{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:31:26Z","timestamp":1774074686924,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.clnu.2021.06.012","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T01:05:54Z","timestamp":1623891954000},"page":"4616-4623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Home parenteral nutrition patients on mixed oil lipid emulsion have a higher rate of hospitalizations compare to those on soybean oil\u2013 a prospective 2-year cohort study"],"prefix":"10.1016","volume":"40","author":[{"given":"Nayima M.","family":"Clermont-Dejean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine J.P.","family":"Schwenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennaliza","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Faganello","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-4476","authenticated-orcid":false,"given":"Zihang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Gramlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Jurewitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitreyi","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Duerksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"McHattie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johane P.","family":"Allard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.clnu.2016.12.026","article-title":"Influence of different intravenous lipid emulsions on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: a systematic review","volume":"37","author":"Jones","year":"2018","journal-title":"Clin Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.06.012_bib2","first-page":"S21","article-title":"Lipids in parenteral nutrition: biological aspects","volume":"44","author":"Calder","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2021.06.012_bib3","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/ajcn\/85.5.1171","article-title":"Immune modulation by parenteral lipid emulsions","volume":"85","author":"Wanten","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.06.012_bib4","first-page":"S39","article-title":"Use of lipids in adult patients requiring parenteral nutrition in the home setting","volume":"44","author":"Mundi","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2021.06.012_bib5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/0884533616663635","article-title":"Home parenteral nutrition: fat emulsions and potential complications","volume":"31","author":"Mundi","year":"2016","journal-title":"Nutr Clin Pract"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/MOT.0b013e3283394879","article-title":"Prevention of parenteral nutrition-associated liver disease: role of omega-3 fish oil","volume":"15","author":"Fallon","year":"2010","journal-title":"Curr Opin Organ Transplant"},{"issue":"2","key":"10.1016\/j.clnu.2021.06.012_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/MOT.0000000000000620","article-title":"Current status of lipid emulsions in the prevention of intestinal failure-associated liver disease","volume":"24","author":"Lim","year":"2019","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.clnu.2021.06.012_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2019.10.004","article-title":"Fish oil supplementation with various lipid emulsions suppresses in\u00a0vitro cytokine release in home parenteral nutrition patients: a crossover study","volume":"72","author":"Novak","year":"2019","journal-title":"Nutr Res"},{"issue":"2","key":"10.1016\/j.clnu.2021.06.012_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.clnu.2012.06.011","article-title":"Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults","volume":"32","author":"Klek","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.06.012_bib10","first-page":"6301293","article-title":"Current evidence for the use of smoflipid(R) emulsion in critical care patients for parenteral nutrition","author":"Leguina-Ruzzi","year":"2018","journal-title":"Crit Care Res Pract"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.06.012_bib11","first-page":"S28","article-title":"Lipid use in hospitalized adults requiring parenteral nutrition","volume":"44","author":"Mayer","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2021.06.012_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jpen.1526","article-title":"Long-term use of mixed-oil lipid emulsion in soybean oil-intolerant home parenteral nutrition patients","volume":"44","author":"Mundi","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2021.06.012_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jpen.1972","article-title":"Cost-effectiveness of parenteral nutrition containing omega-3 fatty acids in hospitalized adult patients from 5 European countries and the US","author":"Pradelli","year":"2021","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jpen.1672","article-title":"omega-3 fatty-acid enriched parenteral nutrition in hospitalized patients: systematic review with meta-analysis and trial sequential analysis","volume":"44","author":"Pradelli","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"12","key":"10.1016\/j.clnu.2021.06.012_bib15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/nure.12053","article-title":"Safety and efficacy of a new parenteral lipid emulsion (SMOF) for surgical patients: a systematic review and meta-analysis of randomized controlled trials","volume":"71","author":"Tian","year":"2013","journal-title":"Nutr Rev"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/MPG.0b013e3181de210c","article-title":"Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition","volume":"51","author":"Tomsits","year":"2010","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"12","key":"10.1016\/j.clnu.2021.06.012_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2146\/ajhp151015","article-title":"Outcomes with perioperative fat emulsions containing omega-3 fatty acid: a meta-analysis of randomized controlled trials","volume":"74","author":"Bae","year":"2017","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.clnu.2021.06.012_bib18","doi-asserted-by":"crossref","DOI":"10.2147\/CEOR.S139902","article-title":"Parenteral nutrition including an omega-3 fatty-acid-containing lipid emulsion for intensive care patients in China: a pharmacoeconomic analysis","volume":"9","author":"Feng","year":"2017","journal-title":"Clinicoecon Outcomes Res"},{"issue":"1_suppl","key":"10.1016\/j.clnu.2021.06.012_bib19","article-title":"Use of mixed-oil fat emulsion to improve intestinal failure-associated liver disease in long-term home parenteral nutrition: a case report","volume":"41","author":"Hurt","year":"2017","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib20","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.clnu.2018.05.028","article-title":"Effect of changing the lipid component of home parenteral nutrition in adults","volume":"38","author":"Osowska","year":"2019","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.06.012_bib21","first-page":"111029","article-title":"Intravenous lipid emulsions and liver function in adult chronic intestinal failure patients: results after 5 y of home parenteral nutrition","author":"Klek","year":"2020","journal-title":"Nutrition"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/0148607111434599","article-title":"Canadian home parenteral nutrition (HPN) registry: validation and patient outcomes","volume":"36","author":"Fernandes","year":"2012","journal-title":"J\u00a0Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2021.06.012_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nut.2019.01.021","article-title":"Variations in practice patterns for adult cancer patients on home parenteral nutrition in Canada","volume":"65","author":"Tran","year":"2019","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.clnu.2021.06.012_bib24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/0148607105029006408","article-title":"Line sepsis in home parenteral nutrition patients: are there socioeconomic risk factors? A Canadian study","volume":"29","author":"Chang","year":"2005","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"10","key":"10.1016\/j.clnu.2021.06.012_bib25","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1155\/2007\/217897","article-title":"Canadian home total parenteral nutrition registry: preliminary data on the patient population","volume":"21","author":"Raman","year":"2007","journal-title":"Can J Gastroenterol"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib26","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1053\/j.gastro.2016.12.026","article-title":"American gastroenterological association Institute guidelines for the diagnosis and management of acute liver failure","volume":"152","author":"Flamm","year":"2017","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.clnu.2021.06.012_bib27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/hep.31065","article-title":"Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American association for the study of liver diseases","volume":"72","author":"Mack","year":"2020","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib28","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib29","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/hep.25551","article-title":"Introduction to the revised American association for the study of liver diseases position paper on acute liver failure 2011","volume":"55","author":"Lee","year":"2012","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib30","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.22742","article-title":"American association for the study of liver D. Liver biopsy","volume":"49","author":"Rockey","year":"2009","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.clnu.2021.06.012_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/cld.888","article-title":"Parenteral nutrition-associated liver disease","volume":"15","author":"Nowak","year":"2020","journal-title":"Clin Liver Dis"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib32","article-title":"Canada: Health system review","volume":"22","author":"Marchildon","year":"2020","journal-title":"Health Systems in Transition"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.06.012_bib33","first-page":"S74","article-title":"Use of intravenous lipid emulsions with parenteral nutrition: practical handling aspects","volume":"44","author":"Boullata","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2021.06.012_bib34","first-page":"449","article-title":"Lipids in the nutritional support of the critically ill patients","volume":"10","author":"Hasselmann","year":"2004","journal-title":"Curr Opin Crit Care"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1017\/S0029665100000793","article-title":"The scientific basis of immunonutrition","volume":"59","author":"Suchner","year":"2000","journal-title":"Proc Nutr Soc"},{"issue":"5","key":"10.1016\/j.clnu.2021.06.012_bib36","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0148607115609289","article-title":"Changes in home parenteral nutrition practice based on the Canadian home parenteral nutrition patient registry","volume":"41","author":"Hortencio","year":"2017","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2021.06.012_bib37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jpen.1866","article-title":"Patients with severe gastrointestinal dysmotility disorders receiving home parenteral nutrition have similar survival as those with short-bowel syndrome: a prospective cohort study","volume":"45","author":"Salazar","year":"2021","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0148607112452001","article-title":"A.S.P.E.N. Clinical guidelines: nutrition support of adult patients with hyperglycemia","volume":"37","author":"McMahon","year":"2013","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"10","key":"10.1016\/j.clnu.2021.06.012_bib39","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.2337\/diacare.28.10.2367","article-title":"Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition","volume":"28","author":"Cheung","year":"2005","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.clnu.2021.06.012_bib40","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/apt.15432","article-title":"Review article: diagnosis and management of intestinal failure-associated liver disease in adults","volume":"50","author":"Bond","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib41","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.clnu.2009.04.001","article-title":"ESPEN Guidelines on Parenteral Nutrition: home parenteral nutrition (HPN) in adult patients","volume":"28","author":"Staun","year":"2009","journal-title":"Clin Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.06.012_bib42","first-page":"S7","article-title":"Summary of proceedings and expert consensus statements from the international summit \"lipids in parenteral nutrition\"","volume":"44","author":"Martindale","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0148607111420157","article-title":"Clinical guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients: applying the GRADE system to development of A.S.P.E.N. Clinical guidelines","volume":"36","author":"Druyan","year":"2012","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2021.06.012_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/011542650702200157","article-title":"Home initiation of parenteral nutrition","volume":"22","author":"Newton","year":"2007","journal-title":"Nutr Clin Pract"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib45","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.clnu.2018.07.024","article-title":"An international study of the quality of life of adult patients treated with home parenteral nutrition","volume":"38","author":"Baxter","year":"2019","journal-title":"Clin Nutr"},{"issue":"8","key":"10.1016\/j.clnu.2021.06.012_bib46","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1177\/0148607115586575","article-title":"Characteristics of a cohort of home parenteral nutrition patients at the time of enrollment in the sustain registry","volume":"40","author":"Winkler","year":"2016","journal-title":"J\u00a0Parenter Enter Nutr"},{"issue":"4","key":"10.1016\/j.clnu.2021.06.012_bib47","first-page":"654","article-title":"Serrano Aguayo Pilar et\u00a0al Nuestra experiencia de ocho a\u00f1os en nutrici\u00f3n parenteral domiciliaria de pacientes adultos","volume":"37","author":"Mej\u00edas Trueba Marta","year":"2020","journal-title":"Nutr Hosp"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421002995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421002995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:59:32Z","timestamp":1759366772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561421002995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0261561421002995"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2021.06.012","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Home parenteral nutrition patients on mixed oil lipid emulsion have a higher rate of hospitalizations compare to those on soybean oil\u2013 a prospective 2-year cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2021.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}