{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:36:35Z","timestamp":1789605395930,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.clnu.2015.07.005","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T19:10:47Z","timestamp":1437073847000},"page":"924-927","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Sarcopenia is associated with an increased inflammatory response to surgery in colorectal cancer"],"prefix":"10.1016","volume":"35","author":[{"given":"Kostan W.","family":"Reisinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep P.M.","family":"Derikx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen L.A.","family":"van Vugt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F.","family":"Von Meyenfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel W.","family":"Hulsew\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.M.B.","family":"Stoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"Poeze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2015.07.005_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.amjsurg.2011.08.012","article-title":"Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized","volume":"204","author":"Tan","year":"2012","journal-title":"Am J Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.amjsurg.2011.06.017","article-title":"Frailty predicts increased hospital and six-month healthcare cost following colorectal surgery in older adults","volume":"202","author":"Robinson","year":"2011","journal-title":"Am J Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/SLA.0000000000000628","article-title":"Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery","volume":"261","author":"Reisinger","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib4","doi-asserted-by":"crossref","first-page":"pe24","DOI":"10.1126\/sageke.2005.31.pe24","article-title":"From bedside to bench: research agenda for frailty","volume":"2005","author":"Fried","year":"2005","journal-title":"Sci Aging Knowledge Environ"},{"key":"10.1016\/j.clnu.2015.07.005_bib5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/bjc.2012.350","article-title":"Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery","volume":"107","author":"Lieffers","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clnu.2015.07.005_bib6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/bjs.7823","article-title":"Body composition and outcome in patients undergoing resection of colorectal liver metastases","volume":"99","author":"van Vledder","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clnu.2009.12.004","article-title":"Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) \u201ccachexia-anorexia in chronic wasting diseases\u201d and \u201cnutrition in geriatrics\u201d","volume":"29","author":"Muscaritoli","year":"2010","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.005_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clnu.2011.07.010","article-title":"Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia?","volume":"31","author":"Scheede-Bergdahl","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.005_bib9","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/SLA.0b013e3182a6f45e","article-title":"The HARM score: a novel, easy measure to evaluate quality and outcomes in colorectal surgery","volume":"259","author":"Keller","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib10","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/sj.ijo.0801825","article-title":"Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals","volume":"25","author":"van Dielen","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.clnu.2015.07.005_bib11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0140-6736(90)93237-J","article-title":"Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin","volume":"336","author":"Steinbakk","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2015.07.005_bib12","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(00)03224-4","article-title":"Calprotectin, a faecal marker of organic gastrointestinal abnormality","volume":"356","author":"Fagerhol","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2015.07.005_bib13","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1172\/JCI115767","article-title":"Evidence for the involvement of interleukin 6 in experimental cancer cachexia","volume":"89","author":"Strassmann","year":"1992","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.clnu.2015.07.005_bib14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2015.07.005_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/SLA.0b013e3181784cc5","article-title":"Visceral injury and systemic inflammation in patients undergoing extracorporeal circulation during aortic surgery","volume":"248","author":"Hanssen","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib16","doi-asserted-by":"crossref","first-page":"e41883","DOI":"10.1371\/journal.pone.0041883","article-title":"The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancer","volume":"7","author":"Richards","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2015.07.005_bib17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1445-2197.1988.tb01101.x","article-title":"Protein depletion and surgical risk","volume":"58","author":"Windsor","year":"1988","journal-title":"Aust N Z J Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.bjc.6604828","article-title":"The influence of systemic inflammation, dietary intake and stage of disease on rate of weight loss in patients with gastro-oesophageal cancer","volume":"100","author":"Deans","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clnu.2015.07.005_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.clnu.2015.07.005_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clnu.2013.04.002","article-title":"Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease","volume":"33","author":"Kim","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.005_bib21","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1245\/s10434-012-2498-9","article-title":"C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer","volume":"19","author":"Platt","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clnu.2015.07.005_bib22","first-page":"e345","article-title":"C-reactive protein and procalcitonin for the early detection of anastomotic leakage after elective colorectal surgery: pilot study in 100 patients","volume":"149","author":"Lagoutte","year":"2012","journal-title":"J\u00a0Visc Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/SLA.0b013e31819a4789","article-title":"Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial","volume":"249","author":"Ryan","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2015.07.005_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.clnu.2004.06.009","article-title":"The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively\u2013a randomised clinical trial","volume":"24","author":"Yuill","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2015.07.005_bib25","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clnu.2015.07.005_bib26","doi-asserted-by":"crossref","DOI":"10.1245\/s10434-014-4281-6","article-title":"Sarcopenia is a negative prognostic factor after curative resection of colorectal cancer","author":"Miyamoto","year":"2015","journal-title":"Ann Surg Onol"},{"key":"10.1016\/j.clnu.2015.07.005_bib27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01635581.2014.894103","article-title":"Sarcopenia is linked to treatment toxicity in patients with metastatic colorectal cancer","volume":"66","author":"Barret","year":"2014","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clnu.2015.07.005_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil\u2013lymphocyte ratio: experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.clnu.2015.07.005_bib29","doi-asserted-by":"crossref","first-page":"601S","DOI":"10.1080\/07315724.2004.10719430","article-title":"Protein nutrition, exercise and aging","volume":"23","author":"Evans","year":"2004","journal-title":"J\u00a0Am Coll Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156141500179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156141500179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T18:27:25Z","timestamp":1537468045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156141500179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S026156141500179X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2015.07.005","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcopenia is associated with an increased inflammatory response to surgery in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2015.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}