{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:18:41Z","timestamp":1775661521028,"version":"3.50.1"},"reference-count":133,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 HL111895"],"award-info":[{"award-number":["R24 HL111895"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL105654"],"award-info":[{"award-number":["K23HL105654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.clnu.2015.07.003","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T23:02:29Z","timestamp":1437087749000},"page":"1196-1206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues"],"prefix":"10.1016","volume":"35","author":[{"given":"Daren K.","family":"Heyland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee D.","family":"Stapleton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Mourtzakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine L.","family":"Hough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas E.","family":"Deutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Colantuoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla M.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale M.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.clnu.2015.07.003_bib1","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1056\/NEJMra1209390","article-title":"ICU-acquired weakness and recovery from critical illness","volume":"370","author":"Kress","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/CCM.0000000000000040","article-title":"Physical complications in acute lung injury survivors: a two-year longitudinal prospective study","volume":"42","author":"Fan","year":"2014","journal-title":"Crit Care Med"},{"issue":"22","key":"10.1016\/j.clnu.2015.07.003_bib3","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1001\/jama.288.22.2859","article-title":"Paresis acquired in the intensive care unit: a prospective multicenter study","volume":"288","author":"De Jonghe","year":"2002","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1164\/rccm.201312-2257OC","article-title":"Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis","volume":"190","author":"Hermans","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1164\/rccm.201411-2011ST","article-title":"An official American Thoracic Society clinical practice guideline: the diagnosis of intensive care unit-acquired weakness in adults","volume":"190","author":"Fan","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib6","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1007\/s00134-009-1567-4","article-title":"The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observation study","volume":"35","author":"Alberda","year":"2009","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.clnu.2010.09.011","article-title":"The success of enteral nutrition and ICU-acquired infections: a multicenter observational study","volume":"30","author":"Heyland","year":"2011","journal-title":"Clin Nutr"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib8","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1097\/CCM.0b013e318226641d","article-title":"Optimal amount of calories for critically ill patients: depends on how you slice the cake!","volume":"39","author":"Heyland","year":"2011","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib9","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1097\/CCM.0000000000001000","article-title":"Nutritional adequacy and health-related quality of life in critically ill patients requiring prolonged mechanical ventilation","volume":"43","author":"Wei","year":"2015","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.clnu.2011.12.006","article-title":"Provision of protein and energy in relation to measured requirements in intensive care patients","volume":"31","author":"Allingstrup","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.003_bib11","article-title":"Clinical outcomes related to protein delivery in a critically ill population: a multicenter, multinational observation study","author":"Nicolo","year":"2015","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib12","first-page":"544","article-title":"Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit","volume":"15","author":"Hsieh","year":"2006","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.003_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f1532","article-title":"One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial","volume":"346","author":"Needham","year":"2013","journal-title":"BMJ"},{"issue":"20","key":"10.1016\/j.clnu.2015.07.003_bib14","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1001\/jama.2013.5124","article-title":"Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial","volume":"309","author":"Doig","year":"2013","journal-title":"JAMA"},{"issue":"15","key":"10.1016\/j.clnu.2015.07.003_bib15","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.2013.278481","article-title":"Acute skeletal muscle wasting in critical illness","volume":"310","author":"Puthucheary","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1164\/rccm.201206-0999OC","article-title":"Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis","volume":"187","author":"Casaer","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/cc12701","article-title":"Does artificial nutrition improve outcome of critical illness? An alternative view point!","volume":"17","author":"Heyland","year":"2013","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3945\/ajcn.111.032078","article-title":"Appropriate protein provision in critical illness: a systematic and narrative review","volume":"96","author":"Hoffer","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib19","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1097\/CCM.0b013e31827ca637","article-title":"Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis","volume":"41","author":"Kayambu","year":"2013","journal-title":"Crit Care Med"},{"issue":"9678","key":"10.1016\/j.clnu.2015.07.003_bib20","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0140-6736(09)60658-9","article-title":"Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial","volume":"373","author":"Schweickert","year":"2009","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib21","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1097\/CCM.0b013e318180b90e","article-title":"Early intensive care unit mobility therapy in the treatment of acute respiratory failure","volume":"36","author":"Morris","year":"2008","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.clnu.2015.07.003_bib22","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1097\/CCM.0b013e3181a38937","article-title":"Early exercise in critically ill patients enhances short-term functional recovery","volume":"37","author":"Burtin","year":"2009","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib23","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1186\/cc12835","article-title":"Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months follow up","volume":"17","author":"Denehy","year":"2013","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12603-010-0319-z","article-title":"The anabolic response to resistance exercise and a protein-rich meal is not diminished by age","volume":"15","author":"Symons","year":"2011","journal-title":"J\u00a0Nutr Health Aging"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MCO.0b013e328333aa66","article-title":"Protecting muscle mass and function in older adults during bed rest","volume":"13","author":"English","year":"2010","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jamda.2012.05.020","article-title":"Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial","volume":"13","author":"Tieland","year":"2012","journal-title":"J\u00a0Am Med Dir Assoc"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1079\/BJN2003836","article-title":"The effects of exercise and protein-energy supplements on body composition and muscle function in frail elderly individuals: a long-term controlled randomised study","volume":"89","author":"Bonnefoy","year":"2003","journal-title":"Br J Nutr"},{"issue":"25","key":"10.1016\/j.clnu.2015.07.003_bib28","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1056\/NEJM199406233302501","article-title":"Exercise training and nutritional supplementation for physical frailty in very elderly people","volume":"330","author":"Fiatarone","year":"1994","journal-title":"N\u00a0Engl J Med"},{"issue":"13","key":"10.1016\/j.clnu.2015.07.003_bib29","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1056\/NEJMoa1008234","article-title":"Weight loss, exercise, or both and physical function in obese older adults","volume":"364","author":"Villareal","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib30","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11904-012-0135-7","article-title":"Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals","volume":"9","author":"Botros","year":"2012","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib31","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.3747\/co.20.1431","article-title":"Exercise and nutrition interventions in advanced lung cancer: a systematic review","volume":"20","author":"Payne","year":"2013","journal-title":"Curr Oncol"},{"issue":"7","key":"10.1016\/j.clnu.2015.07.003_bib32","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.ultrasmedbio.2009.01.004","article-title":"Quantification of muscle volume by echography: comparison with MRI data on subjects in long-term bedrest","volume":"35","author":"Arbeille","year":"2009","journal-title":"Ultrasound Med Biol"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1748-1716.2007.01728.x","article-title":"Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women","volume":"191","author":"Trappe","year":"2007","journal-title":"Acta Physiol (Oxf)"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib34","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3945\/ajcn.112.037556","article-title":"Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis","volume":"96","author":"Cermak","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib35","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","article-title":"Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group","volume":"33","author":"Deutz","year":"2014","journal-title":"Clin Nutr"},{"issue":"10 Suppl","key":"10.1016\/j.clnu.2015.07.003_bib36","doi-asserted-by":"crossref","first-page":"S676","DOI":"10.1097\/CCM.0b013e3181f2458d","article-title":"Skeletal muscle dysfunction in critical care: wasting, weakness, and rehabilitation strategies","volume":"38","author":"Puthucheary","year":"2010","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib37","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1210\/jc.2007-1684","article-title":"Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3","volume":"93","author":"Bosutti","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5 Pt 1","key":"10.1016\/j.clnu.2015.07.003_bib38","first-page":"E727","article-title":"Tumor necrosis factor induces skeletal muscle protein breakdown in rats","volume":"260","author":"Goodman","year":"1991","journal-title":"Am J Physiol"},{"issue":"Pt 15","key":"10.1016\/j.clnu.2015.07.003_bib39","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1113\/jphysiol.2011.206193","article-title":"Novel events in the molecular regulation of muscle mass in critically ill patients","volume":"589","author":"Constantin","year":"2011","journal-title":"J\u00a0Physiol"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib40","doi-asserted-by":"crossref","first-page":"R216","DOI":"10.1152\/ajpregu.00072.2013","article-title":"Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults","volume":"305","author":"Drummond","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib41","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2337\/diabetes.48.5.949","article-title":"Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise","volume":"48","author":"Biolo","year":"1999","journal-title":"Diabetes"},{"issue":"18","key":"10.1016\/j.clnu.2015.07.003_bib42","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJM199610313351804","article-title":"Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects","volume":"335","author":"Perseghin","year":"1996","journal-title":"N\u00a0Engl J Med"},{"issue":"10 Suppl","key":"10.1016\/j.clnu.2015.07.003_bib43","doi-asserted-by":"crossref","first-page":"S398","DOI":"10.1097\/CCM.0b013e3181b6ec1f","article-title":"Anabolic resistance in critically ill patients","volume":"37","author":"Rennie","year":"2009","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/0148607108316195","article-title":"Prevalence, incidence, and clinical resolution of insulin resistance in critically ill patients: an observational study","volume":"32","author":"Saberi","year":"2008","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib45","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1177\/000313481007601223","article-title":"Glucose metabolism, not obesity, predicts mortality in critically ill surgical patients","volume":"76","author":"Mowery","year":"2010","journal-title":"Am Surg"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib46","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/0885066609335663","article-title":"Insulin resistance despite tight glucose control is associated with mortality in critically ill surgical patients","volume":"24","author":"Mowery","year":"2009","journal-title":"J\u00a0Intensive Care Med"},{"issue":"11\u201312","key":"10.1016\/j.clnu.2015.07.003_bib47","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2119\/2008-00081.Thompson","article-title":"Acute, muscle-type specific insulin resistance following injury","volume":"14","author":"Thompson","year":"2008","journal-title":"Mol Med"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1210\/en.2008-0742","article-title":"Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury","volume":"150","author":"Li","year":"2009","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib49","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1210\/jc.2007-0813","article-title":"Effect of intensive insulin therapy on insulin sensitivity in the critically ill","volume":"92","author":"Langouche","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib50","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/hep.26393","article-title":"Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial)","volume":"58","author":"Bacchi","year":"2013","journal-title":"Hepatology"},{"issue":"1 Suppl","key":"10.1016\/j.clnu.2015.07.003_bib51","first-page":"319S","article-title":"Potential importance of leucine in treatment of obesity and the metabolic syndrome","volume":"136","author":"Layman","year":"2006","journal-title":"J\u00a0Nutr"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib52","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/gerona\/63.10.1076","article-title":"Functional impact of 10 days of bed rest in healthy older adults","volume":"63","author":"Kortebein","year":"2008","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib53","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1152\/japplphysiol.00346.2003","article-title":"Skeletal muscle unweighting: spaceflight and ground-based models","volume":"95","author":"Adams","year":"2003","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib54","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1164\/rccm.201401-0158OC","article-title":"Risk factors for physical impairment after acute lung injury in a national, multicenter study","volume":"189","author":"Needham","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"Pt 24","key":"10.1016\/j.clnu.2015.07.003_bib55","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1113\/jphysiol.2008.160333","article-title":"Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion","volume":"586","author":"Glover","year":"2008","journal-title":"J\u00a0Physiol"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib56","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1210\/jc.2006-0651","article-title":"Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress","volume":"91","author":"Paddon-Jones","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib57","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1152\/japplphysiol.00452.2009","article-title":"Alterations of protein turnover underlying disuse atrophy in human skeletal muscle","volume":"107","author":"Phillips","year":"2009","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib58","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1378\/chest.13-2046","article-title":"Impact of the early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated","volume":"146","author":"Patel","year":"2014","journal-title":"Chest"},{"issue":"3 Pt 1","key":"10.1016\/j.clnu.2015.07.003_bib59","first-page":"E514","article-title":"Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans","volume":"268","author":"Biolo","year":"1995","journal-title":"Am J Physiol"},{"issue":"1 Pt 1","key":"10.1016\/j.clnu.2015.07.003_bib60","first-page":"E122","article-title":"An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein","volume":"273","author":"Biolo","year":"1997","journal-title":"Am J Physiol"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib61","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1096\/fj.09-150177","article-title":"Age-related anabolic resistance after endurance-type exercise in healthy humans","volume":"24","author":"Durham","year":"2010","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1249\/MSS.0000000000000447","article-title":"Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise","volume":"47","author":"Rowlands","year":"2015","journal-title":"Med Sci Sports Exerc"},{"issue":"Pt 16","key":"10.1016\/j.clnu.2015.07.003_bib63","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1113\/jphysiol.2011.211888","article-title":"The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis","volume":"589","author":"Breen","year":"2011","journal-title":"J\u00a0Physiol"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib64","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/cc12837","article-title":"Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients","volume":"17","author":"Berg","year":"2013","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib65","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/SPC.0b013e328359b668","article-title":"Evidence base for multimodal therapy in cachexia","volume":"6","author":"Solheim","year":"2012","journal-title":"Curr Opin Support Palliat Care"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00520-007-0388-7","article-title":"Nutritional support in multimodal therapy for cancer cachexia","volume":"16","author":"Bosaeus","year":"2008","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clnu.2015.07.003_bib67","unstructured":"Karra S, Fearon K. A feasibility study of multimodal exercise\/nutrition\/anti-inflammatory treatment for cachexia\u2014the pre-MENAC study. ClinicalTrials.gov, http:\/\/clinicaltrials.gov\/show\/NCT01419145 [accessed 28.05.14]."},{"issue":"16","key":"10.1016\/j.clnu.2015.07.003_bib68","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1212722","article-title":"A\u00a0randomized trial of glutamine and antioxidants in critically ill patients","volume":"368","author":"Heyland","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib69","doi-asserted-by":"crossref","first-page":"R268","DOI":"10.1186\/cc10546","article-title":"Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool","volume":"15","author":"Heyland","year":"2011","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib70","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1378\/chest.125.4.1446","article-title":"Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol","volume":"125","author":"Barr","year":"2004","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib71","doi-asserted-by":"crossref","first-page":"R218","DOI":"10.1186\/cc3504","article-title":"Daily enteral feeding practice on the ICU: attainment of goals and interfering factors","volume":"9","author":"Binnekade","year":"2005","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003246-200101000-00002","article-title":"A\u00a0prospective survey of nutritional support practices in intensive care unit patients: what is prescribed? What is delivered?","volume":"29","author":"De Jonghe","year":"2001","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib73","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/014860710302700174","article-title":"Nutrition support in the critical care setting: current practice in canadian ICUs \u2013 opportunities for improvement?","volume":"27","author":"Heyland","year":"2003","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1378\/chest.124.1.297","article-title":"Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes","volume":"124","author":"Krishnan","year":"2003","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.clnu.2015.07.003_bib75","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/00003246-199907000-00003","article-title":"Enteral tube feeding in the intensive care unit: factors impeding adequate delivery","volume":"27","author":"McClave","year":"1999","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib76","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.CCM.0000089641.06306.68","article-title":"Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit","volume":"32","author":"Rubinson","year":"2004","journal-title":"Crit Care Med"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib77","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1097\/CCM.0b013e31829efef5","article-title":"Enhanced protein-energy provision via the enteral route feeding protocol in critically ill patients (the PEP uP protocol): results of a cluster randomized trial","volume":"41","author":"Heyland","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnu.2015.07.003_bib78","unstructured":"Doig G. Nephro-protective effects of l-amino acids in critically ill patients. A phase II multicentre randomised controlled trial (ACTRN12609001015235). Australian New Zealand Clinical Trials Registry, https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?ACTRN=12609001015235 [accessed 19.01.15]."},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib79","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.arr.2011.12.008","article-title":"Systematic review and meta-analyses of the effects of high protein oral nutritional supplements","volume":"11","author":"Cawood","year":"2012","journal-title":"Ageing Res Rev"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib80","first-page":"2152","article-title":"Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs","volume":"141","author":"Gazzaneo","year":"2011","journal-title":"J\u00a0Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib81","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/cc12884","article-title":"Critical care rehabilitation trials: the importance of \u2018usual care\u2019","volume":"17","author":"Parker","year":"2013","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib82","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcrc.2014.09.014","article-title":"Neuromuscular electrical stimulation in mechanically ventilated patients: a randomized, sham-controlled pilot trial with blinded outcome assessment","volume":"30","author":"Kho","year":"2015","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.clnu.2015.07.003_bib83","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1186\/s13054-014-0573-2","article-title":"A\u00a0promising new therapy may assist efforts to combat ICU-acquired weakness","volume":"18","author":"Bain","year":"2014","journal-title":"Crit Care"},{"issue":"10 Suppl","key":"10.1016\/j.clnu.2015.07.003_bib84","doi-asserted-by":"crossref","first-page":"S436","DOI":"10.1097\/CCM.0b013e3181b6fa29","article-title":"Technology to enhance physical rehabilitation of critically ill patients","volume":"37","author":"Needham","year":"2009","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib85","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0148607103027005355","article-title":"Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients","volume":"27","author":"Heyland","year":"2003","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib86","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/0148607109335234","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)","volume":"33","author":"McClave","year":"2009","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib87","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/MCO.0b013e32835a88ee","article-title":"Muscle protein anabolism in type 2 diabetes","volume":"16","author":"Bassil","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib88","doi-asserted-by":"crossref","first-page":"E95","DOI":"10.1503\/cmaj.130639","article-title":"Association between frailty and short- and long-term outcomes among critically ill patients: a multicenter prospective cohort study","volume":"186","author":"Bagshaw","year":"2014","journal-title":"CMAJ"},{"key":"10.1016\/j.clnu.2015.07.003_bib89","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function","volume":"185","author":"Katz","year":"1963","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib90","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.1016\/j.clnu.2015.07.003_bib91","series-title":"Quality of life and pharmacoeconomics in clinical trials","first-page":"337","article-title":"The SF-36 health survey","author":"Ware","year":"1996"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib92","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/CCM.0b013e3181cd10c7","article-title":"Baseline quality of life before intensive care: a comparison of patient versus proxy responses","volume":"38","author":"Gifford","year":"2010","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.clnu.2015.07.003_bib93","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00134-006-0333-0","article-title":"Difference in reported pre-morbid health-related quality of life between ARDS survivors and their substitute decision makers","volume":"32","author":"Scales","year":"2006","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cger.2010.08.008","article-title":"Frailty defined by deficit accumulation and geriatric medicine defined by frailty","volume":"27","author":"Rockwood","year":"2011","journal-title":"Clin Geriatr Med"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib95","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/ageing\/afu163","article-title":"Functional status after critical illness: agreement between patient and proxy assessments","volume":"44","author":"Ahasic","year":"2015","journal-title":"Age Ageing"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib96","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1365-2044.1997.240-az0374.x","article-title":"Reliability of the next of kins' estimates of critically ill patients' quality of life","volume":"52","author":"Rogers","year":"1997","journal-title":"Anaesthesia"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib97","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1164\/rccm.201402-0362ED","article-title":"Understanding and improving clinical trial outcome measures in acute respiratory failure","volume":"189","author":"Needham","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.clnu.2015.07.003_bib98","unstructured":"http:\/\/www.comet-initiative.org\/."},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib99","first-page":"302","article-title":"A\u00a0systematic review of measurements of physical function in critically ill adults","volume":"14","author":"Tipping","year":"2012","journal-title":"Crit Care Resusc"},{"issue":"4","key":"10.1016\/j.clnu.2015.07.003_bib100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1055\/s-0032-1321982","article-title":"The burdens of survivorship: an approach to thinking about the long-term outcomes after critical illness","volume":"33","author":"Iwashyna","year":"2012","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.clnu.2015.07.003_bib101","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2318-13-74","article-title":"Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Geriatr"},{"issue":"8","key":"10.1016\/j.clnu.2015.07.003_bib102","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1177\/0148607114550189","article-title":"Lean tissue imaging: a new era for nutritional assessment and intervention","volume":"38","author":"Prado","year":"2014","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib103","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/SLA.0b013e31825ffc1f","article-title":"The anabolic effect of perioperative nutrition depends on the patient's catabolic state before surgery","volume":"257","author":"Schricker","year":"2013","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib104","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/cc12901","article-title":"Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients","volume":"17","author":"Moisey","year":"2013","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib105","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0197-2456(99)00022-7","article-title":"Worst-rank score analysis with informatively missing observations in clinical trials","volume":"20","author":"Lachin","year":"1999","journal-title":"Control Clin Trials"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib106","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chronic Dis"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib107","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jclinepi.2004.10.018","article-title":"The development of a co-morbidity index with physical function as the outcome","volume":"58","author":"Groll","year":"2005","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"7","key":"10.1016\/j.clnu.2015.07.003_bib108","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/01.phm.0000223220.91914.61","article-title":"Assessment of long-term physical function in acute respiratory distress syndrome (ARDS) patients. Comparison of the Charlson comorbidity index and the functional comorbidity index","volume":"85","author":"Groll","year":"2006","journal-title":"Am J Phys Med Rehabil"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib109","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.clnu.2015.07.003_bib110","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s001340050931","article-title":"The use of maximum SOFA score to quantify organ dysfunction\/failure in intensive care. Results of a prospective, multicentre study. Working group on sepsis related problems of the ESICM","volume":"25","author":"Moreno","year":"1999","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib111","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00134-002-1624-8","article-title":"Surviving intensive care: a report from the 2002 Brussels Roundtable","volume":"29","author":"Angus","year":"2003","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.clnu.2015.07.003_bib112","series-title":"How to score version 2 of the SF-36 health survey","author":"Ware","year":"2000"},{"key":"10.1016\/j.clnu.2015.07.003_bib113","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.26.1_supplement.42.1","article-title":"Using the phenylalanine (PHE) stable isotope pulse method to measure intracellular protein breakdown and metabolic shunting in the context of sepsis in the pig","volume":"26","author":"Ten Have","year":"2012","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib114","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.clnu.2013.11.004","article-title":"New stable isotope method to measure protein digestibility and response to pancreatic enzyme intake in cystic fibrosis","volume":"33","author":"Engelen","year":"2014","journal-title":"Clin Nutr"},{"issue":"7","key":"10.1016\/j.clnu.2015.07.003_bib115","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/0148607113501327","article-title":"Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness","volume":"38","author":"Tilquist","year":"2014","journal-title":"J\u00a0Parenter Enteral Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib116","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00134-014-3251-6","article-title":"Screening for critical illness polyneuromyopathy with single nerve conduction studies","volume":"40","author":"Moss","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.clnu.2015.07.003_bib117","article-title":"Manual muscle testing: a method of measuring extremity muscle strength applied to critically ill patients","volume":"50","author":"Ciesla","year":"2011","journal-title":"J\u00a0Vis Exp"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib118","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/mus.880120302","article-title":"Relationship of manual muscle testing to objective strength measurements","volume":"12","author":"Aitkens","year":"1989","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib119","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jcrc.2012.03.001","article-title":"Muscle strength assessment in critically ill patients with handheld dynamometry: an investigation of reliability, minimal detectable change, and time to peak force generation","volume":"28","author":"Baldwin","year":"2013","journal-title":"J\u00a0Crit Care"},{"issue":"3","key":"10.1016\/j.clnu.2015.07.003_bib120","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/CCM.0000000000000030","article-title":"Assessment of limb muscle strength in critically ill patients: a systematic review","volume":"42","author":"Vanpee","year":"2014","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.clnu.2015.07.003_bib121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0003-9993(97)90005-8","article-title":"Reference values for extremity muscle strength obtained by hand-held dynamometry from adults aged 20 to 79 years","volume":"78","author":"Bohannon","year":"1997","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib122","first-page":"69","article-title":"Grip and pinch strength: normative data for adults","volume":"66","author":"Mathiowetz","year":"1985","journal-title":"Arch Phys Med Rehabil"},{"issue":"6","key":"10.1016\/j.clnu.2015.07.003_bib123","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1183\/09031936.00150314","article-title":"An official European Respiratory Society\/American Thoracic Society technical standard: field walking tests in chronic respiratory disease","volume":"44","author":"Holland","year":"2014","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.clnu.2015.07.003_bib124","first-page":"1316","article-title":"Construct validity and minimal important difference of 6-minute walk distance in survivors of acute respiratory failure","volume":"147","author":"Chan","year":"2015"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib125","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.2522\/ptj.20110410","article-title":"Repeatability of the six-minute walk test and relation to physical function in survivors of a critical illness","volume":"92","author":"Alison","year":"2012","journal-title":"Phys Ther"},{"issue":"2","key":"10.1016\/j.clnu.2015.07.003_bib126","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A\u00a0short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"Guralnik","year":"1994","journal-title":"J\u00a0Gerontol"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib127","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1007\/s00134-014-3513-3","article-title":"Outcome measures report different aspects of patient function three months following critical care","volume":"40","author":"Denehy","year":"2014","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib128","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.apmr.2014.06.008","article-title":"Using timed up-and-go and usual gait speed to predict incident difficulty in daily activities among community-dwelling adults aged 65 and older","volume":"95","author":"Donoghue","year":"2014","journal-title":"Arch Phys Med Rehab"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib129","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.2522\/ptj.20120310","article-title":"A\u00a0physical function test for use in the intensive care unit: validity, responsiveness, and predictive utility of the physical function ICU test (scored)","volume":"93","author":"Denehy","year":"2013","journal-title":"Phys Ther"},{"issue":"10","key":"10.1016\/j.clnu.2015.07.003_bib130","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.2522\/ptj.20130451","article-title":"The physical function intensive care test: implementation in survivors of critical illness","volume":"94","author":"Nordon-Craft","year":"2014","journal-title":"Phys Ther"},{"issue":"12","key":"10.1016\/j.clnu.2015.07.003_bib131","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0003-9993(96)90184-7","article-title":"The reliability of the functional independence measure: a quantitative review","volume":"77","author":"Ottenbacher","year":"1996","journal-title":"Arch Phys Med Rehabil"},{"issue":"24","key":"10.1016\/j.clnu.2015.07.003_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta4240","article-title":"Outcome measures for adult critical care: a systematic review","volume":"4","author":"Hayes","year":"2000","journal-title":"Health Technol Assess"},{"issue":"11","key":"10.1016\/j.clnu.2015.07.003_bib133","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/01.mlr.0000182493.57090.c1","article-title":"Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index","volume":"43","author":"Luo","year":"2005","journal-title":"Med Care"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561415001776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561415001776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T07:10:26Z","timestamp":1652857826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561415001776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":133,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0261561415001776"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2015.07.003","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2015.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}