{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:02:48Z","timestamp":1792526568059,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","award":["2022\\u20132026"],"award-info":[{"award-number":["2022\\u20132026"]}],"id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID1099480"],"award-info":[{"award-number":["ID1099480"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011025","name":"Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012155","name":"Channel 7 Telethon Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.clnu.2024.02.030","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T05:16:08Z","timestamp":1709270168000},"page":"969-980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant"],"prefix":"10.1016","volume":"43","author":[{"given":"Jacquelyn M.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-0330","authenticated-orcid":false,"given":"Stacey N.","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2299-2050","authenticated-orcid":false,"given":"Mahsa","family":"Mousavi-Derazmahalleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9182","authenticated-orcid":false,"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5366","authenticated-orcid":false,"given":"Maria C.","family":"Jenmalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravisha","family":"Srinivasjois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-6266","authenticated-orcid":false,"given":"Jeffrey","family":"Keelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-8590","authenticated-orcid":false,"given":"Susan L.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra J.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus T.","family":"Christophersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2024.02.030_bib1","first-page":"131","article-title":"The human microbiome and child growth \u2013 first 1000 Days and beyondMicrobiology","author":"Robertson","year":"2019","journal-title":"Elsevier"},{"key":"10.1016\/j.clnu.2024.02.030_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00365","article-title":"The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma","author":"Gray","year":"2017","journal-title":"Frontiers in Immunology. Frontiers Media SA"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib3","first-page":"56","article-title":"Gut microbiota and mucosal immunity in the neonate","volume":"6","author":"Dzidic","year":"2018","journal-title":"Med Sci"},{"key":"10.1016\/j.clnu.2024.02.030_bib4","first-page":"222","article-title":"Human gut microbiome viewed across age and geography","author":"Yatsunenko","year":"2012","journal-title":"Nature. Nature Publishing Group"},{"key":"10.1016\/j.clnu.2024.02.030_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114514004127","article-title":"Dietary effects on human gut microbiome diversity","volume":"113","author":"Xu","year":"2015","journal-title":"Br J Nutr"},{"issue":"203","key":"10.1016\/j.clnu.2024.02.030_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00203-017-1459-x","article-title":"A\u00a0review of metabolic potential of human gut microbiome in human nutrition","volume":"200","author":"Yadav","year":"2018","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.clnu.2024.02.030_bib7","series-title":"The maternal gut microbiome during pregnancy and its role in maternal and infant health. Current opinion in microbiology","author":"Sinha","year":"2023"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1467-3010.2008.00706.x","article-title":"Dietary fibre and the gut microbiota","volume":"33","author":"Scott","year":"2008","journal-title":"Nutr Bull"},{"issue":"2","key":"10.1016\/j.clnu.2024.02.030_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/apt.13662","article-title":"Scott M.Systematic review with meta-analysis: effect of fibre supplementation on chronic idiopathic constipation in adults","volume":"44","author":"Christodoulides","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2024.02.030_bib10","first-page":"2159","article-title":"Dietary fibre intervention for gut microbiota, sleep and mental health in adults with irritable bowel syndrome: a scoping review","author":"Yan","year":"2021","journal-title":"Nutrients. Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.clnu.2024.02.030_bib11","series-title":"Nutrients","first-page":"4200","article-title":"Term infant formulas influencing gut microbiota: an overview","author":"Fabiano","year":"2021"},{"issue":"125","key":"10.1016\/j.clnu.2024.02.030_bib12","article-title":"Dietary fiber and the human gut microbiota: application of evidence mapping methodology","volume":"9","author":"Sawicki","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2024.02.030_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","author":"Venegas","year":"2019","journal-title":"Frontiers in Immunology. Frontiers Media S.A."},{"key":"10.1016\/j.clnu.2024.02.030_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010133","article-title":"The evolving microbiome from pregnancy to early infancy: a comprehensive review","author":"Mesa","year":"2020","journal-title":"Nutrients, MDPI AG"},{"issue":"1","key":"10.1016\/j.clnu.2024.02.030_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-065X.2011.01080.x","article-title":"Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases","volume":"245","author":"Macia","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1016\/j.clnu.2024.02.030_bib16","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3389\/fimmu.2017.00584","article-title":"Innate immunity and breast milk","volume":"8","author":"Cacho","year":"2017","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3945\/ajcn.115.120881","article-title":"Impact of maternal nutrition on breast-milk composition: a systematic review","volume":"104","author":"Bravi","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2024.02.030_bib18","doi-asserted-by":"crossref","unstructured":"Maher S.E., O'Brien E.C., Moore R.L., Byrne D.F., Geraghty A.A., Saldova R., et\u00a0al. The association between the maternal diet and the maternal and infant gut microbiome: a systematic review. British Journal of Nutrition. Cambridge University Press; 2020. p. 1491\u20131499. doi:10.1017\/S0007114520000847.","DOI":"10.1017\/S0007114520000847"},{"issue":"13","key":"10.1016\/j.clnu.2024.02.030_bib19","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.3390\/nu14132753","article-title":"Study protocol for a randomised controlled trial investigating the effects of maternal prebiotic fibre dietary supplementation from mid-pregnancy to six months\u2019 post-partum on child allergic disease outcomes","volume":"14","author":"Palmer","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/reveh-2020-0057","article-title":"Introducing the ORIGINS project: a community-based interventional birth cohort","volume":"35","author":"Silva","year":"2020","journal-title":"Rev Environ Health"},{"issue":"5","key":"10.1016\/j.clnu.2024.02.030_bib21","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/ajcn\/86.5.1426","article-title":"Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity - a randomized, double-blind, placebo-controlled study","volume":"86","author":"Shadid","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2024.02.030_bib22","first-page":"1","article-title":"Fructooligosaccharide (FOS) and galactooligosaccharide (GOS) increase Bifidobacterium but reduce butyrate producing bacteria with adverse glycemic metabolism in healthy young population 20177:1","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2024.02.030_bib23","series-title":"The Bristol scale - a useful system to assess stool form?","first-page":"305","author":"M\u00ednguez P\u00e9rez","year":"2009"},{"issue":"7","key":"10.1016\/j.clnu.2024.02.030_bib24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.clnu.2024.02.030_bib25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/edn3.11","article-title":"R.microDecon: a highly accurate read-subtraction tool for the post-sequencing removal of contamination in metabarcoding studies","volume":"1","author":"McKnight","year":"2019","journal-title":"Environ DNA"},{"issue":"11","key":"10.1016\/j.clnu.2024.02.030_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population-scale meta-omics studies","volume":"17","author":"Mallick","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.clnu.2024.02.030_bib27","series-title":"PERMANOVA+ for PRIMER: guide to software and statistical methods","author":"Anderson","year":"2008"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host remodeling of the gut microbiome and metabolic changes during pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2024.02.030_bib29","series-title":"Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature reviews gastroenterology and hepatology","first-page":"605","author":"Sanders","year":"2019"},{"issue":"1","key":"10.1016\/j.clnu.2024.02.030_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5223\/pghn.2020.23.1.1","article-title":"Prebiotics in the infant microbiome: the past, present, and future","volume":"23","author":"Miqdady","year":"2020","journal-title":"Ped Gastroenterol Hepatol Nutr"},{"key":"10.1016\/j.clnu.2024.02.030_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.anaerobe.2018.04.018","article-title":"The ability of human intestinal anaerobes to metabolize different oligosaccharides: novel means for microbiota modulation?","volume":"51","author":"Ose","year":"2018","journal-title":"Anaerobe"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu9030196","article-title":"Maternal prebiotic ingestion increased the number of fecal bifidobacteria in pregnant women but not in their neonates aged one month","volume":"9","author":"Jinno","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2024.02.030_bib33","article-title":"Distribution characteristics of intestinal microbiota during pregnancy and postpartum in healthy women","author":"Qin","year":"2021","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"5","key":"10.1016\/j.clnu.2024.02.030_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1503\/cmaj.121189","article-title":"Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months","volume":"185","author":"Azad","year":"2013","journal-title":"CMAJ (Can Med Assoc J)"},{"key":"10.1016\/j.clnu.2024.02.030_bib35","doi-asserted-by":"crossref","first-page":"5140750","DOI":"10.1093\/cdn\/nzab046_047","article-title":"Alterations in the gut microbiome of infants consuming partially hydrolyzed cow milk protein formula","volume":"5","author":"Gilley","year":"2021","journal-title":"Curr Dev Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2024.02.030_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1710-1492-9-15","article-title":"Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity","volume":"9","author":"Azad","year":"2013","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.clnu.2024.02.030_bib37","first-page":"1","article-title":"Distinguishable influence of the delivery mode, feeding pattern, and infant sex on dynamic alterations in the intestinal microbiota in the first year of life","volume":"1","author":"Ma","year":"2023","journal-title":"Microb Ecol"},{"issue":"MAR","key":"10.1016\/j.clnu.2024.02.030_bib38","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fmicb.2019.00598","article-title":"The perturbation of infant gut microbiota caused by cesarean delivery is partially restored by exclusive breastfeeding","volume":"10","author":"Liu","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.clnu.2024.02.030_bib39","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3389\/fimmu.2021.712614","article-title":"Prebiotic supplementation during pregnancy modifies the gut microbiota and increases metabolites in amniotic fluid, driving a tolerogenic environment in utero","volume":"12","author":"Brosseau","year":"2021","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.clnu.2024.02.030_bib40","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1017\/S0007114516002269","article-title":"Fermentation properties and potential prebiotic activity of Bimuno\u00ae galacto-oligosaccharide (65 % galacto-oligosaccharide content) on in\u00a0vitro gut microbiota parameters","volume":"116","author":"Grimaldi","year":"2016","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2024.02.030_bib41","series-title":"\u2018Short-chain fatty acids, maternal microbiota and metabolism in pregnancy\u2019, Nutrients","first-page":"1244","author":"Zi\u0119tek","year":"2021"},{"issue":"2","key":"10.1016\/j.clnu.2024.02.030_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/apt.13248","article-title":"Review article: dietary fibre\u2013microbiota interactions","volume":"42","author":"Simpson","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2024.02.030_bib43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.3390\/nu14102096","article-title":"Prebiotics and the human gut microbiota: from breakdown mechanisms to the impact on metabolic health","author":"Bedu-Ferrari","year":"2022","journal-title":"Nutrients: Multidisciplinary Digital Publishing Institute"},{"issue":"2","key":"10.1016\/j.clnu.2024.02.030_bib44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1574-6968.2002.tb11467.x","article-title":"The microbiology of butyrate formation in the human colon","volume":"217","author":"Pryde","year":"2002","journal-title":"FEMS (Fed Eur Microbiol Soc) Microbiol Lett"},{"issue":"9","key":"10.1016\/j.clnu.2024.02.030_bib45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/gut.21.9.793","article-title":"Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man","volume":"21","author":"Roediger","year":"1980","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.clnu.2024.02.030_bib46","first-page":"305","article-title":"Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics","volume":"104","author":"Macfarlane","year":"2008","journal-title":"J\u00a0Appl Microbiol"},{"issue":"6","key":"10.1016\/j.clnu.2024.02.030_bib47","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1053\/j.gastro.2020.01.024","article-title":"Development of the microbiota and associations with birth mode, diet, and atopic disorders in a longitudinal analysis of stool samples, collected from infancy through early childhood","volume":"158","author":"Galazzo","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.clnu.2024.02.030_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tim.2012.12.001","article-title":"Development of intestinal microbiota in infants and its impact on health","volume":"21","author":"Matamoros","year":"2013","journal-title":"Trends Microbiol"},{"issue":"4","key":"10.1016\/j.clnu.2024.02.030_bib49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gutjnl-2012-303249","article-title":"Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section","volume":"63","author":"Jakobsson","year":"2014","journal-title":"Gut"},{"issue":"343","key":"10.1016\/j.clnu.2024.02.030_bib50","doi-asserted-by":"crossref","first-page":"343ra81","DOI":"10.1126\/scitranslmed.aad0917","article-title":"Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability","volume":"8","author":"Yassour","year":"2016","journal-title":"Sci Transl Med"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561424000748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561424000748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:56:18Z","timestamp":1777532178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561424000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0261561424000748"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2024.02.030","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal prebiotic supplementation during pregnancy and lactation modifies the microbiome and short chain fatty acid profile of both mother and infant","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2024.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}