{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:26:26Z","timestamp":1781875586056,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR202397"],"award-info":[{"award-number":["NIHR202397"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["208363\/A\/17\/Z"],"award-info":[{"award-number":["208363\/A\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00006 \/3"],"award-info":[{"award-number":["MC_UU_00006 \/3"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CL-2022-14-004"],"award-info":[{"award-number":["CL-2022-14-004"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["CA-D-NTR-2618-H"],"award-info":[{"award-number":["CA-D-NTR-2618-H"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.clnu.2024.12.028","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T19:09:50Z","timestamp":1735585790000},"page":"262-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0690-1478","authenticated-orcid":false,"given":"Grigorios","family":"Panagiotou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demsina","family":"Babazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario F.","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Azghadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Cawood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita G.","family":"Forouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit J.","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser G.","family":"Abdelhafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsey D.","family":"Badawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chondronikola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.clnu.2024.12.028_bib1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.clnu.2024.12.028_bib2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group","volume":"69","author":"Dewys","year":"1980","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s13539-012-0087-1","article-title":"Cancer cachexia: impact, mechanisms and emerging treatments","volume":"4","author":"Vaughan","year":"2013","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"6","key":"10.1016\/j.clnu.2024.12.028_bib4","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/ajcn\/83.6.1345","article-title":"Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis","volume":"83","author":"Fearon","year":"2006","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejca.2005.07.026","article-title":"Prevention and treatment of cancer cachexia: new insights into an old problem","volume":"42","author":"Muscaritoli","year":"2006","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.clnu.2024.12.028_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.smhs.2020.10.003","article-title":"Development and progression of cancer cachexia: perspectives from bench to bedside","volume":"2","author":"Lim","year":"2020","journal-title":"Sports Med Health Sci"},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metabol"},{"key":"10.1016\/j.clnu.2024.12.028_bib8","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat Rev Dis Prim"},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"issue":"21","key":"10.1016\/j.clnu.2024.12.028_bib10","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of cancer cachexia: ASCO guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J\u00a0Clin Oncol"},{"issue":"24","key":"10.1016\/j.clnu.2024.12.028_bib11","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1056\/NEJMoa2409515","article-title":"Ponsegromab for the treatment of cancer cachexia","volume":"391","author":"Groarke","year":"2024","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.clnu.2024.12.028_bib12","first-page":"282","article-title":"The role of brown adipose tissue and the thermogenic adipocytes in glucose metabolism: recent advances and open questions","volume":"23","author":"Chondronikola","year":"2020","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"12","key":"10.1016\/j.clnu.2024.12.028_bib13","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.2337\/db14-0746","article-title":"Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans","volume":"63","author":"Chondronikola","year":"2014","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.clnu.2024.12.028_bib14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmet.2016.04.029","article-title":"Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans","volume":"23","author":"Chondronikola","year":"2016","journal-title":"Cell Metabol"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2023.101370","article-title":"Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight\/obesity","volume":"5","author":"Chondronikola","year":"2024","journal-title":"Cell Reports Medicine"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib16","first-page":"101370","article-title":"Brown fat is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity","volume":"5","author":"Wibmer Ag","year":"2024","journal-title":"Cell Rep Med Medicine"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41591-020-1126-7","article-title":"Brown adipose tissue is associated with cardiometabolic health","volume":"27","author":"Becher","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbalip.2018.05.014","article-title":"Brown and beige fat: from molecules to physiology","volume":"1864","author":"Chondronikola","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"7516","key":"10.1016\/j.clnu.2024.12.028_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature13528","article-title":"Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia","volume":"513","author":"Kir","year":"2014","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.clnu.2024.12.028_bib20","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-11-3536","article-title":"Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice","volume":"72","author":"Tsoli","year":"2012","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.clnu.2024.12.028_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A\u00a0switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Petruzzelli","year":"2014","journal-title":"Cell Metabol"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12944-018-0657-0","article-title":"Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning","volume":"17","author":"Han","year":"2018","journal-title":"Lipids Health Dis"},{"issue":"9","key":"10.1016\/j.clnu.2024.12.028_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112840119","article-title":"An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia","volume":"119","author":"Xie","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF00402783","article-title":"Brown adipose tissue in cancer patients: possible cause of cancer-induced cachexia","volume":"111","author":"Shellock","year":"1986","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"4","key":"10.1016\/j.clnu.2024.12.028_bib25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00256-019-03322-w","article-title":"Brown adipose tissue and cancer progression","volume":"49","author":"Chu","year":"2020","journal-title":"Skeletal Radiol"},{"issue":"10","key":"10.1016\/j.clnu.2024.12.028_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239990","article-title":"Brown fat does not cause cachexia in cancer patients: a large retrospective longitudinal FDG-PET\/CT cohort study","volume":"15","author":"Becker","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib27","doi-asserted-by":"crossref","first-page":"E144","DOI":"10.1152\/ajpendo.00187.2022","article-title":"Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer","volume":"324","author":"Eljalby","year":"2023","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clnu.2024.12.028_bib28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00256-018-3046-x","article-title":"Preliminary investigation of brown adipose tissue assessed by PET\/CT and cancer activity","volume":"48","author":"Bos","year":"2019","journal-title":"Skeletal Radiol"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cmet.2019.05.019","article-title":"Repeatability of quantitative brown adipose tissue imaging metrics on positron emission tomography with 18F-fluorodeoxyglucose in humans","volume":"30","author":"Fraum","year":"2019","journal-title":"Cell Metabol"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.2014.56.1894","article-title":"Diagnostic criteria for the classification of cancer-associated weight loss","volume":"33","author":"Martin","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.clnu.2024.12.028_bib31","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.clnu.2024.12.028_bib32","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1634\/theoncologist.2017-0659","article-title":"The eighth edition of TNM staging of lung cancer: reference chart and diagrams","volume":"23","author":"Lababede","year":"2018","journal-title":"Oncol"},{"key":"10.1016\/j.clnu.2024.12.028_bib33","unstructured":"National Centers for Environmental Information. [cited 2020 November 3]; Available from: https:\/\/www.ncdc.noaa.gov\/cdo-web\/search."},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cmet.2016.07.014","article-title":"Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): recommendations for standardized FDG-PET\/CT experiments in humans","volume":"24","author":"Chen","year":"2016","journal-title":"Cell Metabol"},{"issue":"16","key":"10.1016\/j.clnu.2024.12.028_bib35","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1158\/0008-5472.CAN-18-0125","article-title":"LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity","volume":"78","author":"Nioche","year":"2018","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.clnu.2024.12.028_bib36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s13139-012-0146-8","article-title":"Comparison of SUVs normalized by lean body mass determined by CT with those normalized by lean body mass estimated by predictive equations in normal tissues","volume":"46","author":"Kim","year":"2012","journal-title":"Nucl Med Mol Imaging"},{"issue":"7922","key":"10.1016\/j.clnu.2024.12.028_bib37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41586-022-05030-3","article-title":"Brown-fat-mediated tumour suppression by cold-altered global metabolism","volume":"608","author":"Seki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.clnu.2024.12.028_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-physiol-031620-095446","article-title":"Cellular heterogeneity in adipose tissues","volume":"83","author":"Corvera","year":"2021","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib39","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1038\/s41467-023-39282-y","article-title":"Longitudinal body mass index and cancer risk: a cohort study of 2.6 million Catalan adults","volume":"14","author":"Recalde","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib40","article-title":"A\u00a0systematic Review: does insulin resistance affect the risk and survival outcome of breast cancer in women?","volume":"14","author":"Srinivasan","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.clnu.2024.12.028_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.3520","article-title":"Association of obesity with survival outcomes in patients with cancer: a systematic Review and meta-analysis","volume":"4","author":"Petrelli","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"8","key":"10.1016\/j.clnu.2024.12.028_bib42","article-title":"Chronic inflammation in obesity and cancer cachexia","volume":"11","author":"Divella","year":"2022","journal-title":"J\u00a0Clin Med"},{"issue":"7","key":"10.1016\/j.clnu.2024.12.028_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076192","article-title":"Systematic Review and meta-analysis of the impact of bariatric surgery on future cancer risk","volume":"24","author":"Wilson","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.clnu.2024.12.028_bib44","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/jamaoncol.2023.5573","article-title":"GLP-1 receptor agonists and colorectal cancer risk in drug-naive patients with type 2 diabetes, with and without overweight\/obesity","volume":"10","author":"Wang","year":"2024","journal-title":"JAMA Oncol"},{"issue":"24","key":"10.1016\/j.clnu.2024.12.028_bib45","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1001\/jama.2022.9009","article-title":"Association of bariatric surgery with cancer risk and mortality in adults with obesity","volume":"327","author":"Aminian","year":"2022","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.clnu.2024.12.028_bib46","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1124\/molpharm.121.000328","article-title":"The heartwarming effect of Brown adipose tissue","volume":"102","author":"Pinckard","year":"2022","journal-title":"Mol Pharmacol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561424004692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561424004692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:08:16Z","timestamp":1778677696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561424004692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":46,"alternative-id":["S0261561424004692"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2024.12.028","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2024.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}