{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:53:53Z","timestamp":1774968833671,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Baxter IIS","award":["GHOL6273"],"award-info":[{"award-number":["GHOL6273"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.clnu.2016.09.012","type":"journal-article","created":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:07:43Z","timestamp":1474762063000},"page":"1403-1410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease"],"prefix":"10.1016","volume":"36","author":[{"given":"Kiran V.K.","family":"Koelfat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Schaap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.J.M.","family":"Hodin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben G.J.","family":"Visschers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn I.","family":"Svavarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lenicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Shiri-Sverdlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaatje","family":"Lenaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2016.09.012_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"Home artificial N, chronic intestinal F, acute intestinal failure special interest groups of E. ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults","volume":"34","author":"Pironi","year":"2015","journal-title":"Clin Nutr"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.clnu.2016.09.012_bib2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-2036.2000.014s2054.x","article-title":"Review article: hepatobiliary complications associated with total parenteral nutrition","volume":"14","author":"Angelico","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2016.09.012_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/abbi.1999.1295","article-title":"Small and large unilamellar vesicle membranes as model system for bile acid diffusion in hepatocytes","volume":"368","author":"Hofmann","year":"1999","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.clnu.2016.09.012_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7326\/0003-4819-132-7-200004040-00003","article-title":"Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure","volume":"132","author":"Cavicchi","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clnu.2016.09.012_bib5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/0148607113491436","article-title":"Omega-3 fatty acids prevent hepatic steatosis, independent of PPAR-alpha activity, in a murine model of parenteral nutrition-associated liver disease","volume":"38","author":"Prince","year":"2014","journal-title":"J\u00a0Parenter Enternal Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jpedsurg.2012.08.016","article-title":"The effect of lipid restriction on the prevention of parenteral nutrition-associated cholestasis in surgical infants","volume":"48","author":"Sanchez","year":"2013","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2016.09.012_bib7","first-page":"234","article-title":"Evaluation of parenteral nutrition-associated liver disease in infants with necrotizing enterocolitis before and after the implementation of feeding guidelines","volume":"29","author":"Tillman","year":"2014","journal-title":"Nutr Clin Pract Off Publ Am Soc Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/gastro\/gov011","article-title":"Fish oil-based lipid emulsion: current updates on a promising novel therapy for the management of parenteral nutrition-associated liver disease","volume":"3","author":"Bharadwaj","year":"2015","journal-title":"Gastroenterol Rep"},{"key":"10.1016\/j.clnu.2016.09.012_bib9","first-page":"39S","article-title":"Phytosterols, lipid administration, and liver disease during parenteral nutrition","volume":"39","author":"Zaloga","year":"2015","journal-title":"J\u00a0Parenter Enternall Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib10","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/BF02088759","article-title":"Total parenteral nutrition impairs bile flow and alters bile composition in newborn piglet","volume":"41","author":"Duerksen","year":"1996","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.clnu.2016.09.012_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.WNO.0000161661.29391.0D","article-title":"Reduced bile flow associated with parenteral nutrition is independent of oxidant load and parenteral multivitamins","volume":"41","author":"Lavoie","year":"2005","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib12","doi-asserted-by":"crossref","first-page":"G93","DOI":"10.1152\/ajpgi.00252.2015","article-title":"Dysregulation of bile acid homeostasis in parenteral nutrition mouse model","volume":"310","author":"Zhan","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2016.09.012_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006898","article-title":"Phytosterols promote liver injury and kupffer cell activation in parenteral nutrition-associated liver disease","volume":"5","author":"Kasmi","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.clnu.2016.09.012_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrgastro.2013.151","article-title":"Bile acid receptors as targets for drug development","volume":"11","author":"Schaap","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2016.09.012_bib15","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1194\/jlr.R049437","article-title":"Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades","volume":"55","author":"Hofmann","year":"2014","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clnu.2016.09.012_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell metab"},{"key":"10.1016\/j.clnu.2016.09.012_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A\u00a0regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol cell"},{"key":"10.1016\/j.clnu.2016.09.012_bib18","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep.25740","article-title":"Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2016.09.012_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/j.gastro.2011.10.028","article-title":"Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis","volume":"142","author":"Modica","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2016.09.012_bib20","doi-asserted-by":"crossref","first-page":"G218","DOI":"10.1152\/ajpgi.00280.2011","article-title":"Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs","volume":"302","author":"Jain","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2016.09.012_bib21","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hep.25500","article-title":"Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury","volume":"55","author":"El Kasmi","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2016.09.012_bib22","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s00383-005-1541-3","article-title":"Taurine and cholestasis associated to TPN. Experimental study in rabbit model","volume":"21","author":"Moran","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.clnu.2016.09.012_bib23","first-page":"96","article-title":"Development of a reproducible model of parenteral nutrition-associated liver disease in rats","volume":"26","author":"Whitehead","year":"2015","journal-title":"Eur J Pediatr Surg Off J Austrian Assoc Pediatr Surg [et\u00a0al] Z Kinderchir"},{"key":"10.1016\/j.clnu.2016.09.012_bib24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1194\/jlr.M044545","article-title":"New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs","volume":"55","author":"Vlaardingerbroek","year":"2014","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clnu.2016.09.012_bib25","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.amjsurg.2007.07.017","article-title":"Decreased bile acid synthesis with total parenteral nutrition","volume":"194","author":"Dawes","year":"2007","journal-title":"Am J Surg"},{"key":"10.1016\/j.clnu.2016.09.012_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/jsre.1996.4953","article-title":"Cholecystokinin increases bile acid synthesis with total parenteral nutrition but does not prevent stone formation","volume":"67","author":"Dawes","year":"1997","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.clnu.2016.09.012_bib27","first-page":"2141","article-title":"Total parenteral nutrition induces a shift in the Firmicutes to Bacteroidetes ratio in association with Paneth cell activation in rats","volume":"142","author":"Hodin","year":"2012","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jhep.2005.10.033","article-title":"Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates","volume":"44","author":"Shiri-Sverdlov","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.clnu.2016.09.012_bib29","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1177\/014860710202600512","article-title":"Total parenteral nutrition-associated liver disease","volume":"26","author":"Buchman","year":"2002","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib30","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1053\/j.gastro.2005.10.066","article-title":"Intestinal failure-associated liver disease: what do we know today?","volume":"130","author":"Kelly","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2016.09.012_bib31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/0148607190014005442","article-title":"Bulk prevents bacterial translocation induced by the oral administration of total parenteral nutrition solution","volume":"14","author":"Spaeth","year":"1990","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib32","doi-asserted-by":"crossref","first-page":"G1162","DOI":"10.1152\/ajpgi.00243.2003","article-title":"Total parenteral nutrition adversely affects gut barrier function in neonatal piglets","volume":"285","author":"Kansagra","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2016.09.012_bib33","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.clnu.2016.09.012_bib34","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1152\/ajpendo.00064.2004","article-title":"Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population","volume":"288","author":"Szczepaniak","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.clnu.2016.09.012_bib35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.clnu.2009.03.001","article-title":"Development of hypertriglyceridemia in patients with enterocutaneous fistulas","volume":"28","author":"Visschers","year":"2009","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1177\/0148607110389616","article-title":"Treatment of hypertriglyceridemia in patients receiving parenteral nutrition","volume":"35","author":"Visschers","year":"2011","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0899-9007(97)00232-3","article-title":"Liver complications of pediatric parenteral nutrition\u2014epidemiology","volume":"14","author":"Kelly","year":"1998","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2016.09.012_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00003246-199702000-00009","article-title":"Randomized, double-blind study of intravenous human albumin in hypoalbuminemic patients receiving total parenteral nutrition","volume":"25","author":"Rubin","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnu.2016.09.012_bib39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0261-5614(86)90024-5","article-title":"The role of hypoalbuminemia in the development of the TPN-associated cholestasis","volume":"5","author":"Kalfarentzos","year":"1986","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib40","doi-asserted-by":"crossref","first-page":"743","DOI":"10.7326\/0003-4819-79-5-743","article-title":"Editorial: bile acid breath test: extremely simple, moderately useful","volume":"79","author":"Hofmann","year":"1973","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clnu.2016.09.012_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbadis.2014.02.004","article-title":"FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model","volume":"1842","author":"Kunne","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clnu.2016.09.012_bib42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1203\/PDR.0b013e3181256492","article-title":"Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR","volume":"62","author":"Carter","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clnu.2016.09.012_bib43","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1534-5807(02)00187-9","article-title":"Redundant pathways for negative feedback regulation of bile acid production","volume":"2","author":"Wang","year":"2002","journal-title":"Dev Cell"},{"issue":"9","key":"10.1016\/j.clnu.2016.09.012_bib44","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.ajpath.2016.05.006","article-title":"The detrimental role played by Lipocalin-2 in alcoholic fatty liver in mice","volume":"186","author":"Yan","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clnu.2016.09.012_bib45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/0148607113476751","article-title":"Vivo degradation of cholesterol to bile acids is reduced in patients receiving parenteral nutrition","volume":"38","author":"Carulli","year":"2013","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2016.09.012_bib46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/0148607115595596","article-title":"Glucagon-like Peptide-2 alters bile acid metabolism in parenteral nutrition\u2013associated liver disease","volume":"40","author":"Lim","year":"2016","journal-title":"J\u00a0Parenter Enteral Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156141631250X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156141631250X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T21:13:02Z","timestamp":1770844382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156141631250X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S026156141631250X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2016.09.012","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2016.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}