{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:43:32Z","timestamp":1790952212034,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004374","name":"The First Affiliated Hospital of Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.clnu.2023.11.004","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:01:03Z","timestamp":1700625663000},"page":"52-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["LncRNA MIR22HG\/microRNA-9-3p\/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis"],"prefix":"10.1016","volume":"43","author":[{"given":"Xuanxin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2023.11.004_bib1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a systematic review and meta-analysis","volume":"70","author":"Feng","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2023.11.004_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clnu.2023.11.004_bib3","doi-asserted-by":"crossref","first-page":"110642","DOI":"10.1016\/j.biopha.2020.110642","article-title":"The emerging role of lncRNAs in chondrocytes from osteoarthritis patients","volume":"131","author":"Tu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clnu.2023.11.004_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13287-019-1458-8","article-title":"lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.clnu.2023.11.004_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2014.04.002","article-title":"lncRNAs: insights into their function and mechanics in underlying disorders","volume":"762","author":"Li","year":"2014","journal-title":"Mutat Res Rev Mutat Res"},{"key":"10.1016\/j.clnu.2023.11.004_bib6","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1158\/0008-5472.CAN-18-0222","article-title":"MIR22HGSilencing of long noncoding RNA triggers cell survival\/death signaling via oncogenes YBX1, MET, and p21 in lung cancer","volume":"78","author":"Su","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.clnu.2023.11.004_bib7","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.7150\/thno.22493","article-title":"MIR22HGIdentification and functional characterization of long non-coding RNA as a tumor suppressor for hepatocellular carcinoma","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.clnu.2023.11.004_bib8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/brain\/awz406","article-title":"Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt\/\u03b2-catenin signalling","volume":"143","author":"Han","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.clnu.2023.11.004_bib9","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1080\/21655979.2021.1945362","article-title":"LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p\/ADAMTS5 pathway","volume":"12","author":"Long","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.clnu.2023.11.004_bib10","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","article-title":"MicroRNA","volume":"141","author":"Lu","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.clnu.2023.11.004_bib11","doi-asserted-by":"crossref","first-page":"7332298","DOI":"10.1155\/2022\/7332298","article-title":"MIR22HG aggravates oxygen-glucose deprivation and reoxygenation-induced cardiomyocyte injury through the miR-9-3p\/SH2B3 Axis","volume":"2022","author":"Ge","year":"2022","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.clnu.2023.11.004_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-2823-2_1","article-title":"MiRNA biogenesis and regulation of diseases. An updated overview","volume":"2595","author":"Anchal","year":"2023","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.clnu.2023.11.004_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rajesha","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.clnu.2023.11.004_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12944-023-01787-2","article-title":"Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p\/ATG2B\/PTEN-AKT axis to mediate autophagy and pyroptosis","volume":"22","author":"Chen","year":"2023","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.clnu.2023.11.004_bib15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.parkreldis.2014.10.018","article-title":"miRNA expression is highly sensitive to a drug therapy in Parkinson\u2019s disease","volume":"21","author":"Alieva Anelya","year":"2015","journal-title":"Parkinsonism Relat Disorders"},{"key":"10.1016\/j.clnu.2023.11.004_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2019.02.015","article-title":"Identification of microRNA-mRNA networks involved in cisplatin-induced renal tubular epithelial cells injury","volume":"851","author":"Wu","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.clnu.2023.11.004_bib17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/CS20180873","article-title":"Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis","volume":"133","author":"Li","year":"2019","journal-title":"Clin Sci"},{"key":"10.1016\/j.clnu.2023.11.004_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s12967-020-02577-5","article-title":"LncRNA NEAT1\/microRNA-129-5p\/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis","volume":"18","author":"Ye","year":"2020","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.clnu.2023.11.004_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Experimental dissection of long noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2023.11.004_bib20","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-codingRNAs in development and disease: background, mechanisms, and therapeutic approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol Rev"},{"key":"10.1016\/j.clnu.2023.11.004_bib21","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20193991","article-title":"MIR22HG regulates miR-486\/PTEN axis in bladder cancer to promote cell proliferation","volume":"40","author":"Tang","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.clnu.2023.11.004_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-02813-2","article-title":"Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN\/AKT pathway","volume":"11","author":"Jin","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clnu.2023.11.004_bib23","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41374-021-00645-y","article-title":"Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism","volume":"101","author":"Liu","year":"2021","journal-title":"Lab Invest"},{"key":"10.1016\/j.clnu.2023.11.004_bib24","first-page":"5851","article-title":"MIR22HG inhibits cell growth, migration and invasion through regulating the miR-24-3p\/p27kip1 axis in thyroid papillary carcinomas","volume":"23","author":"Chen","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clnu.2023.11.004_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biopha.2018.05.046","article-title":"LncRNA MIR22HG negatively regulates miR-141-3p to enhance DAPK1 expression and inhibits endometrial carcinoma cells proliferation","volume":"104","author":"Cui","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clnu.2023.11.004_bib26","doi-asserted-by":"crossref","first-page":"108348","DOI":"10.1016\/j.clim.2020.108348","article-title":"MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-\u03baB1-RANKL pathway in fibroblast-like synoviocytes","volume":"212","author":"Lee","year":"2020","journal-title":"Clin Immunol"},{"key":"10.1016\/j.clnu.2023.11.004_bib27","first-page":"3804","article-title":"Altered microRNA-9 expression level is directly correlated with pathogenesis of nonalcoholic fatty liver disease by targeting Onecut2 and SIRT1","volume":"22","author":"Ao","year":"2016","journal-title":"Med Sci Mon Int Med J Exp Clin Res"},{"key":"10.1016\/j.clnu.2023.11.004_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40199-023-00458-y","article-title":"Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: role of SIRT-1\/adipokines\/PPAR\u03b3 and IGF-1","volume":"31","author":"Shamardl","year":"2023","journal-title":"Daru"},{"key":"10.1016\/j.clnu.2023.11.004_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040517","article-title":"The role of growth hormone and insulin growth factor 1 in the development of non-alcoholic steato-hepatitis: a systematic review","volume":"12","author":"Cristin","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.clnu.2023.11.004_bib30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41598-017-00826-0","article-title":"Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA\/mRNA regulatory network analysis","volume":"7","author":"Ho","year":"2017","journal-title":"Sci Rep"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142300362X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142300362X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:14:51Z","timestamp":1759367691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156142300362X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S026156142300362X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2023.11.004","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA MIR22HG\/microRNA-9-3p\/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2023.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}