{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:19:19Z","timestamp":1785799159444,"version":"3.56.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.clnu.2024.03.001","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T12:14:51Z","timestamp":1709727291000},"page":"981-987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A novel body composition risk score (B-Score) and overall survival among patients with nonmetastatic breast cancer"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9310","authenticated-orcid":false,"given":"En","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-1206","authenticated-orcid":false,"given":"Wendy Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Cespedes Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2024.03.001_bib1","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/cncr.31638","article-title":"Trends in breast cancer mortality by stage at diagnosis among young women in the United States","volume":"124","author":"Guo","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.clnu.2024.03.001_bib2","first-page":"17","article-title":"Cancer Statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA A Cancer J Clin"},{"key":"10.1016\/j.clnu.2024.03.001_bib3","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1002\/jcp.26379","article-title":"Breast cancer diagnosis: imaging techniques and biochemical markers","volume":"233","author":"Jafari","year":"2018","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.clnu.2024.03.001_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.numecd.2015.12.002","article-title":"Abdominal fat radiodensity, quantity and cardiometabolic risk: the Multi-Ethnic Study of Atherosclerosis","volume":"26","author":"Shah","year":"2016","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.clnu.2024.03.001_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s00330-023-09911-7","article-title":"Adipose tissue composition determines its computed tomography radiodensity","author":"Zoabi","year":"2023","journal-title":"Eur Radiol"},{"key":"10.1016\/j.clnu.2024.03.001_bib6","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/jamaoncol.2018.0137","article-title":"Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer","volume":"4","author":"Caan","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib7","first-page":"1","article-title":"Sarcopenia as a predictor of mortality in women with breast cancer: a meta-analysis and systematic review","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clnu.2024.03.001_bib8","article-title":"Evaluation of body Computed Tomography-determined sarcopenia in breast cancer patients and clinical outcomes: a systematic review","volume":"21","author":"Rossi","year":"2019","journal-title":"Cancer Treat Res Commun"},{"key":"10.1016\/j.clnu.2024.03.001_bib9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10549-019-05352-3","article-title":"Muscle composition and outcomes in patients with breast cancer: meta-analysis and systematic review","volume":"177","author":"Aleixo","year":"2019","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clnu.2024.03.001_bib10","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/oby.22458","article-title":"Adipose tissue distribution and survival among women with nonmetastatic breast cancer","volume":"27","author":"Bradshaw","year":"2019","journal-title":"Obesity"},{"key":"10.1016\/j.clnu.2024.03.001_bib11","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.clnu.2022.09.016","article-title":"Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer","volume":"41","author":"Cheng","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2024.03.001_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4048\/jbc.2020.23.e35","article-title":"Obesity and breast cancer: the role of crown-like structures in breast adipose tissue in tumor progression, prognosis, and therapy","volume":"23","author":"Faria","year":"2020","journal-title":"J\u00a0Breast Cancer"},{"key":"10.1016\/j.clnu.2024.03.001_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.964130","article-title":"Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy","volume":"10","author":"Chen","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.clnu.2024.03.001_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/met.2015.0095","article-title":"Obesity, oxidative stress, adipose tissue dysfunction, and the associated Health risks: causes and therapeutic strategies","volume":"13","author":"Manna","year":"2015","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.clnu.2024.03.001_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.716533","article-title":"The impact of dysmetabolic sarcopenia among insulin sensitive tissues: a narrative review","volume":"12","author":"Armandi","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnu.2024.03.001_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance in obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clnu.2024.03.001_bib17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1001\/jamaoncol.2019.4668","article-title":"Body composition, adherence to anthracycline and taxane-based chemotherapy, and survival after nonmetastatic breast cancer","volume":"6","author":"Feliciano","year":"2020","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SPC.0000000000000382","article-title":"Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition","volume":"12","author":"Pin","year":"2018","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.clnu.2024.03.001_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2021.109943","article-title":"Methodology, clinical applications, and future directions of body composition analysis using computed tomography (CT) images: a review","volume":"145","author":"Tolonen","year":"2021","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.clnu.2024.03.001_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chron Dis"},{"key":"10.1016\/j.clnu.2024.03.001_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-9473(98)00096-6","article-title":"An application of changepoint methods in studying the effect of age on survival in breast cancer","volume":"30","author":"Contal","year":"1999","journal-title":"Comput Stat Data Anal"},{"key":"10.1016\/j.clnu.2024.03.001_bib22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1158\/1055-9965.EPI-17-0200","article-title":"Explaining the obesity paradox: the association between body composition and colorectal cancer survival (C-scans study)","volume":"26","author":"Caan","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clnu.2024.03.001_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12885-019-5319-8","article-title":"Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials","volume":"19","author":"Charette","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clnu.2024.03.001_bib25","doi-asserted-by":"crossref","DOI":"10.1214\/12-STS392","article-title":"A\u00a0selective review of group selection in high-dimensional models","volume":"27","author":"Huang","year":"2012","journal-title":"Stat Sci"},{"key":"10.1016\/j.clnu.2024.03.001_bib26","series-title":"Statistical learning with sparsity: the LASSO and generalizations","author":"Hastie","year":"2015"},{"key":"10.1016\/j.clnu.2024.03.001_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jspi.2018.07.005","article-title":"Optimality of training\/test size and resampling effectiveness in cross-validation","volume":"199","author":"Afendras","year":"2019","journal-title":"J\u00a0Stat Plann Inference"},{"key":"10.1016\/j.clnu.2024.03.001_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric-estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J\u00a0Am Stat Assoc"},{"issue":"2","key":"10.1016\/j.clnu.2024.03.001_bib29","first-page":"185","article-title":"Asymptotically efficient rank invariant test procedures","volume":"135","author":"Peto","year":"1972","journal-title":"J\u00a0Roy Stat Soc"},{"key":"10.1016\/j.clnu.2024.03.001_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J\u00a0Roy Stat Soc B"},{"key":"10.1016\/j.clnu.2024.03.001_bib31","series-title":"Statistical analysis with missing data","author":"Little","year":"2019"},{"key":"10.1016\/j.clnu.2024.03.001_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/biomet\/69.1.239","article-title":"Partial residuals for the proportional hazards regression-model","volume":"69","author":"Schoenfeld","year":"1982","journal-title":"Biometrika"},{"key":"10.1016\/j.clnu.2024.03.001_bib33","series-title":"Statistical inference","author":"Casella","year":"2002"},{"key":"10.1016\/j.clnu.2024.03.001_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1062937","article-title":"Identifying radiomics signatures in body composition imaging for the prediction of outcome following pancreatic cancer resection","volume":"13","author":"van der Kroft","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1749-6632.2000.tb06498.x","article-title":"Body composition in healthy aging","volume":"904","author":"Baumgartner","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clnu.2024.03.001_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094339","article-title":"The role of sarcopenic obesity in cancer and cardiovascular disease: a synthesis of the evidence on pathophysiological aspects and clinical implications","volume":"22","author":"Silveira","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2024.03.001_bib37","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jcsm.12483","article-title":"Sarcopenia: a time for action. An SCWD position paper","volume":"10","author":"Bauer","year":"2019","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clnu.2024.03.001_bib38","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Sarcopenia. Lancet."},{"key":"10.1016\/j.clnu.2024.03.001_bib39","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/annonc\/mdx271","article-title":"Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy","volume":"28","author":"Bozzetti","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib40","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1158\/1055-9965.EPI-23-0227","article-title":"Body composition, relative dose intensity, and adverse events among patients with colon cancer","volume":"32","author":"Cheng","year":"2023","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clnu.2024.03.001_bib41","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1158\/0008-5472.CAN-14-2744","article-title":"Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: a systematic review","volume":"75","author":"Freese","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.clnu.2024.03.001_bib42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrc3967","article-title":"Adiposity and cancer risk: new mechanistic insights from epidemiology","volume":"15","author":"Renehan","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.clnu.2024.03.001_bib43","article-title":"Subcutaneous adipose tissue biology in metabolic syndrome","volume":"33","author":"Jialal","year":"2018","journal-title":"Horm Mol Biol Clin Invest"},{"key":"10.1016\/j.clnu.2024.03.001_bib44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1210\/jc.2013-4296","article-title":"Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality","volume":"100","author":"Rosenquist","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2024.03.001_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.638918","article-title":"Obese adipose tissue as a driver of breast cancer growth and development: update and emerging evidence","volume":"11","author":"Bhardwaj","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clnu.2024.03.001_bib46","first-page":"13","article-title":"Sarcopenia and obesity","volume":"22","author":"Zamboni","year":"2019","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clnu.2024.03.001_bib47","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029801","article-title":"Muscle-adipose tissue cross talk","volume":"8","author":"Stanford","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.clnu.2024.03.001_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.705927","article-title":"Results of the ECHO (eating habits CHanges in oncologic patients) survey: an Italian cross-sectional multicentric study to explore dietary changes and dietary supplement use, in breast cancer survivors","volume":"11","author":"Caprara","year":"2021","journal-title":"Front Oncol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142400075X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142400075X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T01:15:45Z","timestamp":1759367745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156142400075X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S026156142400075X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2024.03.001","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel body composition risk score (B-Score) and overall survival among patients with nonmetastatic breast cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2024.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.","name":"copyright","label":"Copyright"}]}}