{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:39:39Z","timestamp":1789137579714,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.clnu.2018.01.034","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:34:41Z","timestamp":1518701681000},"page":"197-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Vitamin\/mineral and micronutrient status in patients with classical phenylketonuria"],"prefix":"10.1016","volume":"38","author":[{"given":"Engin","family":"Kose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2018.01.034_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ymgme.2015.06.010","article-title":"Vitamin and mineral status in patients with hyperphenylalaninemia","volume":"115","author":"Crujeiras","year":"2015","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib2","unstructured":"Scriver CR, Kaufman S. Hyperphenylalaninemia: phenylalanine hydroxylase deficiency. In: Scriver CR, Beaudet AL, Sly SW, Valle D, editors; Childs B, Kinzler KW, Vogelstein B, assoc editors. The metabolic and molecular bases of inherited disease. 8th ed. New York, NY: McGraw-Hill; 2001. p. 1667\u20131724."},{"key":"10.1016\/j.clnu.2018.01.034_bib3","first-page":"31","article-title":"Phenylketonuria: an inborn error of phenylalanine metabolism","volume":"29","author":"Williams","year":"2008","journal-title":"Clin Biochem Rev"},{"key":"10.1016\/j.clnu.2018.01.034_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2005.06.025","article-title":"Identification of an intestinal heme transporter","volume":"122","author":"Shayeghi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2018.01.034_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1079\/NRR19960016","article-title":"Bioavailability of minerals and trace elements","volume":"9","author":"Fairweather-Tait","year":"1996","journal-title":"Nutr Res Rev"},{"issue":"Suppl","key":"10.1016\/j.clnu.2018.01.034_bib6","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ymgme.2013.08.008","article-title":"Main issues in micronutrient supplementation in phenylketonuria","volume":"110","author":"Lammardo","year":"2013","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/gim.2013.157","article-title":"Phenylalanine hydroxylase deficiency: diagnosis and management guideline","volume":"16","author":"Vockley","year":"2014","journal-title":"Genet Med"},{"key":"10.1016\/j.clnu.2018.01.034_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2010.11.004","article-title":"Risks and benefits of copper in light of new insights of copper homeostasis","volume":"25","author":"de Romana","year":"2011","journal-title":"J\u00a0Trace Elem Med Biol"},{"key":"10.1016\/j.clnu.2018.01.034_bib9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cca.2011.12.005","article-title":"Pediatric reference intervals for serum copper and zinc","volume":"413","author":"Lin","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.clnu.2018.01.034_bib10","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.clinbiochem.2014.03.025","article-title":"Pediatric reference value distributions for vitamins A and E in the CALIPER cohort and establishment of age-stratified reference intervals","volume":"47","author":"Raizman","year":"2014","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clnu.2018.01.034_bib11","series-title":"Tietz textbook of clinical chemistry and molecular diagnostics","first-page":"2251","article-title":"Reference information for the clinical laboratory","author":"Roberts","year":"2006"},{"key":"10.1016\/j.clnu.2018.01.034_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000363391","article-title":"The micronutrient status of patients with phenylketonuria on dietary treatment: an ongoing challenge","volume":"65","author":"Evans","year":"2014","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0899-9007(99)00082-9","article-title":"Plasma zinc, copper, and erythrocyte superoxide dismutase in children with phenylketonuria","volume":"15","author":"Fisberg","year":"1999","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2018.01.034_bib14","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10545-008-0960-4","article-title":"Long-term compliance with a novel vitamin and mineral supplement in older people with PKU","volume":"31","author":"MacDonald","year":"2008","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.clnu.2018.01.034_bib15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/07315724.2001.10719016","article-title":"Iron and protein sufficiency and red cell indices in phenylketonuria","volume":"20","author":"Arnold","year":"2001","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/adc.71.2.114","article-title":"Impaired prenatal and postnatal growth in Dutch patients with phenylketonuria. The National PKU Steering Committee","volume":"71","author":"Verkerk","year":"1994","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clnu.2018.01.034_bib17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1651-2227.1997.tb08603.x","article-title":"Does impaired growth of PKU patients correlate with the strictness of dietary treatment? National Dutch PKU Steering Committee","volume":"86","author":"van Spronsen","year":"1997","journal-title":"Acta Paediatr"},{"issue":"Suppl","key":"10.1016\/j.clnu.2018.01.034_bib18","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.ymgme.2011.07.020","article-title":"Vitamin B12 deficiency and phenylketonuria","volume":"104","author":"Walter","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib19","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-3476(00)90022-2","article-title":"Increased risk of vitamin B12 deficiency in patients with phenylketonuria on an unrestricted or relaxed diet","volume":"136","author":"Robinson","year":"2000","journal-title":"J\u00a0Pediatr"},{"issue":"Suppl","key":"10.1016\/j.clnu.2018.01.034_bib20","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ymgme.2011.08.023","article-title":"Nutrition in phenylketonuria","volume":"104","author":"MacDonald","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/nu8030124","article-title":"Nutritional risk, micronutrient status and clinical outcomes: a prospective observational study in an infectious disease clinic","volume":"8","author":"Dizdar","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2018.01.034_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/1119-3077.181401","article-title":"Evaluation of serum Vitamin B12 level and related nutritional status among apparently healthy obese female individuals","volume":"20","author":"Baltaci","year":"2017","journal-title":"Niger J Clin Pract"},{"key":"10.1016\/j.clnu.2018.01.034_bib23","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3109\/14767058.2011.648244","article-title":"Vitamin B12 and folate statuses are associated with diet in pregnant women, but not with anthropometric measurements in term newborns","volume":"25","author":"Halicioglu","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.clnu.2018.01.034_bib24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1017\/S104795111500150X","article-title":"Comparison of atherogenic risk factors among poorly-controlled and well-controlled adolescent phenylketonuria patients","volume":"26","author":"Gunduz","year":"2016","journal-title":"Cardiol Young"},{"key":"10.1016\/j.clnu.2018.01.034_bib25","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0002-8223(21)02227-6","article-title":"Use of retinol-binding protein and prealbumin as indicators of the response to nutrition therapy","volume":"89","author":"Winkler","year":"1989","journal-title":"J\u00a0Am Diet Assoc"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.clnu.2018.01.034_bib26","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1007\/PL00014231","article-title":"Nutrition studies in treated infants and children with phenylketonuria: vitamins, minerals, trace elements","volume":"155","author":"Acosta","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clnu.2018.01.034_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1067\/mpd.2002.126455","article-title":"Protein insufficiency and linear growth restriction in phenylketonuria","volume":"141","author":"Arnold","year":"2002","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2018.01.034_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000276641","article-title":"The use of prealbumin concentration as a biomarker of nutritional status in treated phenylketonuric patients","volume":"56","author":"Rocha","year":"2010","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.clnu.2018.01.034_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1024063726046","article-title":"Evaluation of nutritional status and pathophysiology of growth retardation in patients with phenylketonuria","volume":"26","author":"Dobbelaere","year":"2003","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.clnu.2018.01.034_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.clnu.2003.09.006","article-title":"The association of serum lipids, lipoproteins and apolipoproteins with selected trace elements and minerals in phenylketonuric patients on diet","volume":"23","author":"Schulpis","year":"2004","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nutres.2007.12.009","article-title":"Poor zinc and selenium status in phenylketonuric children and adolescents in Brazil","volume":"28","author":"Barretto","year":"2008","journal-title":"Nutr Res"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.clnu.2018.01.034_bib32","doi-asserted-by":"crossref","first-page":"A32","DOI":"10.1007\/BF00442054","article-title":"Trace elements nutriture in hyperphenylalaninemic patients. Long-term follow up study","volume":"146","author":"Longhi","year":"1987","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clnu.2018.01.034_bib33","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/ajcn\/55.5.997","article-title":"Bone mineral status in children with phenylketonuria\u2013relationship to nutritional intake and phenylalanine control","volume":"55","author":"McMurry","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/BF01805600","article-title":"The effect of treatment on zinc, copper and calcium status in children with phenylketonuria","volume":"7","author":"Taylor","year":"1984","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.clnu.2018.01.034_bib35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/0148607181005005406","article-title":"Zinc and copper status of treated children with phenylketonuria","volume":"5","author":"Acosta","year":"1981","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib36","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3945\/ajcn.2009.27230G","article-title":"Methods of assessment of zinc status in humans: a systematic review","volume":"89","author":"Lowe","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"Suppl.\u00a03","key":"10.1016\/j.clnu.2018.01.034_bib37","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1017\/S0007114508006818","article-title":"Indicators of zinc status at the population level: a review of the evidence","volume":"99","author":"Gibson","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0002-8223(21)06859-0","article-title":"Trace element status of children with PKU and normal children","volume":"88","author":"Gropper","year":"1988","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.clnu.2018.01.034_bib39","first-page":"568","article-title":"Plasma zinc and copper in infants with protein-calorie malnutrition","volume":"34","author":"Fisberg","year":"1984","journal-title":"Arch Latinoam Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s10545-007-0462-9","article-title":"Peak bone mass in patients with phenylketonuria","volume":"30","author":"Modan-Moses","year":"2007","journal-title":"J\u00a0Inherit Metab Dis"},{"key":"10.1016\/j.clnu.2018.01.034_bib41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4274\/jcrpe.1938","article-title":"Factors influencing serum vitamin D concentration in Turkish children residing in \u0130zmir: a single- center experience","volume":"7","author":"G\u00fclez","year":"2015","journal-title":"J\u00a0Clin Res Pediatr Endocrinol"},{"key":"10.1016\/j.clnu.2018.01.034_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/ajcn\/77.1.185","article-title":"Lipophilic antioxidants in patients with phenylketonuria","volume":"77","author":"Colom\u00e9","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/sj.ejcn.1601529","article-title":"Effect of diet on plasma total antioxidant status in phenylketonuric patients","volume":"57","author":"Schulpis","year":"2003","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2018.01.034_bib44","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/j.1651-2227.2010.01890.x","article-title":"The effect of diet on total antioxidant status, ceruloplasmin, transferrin and ferritin serum levels in phenylketonuric children","volume":"99","author":"Schulpis","year":"2010","journal-title":"Acta Paediatr"},{"issue":"Suppl","key":"10.1016\/j.clnu.2018.01.034_bib45","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.ymgme.2013.09.009","article-title":"Micronutrient status in phenylketonuria","volume":"110","author":"Robert","year":"2013","journal-title":"Mol Genet Metab"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561418300542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561418300542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T22:41:02Z","timestamp":1755902462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561418300542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0261561418300542"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2018.01.034","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin\/mineral and micronutrient status in patients with classical phenylketonuria","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2018.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}