{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:11:02Z","timestamp":1768525862250,"version":"3.49.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/50079-0"],"award-info":[{"award-number":["2012\/50079-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.clnu.2018.09.023","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T03:29:18Z","timestamp":1537846158000},"page":"2219-2230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-0174","authenticated-orcid":false,"given":"Daniela Caetano","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Santos","family":"Lira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex Shimura","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Carnevali Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson","family":"Eder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-3553","authenticated-orcid":false,"given":"Alessandro","family":"Laviano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Cerqueira Leite","family":"Seelaender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2018.09.023_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-5273(02)00235-8","article-title":"Cancer cachexia","volume":"85","author":"Fearon","year":"2002","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clnu.2018.09.023_bib2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: a new definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clin Nutr"},{"issue":"Suppl. 1","key":"10.1016\/j.clnu.2018.09.023_bib3","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.ejphar.2011.07.007","article-title":"Anti-inflammatory therapies in cancer cachexia","volume":"668","author":"Argiles","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.clnu.2018.09.023_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1055-3207(18)30088-7","article-title":"The cancer cachexia syndrome","volume":"10","author":"Fearon","year":"2001","journal-title":"Surg Oncol Clin"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib5","first-page":"363","article-title":"Liver macrophages contribute to pancreatic cancer-related cachexia","volume":"21","author":"Martignoni","year":"2009","journal-title":"Oncol Rep"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib6","first-page":"185","article-title":"Carnitine palmytoiltransferase II activity is decreased in liver mitochondria of cachetic rats bearing the Walker 256 carcinosarcoma: effect of indomethacin treatment","volume":"44","author":"Seelaender","year":"1998","journal-title":"Biochem Mol Biol Int"},{"issue":"5","key":"10.1016\/j.clnu.2018.09.023_bib7","first-page":"1037","article-title":"Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia","volume":"39","author":"Seelaender","year":"1996","journal-title":"Biochem Mol Biol Int"},{"key":"10.1016\/j.clnu.2018.09.023_bib8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s11745-012-3698-6","article-title":"trans-10,cis-12 conjugated linoleic acid enhances endurance capacity by increasing fatty acid oxidation and reducing glycogen utilization in mice","volume":"47","author":"Kim","year":"2012","journal-title":"Lipids"},{"issue":"10","key":"10.1016\/j.clnu.2018.09.023_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jnutbio.2006.10.008","article-title":"Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats","volume":"18","author":"Purushotham","year":"2007","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.clnu.2018.09.023_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1467-789X.2005.00198.x","article-title":"Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue","volume":"6","author":"House","year":"2005","journal-title":"Obes Rev"},{"issue":"9","key":"10.1016\/j.clnu.2018.09.023_bib11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jnutbio.2005.10.010","article-title":"The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters","volume":"17","author":"Bissonauth","year":"2006","journal-title":"J\u00a0Nutr Biochem"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib12","first-page":"422","article-title":"Conjugated linoleic acid (CLA): effect modulation of body composition and lipid profile","volume":"24","author":"Baddini","year":"2009","journal-title":"Nutr Hosp"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4238\/vol7-2gmr417","article-title":"Effects of trans-10, cis-12 conjugated linoleic acid on gene expression and lipid metabolism of adipose tissue of growing pigs","volume":"7","author":"Jos\u00e9","year":"2008","journal-title":"Genet Mol Res"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1271\/bbb.70.355","article-title":"Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF rats","volume":"70","author":"Wang","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cyto.2011.10.008","article-title":"Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors","volume":"57","author":"Batista","year":"2012","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1743-7075-8-60","article-title":"Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats","volume":"8","author":"Lira","year":"2011","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.clnu.2018.09.023_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1746-6148-10-141","article-title":"Supplementation with conjugated linoeic acid decreases pig back fat deposition by inducing adipocyte apoptosis","volume":"10","author":"Qi","year":"2014","journal-title":"BMC Vet Res"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib18","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1016\/j.orcp.2013.04.002","article-title":"Adipocyte response to conjugated linoleic acid","volume":"7","author":"Yamasaki","year":"2013","journal-title":"Obes Res Clin Pract"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib19","first-page":"445","article-title":"Fatty acid oxidation in lymphocytes from Walker 256 tumor-bearing rats","volume":"29","author":"Seelaender","year":"1996","journal-title":"Braz J Med Biol Res"},{"issue":"9","key":"10.1016\/j.clnu.2018.09.023_bib20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s11745-014-3929-0","article-title":"CLA supplementation and aerobic exercise lower blood triacylglycerol, but have no effect on peak oxygen uptake or cardiorespiratory fatigue thresholds","volume":"49","author":"Jenkins","year":"2014","journal-title":"Lipids"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.clnu.2018.09.023_bib21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2527\/jas.53768","article-title":"Dietary conjugated linoleic acid modify gene expression in liver, muscles, and fat tissues of finishing pigs","volume":"90","author":"Tous","year":"2012","journal-title":"J\u00a0Anim Sci"},{"issue":"9","key":"10.1016\/j.clnu.2018.09.023_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013005","article-title":"Expression of adipose microRNAs is sensitive to dietary conjugated linoleic acid treatment in mice","volume":"5","author":"Parra","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.clnu.2018.09.023_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2018.09.023_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1042\/bj2500383","article-title":"Metabolism of pyruvate isolated rat mesenteric lymphocytes mitochondria and isolated mouse macrophage","volume":"250","author":"Curi","year":"1988","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.clnu.2018.09.023_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0076-6879(57)03345-5","article-title":"Chemical procedures for analyses of polisacharides","volume":"3","author":"Hassid","year":"1957","journal-title":"Methods Enzimol"},{"issue":"6","key":"10.1016\/j.clnu.2018.09.023_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/cbf.1495","article-title":"Effect of endurance training upon lipid metabolism in the liver of cachectic tumour-bearing rats","volume":"26","author":"Lira","year":"2008","journal-title":"Cell Biochem Funct"},{"issue":"9","key":"10.1016\/j.clnu.2018.09.023_bib29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1590\/S0100-879X2001000900009","article-title":"Heterogeneous response of adipose tissue to cancer cachexia","volume":"34","author":"Bertevello","year":"2001","journal-title":"Braz J Med Biol Res"},{"issue":"6","key":"10.1016\/j.clnu.2018.09.023_bib30","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/mnfr.201300458","article-title":"N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-\u03b1 upregulation and NF-\u03baB DNA binding abrogation","volume":"58","author":"Tapia","year":"2014","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"10.1016\/j.clnu.2018.09.023_bib31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.clnu.2005.12.008","article-title":"CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD","volume":"25","author":"Bassaganya-Riera","year":"2006","journal-title":"Clin Nutr"},{"issue":"13","key":"10.1016\/j.clnu.2018.09.023_bib32","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1055\/s-0030-1267949","article-title":"Exercise training reduces PGE2 levels and induces recovery from steatosis in tumor-bearing rats","volume":"42","author":"Lira","year":"2010","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.clnu.2018.09.023_bib33","first-page":"932928","article-title":"Dietary conjugated linoleic Acid and hepatic steatosis: species-specific effects on liver and adipose lipid metabolism and gene expression","volume":"2012","author":"Vyas","year":"2012","journal-title":"J\u00a0Nutr Metab"},{"issue":"17","key":"10.1016\/j.clnu.2018.09.023_bib34","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1021\/jf8010728","article-title":"Dietary combination of conjugated linoleic acid (CLA) and pine nut oil prevents CLA-induced fatty liver in mice","volume":"56","author":"Ferramosca","year":"2008","journal-title":"J\u00a0Agric Food Chem"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib35","first-page":"312","article-title":"Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity","volume":"8","author":"Kuhajda","year":"2007","journal-title":"Curr Opin Invest Drugs"},{"issue":"3","key":"10.1016\/j.clnu.2018.09.023_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00441-005-1138-0","article-title":"Cancer cachexia modifies the zonal distribution of lipid metabolism-related proteins in rat liver","volume":"321","author":"Kazantzis","year":"2005","journal-title":"Cell Tissue Res"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13539-011-0017-7","article-title":"l-carnitine and cancer cachexia: clinical and experimental aspects","volume":"2","author":"Silv\u00e9rio","year":"2011","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"8","key":"10.1016\/j.clnu.2018.09.023_bib38","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1590\/S0100-879X2012007500105","article-title":"Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats","volume":"45","author":"Carnevali","year":"2012","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00071668.2012.713464","article-title":"Effects of fish oil and conjugated linoleic acids on carnitine homeostasis in laying hens","volume":"53","author":"Shibani","year":"2012","journal-title":"Br Poultry Sci"},{"key":"10.1016\/j.clnu.2018.09.023_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2891-13-17","article-title":"Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review","volume":"13","author":"Grygiel-G\u00f3rniak","year":"2014","journal-title":"Nutr J"},{"key":"10.1016\/j.clnu.2018.09.023_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1320.001","article-title":"The role of the carnitine system in human metabolism","volume":"1033","author":"Foster","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"10.1016\/j.clnu.2018.09.023_bib42","first-page":"2503","article-title":"Fatty acid regulation of hepatic gene transcription","volume":"135","author":"Jump","year":"2005","journal-title":"J\u00a0Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1017\/S000711450770497X","article-title":"Effects of three different conjugated linoleic acid preparations on insulin signalling, fat oxidation and mitochondrial function in rats fed a high-fat diet","volume":"98","author":"Choi","year":"2007","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib44","first-page":"77","article-title":"Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver","volume":"137","author":"Ringseis","year":"2007","journal-title":"J\u00a0Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib45","doi-asserted-by":"crossref","first-page":"H652","DOI":"10.1152\/ajpheart.00130.2005","article-title":"A\u00a0cis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster","volume":"289","author":"Valeille","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib46","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/MOL.0b013e32835aebe7","article-title":"Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion","volume":"24","author":"Yao","year":"2013","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"10.1016\/j.clnu.2018.09.023_bib47","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/cbf.1476","article-title":"Hepatic denervation impairs the assembly and secretion of VLDL-TAG","volume":"26","author":"Tavares","year":"2008","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/cbf.1047","article-title":"Liver denervation affects hepatocyte mitochondrial fatty acid transport capacity","volume":"22","author":"Carre\u00f1o","year":"2004","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S0007114507793868","article-title":"Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils","volume":"99","author":"Perona","year":"2008","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2009.11.010","article-title":"The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans","volume":"210","author":"Shah","year":"2010","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.clnu.2018.09.023_bib51","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1172\/JCI2912","article-title":"Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia","volume":"102","author":"Merkel","year":"1998","journal-title":"J\u00a0Clin Invest"},{"issue":"12","key":"10.1016\/j.clnu.2018.09.023_bib52","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.bbalip.2010.08.011","article-title":"Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats","volume":"1801","author":"Stringer","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.ATV.12.1.50","article-title":"Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans","volume":"12","author":"Valsta","year":"1992","journal-title":"Arterioscler Thromb"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib54","first-page":"58","article-title":"Influence of dietary therapy containing sunflower oil fortified with phospholipids on the lipid metabolism in patients with hypertension and obesity","volume":"76","author":"Eshigina","year":"2007","journal-title":"Vopr Pitan"},{"key":"10.1016\/j.clnu.2018.09.023_bib55","unstructured":"Degrace P1, Moindrot B, Mohamed I, Gresti J, Du ZY, Chardigny JM, et\u00a0al. Upregulation of liver VLDL receptor and FAT\/CD36 expression in LDLR-\/- apoB100\/100 mice fed trans-10,cis-12 conjugated linoleic acid."},{"key":"10.1016\/j.clnu.2018.09.023_bib56","first-page":"1","article-title":"Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis","author":"Derakhshande-Rishehri","year":"2014","journal-title":"Publ Health Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cbi.2012.09.022","article-title":"Effects of conjugated linoleic acid supplementation and exercise on post-heparin lipoprotein lipase, butyrylcholinesterase, blood lipid profile and glucose metabolism in young men","volume":"203","author":"Bulut","year":"2013","journal-title":"Chem Biol Interact"},{"issue":"3","key":"10.1016\/j.clnu.2018.09.023_bib58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jnutbio.2004.11.004","article-title":"Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells","volume":"16","author":"Mitmesser","year":"2005","journal-title":"J\u00a0Nutr Biochem"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11745-006-5068-8","article-title":"Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters","volume":"41","author":"Wilson","year":"2006","journal-title":"Lipids"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11745-003-1072-2","article-title":"Modulation of body composition and immune cell functions by conjugated linoleic acid in humans and animal models: benefits vs. risks","volume":"38","author":"Kelley","year":"2003","journal-title":"Lipids"},{"issue":"5A","key":"10.1016\/j.clnu.2018.09.023_bib61","first-page":"3111","article-title":"Cachexia induction by EL-4 lymphoma in mice and possible involvement of impaired lipoprotein lipase activity","volume":"20","author":"Tsujimoto","year":"2000","journal-title":"Anticancer Res"},{"issue":"1S Suppl","key":"10.1016\/j.clnu.2018.09.023_bib62","first-page":"243S","article-title":"Wasting in cancer","volume":"129","author":"Tisdale","year":"1999","journal-title":"J\u00a0Nutr"},{"issue":"1A","key":"10.1016\/j.clnu.2018.09.023_bib63","first-page":"341","article-title":"Activation of lipoprotein lipase and inhibition of B16 melanoma-induced cachexia in mice by ponalrestat, an aldose reductase inhibitor","volume":"19","author":"Kawamura","year":"1999","journal-title":"Anticancer Res"},{"issue":"12","key":"10.1016\/j.clnu.2018.09.023_bib64","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/labinvest.2013.123","article-title":"A\u00a0novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance","volume":"93","author":"Adkins","year":"2013","journal-title":"Lab Invest"},{"issue":"6","key":"10.1016\/j.clnu.2018.09.023_bib65","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2337\/db06-0036","article-title":"Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue","volume":"55","author":"Poirier","year":"2006","journal-title":"Diabetes"},{"issue":"46","key":"10.1016\/j.clnu.2018.09.023_bib66","doi-asserted-by":"crossref","first-page":"38445","DOI":"10.1074\/jbc.M508159200","article-title":"Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production","volume":"280","author":"Chung","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.clnu.2018.09.023_bib67","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0029665109990267","volume":"68","author":"Bing","year":"2009","journal-title":"Proc Nutr Soc"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3945\/an.112.003020","article-title":"Macrophage-induced adipose tissue dysfunction and the preadipocyte: should I stay (and differentiate) or should I go?","volume":"4","author":"Sorisky","year":"2013","journal-title":"Adv Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2018.09.023_bib69","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00441-004-0987-2","article-title":"Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration","volume":"318","author":"Machado","year":"2004","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cbf.1540","article-title":"Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise","volume":"27","author":"Lira","year":"2009","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"10.1016\/j.clnu.2018.09.023_bib71","first-page":"5","article-title":"Adipose tissue inflammation and cancer cachexia: the role of steroid hormones","volume":"17","author":"Seelaender","year":"2014","journal-title":"Horm Mol Biol Clin Invest"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib72","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.cyto.2012.10.023","article-title":"Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients","volume":"61","author":"Batista","year":"2013","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.clnu.2018.09.023_bib73","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jnutbio.2009.01.006","article-title":"Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl\/6J mice","volume":"21","author":"Halade","year":"2010","journal-title":"J\u00a0Nutr Biochem"},{"issue":"5","key":"10.1016\/j.clnu.2018.09.023_bib74","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1017\/S0007114508027451","article-title":"Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice","volume":"101","author":"Kelley","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2018.09.023_bib75","doi-asserted-by":"crossref","first-page":"168407","DOI":"10.1155\/2014\/168407","article-title":"Inflammation based regulation of cancer cachexia","volume":"2014","author":"Onesti","year":"2014","journal-title":"BioMed Res Int"},{"issue":"2","key":"10.1016\/j.clnu.2018.09.023_bib76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cyto.2008.10.018","article-title":"Endurance training induces depot-specific changes in IL-10\/TNF-alpha ratio in rat adipose tissue","volume":"45","author":"Lira","year":"2009","journal-title":"Cytokine"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561418324610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561418324610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T22:50:40Z","timestamp":1755903040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561418324610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0261561418324610"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2018.09.023","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2018.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}