{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:21:02Z","timestamp":1787851262596,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"BioActor BV"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.clnu.2017.01.024","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T08:16:17Z","timestamp":1486196177000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial"],"prefix":"10.1016","volume":"37","author":[{"given":"Bouke N.","family":"Salden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy J.","family":"Troost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Wilms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Truchado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro","family":"Vilchez-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar H.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy","family":"J\u00e1uregui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Marzorati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van de Wiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Possemiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad A.","family":"Masclee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clnu.2017.01.024_bib1","first-page":"1077","article-title":"Gut barrier in health and disease: focus on childhood","volume":"19","author":"Viggiano","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"10.1016\/j.clnu.2017.01.024_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1756283X13482996","article-title":"Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ","volume":"6","author":"Guinane","year":"2013","journal-title":"Ther Adv Gastroenterol"},{"issue":"8","key":"10.1016\/j.clnu.2017.01.024_bib3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.clnu.2017.01.024_bib4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"Hotamisligil","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.clnu.2017.01.024_bib5","first-page":"1401","article-title":"Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J\u00a0Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2017.01.024_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1574-6941.2009.00712.x","article-title":"Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem","volume":"69","author":"Grootaert","year":"2009","journal-title":"FEMS Microbiol Ecol"},{"issue":"11","key":"10.1016\/j.clnu.2017.01.024_bib7","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1021\/jf070293g","article-title":"In\u00a0vitro fermentation by human fecal microflora of wheat arabinoxylans","volume":"55","author":"Hughes","year":"2007","journal-title":"J\u00a0Agric food Chem"},{"issue":"4","key":"10.1016\/j.clnu.2017.01.024_bib8","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1021\/jf073127h","article-title":"Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract","volume":"56","author":"Monobe","year":"2008","journal-title":"J\u00a0Agric food Chem"},{"issue":"6","key":"10.1016\/j.clnu.2017.01.024_bib9","doi-asserted-by":"crossref","first-page":"e20944","DOI":"10.1371\/journal.pone.0020944","article-title":"Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides\/Prevotella in diet-induced obese mice","volume":"6","author":"Neyrinck","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.clnu.2017.01.024_bib10","first-page":"51","article-title":"Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets","volume":"145","author":"Chen","year":"2015","journal-title":"J\u00a0Nutr"},{"issue":"41","key":"10.1016\/j.clnu.2017.01.024_bib11","doi-asserted-by":"crossref","first-page":"9819","DOI":"10.1021\/jf4021784","article-title":"Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin","volume":"61","author":"Van den Abbeele","year":"2013","journal-title":"J\u00a0Agric Food Chem"},{"issue":"10","key":"10.1016\/j.clnu.2017.01.024_bib12","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1111\/j.1462-2920.2011.02533.x","article-title":"Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats","volume":"13","author":"Van den Abbeele","year":"2011","journal-title":"Environ Microbiol"},{"issue":"3","key":"10.1016\/j.clnu.2017.01.024_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/apt.12829","article-title":"Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders","volume":"40","author":"Mujagic","year":"2014","journal-title":"Alimentary Pharmacol Ther"},{"issue":"26","key":"10.1016\/j.clnu.2017.01.024_bib14","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1016\/j.jchromb.2011.08.002","article-title":"Novel analytical approach to a multi-sugar whole gut permeability assay","volume":"879","author":"van Wijck","year":"2011","journal-title":"J\u00a0Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.clnu.2017.01.024_bib15","doi-asserted-by":"crossref","first-page":"G147","DOI":"10.1152\/ajpgi.00330.2013","article-title":"Large intestine permeability is increased in patients with compensated liver cirrhosis","volume":"306","author":"Pijls","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.clnu.2017.01.024_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/apt.12842","article-title":"Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome","volume":"40","author":"Keszthelyi","year":"2014","journal-title":"Alimentary Pharmacol Ther"},{"key":"10.1016\/j.clnu.2017.01.024_bib17","doi-asserted-by":"crossref","first-page":"e1602","DOI":"10.7717\/peerj.1602","article-title":"Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene","volume":"4","author":"Verstraelen","year":"2016","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.clnu.2017.01.024_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.femsec.2004.05.002","article-title":"PCR-DGGE-based quantification of stability of the microbial community in a simulator of the human intestinal microbial ecosystem","volume":"49","author":"Possemiers","year":"2004","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.clnu.2017.01.024_bib19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0003-2670(00)88973-4","article-title":"Steam distillation methods for determination of ammonium, nitrate and nitrite","volume":"32","author":"Bremner","year":"1965","journal-title":"Anal Chem Acta"},{"issue":"2","key":"10.1016\/j.clnu.2017.01.024_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01535722","article-title":"GSRS\u2013a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund","year":"1988","journal-title":"Dig Dis Sci"},{"issue":"9","key":"10.1016\/j.clnu.2017.01.024_bib21","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/mnfr.201200082","article-title":"HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice","volume":"56","author":"Kim","year":"2012","journal-title":"Mol Nutr food Res"},{"issue":"5","key":"10.1016\/j.clnu.2017.01.024_bib22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.clnu.2012.02.009","article-title":"Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors","volume":"31","author":"Teixeira","year":"2012","journal-title":"Clin Nutr"},{"issue":"11\u201312","key":"10.1016\/j.clnu.2017.01.024_bib23","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1365-2036.2010.04475.x","article-title":"Pilot study: alterations of intestinal microbiota in obese humans are not associated with colonic inflammation or disturbances of barrier function","volume":"32","author":"Brignardello","year":"2010","journal-title":"Alimentary Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.clnu.2017.01.024_bib24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/1574-6941.12228","article-title":"A\u00a0gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome","volume":"87","author":"Xiao","year":"2014","journal-title":"FEMS Microbiol Ecol"},{"issue":"12","key":"10.1016\/j.clnu.2017.01.024_bib25","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","volume":"17","author":"Canani","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"10","key":"10.1016\/j.clnu.2017.01.024_bib26","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1017\/S0007114511007252","article-title":"Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties","volume":"108","author":"Lecerf","year":"2012","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2017.01.024_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.ejcn.1600668","article-title":"Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects","volume":"53","author":"van Dokkum","year":"1999","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2017.01.024_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1039\/C0FO00101E","article-title":"Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects","volume":"2","author":"Slavin","year":"2011","journal-title":"Food Funct"},{"issue":"9","key":"10.1016\/j.clnu.2017.01.024_bib29","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","article-title":"Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications","volume":"94","author":"Goldberg","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clnu.2017.01.024_bib30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/sj.ejcn.1601857","article-title":"Arabinoxylan fibre improves metabolic control in people with Type II diabetes","volume":"58","author":"Lu","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2017.01.024_bib31","series-title":"Microbiological aspects of production of short-chain fatty acids in the large bowel","author":"Macfarlane","year":"1999"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561417300481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561417300481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T09:02:50Z","timestamp":1529917370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561417300481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0261561417300481"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2017.01.024","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2017.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}