{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:45:17Z","timestamp":1780731917351,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00238039"],"award-info":[{"award-number":["RS-2023-00238039"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.clnu.2025.02.012","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T07:59:54Z","timestamp":1739519994000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities"],"prefix":"10.1016","volume":"47","author":[{"given":"Tom","family":"Ryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ju","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soung Won","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyune","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keungmo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2025.02.012_bib1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A\u00a0multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2025.02.012_bib2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jhep.2012.07.028","article-title":"Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: results from the Rotterdam study","volume":"57","author":"Koehler","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.clnu.2025.02.012_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034934","article-title":"Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in a middle-aged population with overweight and normal liver enzymes, and diagnostic accuracy of noninvasive proxies","volume":"103","author":"van Son","year":"2024","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.clnu.2025.02.012_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A\u00a0phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2025.02.012_bib5","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/ijms24021703","article-title":"GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives","volume":"24","author":"Nevola","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2025.02.012_bib6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.joca.2007.01.014","article-title":"Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation","volume":"15","author":"Derfoul","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.clnu.2025.02.012_bib7","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1111\/febs.14984","article-title":"Bone and connective tissue disorders caused by defects in glycosaminoglycan biosynthesis: a panoramic view","volume":"286","author":"Paganini","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.clnu.2025.02.012_bib8","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.3390\/nu14153213","article-title":"Pharmacokinetic comparison of chitosan-derived and biofermentation-derived glucosamine in nutritional supplement for bone health","volume":"14","author":"Kang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.02.012_bib9","article-title":"Glucosamine improves non-alcoholic fatty liver disease induced by high-fat and high-sugar diet through regulating intestinal barrier function, liver inflammation, and lipid metabolism","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.clnu.2025.02.012_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100699","article-title":"Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation","volume":"8","author":"Lai","year":"2024","journal-title":"Curr Res Food Sci"},{"key":"10.1016\/j.clnu.2025.02.012_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2025.02.012_bib12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2025.02.012_bib13","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/s41598-019-42130-z","article-title":"Glucosamine inhibits IL-1\u03b2 expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome","volume":"9","author":"Chiu","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.02.012_bib14","first-page":"2856","article-title":"Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor\u2013deficient mice","volume":"136","author":"Tannock","year":"2006","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2025.02.012_bib15","article-title":"Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess","volume":"1865","author":"Park","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.clnu.2025.02.012_bib16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.5606\/ArchRheumatol.2016.5632","article-title":"Oral glucosamine effect on blood glucose and insulin levels in patients with non-diabetic osteoarthritis: a double-blind, placebo-controlled clinical trial","volume":"31","author":"Saghafi","year":"2016","journal-title":"Arch Rheumatol"},{"key":"10.1016\/j.clnu.2025.02.012_bib17","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cmet.2024.04.006","article-title":"Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease","volume":"36","author":"Bo","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.02.012_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/scipharm87040034","article-title":"Multifaceted protective role of glucosamine against osteoarthritis: review of its molecular mechanisms","volume":"87","author":"Al-Saadi","year":"2019","journal-title":"Sci Pharm"},{"key":"10.1016\/j.clnu.2025.02.012_bib19","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1053\/j.gastro.2020.02.020","article-title":"Metabolic inflammation\u2014a role for hepatic inflammatory pathways as drivers of comorbidities in nonalcoholic fatty liver disease?","volume":"158","author":"Gehrke","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clnu.2025.02.012_bib20","article-title":"Antioxidant activity of glucosamine and its effects on ROS production, Nrf2, and O-GlcNAc expression in HMEC-1 cells","volume":"5","author":"Fern\u00e1ndez-Rojas","year":"2023","journal-title":"Cur Res Toxicol"},{"key":"10.1016\/j.clnu.2025.02.012_bib21","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302447R","article-title":"Oxidative stress in metabolic dysfunction-associated steatotic liver disease (MASLD): how does the animal model resemble human disease?","volume":"38","author":"Jakubek","year":"2024","journal-title":"FASEB J"},{"key":"10.1016\/j.clnu.2025.02.012_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13293-015-0033-y","article-title":"Sex differences in metabolic homeostasis, diabetes, and obesity","volume":"6","author":"Mauvais-Jarvis","year":"2015","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.clnu.2025.02.012_bib23","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/CIRCRESAHA.118.312806","article-title":"Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk","volume":"123","author":"Chia","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.clnu.2025.02.012_bib24","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2337\/dc19-1836","article-title":"Glucosamine use, inflammation, and genetic susceptibility, and incidence of type 2 diabetes: a prospective study in UK Biobank","volume":"43","author":"Ma","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnu.2025.02.012_bib25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12933-024-02434-5","article-title":"Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk: a comprehensive review","volume":"23","author":"Zheng","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.clnu.2025.02.012_bib26","first-page":"691","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2025.02.012_bib27","doi-asserted-by":"crossref","first-page":"C1243","DOI":"10.1152\/ajpcell.00521.2006","article-title":"Hexosamine biosynthetic pathway flux and cardiomyopathy in type 2 diabetes mellitus. Focus on \u201cImpact of type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.\u201d","volume":"292","author":"McNulty","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.clnu.2025.02.012_bib28","article-title":"Steatotic liver disease, MASLD and risk of chronic kidney disease","author":"Bilson","year":"2023","journal-title":"Diabetes Metabol"},{"key":"10.1016\/j.clnu.2025.02.012_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/ijms21010263","article-title":"Inflammation and oxidative stress in chronic kidney disease\u2014potential therapeutic role of minerals, vitamins and plant-derived metabolites","volume":"21","author":"Rapa","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2025.02.012_bib30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.4093\/dmj.2023.0165","article-title":"The beneficial effect of glycemic control against adverse outcomes in patients with type 2 diabetes mellitus and chronic kidney disease","volume":"47","author":"Lee","year":"2023","journal-title":"Diab Metabol J"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T20:45:38Z","timestamp":1745527538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561425000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":30,"alternative-id":["S0261561425000470"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.02.012","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}