{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:18:29Z","timestamp":1790824709193,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"crossref","award":["3271"],"award-info":[{"award-number":["3271"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.clnu.2016.12.004","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T18:15:44Z","timestamp":1482084944000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial"],"prefix":"10.1016","volume":"37","author":[{"given":"Mohammad Hashem","family":"Hashempur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sadrneshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hamdollah","family":"Mosavat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2016.12.004_bib1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2016.04.035","article-title":"Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: a randomized, double-blind, active-controlled trial","volume":"188","author":"Jabbari","year":"2016","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.clnu.2016.12.004_bib2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/j.1532-5415.1999.tb01563.x","article-title":"Prevalence of significant knee pain among older Americans: results from the third national health and nutrition examination survey","volume":"47","author":"Andersen","year":"1999","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.clnu.2016.12.004_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/1756-185X.12312","article-title":"Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study","volume":"17","author":"Tehrani-Banihashemi","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.clnu.2016.12.004_bib4","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/ard.2004.023564","article-title":"Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study)","volume":"64","author":"Dahaghin","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clnu.2016.12.004_bib5","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet (London)"},{"key":"10.1016\/j.clnu.2016.12.004_bib6","first-page":"335","article-title":"The relationship between disease symptoms, life events, coping and treatment, and depression among older adults with osteoarthritis","volume":"35","author":"Sale","year":"2008","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clnu.2016.12.004_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF03324607","article-title":"Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls","volume":"17","author":"Salaffi","year":"2005","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.clnu.2016.12.004_bib8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/rheumatology\/kem013","article-title":"Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3)","volume":"46","author":"Jinks","year":"2007","journal-title":"Rheumatol (Oxford)"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.clnu.2016.12.004_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.semarthrit.2005.02.005","article-title":"Do physicians treat symptomatic osteoarthritis patients properly? Results of the AMICA experience","volume":"35","author":"Sarzi-Puttini","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.clnu.2016.12.004_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4166\/kjg.2016.67.6.300","article-title":"Nonsteroidal anti-inflammatory drug and aspirin-induced peptic ulcer disease","volume":"67","author":"Shim","year":"2016","journal-title":"Korean J Gastroenterol"},{"key":"10.1016\/j.clnu.2016.12.004_bib11","first-page":"CD002765","article-title":"Effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function","volume":"2","author":"Lee","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clnu.2016.12.004_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S2095-4964(15)60196-0","article-title":"Complementary and alternative medicine use in Iranian patients with diabetes mellitus","volume":"13","author":"Hashempur","year":"2015","journal-title":"J\u00a0Integr Med"},{"key":"10.1016\/j.clnu.2016.12.004_bib13","first-page":"JE01","article-title":"Use of complementary and alternative medicine among osteoarthritic patients: a review","volume":"10","author":"Khan","year":"2016","journal-title":"J\u00a0Clin Diagn Res JCDR"},{"key":"10.1016\/j.clnu.2016.12.004_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/ar3428","article-title":"Green tea: a new option for the prevention or control of osteoarthritis","volume":"13","author":"Katiyar","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clnu.2016.12.004_bib15","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/ar3368","article-title":"Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes","volume":"13","author":"Akhtar","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clnu.2016.12.004_bib16","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.96.8.4524","article-title":"Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea","volume":"96","author":"Haqqi","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2016.12.004_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ctcp.2015.06.003","article-title":"Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for\u00a0knee osteoarthritis: a randomized controlled clinical trial","volume":"21","author":"Shoara","year":"2015","journal-title":"Complement\u00a0Ther Clin Pract"},{"key":"10.1016\/j.clnu.2016.12.004_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4055\/cios.2014.6.1.103","article-title":"How to do random allocation (randomization)","volume":"6","author":"Kim","year":"2014","journal-title":"Clin Orthop Surg"},{"key":"10.1016\/j.clnu.2016.12.004_bib19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.eujim.2015.08.008","article-title":"The effect of leek (Allium iranicum (Wendelbo)) leaves extract cream on hemorrhoid patients: a double blind randomized controlled clinical trial","volume":"7","author":"Mosavat","year":"2015","journal-title":"Eur J Integr Med"},{"key":"10.1016\/j.clnu.2016.12.004_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0261-5614(13)60392-1","article-title":"PP081-MON green tea catechin epigallocatechin-3-gallate (EGCG) increases the anti-tumoural effect of ionizing radiation in an in\u00a0vitro model of advanced prostate cancer","volume":"32","author":"Lecumberri","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2016.12.004_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8546-5-13","article-title":"Beneficial effects of green tea: a literature review","volume":"5","author":"Chacko","year":"2010","journal-title":"Chin Med"},{"key":"10.1016\/j.clnu.2016.12.004_bib22","first-page":"591","article-title":"Green tea: potential health benefits","volume":"79","author":"Schneider","year":"2009","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.clnu.2016.12.004_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.canlet.2008.04.014","article-title":"Multitargeted therapy of cancer by green tea polyphenols","volume":"269","author":"Khan","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.clnu.2016.12.004_bib24","doi-asserted-by":"crossref","first-page":"e0156902","DOI":"10.1371\/journal.pone.0156902","article-title":"Identification of targets of a new nutritional mixture for osteoarthritis management composed by curcuminoids extract, hydrolyzed collagen and green tea extract","volume":"11","author":"Comblain","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2016.12.004_bib25","doi-asserted-by":"crossref","first-page":"e0121654","DOI":"10.1371\/journal.pone.0121654","article-title":"Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer","volume":"10","author":"Comblain","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2016.12.004_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fphar.2013.00051","article-title":"Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in\u00a0vitro","volume":"4","author":"Oliviero","year":"2013","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.clnu.2016.12.004_bib27","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/ar2700","article-title":"Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes","volume":"11","author":"Rasheed","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clnu.2016.12.004_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1124\/jpet.103.059220","article-title":"Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1\u03b2-induced expression of matrix metalloproteinase-1 and-13 in human chondrocytes","volume":"308","author":"Ahmed","year":"2004","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.clnu.2016.12.004_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0091-7435(92)90041-F","article-title":"Green tea composition, consumption, and polyphenol chemistry","volume":"21","author":"Graham","year":"1992","journal-title":"Prev Med"},{"issue":"06","key":"10.1016\/j.clnu.2016.12.004_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-2006-961535","article-title":"Anti-inflammatory activity of gallic acid","volume":"58","author":"Kroes","year":"1992","journal-title":"Planta Med"},{"key":"10.1016\/j.clnu.2016.12.004_bib31","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1021\/jf9602535","article-title":"Antioxidant capacity of tea and common vegetables","volume":"44","author":"Cao","year":"1996","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.clnu.2016.12.004_bib32","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.clnu.2006.01.022","article-title":"The effect of green tea in oxidative stress","volume":"31","author":"Coimbra","year":"2006","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2016.12.004_bib33","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/jcp.21317","article-title":"Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes","volume":"215","author":"Im","year":"2008","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.clnu.2016.12.004_bib34","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/ar2463","article-title":"Nitric oxide in inflammation and pain associated with osteoarthritis","volume":"10","author":"Abramson","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clnu.2016.12.004_bib35","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.clnu.2015.05.003","article-title":"Therapeutic effect of high-dose green tea extract on weight reduction: a randomized, double-blind, placebo-controlled clinical trial","volume":"30","author":"Chen","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2016.12.004_bib36","article-title":"Green tea extract activates AMPK and ameliorates white adipose tissue metabolic dysfunction induced by obesity","author":"Rocha","year":"2015","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.clnu.2016.12.004_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/mnfr.200500102","article-title":"Anti-obesity effects of green tea: from bedside to bench","volume":"50","author":"Wolfram","year":"2006","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.clnu.2016.12.004_bib38","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1016\/j.joca.2013.02.542","article-title":"Changes in knee pain, perceived need for surgery, physical function and quality of life after dietary weight loss in obese women diagnosed with knee osteoarthritis","volume":"21","author":"Coriolano","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.clnu.2016.12.004_bib39","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.joca.2016.01.084","article-title":"Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the intensive diet and exercise for arthritis trial (IDEA)","volume":"24","author":"Loeser","year":"2016","journal-title":"Osteoarthr Cartil"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561416313450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561416313450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:29:34Z","timestamp":1749839374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561416313450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0261561416313450"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2016.12.004","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2016.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}