{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:25:50Z","timestamp":1790749550070,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.clnu.2022.03.022","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:59:17Z","timestamp":1648702757000},"page":"1281-1289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Skeletal muscle mass and abdominal obesity are independent predictors of hepatic steatosis and interact to predict ten-year cardiovascular disease incidence: Data from the ATTICA cohort study"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-194X","authenticated-orcid":false,"given":"Matina","family":"Kouvari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-4042","authenticated-orcid":false,"given":"Stergios A.","family":"Polyzos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Chrysohoou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Skoumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Pitsavos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demosthenes B.","family":"Panagiotakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2022.03.022_bib1","doi-asserted-by":"crossref","first-page":"154822","DOI":"10.1016\/j.metabol.2021.154822","article-title":"Preparing for the NASH epidemic: a call to action","volume":"122","author":"Kanwal","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: from pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib3","doi-asserted-by":"crossref","first-page":"154770","DOI":"10.1016\/j.metabol.2021.154770","article-title":"Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk","volume":"119","author":"Muzurovi\u0107","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib4","doi-asserted-by":"crossref","first-page":"154170","DOI":"10.1016\/j.metabol.2020.154170","article-title":"Complications, morbidity and mortality of nonalcoholic fatty liver disease","volume":"111s","author":"Mantovani","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.clnu.2007.03.008","article-title":"Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia","volume":"26","author":"Thomas","year":"2007","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.03.022_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s42000-018-0049-x","article-title":"Sarcopenic obesity","volume":"17","author":"Polyzos","year":"2018","journal-title":"Hormones (Basel)"},{"key":"10.1016\/j.clnu.2022.03.022_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.metabol.2019.01.011","article-title":"Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study","volume":"93","author":"Wu","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib8","first-page":"88","article-title":"Systematic literature review on the relationship between biomarkers of sarcopenia and quality of life in older people","volume":"5","author":"Woo","year":"2016","journal-title":"J\u00a0Frailty Aging"},{"key":"10.1016\/j.clnu.2022.03.022_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/ggi.12579","article-title":"Association of sarcopenic obesity with the risk of all-cause mortality: a meta-analysis of prospective cohort studies","volume":"16","author":"Tian","year":"2016","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.clnu.2022.03.022_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12072-019-09964-1","article-title":"Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"14","author":"Cai","year":"2020","journal-title":"Hepatol Int"},{"issue":"8","key":"10.1016\/j.clnu.2022.03.022_bib11","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1111\/liv.14852","article-title":"Sarcopenia in nonalcoholic fatty liver disease and all-cause and cause-specific mortality in the United States","volume":"41","author":"Kim","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.clnu.2022.03.022_bib12","doi-asserted-by":"crossref","first-page":"154203","DOI":"10.1016\/j.metabol.2020.154203","article-title":"Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis","volume":"111S","author":"Polyzos","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2458-3-32","article-title":"Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study","volume":"3","author":"Pitsavos","year":"2003","journal-title":"BMC Publ Health"},{"key":"10.1016\/j.clnu.2022.03.022_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease","volume":"42","author":"Lee","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.clnu.2022.03.022_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/liv.12282","article-title":"Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population","volume":"34","author":"Chon","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.clnu.2022.03.022_bib16","article-title":"Non-laboratory-based self-assessment screening score for non-alcoholic fatty liver disease: development, validation and comparison with other scores","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2022.03.022_bib17","first-page":"1907","article-title":"NAFLD in clinical practice: can simple blood and anthropometric markers be used to detect change in liver fat measured by (1) H-MRS? Liver","volume":"37","author":"Keating","year":"2017","journal-title":"Bar Int"},{"key":"10.1016\/j.clnu.2022.03.022_bib18","doi-asserted-by":"crossref","first-page":"100381","DOI":"10.1016\/j.jhepr.2021.100381","article-title":"Prospective comparison of transient elastography, MRI and serum scores for grading steatosis and detecting non-alcoholic steatohepatitis in bariatric surgery candidates","volume":"3","author":"Garteiser","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.clnu.2022.03.022_bib19","article-title":"Comparative assessment and external validation of hepatic steatosis formulae in a community-based setting","volume":"9","author":"Jung","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.clnu.2022.03.022_bib20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/ajcn\/72.3.796","article-title":"Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models","volume":"72","author":"Lee","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2022.03.022_bib21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glu010","article-title":"The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates","volume":"69","author":"Studenski","year":"2014","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.clnu.2022.03.022_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/jcsm.12076","article-title":"Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: a multi-continent study","volume":"7","author":"Tyrovolas","year":"2016","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clnu.2022.03.022_bib23","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3945\/ajcn.113.070466","article-title":"Derivation and validation of simple equations to predict total muscle mass from simple anthropometric and demographic data","volume":"100","author":"Al-Gindan","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2022.03.022_bib24","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.clnu.2020.08.018","article-title":"SARC-F has low correlation and reliability with skeletal muscle mass index in older gastrointestinal cancer patients","volume":"40","author":"Siqueira","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.03.022_bib25","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.clnu.2022.03.022_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmpb.2006.05.003","article-title":"MedDietScore: a computer program that evaluates the adherence to the Mediterranean dietary pattern and its relation to cardiovascular disease risk","volume":"83","author":"Panagiotakos","year":"2006","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.clnu.2022.03.022_bib27","first-page":"283","article-title":"Reliability measures of the short International physical activity questionnaire (IPAQ) in Greek young adults","volume":"50","author":"Papathanasiou","year":"2009","journal-title":"Hellenic J Cardiol"},{"key":"10.1016\/j.clnu.2022.03.022_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.clnu.2022.03.022_bib29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000491015","article-title":"Sarcopenia contributes to the progression of nonalcoholic fatty liver disease- related fibrosis: a meta-analysis","volume":"36","author":"Pan","year":"2018","journal-title":"Dig Dis"},{"key":"10.1016\/j.clnu.2022.03.022_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/sjg.SJG_237_17","article-title":"Sarcopenia and risk of nonalcoholic fatty liver disease: a meta-analysis","volume":"24","author":"Wijarnpreecha","year":"2018","journal-title":"Saudi J Gastroenterol"},{"key":"10.1016\/j.clnu.2022.03.022_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12876-018-0776-0","article-title":"Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis","volume":"18","author":"Yu","year":"2018","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.clnu.2022.03.022_bib32","doi-asserted-by":"crossref","first-page":"8859719","DOI":"10.1155\/2020\/8859719","article-title":"Nonalcoholic fatty liver disease and sarcopenia: where do we stand?","volume":"2020","author":"Mikolasevic","year":"2020","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.clnu.2022.03.022_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.15403\/jgld-3323","article-title":"Association between sarcopenic obesity and nonalcoholic fatty liver disease and fibrosis detected by fibroscan","volume":"30","author":"Wijarnpreecha","year":"2021","journal-title":"J\u00a0Gastrointestin Liver Dis"},{"key":"10.1016\/j.clnu.2022.03.022_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.clnesp.2020.05.025","article-title":"A\u00a0significant association of non-obese non-alcoholic fatty\u00a0liver disease with sarcopenic obesity","volume":"38","author":"Kashiwagi","year":"2020","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clnu.2022.03.022_bib35","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/jgh.13166","article-title":"Nonalcoholic steatohepatitis is strongly associated with sarcopenic obesity in patients with cirrhosis undergoing liver transplant evaluation","volume":"31","author":"Carias","year":"2016","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2022.03.022_bib36","doi-asserted-by":"crossref","first-page":"100171","DOI":"10.1016\/j.jhepr.2020.100171","article-title":"Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease","volume":"2","author":"Golabi","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.clnu.2022.03.022_bib37","doi-asserted-by":"crossref","first-page":"15647","DOI":"10.1038\/s41598-021-95108-1","article-title":"Sarcopenia modifies the associations of nonalcoholic fatty liver disease with all-cause and cardiovascular mortality among older adults","volume":"11","author":"Sun","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2022.03.022_bib38","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/jcsm.12719","article-title":"Non-alcoholic fatty liver disease and sarcopenia additively increase mortality: a Korean nationwide survey","volume":"12","author":"Moon","year":"2021","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clnu.2022.03.022_bib39","doi-asserted-by":"crossref","first-page":"584","DOI":"10.14309\/ajg.0000000000000572","article-title":"Nonalcoholic fatty liver disease and sarcopenia are independently associated with cardiovascular risk","volume":"115","author":"Han","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.clnu.2022.03.022_bib40","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.clnu.2022.03.022_bib41","doi-asserted-by":"crossref","first-page":"154455","DOI":"10.1016\/j.metabol.2020.154455","article-title":"The effect of the magnitude of weight loss on non-alcoholic fatty liver disease:\u00a0a systematic review and meta-analysis","volume":"115","author":"Koutoukidis","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib42","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.dsx.2020.09.030","article-title":"Comparative effectiveness of glucagon-like peptide-1 receptor agonists versus dipeptidyl peptidase-4 inhibitors on noninvasive indices of hepatic steatosis and fibrosis in patients with type 2 diabetes mellitus","volume":"14","author":"Makri","year":"2020","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.clnu.2022.03.022_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.metabol.2013.10.010","article-title":"Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease","volume":"63","author":"Polyzos","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2022.03.022_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3748\/wjg.v5.i4.301","article-title":"Liver biopsy:complications and risk factors","volume":"5","author":"Thampanitchawong","year":"1999","journal-title":"World J Gastroenterol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:08:29Z","timestamp":1759367309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561422001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0261561422001030"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2022.03.022","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal muscle mass and abdominal obesity are independent predictors of hepatic steatosis and interact to predict ten-year cardiovascular disease incidence: Data from the ATTICA cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2022.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}