{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:24:49Z","timestamp":1790367889523,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.clnu.2019.02.036","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T13:05:02Z","timestamp":1553087102000},"page":"388-394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-2899","authenticated-orcid":false,"given":"Gabriel","family":"Olveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Abu\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Herranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Garc\u00eda-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Garc\u00eda-Malpartida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Cancer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Luengo-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Arag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Oc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Garc\u00eda-Manzanares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bret\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-618X","authenticated-orcid":false,"given":"Pilar","family":"Serrano-Aguayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"P\u00e9rez-Ferre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"L\u00f3pez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Arraiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tejera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel L.","family":"Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda R.","family":"Alhambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Zugasti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Torrej\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2019.02.036_bib1","series-title":"IDF diabetes atlas","first-page":"2017","author":"International Diabetes Federation","year":"2017"},{"key":"10.1016\/j.clnu.2019.02.036_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00125-011-2336-9","article-title":"Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@betes Study","volume":"55","author":"Soriguer","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.clnu.2019.02.036_bib3","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.2337\/diacare.28.10.2367","article-title":"Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition","volume":"28","author":"Cheung","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2337\/dc12-1379","article-title":"Parenteral nutrition-associated hyperglycemia in non-critically ill inpatients increases the risk of in-hospital mortality (multicenter study)","volume":"36","author":"Olveira","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0148607112452001","article-title":"American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors, et\u00a0al. A.S.P.E.N. Clinical Guidelines","volume":"37","author":"McMahon","year":"2013","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2337\/dc09-1748","article-title":"Hyperglycemia during total parenteral nutrition: an important marker of poor outcome and mortality in hospitalized patients","volume":"33","author":"Pasquel","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4158\/EP13441.OR","article-title":"Prevalence of diabetes, prediabetes, and stress hyperglycemia: insulin therapy and metabolic control in patients on total parenteral nutrition (prospective multicenter study)","volume":"21","author":"Olveira","year":"2015","journal-title":"Endocr Pract"},{"key":"10.1016\/j.clnu.2019.02.036_bib8","first-page":"1837","article-title":"Recommendations of the GARIN group for managing non-critically ill patients with diabetes or stress hyperglycaemia and artificial nutrition","volume":"27","author":"Olveira","year":"2012","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.clnu.2019.02.036_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0148607111415628","article-title":"An insulin protocol for management of hyperglycemia in patients receiving parenteral nutrition is superior to ad hoc management","volume":"36","author":"Jakoby","year":"2012","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib10","article-title":"Addition of insulin to parenteral nutrition for control of hyperglycemia","author":"McCulloch","year":"2017","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jc.2011-2098","article-title":"Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline","volume":"97","author":"Umpierrez","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2019.02.036_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/014860719301700116","article-title":"Evaluation of a practical technique for determining insulin requirements in diabetic patients receiving total parenteral nutrition","volume":"17","author":"Hongsermeier","year":"1993","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/phar.1546","article-title":"Effectiveness of regular versus glargine insulin in stable critical care patients receiving parenteral nutrition: a randomized controlled trial","volume":"35","author":"Oghazian","year":"2015","journal-title":"Pharmacother J Hum Pharmacol Drug Ther"},{"key":"10.1016\/j.clnu.2019.02.036_bib14","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1177\/0148607116644710","article-title":"Glargine insulin use versus continuous regular insulin in diabetic surgical noncritically ill patients receiving parenteral nutrition: randomized controlled study","volume":"41","author":"Hakeam","year":"2017","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib15","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1038\/s41598-018-24275-5","article-title":"Management of glycemic variation in diabetic patients receiving parenteral nutrition by continuous subcutaneous insulin infusion (CSII) therapy","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2019.02.036_bib16","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.2337\/dc18-S014","article-title":"14. Diabetes care in the hospital: standards of medical care in diabetes-2018","volume":"41","author":"American Diabetes Association AD","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s13300-018-0433-1","article-title":"Differences in glycemic control in diabetic and non-diabetic patients with parenteral nutrition using a basal plus correction insulin regimen: an observational, retrospective study","author":"Ramos","year":"2018","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.clnu.2019.02.036_bib18","first-page":"231","article-title":"Use of neutral protamine lispro (NPL) insulin in a patient affected by acute pancreatitis under parenteral nutrition","volume":"162","author":"Fatati","year":"2011","journal-title":"Clin Ter"},{"key":"10.1016\/j.clnu.2019.02.036_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s12325-018-0709-x","article-title":"Impact of insulin Degludec in hospitalized patients with and without type 2 diabetes requiring parenteral\/enteral nutrition: an observational study","author":"Fatati","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.clnu.2019.02.036_bib20","first-page":"141","article-title":"Management of parenteral nutrition associated hyperglycaemia: a comparison of subcutaneous and intravenous insulin regimen","volume":"107","author":"Neff","year":"2014","journal-title":"Ir Med J"},{"key":"10.1016\/j.clnu.2019.02.036_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4158\/EP13131.OR","article-title":"Glucose variability is an independent predictor of mortality in hospitalized patients treated with total parenteral nutrition","volume":"20","author":"Farrokhi","year":"2014","journal-title":"Endocr Pract"},{"key":"10.1016\/j.clnu.2019.02.036_bib22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.endinu.2017.08.005","article-title":"Transition from intravenous insulin to subcutaneous long-acting insulin in critical care patients on enteral or parenteral nutrition","volume":"64","author":"Ramos","year":"2017","journal-title":"Endocrinol Diabetes y Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib23","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2018","volume":"41","author":"American Diabetes Association AD","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2337\/dc16-2215","article-title":"Glucose concentrations of less than 3.0 mmol\/L (54 mg\/dL) should Be reported in clinical trials: a joint position statement of the American diabetes association and the european association for the study of diabetes","volume":"40","author":"International Hypoglycaemia Study Group IHS","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib25","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.2337\/dc10-0953","article-title":"International HBA1c Consensus Committee O behalf of the IHC. 2010 consensus statement on the worldwide standardization of the hemoglobin A1C measurement","volume":"33","author":"Hanas","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/ajcn\/40.1.168","article-title":"The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass","volume":"40","author":"Roza","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib27","series-title":"Manual de Nutrici\u00f3n Cl\u00ednica y Diet\u00e9tica","author":"Olveira","year":"2016"},{"key":"10.1016\/j.clnu.2019.02.036_bib28","series-title":"ESPEN guideline: clinical nutrition in surgery","author":"Weimann","year":"2017"},{"key":"10.1016\/j.clnu.2019.02.036_bib29","series-title":"ESPEN guideline on nutrition in cancer patients*","author":"Arends","year":"2016"},{"key":"10.1016\/j.clnu.2019.02.036_bib30","series-title":"ESPEN guidelines on nutritional support for polymorbid internal medicine patients","author":"Gomes","year":"2017"},{"key":"10.1016\/j.clnu.2019.02.036_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0148607115621863","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient","volume":"40","author":"McClave","year":"2016","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.036_bib32","series-title":"IBM SPSS statistics for windows, version 22.0","author":"Released","year":"2013"},{"key":"10.1016\/j.clnu.2019.02.036_bib33","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2337\/dc09-9029","article-title":"American association of clinical endocrinologists and American diabetes association consensus statement on inpatient glycemic control","volume":"32","author":"Moghissi","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2019.02.036_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1155\/2010\/718526","article-title":"Parenteral nutrition-associated hyperglycemia in noncritically ill inpatients is associated with higher mortality","volume":"24","author":"Sarkisian","year":"2010","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.clnu.2019.02.036_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000481355","article-title":"Insulin regimens to treat hyperglycemia in hospitalized patients on nutritional support: systematic review and meta-analyses","volume":"71","author":"Ver\u00e7oza Viana","year":"2017","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.clnu.2019.02.036_bib36","series-title":"Management of diabetes and hyperglycemia in hospitalized patients","author":"Corsino","year":"2000"},{"key":"10.1016\/j.clnu.2019.02.036_bib37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nut.2014.04.023","article-title":"Hypoglycemia in noncritically ill patients receiving total parenteral nutrition: a multicenter study. (Study group on the problem of hyperglycemia in parenteral nutrition; nutrition area of the Spanish Society of Endocrinology and Nutrition)","volume":"31","author":"Olveira","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2019.02.036_bib38","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.amjmed.2011.07.011","article-title":"Hypoglycemia-associated mortality is not drug-associated but linked to comorbidities","volume":"124","author":"Boucai","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.clnu.2019.02.036_bib39","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.2337\/dc18-0287","article-title":"Glycemic control and risk of infections among people with type 1 or type 2 diabetes in a large primary care cohort study","volume":"41","author":"Critchley","year":"2018","journal-title":"Diabetes Care"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:54:28Z","timestamp":1759366468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561419300901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0261561419300901"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2019.02.036","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2019.02.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}