{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:58:06Z","timestamp":1773665886402,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010613","name":"Taipei Medical University Hospital","doi-asserted-by":"crossref","award":["107TMU-TMUH-11"],"award-info":[{"award-number":["107TMU-TMUH-11"]}],"id":[{"id":"10.13039\/501100010613","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST107-2320-B-038-010-MY3"],"award-info":[{"award-number":["MOST107-2320-B-038-010-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.clnu.2019.01.019","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:22:22Z","timestamp":1548548542000},"page":"225-233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-1743","authenticated-orcid":false,"given":"Kelvin Yohanes","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-5513","authenticated-orcid":false,"given":"Shih-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Mu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyi-Huey","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-9349","authenticated-orcid":false,"given":"Jung-Su","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2019.01.019_bib1","first-page":"292","article-title":"Time trend of obesity, the metabolic syndrome and related dietary pattern in Taiwan: from NAHSIT 1993\u20131996 to NAHSIT 2005\u20132008","volume":"20","author":"Yeh","year":"2011","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.01.019_bib2","article-title":"Morbid obesity in Taiwan: prevalence, trends, associated social demographics, and lifestyle factors","volume":"12","author":"Chang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2019.01.019_bib3","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1467-789X.2010.00810.x","article-title":"The levelling off of the obesity epidemic since the year 1999 \u2013 a review of evidence and perspectives","volume":"11","author":"Rokholm","year":"2010","journal-title":"Obes Rev"},{"key":"10.1016\/j.clnu.2019.01.019_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ijo.2014.95","article-title":"Overall obesity is leveling-off while abdominal obesity continues to rise in a Chinese population experiencing rapid economic development: analysis of serial cross-sectional health survey data 2002\u20132010","volume":"39","author":"Lao","year":"2015","journal-title":"Int J Obes"},{"key":"10.1016\/j.clnu.2019.01.019_bib5","doi-asserted-by":"crossref","first-page":"21521","DOI":"10.1038\/srep21521","article-title":"Abdominal obesity is strongly associated with cardiovascular disease and its risk factors in elderly and very elderly community-dwelling Chinese","volume":"6","author":"Fan","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.01.019_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2337\/diaclin.34.3.148","article-title":"Role of haptoglobin in health and disease: a focus on diabetes","volume":"34","author":"MacKellar","year":"2016","journal-title":"Clin Diabetes"},{"key":"10.1016\/j.clnu.2019.01.019_bib7","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/clinchem\/42.10.1589","article-title":"Biological and clinical significance of haptoglobin polymorphism in humans","volume":"42","author":"Langlois","year":"1996","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2019.01.019_bib8","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/j.1460-2075.1989.tb03485.x","article-title":"The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6","volume":"8","author":"Oliviero","year":"1989","journal-title":"EMBO J"},{"key":"10.1016\/j.clnu.2019.01.019_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2217\/fca-2016-0008","article-title":"Hp: an inflammatory indicator in cardiovascular disease","volume":"12","author":"Graves","year":"2016","journal-title":"Future Cardiol"},{"key":"10.1016\/j.clnu.2019.01.019_bib10","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1210\/jc.2016-2094","article-title":"Urinary haptoglobin predicts rapid renal function decline in Asians with type 2 diabetes and early kidney disease","volume":"101","author":"Liu","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2019.01.019_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1741-7007-7-87","article-title":"The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)","volume":"7","author":"Maffei","year":"2009","journal-title":"BMC Biol"},{"key":"10.1016\/j.clnu.2019.01.019_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12933-018-0662-7","article-title":"Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients","volume":"17","author":"Wang","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.clnu.2019.01.019_bib13","doi-asserted-by":"crossref","first-page":"14264","DOI":"10.1038\/s41598-017-14302-2","article-title":"Circulating haptoglobin and metabolic syndrome in renal transplant recipients","volume":"7","author":"Minovic","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.01.019_bib14","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1210\/jc.2003-031965","article-title":"Serum haptoglobin: a novel marker of adiposity in humans","volume":"89","author":"Chiellini","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2019.01.019_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/er.2016-1009","article-title":"The multifaceted haptoglobin in the context of adipose tissue and metabolism","volume":"37","author":"Maffei","year":"2016","journal-title":"Endocr Rev"},{"key":"10.1016\/j.clnu.2019.01.019_bib16","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.2337\/db10-1536","article-title":"Obesity-associated hepatosteatosis and impairment of glucose homeostasis are attenuated by haptoglobin deficiency","volume":"60","author":"Lisi","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.clnu.2019.01.019_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MOL.0000000000000037","article-title":"Gene-diet interaction and weight loss","volume":"25","author":"Qi","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.clnu.2019.01.019_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jcp.10061","article-title":"Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha","volume":"190","author":"Chiellini","year":"2002","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.clnu.2019.01.019_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF03346317","article-title":"Haptoglobin serum levels are independently associated with insulinemia in overweight and obese women","volume":"30","author":"De Pergola","year":"2007","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.clnu.2019.01.019_bib20","article-title":"Plasma haptoglobin concentrations are elevated in patients with coronary artery disease","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2019.01.019_bib21","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1038\/s41598-018-23407-1","article-title":"Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians","volume":"8","author":"Gurung","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.01.019_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005606","article-title":"Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women","volume":"4","author":"Alvarez-Blasco","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2019.01.019_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/oby.2009.322","article-title":"Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans","volume":"18","author":"Doumatey","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.clnu.2019.01.019_bib24","first-page":"167","article-title":"Evaluation of haptoglobin genotypes in patients with metabolic syndrome: a preliminary report","volume":"11","author":"Nakhaee","year":"2015","journal-title":"ARYA Atheroscler"},{"key":"10.1016\/j.clnu.2019.01.019_bib25","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s10815-017-1030-3","article-title":"Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome","volume":"34","author":"Carvalho","year":"2017","journal-title":"J\u00a0Assist Reprod Genet"},{"key":"10.1016\/j.clnu.2019.01.019_bib26","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/gps.4354","article-title":"Ethnicity\/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes","volume":"31","author":"Guerrero-Berroa","year":"2016","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.clnu.2019.01.019_bib27","first-page":"71","article-title":"Meta-analysis of the association of the haptoglobin genotype with cardiovascular outcomes and the pharmacogenomic interactions with vitamin E supplementation","volume":"11","author":"Asleh","year":"2018","journal-title":"Pharmgenomics Pers Med"},{"key":"10.1016\/j.clnu.2019.01.019_bib28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/ijo.2009.27","article-title":"Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects","volume":"33","author":"Belza","year":"2009","journal-title":"Int J Obes"},{"key":"10.1016\/j.clnu.2019.01.019_bib29","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.2337\/diacare.27.5.1182","article-title":"Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians?","volume":"27","author":"Tan","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.01.019_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800243","article-title":"A\u00a0moderate interleukin-6 reduction, not a moderate weight reduction, improves the serum iron status in diet-induced weight loss with fish oil supplementation","author":"Huang","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.clnu.2019.01.019_bib31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/ejcn.2014.196","article-title":"A\u00a0calorie-restriction diet supplemented with fish oil and high-protein powder is associated with reduced severity of metabolic syndrome in obese women","volume":"69","author":"Su","year":"2015","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.01.019_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4055\/cios.2014.6.1.103","article-title":"How to do random allocation (randomization)","volume":"6","author":"Kim","year":"2014","journal-title":"Clin Orthop Surg"},{"key":"10.1016\/j.clnu.2019.01.019_bib33","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/ajcn\/85.5.1267","article-title":"Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors","volume":"85","author":"Hill","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.01.019_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clnesp.2018.03.001","article-title":"Omega-3 supplementation effects on body weight and depression among dieter women with co-morbidity of depression and obesity compared with the placebo: a randomized clinical trial","volume":"25","author":"Keshavarz","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clnu.2019.01.019_bib35","doi-asserted-by":"crossref","first-page":"40389","DOI":"10.1038\/srep40389","article-title":"Reproducibility and repeatability of computer tomography-based measurement of abdominal subcutaneous and visceral adipose tissues","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.01.019_bib36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.clinbiochem.2007.04.018","article-title":"Immunochemical property of human haptoglobin phenotypes: determination of plasma haptoglobin using type-matched standards","volume":"40","author":"Cheng","year":"2007","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clnu.2019.01.019_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.pep.2003.09.006","article-title":"Purification of human haptoglobin 1-1, 2-1, and 2-2 using monoclonal antibody affinity chromatography","volume":"33","author":"Tseng","year":"2004","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.clnu.2019.01.019_bib38","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3945\/ajcn.113.082164","article-title":"FTO genotype, dietary protein, and change in appetite: the preventing overweight using novel dietary strategies trial","volume":"99","author":"Huang","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.01.019_bib39","first-page":"2195059","article-title":"The association of haptoglobin gene variants and retinopathy in type 2 diabetic patients: a meta-analysis","volume":"2017","author":"Wu","year":"2017","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.clnu.2019.01.019_bib40","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/en.2009-0800","article-title":"Regulation of adipogenesis by natural and synthetic REV-ERB ligands","volume":"151","author":"Kumar","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnu.2019.01.019_bib41","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1038\/s41598-017-05597-2","article-title":"Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism","volume":"7","author":"Moreno-Navarrete","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.01.019_bib42","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/07853890903089453","article-title":"Haptoglobin and risk of myocardial infarction, stroke, and congestive heart failure in 342,125 men and women in the Apolipoprotein MOrtality RISk study (AMORIS)","volume":"41","author":"Holme","year":"2009","journal-title":"Ann Med"},{"key":"10.1016\/j.clnu.2019.01.019_bib43","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng.3510","article-title":"Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels","volume":"48","author":"Boettger","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.clnu.2019.01.019_bib44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/jhg.2017.66","article-title":"A\u00a0common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women","volume":"62","author":"Zheng","year":"2017","journal-title":"J\u00a0Hum Genet"},{"key":"10.1016\/j.clnu.2019.01.019_bib45","first-page":"6125420","article-title":"Haptoglobin genotype is a determinant of hemoglobin adducts and vitamin E content in HDL","volume":"2018","author":"Goldenstein","year":"2018","journal-title":"J\u00a0Diabetes Res"},{"key":"10.1016\/j.clnu.2019.01.019_bib46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1471-4159.2009.06121.x","article-title":"Haptoglobin binds apolipoprotein E and influences cholesterol esterification in the cerebrospinal fluid","volume":"110","author":"Salvatore","year":"2009","journal-title":"J\u00a0Neurochem"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T10:18:28Z","timestamp":1606213108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561419300378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0261561419300378"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2019.01.019","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haptoglobin phenotype influences the effectiveness of diet-induced weight loss in middle-age abdominally obese women with metabolic abnormalities","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2019.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}