{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:15:40Z","timestamp":1786986940917,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.clnu.2019.12.012","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:02:45Z","timestamp":1576238565000},"page":"2824-2831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The relationship between plasma albumin, alkaline phosphatase and pyridoxal phosphate concentrations in plasma and red cells: Implications for assessing vitamin B6 status"],"prefix":"10.1016","volume":"39","author":[{"given":"Dinesh","family":"Talwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-0029","authenticated-orcid":false,"given":"Anthony","family":"Catchpole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Wadsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2019.12.012_bib1","series-title":"Handbook of vitamins","first-page":"341","article-title":"Vitamin B6","author":"Leklem","year":"1991"},{"key":"10.1016\/j.clnu.2019.12.012_bib2","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1016\/S0021-9258(19)42215-1","article-title":"Metabolic interconversions of different forms of vitamin B6","volume":"249","author":"Johansson","year":"1974","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.clnu.2019.12.012_bib3","series-title":"Present knowledge in nutrition","first-page":"174","article-title":"Vitamin B6","author":"Leklem","year":"1991"},{"key":"10.1016\/j.clnu.2019.12.012_bib4","series-title":"Nutritional status assessment: a manual for population studies","first-page":"266","article-title":"Erythrocyte aspartate transaminase; pyridoxal 5-phosphate (PLP) in whole blood by HPLC; pyridoxal 5-phosphate in plasma by radioenzymatic assay using tyrosine decarboxylase apoenzyme; 4-pyridoxic acid in urine by HPLC","author":"Vuilleumier","year":"1991"},{"key":"10.1016\/j.clnu.2019.12.012_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1177\/000456329703400604","article-title":"Vitamin analysis","volume":"34","author":"Bates","year":"1997","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.clnu.2019.12.012_bib6","first-page":"126","article-title":"Clinical chemical methods for the routine assessment of the vitamin status in human populations. Part III. The apoenzyme stimulation tests for vitamin B1, B2 and B6 adapted to the Cobas Bio analyzer","volume":"60","author":"Vuilleumier","year":"1990","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.clnu.2019.12.012_bib7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1373\/49.3.515","article-title":"Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response","volume":"49","author":"Talwar","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2019.12.012_bib8","series-title":"Methods in vitamin B6 nutrition","first-page":"389","article-title":"Recommendations for status assessment of vitamin B6","author":"Leklem","year":"1981"},{"key":"10.1016\/j.clnu.2019.12.012_bib9","first-page":"545","article-title":"Validation of the diagnostic value of plasma pyridoxal 5-phosphate measurements in vitamin B6 nutrition of the rat","volume":"108","author":"Lumeng","year":"1978","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib10","first-page":"185","article-title":"Evaluation of pyridoxine intake and pyridoxine status among aged institutionalised people","volume":"54","author":"Guilland","year":"1984","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.clnu.2019.12.012_bib11","series-title":"Methods in vitamin B6 nutrition","first-page":"297","article-title":"Urinary 4-pyridoxic acid, urinary vitamin B6 and plasma pyridoxal phosphate as measures of vitamin B6 status and dietary intake of adults","author":"Shultz","year":"1981"},{"key":"10.1016\/j.clnu.2019.12.012_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1570-0232(03)00320-9","article-title":"Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation","volume":"792","author":"Talwar","year":"2003","journal-title":"J\u00a0Chromatogr B"},{"key":"10.1016\/j.clnu.2019.12.012_bib13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0899-9007(97)00200-1","article-title":"Micronutrients and outcome","volume":"13","author":"Shenkin","year":"1997","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2019.12.012_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0009-8981(67)90264-1","article-title":"Pyridoxal phosphate concentration and aminotransferase activity in human blood cells","volume":"16","author":"Hamfelt","year":"1967","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.clnu.2019.12.012_bib15","first-page":"226","article-title":"Analysis of vitamin B-6 vitamers in human tissue by cation-exchange high performance liquid chromatography","volume":"491","author":"Shephard","year":"1989","journal-title":"J\u00a0Chromatogr"},{"key":"10.1016\/j.clnu.2019.12.012_bib16","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00003246-199207000-00007","article-title":"Blood vitamin concentrations during the acute phase response","volume":"20","author":"Louw","year":"1992","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnu.2019.12.012_bib17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.clnu.2004.01.013","article-title":"The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplasty","volume":"23","author":"Gray","year":"2004","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2019.12.012_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1017\/S0029665118002501","article-title":"Relationship between nutritional status and the systemic inflammatory response: micronutrients","volume":"78","author":"McMillan","year":"2019","journal-title":"Proc Nutr Soc"},{"issue":"10","key":"10.1016\/j.clnu.2019.12.012_bib19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/BF01745511","article-title":"Compartmentalization of pyridoxal-5'-phosphate during the acute phase of myocardial infarction","volume":"66","author":"Vermaak","year":"1988","journal-title":"Klin Wochenschr"},{"key":"10.1016\/j.clnu.2019.12.012_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/01635581.2012.661512","article-title":"The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer","volume":"64","author":"Leung","year":"2012","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clnu.2019.12.012_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.diabres.2014.09.058","article-title":"Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy","volume":"107","author":"Nix","year":"2015","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.clnu.2019.12.012_bib22","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.clnu.2005.06.004","article-title":"The relationship between plasma and red cell B-vitamin concentrations in critically-ill patients","volume":"24","author":"Quasim","year":"2005","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.ejcn.1601321","article-title":"Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan","volume":"56","author":"Huang","year":"2002","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2019.12.012_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/ajcn\/88.1.140","article-title":"Relation between pyridoxal and pyridoxal phosphate concentrations in plasma, red cells, and white cells in patients with critical illness","volume":"88","author":"Vasilaki","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3945\/ajcn.111.023812","article-title":"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements","volume":"95","author":"Duncan","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib26","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1016\/S0021-9258(18)91090-2","article-title":"Effect of binding to haemoglobin and albumin on pyridoxal transport and metabolism","volume":"259","author":"Ink","year":"1984","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.clnu.2019.12.012_bib27","first-page":"1664","article-title":"Metabolism of vitamin B6 by human liver","volume":"114","author":"Merrill","year":"1984","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib28","first-page":"334","article-title":"Pyridoxal 5'-phosphate in plasma: source, protein binding and cellular transport","volume":"84","author":"Lumeng","year":"1974","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.clnu.2019.12.012_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/gut.21.3.192","article-title":"Hydrolysis of pyridoxal-5'-phosphatein plasma in conditions with raised alkaline phosphatase","volume":"21","author":"Anderson","year":"1980","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2019.12.012_bib30","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1172\/JCI112031","article-title":"Markedly increased circulating pyridoxal-5'-phosphate concentrations in hypophosphatasia: alkaline phosphatase acts in vitamin B6 metabolism","volume":"76","author":"Whyte","year":"1985","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.clnu.2019.12.012_bib31","series-title":"Clinical and physiological applications of vitamin B-6","first-page":"65","author":"Coburn","year":"1988"},{"issue":"suppl","key":"10.1016\/j.clnu.2019.12.012_bib32","first-page":"S39","article-title":"Dietary and other determinants of vitamin B6 parameters","volume":"51","author":"Brussaard","year":"1997","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib33","first-page":"233","article-title":"Hypophosphatasia \u2013 aetiology, nosology, pathogenesis, diagnosis and treatment","volume":"12","author":"Whyte","year":"2016","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.clnu.2019.12.012_bib34","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2019.12.012_bib35","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.clnu.2019.12.012_bib36","first-page":"1503","article-title":"Vitamin B-6. A status report","volume":"120","author":"Leklem","year":"1990","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib37","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/ajcn\/51.6.1058","article-title":"Vitamin B-6 nutrition status and cigarette smoking","volume":"51","author":"Vermaak","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib38","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.nut.2004.11.013","article-title":"Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill","volume":"21","author":"Huang","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2019.12.012_bib39","first-page":"3308","article-title":"Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet","volume":"132","author":"Kwak","year":"2002","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib40","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.ejcn.1602439","article-title":"Vitamin B6 supplementation increases immune responses in critically ill patients","volume":"60","author":"Cheng","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib41","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/ajcn\/59.6.1297","article-title":"Reference ranges for erythrocyte pyridoxal 50-phosphate concentration and the erythrocyte aspartate transaminase stimulation test in lactating mothers and their infants","volume":"59","author":"Heiskanen","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib42","first-page":"38","article-title":"Risk of low vitamin B6 status in infants breast-fed exclusively beyond six months","volume":"23","author":"Heiskanen","year":"1996","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2019.12.012_bib43","first-page":"1777","article-title":"Assessment of vitamin B-6 status in young women consuming a controlled diet containing four levels of vitamin B-6 provides an estimated average requirement and recommended dietary allowance","volume":"131","author":"Hansen","year":"2001","journal-title":"J\u00a0Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419331814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561419331814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:55:27Z","timestamp":1759366527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561419331814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0261561419331814"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2019.12.012","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between plasma albumin, alkaline phosphatase and pyridoxal phosphate concentrations in plasma and red cells: Implications for assessing vitamin B6 status","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2019.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}