{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:10:09Z","timestamp":1792645809662,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.clnu.2021.07.017","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T02:29:28Z","timestamp":1626575368000},"page":"4941-4947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Variation of plasma citrulline as a predictive factor for weaning off long-term parenteral nutrition in children with neonatal short bowel syndrome"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-3342","authenticated-orcid":false,"given":"Francesco","family":"Proli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Faragalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Talbotec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-388X","authenticated-orcid":false,"given":"Boutaina","family":"Zemrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-5650","authenticated-orcid":false,"given":"Christophe","family":"Chardot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-1200","authenticated-orcid":false,"given":"Elie","family":"Abi Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lambe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2021.07.017_bib1","first-page":"250","article-title":"Irreversible intestinal failure","volume":"38","author":"Goulet","year":"2004","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1053\/j.gastro.2005.12.002","article-title":"Causes and management of intestinal failure in children","volume":"130","author":"Goulet","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2021.07.017_bib3","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.transproceed.2007.02.083","article-title":"Prevalence of life-threatening complications in pediatric patients affected by intestinal failure","volume":"39","author":"Diamanti","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.clnu.2021.07.017_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1054\/clnu.2000.0132","article-title":"Central venous catheter- related infections in children on long term home parenteral nutrition: incidence and risk factors","volume":"19","author":"Colomb","year":"2000","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib5","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3390\/nu9111217","article-title":"Pediatric chronic intestinal failure in Italy: report from the 2016 survey on behalf of Italian society for Gastroenterology, Hepatology and nutrition (SIGENP)","volume":"9","author":"Diamanti","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2021.07.017_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dld.2010.04.012","article-title":"Long-term home parenteral nutrition in children with chronic intestinal failure: a 15-year experience at a single Italian center","volume":"43","author":"Gandullia","year":"2011","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.clnu.2021.07.017_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1651-2227.2012.02594.x","article-title":"Ten-year experience of home parenteral nutrition in a single center","volume":"101","author":"Wiskin","year":"2012","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/MPG.0000000000000242","article-title":"Long-term outcome of home parenteral nutrition in patients with ultra-short bowel syndrome","volume":"58","author":"Diamanti","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2021.07.017_bib9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1177\/0884533617718472","article-title":"Prevalence of home parenteral and enteral nutrition in the United States","volume":"32","author":"Mundi","year":"2017","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.clnu.2021.07.017_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000479339","article-title":"Czech home parenteral nutrition group of the society of clinical nutrition and intensive metabolic care. Paediatric home parenteral nutrition in the Czech republic and its development: multicenter retrospective study 1995-2011","volume":"71","author":"St\u00fdblov\u00e1","year":"2017","journal-title":"Ann Nutr Metab"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2021.07.017_bib11","first-page":"S82","article-title":"Chapter 5.2.3. Parenteral nutrition and home parenteral nutrition changed the face of paediatric Gastroenterology","volume":"66","author":"Diamanti","year":"2018","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib12","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.clnu.2018.06.954","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN working group on pediatric parenteral nutrition. ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: home parenteral nutrition","volume":"37","author":"Hill","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0022-3476(05)81032-7","article-title":"Neonatal short bowel syndrome","volume":"119","author":"Goulet","year":"1991","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mpd.2001.114481","article-title":"Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes","volume":"139","author":"Andorsky","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpeds.2004.02.030","article-title":"Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience","volume":"145","author":"Quiros-Tejeira","year":"2004","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-2004-821214","article-title":"Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children","volume":"15","author":"Goulet","year":"2005","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jpedsurg.2009.08.009","article-title":"Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth and nutrition","volume":"45","author":"Olieman","year":"2010","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib18","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jpeds.2013.05.062","article-title":"Successful rehabilitation in pediatric ultrashort small bowel syndrome","volume":"163","author":"Infantino","year":"2013","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jpeds.2015.03.040","article-title":"Predictors of enteral autonomy in children with intestinal failure: a multicenter cohort study","volume":"167","author":"Khan","year":"2015","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib20","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1097\/MPG.0000000000001915","article-title":"Chapter 5.2.1. Short bowel syndrome: half a century of progress","volume":"66","author":"Goulet","year":"2018","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpeds.2016.10.027","article-title":"Outcomes from a 12-week, open-label, multicenter clinical trial of teduglutide in pediatric short bowel syndrome","volume":"181","author":"Carter","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/j.sempedsurg.2018.07.008","article-title":"Advances in glucagon like peptide-2 therapy. physiology, current indications and future directions","volume":"27","author":"Sigalet","year":"2018","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib23","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jpedsurg.2018.02.012","article-title":"Holst JJ the glucagon like peptide-2 'axis': capacity for production and response following intestinal resection or repair of gastroschisis in infants","volume":"53","author":"Sigalet","year":"2018","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jpen.1690","article-title":"Safety and efficacy of teduglutide in pediatric patients with intestinal failure due to short bowel syndrome: a 24-week, phase III study","volume":"44","author":"Kocoshis","year":"2020","journal-title":"J\u00a0Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/SLA.0b013e318265f310","article-title":"Long-term survival, nutritional autonomy, and quality of life after intestinal and multivisceral transplantation","volume":"256","author":"Abu-Elmagd","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib26","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/ajt.14654","article-title":"Life of patients 10 years after a successful pediatric intestinal transplantation in Europe","volume":"18","author":"Norsa","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.clnu.2021.07.017_bib27","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.clnu.2018.02.004","article-title":"Long term outcomes of intestinal rehabilitation in children with neonatal very short bowel syndrome: parenteral nutrition or intestinal transplantation","volume":"38","author":"Norsa","year":"2019","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib28","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0016-5085(03)00170-7","article-title":"Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease","volume":"124","author":"Crenn","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2021.07.017_bib29","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1572-0241.2007.01239.x","article-title":"Plasma citrulline concentration: a reliable marker of small bowel absorptive capacity independent of intestinal inflammation","volume":"102","author":"Papadia","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clnu.2021.07.017_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2050640617737632","article-title":"Citrulline as a marker of intestinal function and absorption in clinical settings: a systematic review and meta-analysis","volume":"6","author":"Fragkos","year":"2018","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.clnu.2021.07.017_bib31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jpeds.2004.12.027","article-title":"Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome","volume":"146","author":"Rhoads","year":"2005","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1203\/PDR.0b013e31819986da","article-title":"Plasma citrulline concentration reflects enterocyte mass in children with short bowel syndrome","volume":"65","author":"Bailly-Botuha","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clnu.2021.07.017_bib33","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jpedsurg.2009.01.034","article-title":"Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome","volume":"44","author":"Fitzgibbons","year":"2009","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib34","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/ajcn\/nqy367","article-title":"The colon as an energy salvage organ for children with short bowel syndrome","volume":"109","author":"Norsa","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib36","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.clnu.2018.05.029","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition","volume":"37","author":"Mihatsch","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib37","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3945\/ajcn.115.121756","article-title":"Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center","volume":"103","author":"Abi Nader","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib38","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.clnu.2012.09.007","article-title":"Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding","volume":"32","author":"Goulet","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jpen.1014","article-title":"A new concept to achieve optimal weight gain in malnourished infants on total parenteral nutrition","volume":"42","author":"Abi Nader","year":"2018","journal-title":"J\u00a0Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib40","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib41","first-page":"111","article-title":"Child growth from 0 to 7 years of age. Measurements of children of the Paris area from 1953 to 1962","volume":"21","author":"Semp\u00e9","year":"1964","journal-title":"Arch Fr Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib42","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.2307\/2533673","article-title":"A\u00a0general framework for random effects survival analysis in the cox proportional hazards setting","volume":"54","author":"Sargent","year":"1998","journal-title":"Biometrics"},{"key":"10.1016\/j.clnu.2021.07.017_bib43","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-2008-1072258","article-title":"Experience with longitudinal intestinal lengthening and tailoring","volume":"9","author":"Bianchi","year":"1999","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.clnu.2021.07.017_bib44","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/MOP.0000000000000103","article-title":"Surgical options to enhance intestinal function in patients with short bowel syndrome","volume":"26","author":"Sommovilla","year":"2014","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.clnu.2021.07.017_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5223\/pghn.2019.22.4.303","article-title":"Short bowel syndrome as the leading cause of intestinal failure in early life: some insights into the management","volume":"22","author":"Goulet","year":"2019","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib46","first-page":"250","article-title":"Intestinal rehabilitation and the short bowel syndrome: part 1","volume":"38","author":"DiBaise","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.clnu.2021.07.017_bib47","first-page":"593","article-title":"Small-intestine length in infants and children","volume":"134","author":"Siebert","year":"1990","journal-title":"Am J Dis Child"},{"issue":"suppl 2","key":"10.1016\/j.clnu.2021.07.017_bib48","first-page":"S66","article-title":"Role of the colon in short bowel syndrome and intestinal transplantation","volume":"48","author":"Goulet","year":"2009","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2021.07.017_bib49","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3945\/ajcn.112.050799","article-title":"Intestinal absorption rate in children after small intestinal transplantation","volume":"97","author":"Ordonez","year":"2013","journal-title":"Am J Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421003514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421003514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:02:47Z","timestamp":1759366967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561421003514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0261561421003514"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2021.07.017","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation of plasma citrulline as a predictive factor for weaning off long-term parenteral nutrition in children with neonatal short bowel syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2021.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}