{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:06:12Z","timestamp":1788825972089,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.clnu.2019.02.039","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T11:40:33Z","timestamp":1551786033000},"page":"540-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition"],"prefix":"10.1016","volume":"39","author":[{"given":"Elisabeth","family":"Bl\u00fcthner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bednarsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich-Frank","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Karber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Maasberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undine A.","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pascher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Wiedenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Pratschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2019.02.039_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cgh.2005.10.002","article-title":"Short bowel syndrome and intestinal failure: consensus definitions and overview","volume":"4","author":"O'Keefe","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2019.02.039_bib2","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1177\/0148607114520994","article-title":"Spectrum of short bowel syndrome in adults","volume":"38","author":"Jeppesen","year":"2014","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib4","first-page":"134","article-title":"Long-term total parenteral nutrition with growth, development, and positive nitrogen balance","volume":"64","author":"Dudrick","year":"1968","journal-title":"Surgery"},{"key":"10.1016\/j.clnu.2019.02.039_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S1590-8658(03)00074-4","article-title":"Safety and efficacy of home parenteral nutrition for chronic intestinal failure: a 16-year experience at a single centre","volume":"35","author":"Pironi","year":"2003","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.clnu.2019.02.039_bib6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/apt.12209","article-title":"Review article: the management of long-term parenteral nutrition","volume":"37","author":"Dibb","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2019.02.039_bib7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1054\/clnu.2002.0578","article-title":"Central venous catheter complications in 447 patients on home parenteral nutrition: an analysis of over 100.000 catheter days","volume":"21","author":"Bozzetti","year":"2002","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1067\/msy.1999.98925","article-title":"Incidence, prognosis, and etiology of end-stage liver disease in patients receiving home total parenteral nutrition","volume":"126","author":"Chan","year":"1999","journal-title":"Surgery"},{"key":"10.1016\/j.clnu.2019.02.039_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/gut.2010.223255","article-title":"Long-term follow-up of patients on home parenteral nutrition in Europe: implications for intestinal transplantation","volume":"60","author":"Pironi","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2019.02.039_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7326\/0003-4819-132-7-200004040-00003","article-title":"Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure","volume":"132","author":"Cavicchi","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clnu.2019.02.039_bib11","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1053\/j.gastro.2005.10.066","article-title":"Intestinal failure\u2013associated liver disease: what do we know today?","volume":"130","author":"Kelly","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.02.039_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/01.PDR.0000153672.43030.75","article-title":"Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease","volume":"57","author":"Alwayn","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clnu.2019.02.039_bib13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/tri.12053","article-title":"Waitlist characteristics of patients at a single-center intestinal and multivisceral transplant program","volume":"26","author":"Gerlach","year":"2013","journal-title":"Transpl Int"},{"key":"10.1016\/j.clnu.2019.02.039_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/SLA.0b013e31825d5d47","article-title":"Physiological and biochemical basis of clinical liver function tests","volume":"257","author":"Hoekstra","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1477-2574.2009.00151.x","article-title":"The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery","volume":"12","author":"Stockmann","year":"2010","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.clnu.2019.02.039_bib16","doi-asserted-by":"crossref","first-page":"R259","DOI":"10.1186\/cc13089","article-title":"Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test","volume":"17","author":"Kaffarnik","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.clnu.2019.02.039_bib17","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1007\/s00268-016-3524-z","article-title":"Regeneration of liver function capacity after partial liver resection is impaired in case of postoperative bile leakage","volume":"40","author":"Bednarsch","year":"2016","journal-title":"World J Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib18","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"12","author":"von Elm","year":"2014","journal-title":"Int J Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0016-5085(99)70388-4","article-title":"Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome","volume":"117","author":"Messing","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.02.039_bib20","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1053\/gast.2000.20227","article-title":"Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans","volume":"119","author":"Crenn","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.02.039_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/SLA.0b013e3181ad85b5","article-title":"Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity","volume":"250","author":"Stockmann","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jss.2014.07.041","article-title":"Reliable assessment of liver function using LiMAx","volume":"193","author":"Jara","year":"2015","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.clnu.2019.02.039_bib23","first-page":"207","article-title":"Assessing liver function","volume":"13","author":"Sakka","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.clnu.2019.02.039_bib24","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.clnu.2019.02.039_bib25","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/S0002-8223(97)00754-2","article-title":"Indirect calorimetry: technical aspects","volume":"97","author":"Matarese","year":"1997","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.clnu.2019.02.039_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000442983","article-title":"Malnutrition predicts clinical outcome in patients with neuroendocrine neoplasia","volume":"104","author":"Maasberg","year":"2017","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.clnu.2019.02.039_bib27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S1499-3872(12)60229-X","article-title":"Pathogenesis and treatment of parenteral nutrition-associated liver disease","volume":"11","author":"Xu","year":"2012","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.clnu.2019.02.039_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpedsurg.2009.10.020","article-title":"Relationship between biopsy-proven parenteralnutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndrome","volume":"45","author":"Fitzgibbons","year":"2010","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/0148607114538057","article-title":"Transient elastography (FibroScan) is not correlated with liver fibrosis but with cholestasis in patients with long-term home parenteral nutrition","volume":"39","author":"Van Gossum","year":"2015","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.clnu.2011.10.001","article-title":"Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults","volume":"31","author":"Xu","year":"2012","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib31","first-page":"34","article-title":"Omega-3 fatty acids in modern parenteral nutrition: a review of the current evidence","volume":"5","author":"Klek","year":"2016","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.clnu.2019.02.039_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/liv.12887","article-title":"Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in paediatric intestinal failure","volume":"36","author":"Hukkinen","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.clnu.2019.02.039_bib33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.clnu.2009.04.001","article-title":"ESPEN Guidelines on Parenteral Nutrition: home parenteral nutrition (HPN) in adult patients","volume":"28","author":"Staun","year":"2009","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib34","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.1016\/j.eclnm.2010.08.003","article-title":"Fish oil-based emulsion for the treatment of parenteral nutrition associated liver disease in an adult patient","volume":"5","author":"Pironi","year":"2010","journal-title":"E\u00a0Spen Eur E J Clin Nutr Metab"},{"key":"10.1016\/j.clnu.2019.02.039_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.26360","article-title":"Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure","volume":"58","author":"Mutanen","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2019.02.039_bib36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C","volume":"128","author":"Cast\u00e9ra","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.02.039_bib37","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1373\/clinchem.2004.032227","article-title":"Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C","volume":"50","author":"Poynard","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2019.02.039_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/ajt.14127","article-title":"OPTN\/SRTR 2015 annual data report: intestine","volume":"17","author":"Smith","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.clnu.2019.02.039_bib39","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1097\/TP.0b013e31816dd513","article-title":"Collaborative strategies to reduce mortality and morbidity in patients with chronic intestinal failure including those who are referred for small bowel transplantation","volume":"85","author":"Beath","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.clnu.2019.02.039_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1054\/clnu.2002.0554","article-title":"Prevalence, outcome and associated factors of deranged liver function tests in patients on home parenteral nutrition","volume":"21","author":"Luman","year":"2002","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib41","first-page":"1","article-title":"Ultrastructural changes and Cd14 expression in the liver in the short bowel syndrome","volume":"6","author":"G\u00f6ll\u00fc","year":"2017","journal-title":"Turkish J Pediatr Dis"},{"key":"10.1016\/j.clnu.2019.02.039_bib42","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00423-012-0972-2","article-title":"Function and volume recovery after partial hepatectomy: influence of preoperative liver function, residual liver volume, and obesity","volume":"397","author":"Lock","year":"2012","journal-title":"Langenbeck's Arch Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib43","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1007\/s10620-014-3250-z","article-title":"Enzymatic liver function capacity correlates with disease severity of patients with liver cirrhosis: a study with the LiMAx test","volume":"59","author":"Malinowski","year":"2014","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.clnu.2019.02.039_bib44","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/hpb.12424","article-title":"Reductions in post-hepatectomy liver failure and related mortality after implementation of the LiMAx algorithm in preoperative work-up: a single-centre analysis of 1170 hepatectomies of one or more segments","volume":"17","author":"Jara","year":"2015","journal-title":"HPB"},{"key":"10.1016\/j.clnu.2019.02.039_bib45","first-page":"1","article-title":"Liver maximum capacity: a novel test to accurately diagnose different stages of liver fibrosis","author":"Buechter","year":"2018","journal-title":"Digestion"},{"key":"10.1016\/j.clnu.2019.02.039_bib46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpedsurg.2008.10.046","article-title":"Novel intravenous (13)C-methionine breath test as a measure of liver function in children with short bowel syndrome","volume":"44","author":"Duro","year":"2009","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2019.02.039_bib47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MPG.0b013e318299fdbd","article-title":"Aspartate aminotransferase to platelet ratio index correlates with hepatic cirrhosis but not with fibrosis in pediatric patients with intestinal failure","volume":"57","author":"D\u00edaz","year":"2013","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2019.02.039_bib48","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-Like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"Paik","year":"2003","journal-title":"Hepatology"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419300937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:55:40Z","timestamp":1759366540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561419300937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0261561419300937"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2019.02.039","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2019.02.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}