884533612449654","article-title":"Higher plasma homocysteine is associated with lower vitamin B6 status in critically ill surgical patients","volume":"27","author":"Hou","year":"2012","journal-title":"Nutr Clin Pract Off Publ Am Soc Parenter Enteral Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2015.04.022_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.ejcn.1601321","article-title":"Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan","volume":"56","author":"Huang","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"7","key":"10.1016\/j.clnu.2015.04.022_bib12","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00003246-199207000-00007","article-title":"Blood vitamin concentrations during the acute-phase response","volume":"20","author":"Louw","year":"1992","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.clnu.2015.04.022_bib13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3945\/ajcn.2009.28571","article-title":"Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study","volume":"91","author":"Shen","year":"2010","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2015.04.022_bib14","doi-asserted-by":"crossref","first-page":"R146","DOI":"10.1186\/cc5068","article-title":"Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study","volume":"10","author":"Abil\u00e9s","year":"2006","journal-title":"Crit Care Lond Engl"},{"issue":"9","key":"10.1016\/j.clnu.2015.04.022_bib15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1474-4422(10)70187-3","article-title":"B\u00a0vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial","volume":"9","year":"2010","journal-title":"Lancet Neurol"},{"issue":"23","key":"10.1016\/j.clnu.2015.04.022_bib16","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1161\/01.CIR.103.23.2788","article-title":"Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels","volume":"103","author":"Friso","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.clnu.2015.04.022_bib17","series-title":"Nutriber","author":"Mataix","year":"2005"},{"key":"10.1016\/j.clnu.2015.04.022_bib18","year":"1998"},{"issue":"3","key":"10.1016\/j.clnu.2015.04.022_bib19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/0148607109335234","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of critical care Medicine (SCCM) and American Society for parenteral and enteral nutrition (A.S.P.E.N.)","volume":"33","author":"McClave","year":"2009","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib20","first-page":"359","article-title":"Clinical chemical methods for the routine assessment of the vitamin status in human populations. Part II: the water-soluble vitamins B1, B2 and B6","volume":"53","author":"Vuilleumier","year":"1983","journal-title":"Int J Vitam Nutr Res"},{"issue":"3","key":"10.1016\/j.clnu.2015.04.022_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1041-2972.2005.0016.x","article-title":"Homocysteine and cardiovascular disease: a review of current recommendations for screening and treatment","volume":"17","author":"Chamberlain","year":"2005","journal-title":"J\u00a0Am Acad Nurse Pract"},{"key":"10.1016\/j.clnu.2015.04.022_bib22","first-page":"572081","article-title":"Determinants of hyperhomocysteinemia: a matter of nature and nurture","author":"Cheng","year":"1996","journal-title":"Biomed Res Int"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1365-2796.2004.01373.x","article-title":"Oxidative stress and its association with coronary artery disease and different atherogenic risk factors","volume":"256","author":"Vassalle","year":"2004","journal-title":"J\u00a0Intern Med"},{"issue":"11\u201312","key":"10.1016\/j.clnu.2015.04.022_bib24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2119\/molmed.2010.00008","article-title":"Early increase of plasma homocysteine in sepsis patients with poor outcome","volume":"16","author":"Ploder","year":"2010","journal-title":"Mol Med"},{"issue":"8","key":"10.1016\/j.clnu.2015.04.022_bib25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/jama.288.8.973","article-title":"Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the swiss heart study: a randomized controlled trial","volume":"288","author":"Schnyder","year":"2002","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.clnu.2015.04.022_bib26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11883-007-0048-x","article-title":"Should hyperhomocysteinemia be treated in patients with atherosclerotic disease?","volume":"9","author":"Maron","year":"2007","journal-title":"Curr Atheroscler Rep"},{"issue":"12","key":"10.1016\/j.clnu.2015.04.022_bib27","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1515\/CCLM.2007.347","article-title":"Association between homocysteine, vitamin B6 concentrations and inflammation","volume":"45","author":"Gori","year":"2007","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.04.022_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.clnu.2014.01.006","article-title":"Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials","volume":"33","author":"Qin","year":"2014","journal-title":"Clin Nutr Edinb Scotl"},{"issue":"5","key":"10.1016\/j.clnu.2015.04.022_bib29","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1016\/j.eclnm.2008.06.011","article-title":"High prevalence of hyperhomocysteinemia in critically ill patients: Vascular damage and adequate vitamin intake","volume":"3","author":"Abil\u00e9s","year":"2008","journal-title":"E\u00a0SPEN Eur E J Clin Nutr Metab"},{"issue":"3","key":"10.1016\/j.clnu.2015.04.022_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nut.2007.12.003","article-title":"Plasma pyridoxal 5\u2032-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease","volume":"24","author":"Cheng","year":"2008","journal-title":"Nutrition"},{"issue":"7\u20138","key":"10.1016\/j.clnu.2015.04.022_bib31","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.nut.2004.11.013","article-title":"Plasma pyridoxal 5\u2032-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill","volume":"21","author":"Huang","year":"2005","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/j.clnu.2015.04.022_bib32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/ajcn.111.023812","article-title":"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements","volume":"95","author":"Duncan","year":"2012","journal-title":"Am J Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561415001363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561415001363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T10:08:52Z","timestamp":1566727732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561415001363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0261561415001363"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2015.04.022","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyridoxal-5\u2032-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate status in critically ill patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2015.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}