{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:57Z","timestamp":1787500437478,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NUTRICIA France"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.clnu.2019.03.037","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T11:30:07Z","timestamp":1554204607000},"page":"928-934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-3035","authenticated-orcid":false,"given":"Thomas","family":"Mouillot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Beylot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Drai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Lauverjat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Chambrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2019.03.037_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.03.037_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.clnu.2012.08.007","article-title":"Determinants of home parenteral nutrition dependence and survival of 268 patients with non-malignant short bowel syndrome","volume":"32","author":"Amiot","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.03.037_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-0036-1597771","article-title":"The differentiation of intestinal-failure-associated liver disease from nonalcoholic fatty liver and nonalcoholic steatohepatitis","volume":"37","author":"Buchman","year":"2017","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.clnu.2019.03.037_bib4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/gut.35.8.1116","article-title":"Apparent selective bile acid malabsorption as a consequence of ileal exclusion: effects on bile acid, cholesterol, and lipoprotein metabolism","volume":"35","author":"Akerlund","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2019.03.037_bib5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1194\/jlr.M300030-JLR200","article-title":"Stimulation of cholesterol synthesis and hepatic lipogenesis in patients with severe malabsorption","volume":"44","author":"Cachefo","year":"2003","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clnu.2019.03.037_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrgastro.2013.151","article-title":"Bile acid receptors as targets for drug development","volume":"11","author":"Schaap","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2019.03.037_bib7","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.clnu.2019.03.037_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2016.07.027","article-title":"Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression","volume":"436","author":"Liu","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.clnu.2019.03.037_bib9","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0168-8278(05)80064-9","article-title":"Is ursodeoxycholic acid an effective therapy for total parenteral nutrition-related liver disease?","volume":"20","author":"Beau","year":"1994","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.clnu.2019.03.037_bib10","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1053\/j.gastro.2005.10.066","article-title":"Intestinal failure-associated liver disease: what do we know today?","volume":"130","author":"Kelly","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.03.037_bib11","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/jhep.2002.36088","article-title":"Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited","volume":"36","author":"Paumgartner","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2019.03.037_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0026-0495(96)90152-3","article-title":"In\u00a0vivo measurement of plasma cholesterol and fatty acid synthesis with deuterated water: determination of the average number of deuterium atoms incorporated","volume":"45","author":"Diraison","year":"1996","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.clnu.2019.03.037_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/(SICI)1096-9888(199701)32:1<81::AID-JMS454>3.0.CO;2-2","article-title":"Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic\/mass spectrometric techniques","volume":"32","author":"Diraison","year":"1997","journal-title":"J\u00a0Mass Spectrom"},{"key":"10.1016\/j.clnu.2019.03.037_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00004424-199304000-00006","article-title":"Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography","volume":"28","author":"Longo","year":"1993","journal-title":"Invest Radiol"},{"key":"10.1016\/j.clnu.2019.03.037_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jmri.1880050311","article-title":"Proton MR spectroscopy in quantitative in\u00a0vivo determination of fat content in human liver steatosis","volume":"5","author":"Longo","year":"1995","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.clnu.2019.03.037_bib16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.clnu.2019.03.037_bib17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0022-2275(20)40190-7","article-title":"Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol","volume":"5","author":"Morrison","year":"1964","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clnu.2019.03.037_bib18","first-page":"E529","article-title":"Noninvasive tracing of human liver metabolism: comparison of phenylacetate and apoB-100 to sample glutamine","volume":"277","author":"Diraison","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.clnu.2019.03.037_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0021-9673(01)99010-7","article-title":"Gas chromatography of bile acids as their hexafluoroisopropyl ester-trifluoroacetyl derivatives","volume":"120","author":"Imai","year":"1976","journal-title":"J\u00a0Chromatogr"},{"key":"10.1016\/j.clnu.2019.03.037_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/abio.1998.2632","article-title":"Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry","volume":"258","author":"Yang","year":"1998","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2019.03.037_bib21","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1210\/jcem.86.11.7981","article-title":"Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients","volume":"86","author":"Cachefo","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2019.03.037_bib22","first-page":"257","article-title":"Prediction of the parameters of whole body cholesterol metabolism in humans","volume":"92","author":"DeWitt","year":"1979","journal-title":"Trans Assoc Am Phys"},{"key":"10.1016\/j.clnu.2019.03.037_bib23","first-page":"69","article-title":"Blood volume measurement: a critical study prediction of normal values: controlled measurement of sequential changes: choice of a bedside method","volume":"1","author":"Dagher","year":"1965","journal-title":"Adv Surg"},{"key":"10.1016\/j.clnu.2019.03.037_bib24","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1139\/y03-079","article-title":"Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster","volume":"81","author":"Souidi","year":"2003","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.clnu.2019.03.037_bib25","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1006\/mgme.2000.3106","article-title":"Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids","volume":"71","author":"Bramlett","year":"2000","journal-title":"Mol Genet Metab"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.clnu.2019.03.037_bib26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S2210-7401(12)70015-3","article-title":"Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action","volume":"36","author":"Poupon","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.clnu.2019.03.037_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11745-017-4242-5","article-title":"Ursodeoxycholic acid suppresses lipogenesis in mouse liver: possible role of the decrease in \u03b2-muricholic acid, a farnesoid X receptor antagonist","volume":"52","author":"Fujita","year":"2017","journal-title":"Lipids"},{"key":"10.1016\/j.clnu.2019.03.037_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0009-8981(95)06252-1","article-title":"Bile acid conjugation in early stage cholestatic liver disease before and during treatment with ursodeoxycholic acid","volume":"248","author":"Fracchia","year":"1996","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.clnu.2019.03.037_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160789","article-title":"Stereological analysis of liver biopsy histology sections as a reference standard for validating non-invasive liver fat fraction measurements by MRI","volume":"11","author":"St Pierre","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2019.03.037_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1515\/JPEM.1999.12.4.549","article-title":"Parenteral nutrition-associated cholestasis in preterm neonates: evaluation of ursodeoxycholic acid treatment","volume":"12","author":"Levine","year":"1999","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.clnu.2019.03.037_bib31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1055-8586(99)70015-6","article-title":"New approaches to understanding the etiology and treatment of total parenteral nutrition-associated cholestasis","volume":"8","author":"Moss","year":"1999","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.clnu.2019.03.037_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2036.2006.02972.x","article-title":"Early treatment with ursodeoxycholic acid for cholestasis in children on parenteral nutrition because of primary intestinal failure","volume":"24","author":"De Marco","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2019.03.037_bib33","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/gast.1996.v111.pm8780577","article-title":"Ursodeoxycholic acid for treatment of cholestasis in children on long-term total parenteral nutrition: a pilot study","volume":"111","author":"Spagnuolo","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2019.03.037_bib34","doi-asserted-by":"crossref","first-page":"G218","DOI":"10.1152\/ajpgi.00280.2011","article-title":"Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs","volume":"302","author":"Jain","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2019.03.037_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jpeds.2004.05.038","article-title":"Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis","volume":"145","author":"Chen","year":"2004","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2019.03.037_bib36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0002-9343(87)90449-9","article-title":"Hepatic complications of total parenteral nutrition","volume":"82","author":"Baker","year":"1987","journal-title":"Am J Med"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419301517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419301517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:54:31Z","timestamp":1759366471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561419301517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0261561419301517"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2019.03.037","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2019.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}