{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:41:10Z","timestamp":1794004870269,"version":"4.8.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"am","delay-in-days":340,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.clnu.2022.06.035","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T21:09:13Z","timestamp":1656709753000},"page":"1906-1912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Longitudinal association between nutritional status and behavioral and psychological symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer's disease"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-957X","authenticated-orcid":false,"given":"Yoshinobu","family":"Kishino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-514X","authenticated-orcid":false,"given":"Ai","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-1122","authenticated-orcid":false,"given":"Naoki","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Niida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2022.06.035_bib1","unstructured":"Website: World Alzheimer report 2018. (Accessed August 19, 2021, at https:\/\/www.alzint.org\/resource\/world-alzheimer-report-2018\/)."},{"key":"10.1016\/j.clnu.2022.06.035_bib2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study","volume":"288","author":"Lyketsos","year":"2002","journal-title":"JAMA"},{"issue":"Suppl 2","key":"10.1016\/j.clnu.2022.06.035_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/ggi.12260","article-title":"Factors associated with increased caregivers' burden in several cognitive stages of Alzheimer's disease","volume":"14","author":"Kamiya","year":"2014","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.clnu.2022.06.035_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/inr.12194","article-title":"Caregiver burden for informal caregivers of patients with dementia: a systematic review","volume":"62","author":"Chiao","year":"2015","journal-title":"Int Nurs Rev"},{"key":"10.1016\/j.clnu.2022.06.035_bib5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12603-010-0063-4","article-title":"Predictive factors of hospitalizations in Alzheimer's disease: a two-year prospective study in 686 patients of the REAL.FR study","volume":"14","author":"Voisin","year":"2010","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.clnu.2022.06.035_bib6","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3233\/JAD-161135","article-title":"Severity of depression impacts imminent conversion from mild cognitive impairment to Alzheimer's disease","volume":"59","author":"Defrancesco","year":"2017","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.clnu.2022.06.035_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1440-1819.2005.01371.x","article-title":"Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients","volume":"59","author":"Shimabukuro","year":"2005","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.clnu.2022.06.035_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000351009","article-title":"Risk factors for behavioral abnormalities in mild cognitive impairment and mild Alzheimer's disease","volume":"37","author":"Apostolova","year":"2014","journal-title":"Dement Geriatr Cognit Disord"},{"key":"10.1016\/j.clnu.2022.06.035_bib9","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/gps.1567","article-title":"Risk factors for neuropsychiatric symptoms in dementia: the Cache County Study","volume":"21","author":"Steinberg","year":"2006","journal-title":"Int J Geriatr Psychiatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib10","unstructured":"Website: The IPA complete guides to behavioral and psychological symptoms of dementia (Accessed August 19, 2021, at http:\/\/myalzheimersstory.com\/wp-content\/uploads\/2018\/05\/IPA_BPSD_Specialists_Guide_Online-1.pdf)."},{"key":"10.1016\/j.clnu.2022.06.035_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jad.2015.09.069","article-title":"The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis","volume":"190","author":"Zhao","year":"2016","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.clnu.2022.06.035_bib12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.archger.2008.03.002","article-title":"Influence of nutritional status on cognitive, functional and neuropsychiatric deficits in Alzheimer's disease","volume":"48","author":"Spaccavento","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"issue":"8","key":"10.1016\/j.clnu.2022.06.035_bib13","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3390\/nu11081951","article-title":"Malnutrition is associated with behavioral and psychiatric symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer's disease","volume":"11","author":"Kimura","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2022.06.035_bib14","first-page":"81","article-title":"Nutritional status assessment during Alzheimer's disease: results after one year (the REAL French Study Group)","volume":"9","author":"Guerin","year":"2005","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.clnu.2022.06.035_bib15","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4088\/JCP.11m07614","article-title":"Gender differences in clinical manifestations and outcomes among hospitalized patients with behavioral and psychological symptoms of dementia","volume":"73","author":"Kitamura","year":"2012","journal-title":"J\u00a0Clin Psychiatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.clnu.2022.06.035_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.clnu.2022.06.035_bib18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.JGP.0000192478.82189.a8","article-title":"Mapping scores onto stages: mini-mental state examination and clinical dementia rating","volume":"14","author":"Perneczky","year":"2006","journal-title":"Am J Geriatr Psychiatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib19","doi-asserted-by":"crossref","first-page":"M366","DOI":"10.1093\/gerona\/56.6.M366","article-title":"Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF)","volume":"56","author":"Rubenstein","year":"2001","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.clnu.2022.06.035_bib20","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status","volume":"13","author":"Kaiser","year":"2009","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.clnu.2022.06.035_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-nutr-071715-050947","article-title":"Homocysteine, B vitamins, and cognitive impairment","volume":"36","author":"Smith","year":"2016","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.clnu.2022.06.035_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1532-5415.1990.tb03495.x","article-title":"Validity and reliability of the dementia behavior disturbance scale","volume":"38","author":"Baumgarten","year":"1990","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.clnu.2022.06.035_bib23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3143\/geriatrics.30.835","article-title":"[Reliability and validity of a Japanese version of the dementia behavior disturbance scale]","volume":"30","author":"Mizoguchi","year":"1993","journal-title":"Nihon Ronen Igakkai Zasshi"},{"key":"10.1016\/j.clnu.2022.06.035_bib24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jclinepi.2012.02.018","article-title":"Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes","volume":"65","author":"Gnjidic","year":"2012","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.clnu.2022.06.035_bib25","first-page":"61","article-title":"Functional evaluation: the BARTHEL index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md State Med J"},{"key":"10.1016\/j.clnu.2022.06.035_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1444-1586.2002.00016.x","article-title":"Vitality Index as a useful tool to assess elderly with dementia","volume":"2","author":"Toba","year":"2002","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.clnu.2022.06.035_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.clnu.2022.06.035_bib28","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.clnu.2018.09.017","article-title":"Adequacy of nutrition and body weight in patients with early stage dementia: the cognition and aging study","volume":"38","author":"Hsiao","year":"2019","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.06.035_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12603-012-0401-9","article-title":"Malnutrition in community-dwelling adults with dementia (NutriAlz Trial)","volume":"17","author":"Roque","year":"2013","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.clnu.2022.06.035_bib30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12877-020-01903-2","article-title":"Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study","volume":"20","author":"Fan","year":"2020","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3233\/JAD-190278","article-title":"Prevalence of mild behavioral impairment and risk of dementia in a psychiatric outpatient clinic","volume":"70","author":"Matsuoka","year":"2019","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.clnu.2022.06.035_bib32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jalz.2015.05.017","article-title":"Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment","volume":"12","author":"Ismail","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.clnu.2022.06.035_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.clnu.2022.06.035_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2020.104268","article-title":"Sarcopenia and frailty in individuals with dementia: a systematic review","volume":"92","author":"Waite","year":"2021","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib35","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2174\/1567205013666160211124828","article-title":"Prevalence and associated factors of sarcopenia in elderly subjects with amnestic mild cognitive impairment or Alzheimer disease","volume":"13","author":"Sugimoto","year":"2016","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.clnu.2022.06.035_bib36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/WAD.0000000000000175","article-title":"Sarcopenia is associated with impairment of activities of daily living in Japanese patients with early-stage alzheimer disease","volume":"31","author":"Sugimoto","year":"2017","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.clnu.2022.06.035_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fnut.2018.00128","article-title":"Association between appetite and sarcopenia in patients with mild cognitive impairment and early-stage Alzheimer's disease: a case-control study","volume":"5","author":"Kimura","year":"2018","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnu.2022.06.035_bib38","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/PHM.0000000000001572","article-title":"Rehabilitative good practices in the treatment of sarcopenia: a narrative review","volume":"100","author":"Agostini","year":"2021","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.clnu.2022.06.035_bib39","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/ene.13076","article-title":"Neuroimaging correlates of neuropsychiatric symptoms in Alzheimer's disease: a review of 20 years of research","volume":"23","author":"Boublay","year":"2016","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.clnu.2022.06.035_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jns.2008.03.023","article-title":"A\u00a0functional neuroimaging study of appetite loss in Alzheimer's disease","volume":"271","author":"Ismail","year":"2008","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.clnu.2022.06.035_bib41","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/archneur.64.7.1015","article-title":"Positron emission tomography metabolic correlates of apathy in Alzheimer disease","volume":"64","author":"Marshall","year":"2007","journal-title":"Arch Neurol"},{"key":"10.1016\/j.clnu.2022.06.035_bib42","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/gps.2379","article-title":"Apathy is a prominent neuropsychiatric feature of radiological white-matter changes in patients with dementia","volume":"25","author":"Jonsson","year":"2010","journal-title":"Int J Geriatr Psychiatr"},{"key":"10.1016\/j.clnu.2022.06.035_bib43","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.jalz.2012.10.005","article-title":"Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease","volume":"9","author":"Trzepacz","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.clnu.2022.06.035_bib44","article-title":"Nutritional status and structural brain changes in Alzheimer's disease: the NUDAD project","volume":"12","author":"Verhaar","year":"2020","journal-title":"Alzheimers Dement (Amst)."},{"key":"10.1016\/j.clnu.2022.06.035_bib45","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1212\/WNL.46.6.1585","article-title":"Low body weight in Alzheimer's disease is associated with mesial temporal cortex atrophy","volume":"46","author":"Grundman","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.clnu.2022.06.035_bib46","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1111\/jgs.14385","article-title":"Malnutrition and risk of structural brain changes seen on magnetic resonance imaging in older adults","volume":"64","author":"de van der Schueren","year":"2016","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.clnu.2022.06.035_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3233\/JAD-170257","article-title":"Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease","volume":"60","author":"Sugimoto","year":"2017","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.clnu.2022.06.035_bib48","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.trci.2017.06.002","article-title":"Lower brain and blood nutrient status in Alzheimer's disease: results from meta-analyses","volume":"3","author":"de Wilde","year":"2017","journal-title":"Alzheimers Dement (NY)"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422002291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422002291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:07:58Z","timestamp":1759367278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561422002291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0261561422002291"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2022.06.035","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal association between nutritional status and behavioral and psychological symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2022.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}