{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:34:55Z","timestamp":1790199295616,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100018440","name":"Mikati Foundation","doi-asserted-by":"publisher","award":["R56HL141744"],"award-info":[{"award-number":["R56HL141744"]}],"id":[{"id":"10.13039\/100018440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES023512"],"award-info":[{"award-number":["P30ES023512"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AA024333"],"award-info":[{"award-number":["P50 AA024333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AA022742"],"award-info":[{"award-number":["R21 AA022742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 DK 113196"],"award-info":[{"award-number":["RO1 DK 113196"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 GM119174"],"award-info":[{"award-number":["RO1 GM119174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1 AA021890"],"award-info":[{"award-number":["UO1 AA021890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1 AA026975"],"award-info":[{"award-number":["UO1 AA026975"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UO1 DK061732"],"award-info":[{"award-number":["UO1 DK061732"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.clnu.2020.01.010","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T02:34:15Z","timestamp":1580265255000},"page":"3056-3065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD"],"prefix":"10.1016","volume":"39","author":[{"given":"Mari\u00eblle P.K.J.","family":"Engelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Jonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Thaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella A.M.","family":"Ten Have","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Sun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Dasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas E.P.","family":"Deutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.clnu.2020.01.010_bib1","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1164\/rccm.201402-0373ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease","volume":"189","author":"Maltais","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.clnu.2020.01.010_bib2","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.rmed.2010.05.001","article-title":"Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations","volume":"104","author":"Vilaro","year":"2010","journal-title":"Respir Med"},{"issue":"6","key":"10.1016\/j.clnu.2020.01.010_bib3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00109-011-0732-8","article-title":"Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema","volume":"89","author":"Min","year":"2011","journal-title":"J\u00a0Mol Med"},{"issue":"6","key":"10.1016\/j.clnu.2020.01.010_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/metabo9060111","article-title":"An updated overview of metabolomic profile changes in chronic obstructive pulmonary disease","volume":"9","author":"Ran","year":"2019","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.clnu.2020.01.010_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1183\/09031936.00112411","article-title":"Metabolic profiling detects biomarkers of protein degradation in COPD patients","volume":"40","author":"Ubhi","year":"2012","journal-title":"Eur Respir J"},{"issue":"12","key":"10.1016\/j.clnu.2020.01.010_bib6","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1039\/c2mb25194a","article-title":"Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD","volume":"8","author":"Ubhi","year":"2012","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.clnu.2020.01.010_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jpba.2016.09.034","article-title":"Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease","volume":"132","author":"Singh","year":"2017","journal-title":"J\u00a0Pharmaceut Biomed Anal"},{"issue":"6","key":"10.1016\/j.clnu.2020.01.010_bib8","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/ajcn\/72.6.1480","article-title":"Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease","volume":"72","author":"Engelen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2020.01.010_bib9","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.2147\/COPD.S152134","article-title":"Metabolic changes of different high-resolution computed tomography phenotypes of COPD after budesonide\u2013formoterol treatment","volume":"12","author":"Wang","year":"2017","journal-title":"Int J Chronic Obstr Pulm Dis"},{"issue":"4","key":"10.1016\/j.clnu.2020.01.010_bib10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.17219\/acem\/68763","article-title":"A\u00a0pilot data analysis of a metabolomic HPLC-MS\/MS study of patients with COPD","volume":"27","author":"Novotna","year":"2018","journal-title":"Adv Clin Exp Med"},{"issue":"4","key":"10.1016\/j.clnu.2020.01.010_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ajcn\/83.4.829","article-title":"Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease","volume":"83","author":"Rutten","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2020.01.010_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.metabol.2017.09.015","article-title":"Metabolic phenotyping using kinetic measurements in young and older healthy adults","volume":"78","author":"Deutz","year":"2018","journal-title":"Metab Clin Exp"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib13","first-page":"96","article-title":"Taurine and skeletal muscle function","volume":"18","author":"Spriet","year":"2015","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"4","key":"10.1016\/j.clnu.2020.01.010_bib14","first-page":"237","article-title":"Glycine metabolism in skeletal muscle: implications for metabolic homeostasis","volume":"20","author":"Koopman","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"10","key":"10.1016\/j.clnu.2020.01.010_bib15","doi-asserted-by":"crossref","first-page":"E1177","DOI":"10.1152\/ajpendo.00284.2012","article-title":"Arginine de novo and nitric oxide production in disease states","volume":"303","author":"Luiking","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1164\/rccm.201701-0218PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary","volume":"195","author":"Vogelmeier","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general U.S. population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.clnu.2020.01.010_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","article-title":"The physical activity scale for the elderly (PASE): development and evaluation","volume":"46","author":"Washburn","year":"1993","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"11","key":"10.1016\/j.clnu.2020.01.010_bib19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"9","key":"10.1016\/j.clnu.2020.01.010_bib20","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/0026-0495(81)90074-3","article-title":"Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man","volume":"30","author":"Abumrad","year":"1981","journal-title":"Metab Clin Exp"},{"issue":"9","key":"10.1016\/j.clnu.2020.01.010_bib21","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1093\/annonc\/mdv271","article-title":"High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer","volume":"26","author":"Engelen","year":"2015","journal-title":"Ann Oncol \u2013 Off J Eur Soc Med Oncol \/ ESMO"},{"key":"10.1016\/j.clnu.2020.01.010_bib22","series-title":"Isotope tracers in metabolic research: principles and practice of kinetic analysis. New York","first-page":"1","author":"Wolfe","year":"2005"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib23","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1152\/ajpendo.00362.2016","article-title":"A\u00a0four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans","volume":"313","author":"Mason","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib24","first-page":"29","article-title":"Discrepancy between muscle and whole body protein turnover","volume":"2","author":"Deutz","year":"1999","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-200101000-00003","article-title":"Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation","volume":"233","author":"Hasselgren","year":"2001","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.clnu.2012.04.006","article-title":"Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids","volume":"31","author":"Engelen","year":"2012","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1172\/JCI114421","article-title":"Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain alpha-keto acid dehydrogenase","volume":"85","author":"Nawabi","year":"1990","journal-title":"J\u00a0Clin Invest"},{"issue":"1 Suppl","key":"10.1016\/j.clnu.2020.01.010_bib28","article-title":"Symposium on branched-chain amino acids: conference summary","volume":"136","author":"Cynober","year":"2006","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2020.01.010_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exger.2016.04.013","article-title":"The relationship of endogenous plasma concentrations of beta-Hydroxy beta-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans","volume":"81","author":"Kuriyan","year":"2016","journal-title":"Exp Gerontol"},{"issue":"3","key":"10.1016\/j.clnu.2020.01.010_bib30","first-page":"207","article-title":"Is beta-hydroxy beta-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?","volume":"21","author":"Engelen","year":"2018","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jcsm.12032","article-title":"Conversion of leucine to beta-hydroxy-beta-methylbutyrate by alpha-keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes","volume":"7","author":"Giron","year":"2016","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"6 Pt A","key":"10.1016\/j.clnu.2020.01.010_bib32","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.clnu.2017.09.024","article-title":"Impact of the calcium form of beta-hydroxy-beta-methylbutyrate upon human skeletal muscle protein metabolism","volume":"37","author":"Wilkinson","year":"2018","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1249\/MSS.0b013e318194cc75","article-title":"Effects of amino acids supplement on physiological adaptations to resistance training","volume":"41","author":"Kraemer","year":"2009","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"10.1016\/j.clnu.2020.01.010_bib34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jcsm.12208","article-title":"Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions","volume":"8","author":"Holecek","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.clnu.2020.01.010_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clnu.2015.12.010","article-title":"Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: a randomized clinical trial","volume":"35","author":"Deutz","year":"2016","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib36","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.clnu.2015.10.001","article-title":"Oral supplement enriched in HMB combined with pulmonary rehabilitation improves body composition and health related quality of life in patients with bronchiectasis (Prospective, Randomised Study)","volume":"35","author":"Olveira","year":"2016","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2020.01.010_bib37","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3945\/ajcn.115.125187","article-title":"Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease","volume":"103","author":"Jonker","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2020.01.010_bib38","doi-asserted-by":"crossref","first-page":"271918","DOI":"10.1155\/2014\/271918","article-title":"Exhaled nitric oxide as a biomarker in COPD and related comorbidities","volume":"2014","author":"Malerba","year":"2014","journal-title":"BioMed Res Int"},{"issue":"6\u20137","key":"10.1016\/j.clnu.2020.01.010_bib39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0960-8966(01)00215-2","article-title":"Nitric oxide: biologic effects on muscle and role in muscle diseases","volume":"11","author":"Kaminski","year":"2001","journal-title":"Neuromuscul Disord"},{"issue":"16","key":"10.1016\/j.clnu.2020.01.010_bib40","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1161\/01.CIR.99.16.2113","article-title":"Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure","volume":"99","author":"Katz","year":"1999","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.clnu.2020.01.010_bib41","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.metabol.2012.05.003","article-title":"Differential nitric oxide levels in the blood and skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a preliminary study","volume":"61","author":"Krause","year":"2012","journal-title":"Metab Clin Exp"},{"issue":"9","key":"10.1016\/j.clnu.2020.01.010_bib42","first-page":"2166","article-title":"Decreased whole-body and splanchnic glutamate metabolism in healthy elderly men and patients with chronic obstructive pulmonary disease in the postabsorptive state and in response to feeding","volume":"135","author":"Rutten","year":"2005","journal-title":"J\u00a0Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib43","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1164\/ajrccm.162.5.9910066","article-title":"Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease","volume":"162","author":"Engelen","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.clnu.2020.01.010_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/cs0950339","article-title":"Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate","volume":"95","author":"Van Acker","year":"1998","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"10.1016\/j.clnu.2020.01.010_bib45","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.clnu.2013.06.013","article-title":"Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia","volume":"33","author":"Ham","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2020.01.010_bib46","first-page":"A2471","article-title":"Enhanced de novo arginine synthesis and protein turnover in pediatric cystic fibrosis patients with nutritional failure","volume":"185","author":"Engelen","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jcf.2012.12.011","article-title":"Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis","volume":"12","author":"Engelen","year":"2013","journal-title":"J\u00a0Cyst Fibros \u2013 Off J Eur Cystic Fibros Soc"},{"issue":"5","key":"10.1016\/j.clnu.2020.01.010_bib48","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.clnu.2017.07.019","article-title":"Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer","volume":"37","author":"Engelen","year":"2018","journal-title":"Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561420300303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561420300303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:55:57Z","timestamp":1759366557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561420300303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0261561420300303"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2020.01.010","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2020.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}