{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:32:36Z","timestamp":1791347556435,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"am","delay-in-days":324,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100020083","name":"Forschungsrat des Kantonsspitals Aarau","doi-asserted-by":"publisher","award":["1410.000.044"],"award-info":[{"award-number":["1410.000.044"]}],"id":[{"id":"10.13039\/501100020083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020083","name":"Forschungsrat des Kantonsspitals Aarau","doi-asserted-by":"publisher","award":["1410.000.058"],"award-info":[{"award-number":["1410.000.058"]}],"id":[{"id":"10.13039\/501100020083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020083","name":"Forschungsrat des Kantonsspitals Aarau","doi-asserted-by":"publisher","award":["1410.000.151"],"award-info":[{"award-number":["1410.000.151"]}],"id":[{"id":"10.13039\/501100020083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.clnu.2022.12.006","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T02:12:57Z","timestamp":1671675177000},"page":"199-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association of CT-based diagnosis of sarcopenia with prognosis and treatment response in patients at risk of malnutrition \u2013 A secondary analysis of the Effect of early nutritional support on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT) trial"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-0129","authenticated-orcid":false,"given":"Annic","family":"Baumgartner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Olpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Griot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Mentil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Staub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Burn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schindera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kaegi-Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Tribolet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-6789","authenticated-orcid":false,"given":"Claus","family":"Hoess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vojtech","family":"Pavlicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-2791","authenticated-orcid":false,"given":"Stefan","family":"Bilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sigrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Br\u00e4ndle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-8947","authenticated-orcid":false,"given":"Christoph","family":"Henzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-3064","authenticated-orcid":false,"given":"Robert","family":"Thomann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rutishauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drahomir","family":"Aujesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-6896","authenticated-orcid":false,"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Donz\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Stanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-7603","authenticated-orcid":false,"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2022.12.006_bib1","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.clnu.2019.11.041","article-title":"Nutritional risk screening (NRS 2002) is a strong and modifiable predictor risk score for short-term and long-term clinical outcomes: secondary analysis of a prospective randomised trial","volume":"39","author":"Hersberger","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.clnu.2017.06.025","article-title":"ESPEN guidelines on nutritional support for polymorbid internal medicine patients","volume":"37","author":"Gomes","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.nut.2004.06.023","article-title":"Social risk factors for hospital malnutrition","volume":"21","author":"Pirlich","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2022.12.006_bib4","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(21)01451-3","article-title":"Management of disease-related malnutrition for patients being treated in hospital","volume":"398","author":"Schuetz","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2022.12.006_bib5","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2014.13957","article-title":"Loss of appetite in acutely ill medical inpatients: physiological response or therapeutic target?","volume":"144","author":"Schutz","year":"2014","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.clnu.2022.12.006_bib6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clnu.2022.12.006_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0148607115612054","article-title":"Prevalence of sarcopenia and its impact on postoperative outcome in patients with crohn's disease undergoing bowel resection","volume":"41","author":"Zhang","year":"2017","journal-title":"JPEN - J Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib8","article-title":"Impact of CT-determined sarcopenia and body composition on survival outcome in patients with advanced-stage high-grade serous ovarian carcinoma","volume":"12","author":"Kim","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.clnu.2022.12.006_bib9","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.3748\/wjg.v20.i25.8061","article-title":"Clinical relevance of sarcopenia in patients with cirrhosis","volume":"20","author":"Montano-Loza","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clnu.2022.12.006_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.clnu.2022.12.006_bib11","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clnu.2022.12.006_bib12","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.acra.2017.02.008","article-title":"Diagnosing sarcopenia on thoracic computed tomography: quantitative assessment of skeletal muscle mass in patients undergoing transcatheter aortic valve replacement","volume":"24","author":"Nemec","year":"2017","journal-title":"Acad Radiol"},{"issue":"5","key":"10.1016\/j.clnu.2022.12.006_bib13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clnu.2022.12.006_bib14","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2022.12.006_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.18203\/2349-3259.ijct20182085","article-title":"Design and rationale of the effect of early nutritional therapy on frailty, functional outcomes and recovery of malnourished medical inpatients (EFFORT): a pragmatic, multicenter, randomized-controlled trial-Protocol","volume":"5","author":"Schuetz","year":"2018","journal-title":"International Journal of Clinical Trials"},{"key":"10.1016\/j.clnu.2022.12.006_bib16","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.clnu.2020.08.019","article-title":"Six-month outcomes after individualized nutritional support during the hospital stay in medical patients at nutritional risk: secondary analysis of a prospective randomized trial","volume":"40","author":"Kaegi-Braun","year":"2021","journal-title":"Clin Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2022.12.006_bib17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/ajcn\/nqab042","article-title":"Value of handgrip strength to predict clinical outcomes and therapeutic response in malnourished medical inpatients: secondary analysis of a randomized controlled trial","volume":"114","author":"Kaegi-Braun","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib18","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1016\/j.clnu.2021.03.013","article-title":"Admission kidney function is a strong predictor for the response to nutritional support in patients at nutritional risk","volume":"40","author":"Bargetzi","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.0663","article-title":"Association of baseline inflammation with effectiveness of nutritional support among patients with disease-related malnutrition: a secondary analysis of a randomized clinical trial","volume":"3","author":"Merker","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.clnu.2022.12.006_bib20","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.clnu.2020.10.009","article-title":"Effect of nutritional support in patients with lower respiratory tract infection: secondary analysis of a randomized clinical trial","volume":"40","author":"Baumgartner","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib21","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000018113","article-title":"Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality: a prospective cohort study","volume":"98","author":"Merker","year":"2019","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.clnu.2022.12.006_bib22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0261-5614(02)00214-5","article-title":"Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.nut.2016.01.019","article-title":"Detection and treatment of medical inpatients with or at-risk of malnutrition: suggested procedures based on validated guidelines","volume":"32","author":"Bounoure","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2022.12.006_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0899-9007(02)01033-X","article-title":"Comparison of formulaic equations to determine energy expenditure in the critically ill patient","volume":"19","author":"MacDonald","year":"2003","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2022.12.006_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1024\/0300-9831\/a000058","article-title":"Protein catabolism and requirements in severe illness","volume":"81","author":"Genton","year":"2011","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1016\/j.clnu.2022.12.006_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/0148607101025006323","article-title":"Protein energy supplements in unwell elderly patients-a randomized controlled trial","volume":"25","author":"Potter","year":"2001","journal-title":"JPEN - J Parenter Enter Nutr"},{"key":"10.1016\/j.clnu.2022.12.006_bib27","first-page":"CD003288","article-title":"Protein and energy supplementation in elderly people at risk from malnutrition","volume":"2009","author":"Milne","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clnu.2022.12.006_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1152\/jappl.1998.85.1.115","article-title":"Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography","volume":"85","author":"Mitsiopoulos","year":"1998","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clnu.2022.12.006_bib29","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1245\/s10434-018-6652-x","article-title":"Assessment of computed tomography (CT)-Defined muscle and adipose tissue features in relation to short-term outcomes after elective surgery for colorectal cancer: a multicenter approach","volume":"25","author":"Martin","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clnu.2022.12.006_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/nu13092937","article-title":"Disease-related malnutrition and sarcopenia predict worse outcome in medical inpatients: a cohort study","volume":"13","author":"Ballesteros-Pomar","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2022.12.006_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/nu11122883","article-title":"Malnutrition as a strong predictor of the onset of sarcopenia","volume":"11","author":"Beaudart","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2022.12.006_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082647","article-title":"CT-determined sarcopenia in GLIM-defined malnutrition and prediction of 6-month mortality in cancer inpatients","volume":"13","author":"Sanchez-Torralvo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2022.12.006_bib33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.clnu.2022.12.006_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejca.2015.12.030","article-title":"Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review","volume":"57","author":"Shachar","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clnu.2022.12.006_bib35","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.118.033887","article-title":"Malnutrition and mortality in frail and non-frail older adults undergoing aortic valve replacement","volume":"138","author":"Goldfarb","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.clnu.2022.12.006_bib36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12877-021-02276-w","article-title":"Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.clnu.2022.12.006_bib37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1017\/S0029665115002311","article-title":"The effectiveness of nutritional interventions in malnutrition and cachexia","volume":"74","author":"Baldwin","year":"2015","journal-title":"Proc Nutr Soc"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422004344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561422004344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:11:13Z","timestamp":1759367473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561422004344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0261561422004344"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2022.12.006","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of CT-based diagnosis of sarcopenia with prognosis and treatment response in patients at risk of malnutrition \u2013 A secondary analysis of the Effect of early nutritional support on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT) trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2022.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}