{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:25:58Z","timestamp":1772083558474,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007743","name":"European Society for Clinical Nutrition and Metabolism","doi-asserted-by":"publisher","award":["5,6,24"],"award-info":[{"award-number":["5,6,24"]}],"id":[{"id":"10.13039\/501100007743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.clnu.2021.10.020","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T12:20:12Z","timestamp":1635769212000},"page":"2940-2946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nutritional management and clinical outcome of critically ill patients with COVID-19: A retrospective study in a tertiary hospital"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-4652","authenticated-orcid":false,"given":"M.","family":"Migu\u00e9lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9078-6091","authenticated-orcid":false,"given":"C.","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Camblor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cede\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-716X","authenticated-orcid":false,"given":"C.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bret\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4630-7844","authenticated-orcid":false,"given":"L.","family":"Arhip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Motilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Carrascal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cuerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.clnu.2021.10.020_bib1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention","volume":"323","author":"Wu","year":"2020","journal-title":"J\u00a0Am Med Assoc"},{"issue":"5","key":"10.1016\/j.clnu.2021.10.020_bib2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/ncp.10566","article-title":"Relevant nutrition therapy in COVID-19 and the constraints on its delivery by a unique disease process","volume":"35","author":"Patel","year":"2020","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.clnu.2021.10.020_bib3","series-title":"Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: a prospective, cohort, multicentre study","author":"Ferrando","year":"2020"},{"issue":"6","key":"10.1016\/j.clnu.2021.10.020_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235107","article-title":"Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: a retrospective observational study","volume":"15","author":"Rivera-Izquierdo","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2021.10.020_bib5","doi-asserted-by":"crossref","first-page":"104354","DOI":"10.1016\/j.jcv.2020.104354","article-title":"Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome","author":"Roncon","year":"2020","journal-title":"J\u00a0Clin Virol"},{"key":"10.1016\/j.clnu.2021.10.020_bib6","first-page":"e3388","article-title":"Characteristics and outcomes of COVID-19 in hospitalized patients with and without diabetes","author":"Al-Salameh","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"issue":"1","key":"10.1016\/j.clnu.2021.10.020_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12933-020-01140-2","article-title":"Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II)","volume":"19","author":"Maddaloni","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.clnu.2021.10.020_bib8","doi-asserted-by":"crossref","first-page":"154262","DOI":"10.1016\/j.metabol.2020.154262","article-title":"Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York","volume":"108","author":"Palaiodimos","year":"2020","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.clnu.2021.10.020_bib9","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/oby.22918","article-title":"Obesity and COVID-19: an Italian snapshot","volume":"28","author":"Busetto","year":"2020","journal-title":"Obesity"},{"issue":"7","key":"10.1016\/j.clnu.2021.10.020_bib10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/oby.22859","article-title":"Association of obesity with disease severity among patients with coronavirus disease 2019","volume":"28","author":"Kalligeros","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.clnu.2021.10.020_bib11","doi-asserted-by":"crossref","first-page":"104185","DOI":"10.1016\/j.archger.2020.104185","article-title":"Clinical characteristics of 312 hospitalized older patients with COVID-19 in Wuhan, China","volume":"91","author":"Li","year":"2020","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.clnu.2021.10.020_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40249-020-00703-5","article-title":"Association between obesity and clinical prognosis in patients infected with SARS-CoV-2","author":"Cai","year":"2020","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.clnu.2021.10.020_bib13","doi-asserted-by":"crossref","first-page":"154378","DOI":"10.1016\/j.metabol.2020.154378","article-title":"Obesity in patients with COVID-19: a systematic review and meta-analysis","volume":"113","author":"Huang","year":"2020","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.clnu.2021.10.020_bib14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2337\/dc20-1714","article-title":"Metabolic syndrome and COVID-19 mortality among adult black patients in new orleans","volume":"44","author":"Xie","year":"2020","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.clnu.2021.10.020_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23415","article-title":"Analysis of clinical features and outcomes of 161 patients with severe and critical COVID-19: a multicenter descriptive study","volume":"34","author":"Shi","year":"2020","journal-title":"J\u00a0Clin Lab Anal"},{"key":"10.1016\/j.clnu.2021.10.020_bib16","doi-asserted-by":"crossref","DOI":"10.15585\/mmwr.mm6915e3","article-title":"Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 \u2014 COVID-NET, 14 states, March 1\u201330, 2020","author":"Garg","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"10.1016\/j.clnu.2021.10.020_bib17","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jiph.2020.06.002","article-title":"Clinical characteristics and outcomes of the first 63 adult patients hospitalized with COVID-19: an experience from Oman","volume":"13","author":"Khamis","year":"2020","journal-title":"J\u00a0Infect Public Health"},{"issue":"7","key":"10.1016\/j.clnu.2021.10.020_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/07853890.2020.1791356","article-title":"Demographics, comorbidities and outcomes in hospitalized Covid-19 patients in rural southwest Georgia","volume":"52","author":"Shah","year":"2020","journal-title":"Ann Med"},{"issue":"12","key":"10.1016\/j.clnu.2021.10.020_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123679","article-title":"Malnutrition: percentage and association with prognosis in patients hospitalized for coronavirus disease 2019","volume":"12","author":"Allard","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2021.10.020_bib20","doi-asserted-by":"crossref","first-page":"111123","DOI":"10.1016\/j.nut.2020.111123","article-title":"Predictive value of the prognostic nutritional index for the severity of coronavirus disease 2019","volume":"84","author":"Hu","year":"2021","journal-title":"Nutrition"},{"issue":"4","key":"10.1016\/j.clnu.2021.10.020_bib21","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.clnu.2020.09.040","article-title":"Nutritional risk and therapy for severe and critical COVID-19 patients: a multicenter retrospective observational study","volume":"40","author":"Li","year":"2021","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2021.10.020_bib22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41430-020-0642-3","article-title":"Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China","volume":"74","author":"Li","year":"2020","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2021.10.020_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/oby.23096","article-title":"Visceral adiposity elevates the risk of critical condition in COVID-19: a systematic review and meta-analysis","volume":"29","author":"F\u00f6ldi","year":"2021","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.clnu.2021.10.020_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clnu.2018.08.037","article-title":"ESPEN guideline on clinical nutrition in the intensive care unit","volume":"38","author":"Singer","year":"2019","journal-title":"Clin Nutr"},{"issue":"10188","key":"10.1016\/j.clnu.2021.10.020_bib25","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.clnu.2021.10.020_bib26","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.2013.278481","article-title":"Acute skeletal muscle wasting in critical illness","volume":"310","author":"Puthucheary","year":"2013","journal-title":"J\u00a0Am Med Assoc"},{"issue":"5","key":"10.1016\/j.clnu.2021.10.020_bib27","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.clnu.2019.05.027","article-title":"Muscle weakness: understanding the principles of myopathy and neuropathy in the critically ill patient and the management options","volume":"39","author":"Garc\u00eda-Mart\u00ednez","year":"2020","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2021.10.020_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s13054-016-1538-4","article-title":"Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study","volume":"20","author":"Zusman","year":"2016","journal-title":"Crit Care"},{"issue":"10223","key":"10.1016\/j.clnu.2021.10.020_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"10223","key":"10.1016\/j.clnu.2021.10.020_bib30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.clnu.2021.10.020_bib31","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region","volume":"323","author":"Grasselli","year":"2020","journal-title":"Italy. JAMA."},{"key":"10.1016\/j.clnu.2021.10.020_bib32","article-title":"Early caloric deficit is associated with a higher risk of death in invasive ventilated COVID-19 patients","author":"Cereda","year":"2021","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2021.10.020_bib33","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.clnu.2020.03.022","article-title":"ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection","volume":"39","author":"Barazzoni","year":"2020","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2021.10.020_bib34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJMoa1102662","article-title":"Early versus late parenteral nutrition in critically ill adults","volume":"365","author":"Casaer","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"20","key":"10.1016\/j.clnu.2021.10.020_bib35","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1001\/jama.2013.5124","article-title":"Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial","volume":"309","author":"Doig","year":"2013","journal-title":"J\u00a0Am Med Assoc"},{"issue":"9864","key":"10.1016\/j.clnu.2021.10.020_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(12)61351-8","article-title":"Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial","volume":"381","author":"Heidegger","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clnu.2021.10.020_bib37","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13054-019-2657-5","article-title":"Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases","volume":"23","author":"van Zanten","year":"2019","journal-title":"Crit Care"},{"issue":"11","key":"10.1016\/j.clnu.2021.10.020_bib38","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00134-017-4880-3","article-title":"Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial","volume":"43","author":"Allingstrup","year":"2017","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.clnu.2021.10.020_bib39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1932296820924469","article-title":"Glycemic characteristics and clinical outcomes of COVID-19 patients hospitalized in the United States","volume":"14","author":"Bode","year":"2020","journal-title":"J\u00a0Diabetes Sci Technol"},{"key":"10.1016\/j.clnu.2021.10.020_bib40","article-title":"Analysis of glucose levels in patients hospitalized with COVID-19 during the first phase of this pandemic in west Texas","volume":"11","author":"Rao","year":"2020","journal-title":"J\u00a0Prim Care Community Health"},{"key":"10.1016\/j.clnu.2021.10.020_bib41","unstructured":"Martindale R, Patel JJ, Taylor B, Warren M, Mc Clave SA. Nutrition therapy in the patient with COVID-19 disease requiring ICU care."},{"key":"10.1016\/j.clnu.2021.10.020_bib42","article-title":"Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance","author":"Barazzoni","year":"2021","journal-title":"Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421004994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561421004994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:13:28Z","timestamp":1759367608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561421004994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0261561421004994"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2021.10.020","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nutritional management and clinical outcome of critically ill patients with COVID-19: A retrospective study in a tertiary hospital","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2021.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}