{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:05:33Z","timestamp":1780520733541,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007254","name":"Creighton University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.clnu.2017.04.020","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T20:46:04Z","timestamp":1493498764000},"page":"1041-1045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2\u00a0and\u00a0D3 Supplementation in patients with chronic kidney disease\u00a0on\u00a0hemodialysis"],"prefix":"10.1016","volume":"37","author":[{"given":"Laura A.","family":"Graeff-Armas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenville","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2017.04.020_bib1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1525-139X.2007.00302.x","article-title":"Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3)","volume":"20","author":"Jones","year":"2007","journal-title":"Semin Dial"},{"key":"10.1016\/j.clnu.2017.04.020_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000098561","article-title":"Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney disease","volume":"27","author":"Zisman","year":"2007","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.clnu.2017.04.020_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.ajkd.2007.04.010","article-title":"Changes in serum 25-hydroxyvitamin D and plasma intact PTH levels following treatment with ergocalciferol in patients with CKD","volume":"50","author":"Al-Aly","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clnu.2017.04.020_bib4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2215\/CJN.08610812","article-title":"Calcium absorption response to cholecalciferol supplementation in hemodialysis","volume":"8","author":"Armas","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clnu.2017.04.020_bib5","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2215\/CJN.12761211","article-title":"25-hydroxyvitamin D response to cholecalciferol supplementation in hemodialysis","volume":"7","author":"Armas","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clnu.2017.04.020_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-nutr-071812-161203","article-title":"Extrarenal vitamin D activation and interactions between vitamin D(2), vitamin D(3), and vitamin D analogs","volume":"33","author":"Jones","year":"2013","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.clnu.2017.04.020_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/bbrc.1996.1154","article-title":"Evidence for a 24R,25(OH)2-vitamin D3 receptor\/binding protein in a membrane fraction isolated from a chick tibial fracture-healing callus","volume":"225","author":"Seo","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.clnu.2017.04.020_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S8756-3282(98)00085-4","article-title":"Studies on 24R,25-dihydroxyvitamin D3: evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus","volume":"23","author":"Kato","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.clnu.2017.04.020_bib9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/jcem-46-2-284","article-title":"Vitamin D metabolites and bone mineralization in man","volume":"46","author":"Bordier","year":"1978","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2017.04.020_bib10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mce.2011.05.018","article-title":"Vitamin D metabolism, cartilage and bone fracture repair","volume":"347","author":"St-Arnaud","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.clnu.2017.04.020_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI110023","article-title":"Impaired 24,25-dihydroxyvitamin D production in anephric human and pig","volume":"67","author":"Horst","year":"1981","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.clnu.2017.04.020_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ki.1983.33","article-title":"Extra-renal production of 24,25-dihydroxyvitamin D in chronic renal failure during 25 hydroxyvitamin D3 therapy","volume":"23","author":"Zerwekh","year":"1983","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J\u00a0Bone Min Res"},{"key":"10.1016\/j.clnu.2017.04.020_bib14","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib15","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/ki.2008.453","article-title":"Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation","volume":"74","author":"Zehnder","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ki.2010.168","article-title":"Dysregulation of renal vitamin D metabolism in the uremic rat","volume":"78","author":"Helvig","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.abb.2011.11.003","article-title":"25-hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D","volume":"523","author":"Jones","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.clnu.2017.04.020_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MNH.0b013e3283477a7b","article-title":"CYP24A1 and kidney disease","volume":"20","author":"Petkovich","year":"2011","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.clnu.2017.04.020_bib19","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1046\/j.1523-1755.1999.0550031019.x","article-title":"Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure","volume":"55","author":"Ishimura","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ki.2012.222","article-title":"Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites","volume":"82","author":"Dai","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib21","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1210\/jc.2013-4388","article-title":"Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS\/MS involving derivatization with DMEQ-TAD","volume":"99","author":"Kaufmann","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2017.04.020_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1053\/j.ajkd.2014.02.015","article-title":"Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials","volume":"64","author":"de Boer","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clnu.2017.04.020_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2011.05.003","article-title":"The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation","volume":"126","author":"Wagner","year":"2011","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.clnu.2017.04.020_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ki.2012.193","article-title":"The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease","volume":"82","author":"Bosworth","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.clnu.2017.04.020_bib25","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.2215\/CJN.03130314","article-title":"Decreased conversion of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 following cholecalciferol therapy in patients with CKD","volume":"9","author":"Stubbs","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clnu.2017.04.020_bib26","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1373\/clinchem.2014.234955","article-title":"Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: a double-edged sword?","volume":"61","author":"Cashman","year":"2015","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2017.04.020_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1172\/JCI81928","article-title":"CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders","volume":"126","author":"Bai","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.clnu.2017.04.020_bib28","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1210\/en.2015-1664","article-title":"Both a high-calcium, high lactose rescue diet and VDR-expressing transgenes normalize serum vitamin D metabolite profiles and renal CYP27B1 and CYP24A1 expression in VDR-null mice. [Electronic version]","volume":"156","author":"Kaufmann","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnu.2017.04.020_bib29","series-title":"DRI dietary reference intakes for calcium\u00a0and vitamin D","author":"Ross","year":"2011"},{"key":"10.1016\/j.clnu.2017.04.020_bib30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jbmr.328","article-title":"Why the IOM recommendations for vitamin D are deficient","volume":"26","author":"Heaney","year":"2011","journal-title":"J\u00a0Bone Min Res"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561417301590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561417301590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T18:07:54Z","timestamp":1571249274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561417301590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0261561417301590"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2017.04.020","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2\u00a0and\u00a0D3 Supplementation in patients with chronic kidney disease\u00a0on\u00a0hemodialysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2017.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}