{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:10:53Z","timestamp":1759450253565,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["RM11615500F8855D"],"award-info":[{"award-number":["RM11615500F8855D"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.clnu.2022.11.013","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T13:54:42Z","timestamp":1669211682000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes of gene expression in peripheral blood mononuclear cells of lung cancer patients with or without anorexia"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-0236","authenticated-orcid":false,"given":"Alessio","family":"Molfino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ambrosani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-3459","authenticated-orcid":false,"given":"Federica","family":"Tambaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Belli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Imbimbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-497X","authenticated-orcid":false,"given":"Silvia","family":"Udali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Moruzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pattini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesarina","family":"Ramaccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-6116","authenticated-orcid":false,"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-6711","authenticated-orcid":false,"given":"Simonetta","family":"Friso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clnu.2022.11.013_bib1","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1016\/j.clnu.2021.02.016","article-title":"Cancer-associated anorexia: validity and performance overtime of different appetite tools among patients at their first cancer diagnosis","volume":"40","author":"Molfino","year":"2021","journal-title":"Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2022.11.013_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jcsm.12528","article-title":"Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia","volume":"11","author":"Peixoto da Silva","year":"2020","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"11","key":"10.1016\/j.clnu.2022.11.013_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224540","article-title":"Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer","volume":"14","author":"Abraham","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41574-018-0123-0","article-title":"Inter-tissue communication in cancer cachexia","volume":"15","author":"Argil\u00e9s","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.clnu.2022.11.013_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/801685","article-title":"Contribution of neuroinflammation to the pathogenesis of cancer cachexia","volume":"2015","author":"Molfino","year":"2015","journal-title":"Mediat Inflamm"},{"issue":"4","key":"10.1016\/j.clnu.2022.11.013_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/SPC.0b013e32833e4aa5","article-title":"Contribution of anorexia to tissue wasting in cachexia","volume":"4","author":"Molfino","year":"2010","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.clnu.2022.11.013_bib7","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Prim"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clnu.2016.09.004","article-title":"ESPEN guidelines on definitions and terminology of clinical nutrition","volume":"36","author":"Cederholm","year":"2017","journal-title":"Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2022.11.013_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s13539-012-0064-8","article-title":"European Palliative Care Research Collaborative (EPCRC) and the European Pharmacogenetic Study (EPOS). Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients","volume":"3","author":"Solheim","year":"2012","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clnu.2022.11.013_bib11","doi-asserted-by":"crossref","first-page":"D377","DOI":"10.1093\/nar\/gks1118","article-title":"PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"Mi","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.clnu.2022.11.013_bib12","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.clnu.2022.11.013_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.clnu.2022.11.013_bib14","first-page":"103","article-title":"Validating appetite assessment tools among patients receiving hemodialysis","volume":"26","author":"Molfino","year":"2016","journal-title":"J\u00a0Ren Nutr"},{"issue":"45","key":"10.1016\/j.clnu.2022.11.013_bib15","doi-asserted-by":"crossref","first-page":"79884","DOI":"10.18632\/oncotarget.20168","article-title":"Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study","volume":"8","author":"Muscaritoli","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.clnu.2022.11.013_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2020.110952","article-title":"Plasma enterobacterial ClpB levels and ClpB- and \u03b1-MSH-reactive immunoglobulins in lung cancer patients with and without anorexia","volume":"78","author":"Molfino","year":"2020","journal-title":"Nutrition"},{"issue":"11","key":"10.1016\/j.clnu.2022.11.013_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41576-019-0150-2","article-title":"RNA sequencing: the teenage years","volume":"20","author":"Stark","year":"2019","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13148-015-0077-1","article-title":"DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma","volume":"7","author":"Udali","year":"2015","journal-title":"Clin Epigenet"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108590","article-title":"Cell-type-specific immune dysregulation in severely ill COVID-19 patients","volume":"34","author":"Yao","year":"2021","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41597-021-01040-4","article-title":"RNA-seq of peripheral blood mononuclear cells of congenital generalized lipodystrophy type 2 patients","volume":"8","author":"Huang","year":"2021","journal-title":"Sci Data"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/cancers13010099","article-title":"Association between growth differentiation factor-15 (GDF-15) serum levels, anorexia and low muscle mass among cancer patients","volume":"13","author":"Molfino","year":"2020","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.clnu.2022.11.013_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jcsm.12441","article-title":"Tumour-derived transforming growth factor-\u03b2 signalling contributes to fibrosis in patients with cancer cachexia","volume":"10","author":"Lima","year":"2019","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12885-017-3178-8","article-title":"Adipose tissue fibrosis in human cancer cachexia: the role of TGF\u03b2 pathway","volume":"17","author":"Alves","year":"2017","journal-title":"BMC Cancer"},{"issue":"16","key":"10.1016\/j.clnu.2022.11.013_bib24","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1007\/s00018-019-03173-7","article-title":"Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system","volume":"76","author":"Hsia","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"10.1016\/j.clnu.2022.11.013_bib25","doi-asserted-by":"crossref","first-page":"E1000","DOI":"10.1152\/ajpendo.90252.2008","article-title":"Neural control of the anorexia-cachexia syndrome","volume":"295","author":"Laviano","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"21","key":"10.1016\/j.clnu.2022.11.013_bib26","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1523\/JNEUROSCI.20-21-07964.2000","article-title":"Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration","volume":"20","author":"Schlomann","year":"2000","journal-title":"J\u00a0Neurosci"},{"issue":"36","key":"10.1016\/j.clnu.2022.11.013_bib27","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1523\/JNEUROSCI.1520-10.2010","article-title":"Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection","volume":"30","author":"Bartsch","year":"2010","journal-title":"J\u00a0Neurosci"},{"issue":"21","key":"10.1016\/j.clnu.2022.11.013_bib28","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.3390\/ijms21218412","article-title":"CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/intimm\/dxu079","article-title":"CCR4 and its ligands: from bench to bedside","volume":"27","author":"Yoshie","year":"2015","journal-title":"Int Immunol"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-021-02112-3","article-title":"Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K\/AKT\/Foxo 1 signaling pathway after ICH in mice","volume":"18","author":"Deng","year":"2021","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.clnu.2022.11.013_bib31","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/ncomms2896","article-title":"Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway","volume":"4","author":"Gil","year":"2013","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.clnu.2022.11.013_bib32","article-title":"Clusterin overexpression protects against western diet-induced obesity and NAFLD","volume":"10","author":"Park","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.clnu.2022.11.013_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.oraloncology.2006.03.014","article-title":"Gene expression changes in peripheral blood cells provide insight into the biological mechanisms associated with regimen-related toxicities in patients being treated for head and neck cancers","volume":"43","author":"Sonis","year":"2007","journal-title":"Oral Oncol"},{"issue":"6","key":"10.1016\/j.clnu.2022.11.013_bib34","first-page":"1521","article-title":"Pro-inflammatory cytokines and oxidative stress\/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients","volume":"18","author":"Fortunati","year":"2007","journal-title":"Oncol Rep"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422003983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422003983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:09:29Z","timestamp":1759367369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561422003983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0261561422003983"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2022.11.013","relation":{},"ISSN":["0261-5614"],"issn-type":[{"type":"print","value":"0261-5614"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes of gene expression in peripheral blood mononuclear cells of lung cancer patients with or without anorexia","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2022.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}