{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:22:11Z","timestamp":1783624931016,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005709","name":"Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000209","name":"National Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.clnu.2025.03.004","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T22:44:01Z","timestamp":1741473841000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Retrospective real world study on vitamin D supplementation: Looking for the most effective molecule and its frequency of use"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-9095","authenticated-orcid":false,"given":"Andrea","family":"Crafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Cannarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Cannarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita A.","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"La Vignera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo E.","family":"Calogero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2025.03.004_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2025.03.004_bib2","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3390\/nu14071354","article-title":"Vitamin D and its target genes","volume":"14","author":"Carlberg","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.03.004_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib4","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: an update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib5","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.03.004_bib6","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1210\/jc.2011-2218","article-title":"IOM committee members respond to Endocrine Society vitamin D guideline","volume":"97","author":"Rosen","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.03.004_bib7","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8863.1","article-title":"Vitamin D supplementation: less controversy, more guidance needed","author":"Stokes","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.clnu.2025.03.004_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/nu5010111","article-title":"Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation","volume":"5","author":"Wacker","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.03.004_bib9","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s11154-021-09693-7","article-title":"Vitamin D: dosing, levels, form, and route of administration: does one approach fit all?","volume":"22","author":"Bilezikian","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.clnu.2025.03.004_bib10","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgae290","article-title":"Vitamin D for the prevention of disease: an endocrine society clinical practice guideline","author":"Demay","year":"2024","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.03.004_bib11","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00198-018-4520-y","article-title":"Is calcifediol better than cholecalciferol for vitamin D supplementation?","volume":"29","author":"Quesada-Gomez","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.clnu.2025.03.004_bib12","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/nu12061617","article-title":"Cholecalciferol or calcifediol in the management of vitamin D deficiency","volume":"12","author":"Sosa Henr\u00edquez","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.03.004_bib13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus statement on vitamin D status assessment and supplementation: whys, whens, and hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr Rev"},{"key":"10.1016\/j.clnu.2025.03.004_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12020-016-1137-9","article-title":"Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D3","volume":"55","author":"Tak\u00e1cs","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.clnu.2025.03.004_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/nu10060659","article-title":"A\u00a0randomized study to compare a monthly to a daily administration of vitamin D3 supplementation","volume":"10","author":"De Niet","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.03.004_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s40266-015-0259-8","article-title":"Vitamin D supplementation in nursing home patients: randomized controlled trial of standard daily dose versus individualized loading dose regimen","volume":"32","author":"Wijnen","year":"2015","journal-title":"Drugs Aging"},{"key":"10.1016\/j.clnu.2025.03.004_bib17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00198-007-0465-2","article-title":"Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents","volume":"19","author":"Chel","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.clnu.2025.03.004_bib18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.3390\/nu12061553","article-title":"Pharmacokinetics of oral cholecalciferol in healthy subjects with vitamin D deficiency: a randomized open-label study","volume":"12","author":"Fassio","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.03.004_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1168115","article-title":"Efficacy of intermittent versus daily vitamin D supplementation on improving circulating 25(OH)D concentration: a Bayesian network meta-analysis of randomized controlled trials","volume":"10","author":"Zhuang","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1210\/jc.2016-3919","article-title":"Effects of cholecalciferol vs calcifediol on total and free 25-hydroxyvitamin D and parathyroid hormone","volume":"102","author":"Shieh","year":"2017","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.03.004_bib21","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00394-023-03103-1","article-title":"Calcifediol: a review of its pharmacological characteristics and clinical use in correcting vitamin D deficiency","volume":"62","author":"Jodar","year":"2023","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib22","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/s41430-020-0697-1","article-title":"Vitamin D supplementation: cholecalciferol, calcifediol, and calcitriol","volume":"74","author":"Vieth","year":"2020","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/MED.0000000000000371","article-title":"Vitamin D in obesity","volume":"24","author":"Walsh","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.clnu.2025.03.004_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJMe1206858","article-title":"Vitamin D--baseline status and effective dose","volume":"367","author":"Heaney","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2025.03.004_bib25","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.clnu.2019.12.028","article-title":"Vitamin D: a magic bullet or a myth?","volume":"39","author":"Reijven","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib26","first-page":"73","article-title":"Supplemental 25-hydroxycholecalciferol is more effective than cholecalciferol in raising serum 25-hydroxyvitamin D concentrations in older adults","volume":"150","author":"Graeff-Armas","year":"2020","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnu.2025.03.004_bib27","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/mas.21768","article-title":"Analysis of vitamin D metabolic markers by mass spectrometry: recent progress regarding the \"gold standard\" method and integration into clinical practice","volume":"42","author":"Alexandridou","year":"2023","journal-title":"Mass Spectrom Rev"},{"key":"10.1016\/j.clnu.2025.03.004_bib28","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1038\/s41598-024-58154-z","article-title":"Unraveling the complex interplay between obesity and vitamin D metabolism","volume":"14","author":"Alzohily","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.03.004_bib29","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jcsm.12759","article-title":"Vitamin D supplementation and risk of falling: outcomes from the randomized, placebo-controlled D-Health Trial","volume":"12","author":"Waterhouse","year":"2021","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clnu.2025.03.004_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa2202106","article-title":"Supplemental\u00a0vitamin D and incident fractures in midlife and older adults","volume":"387","author":"LeBoff","year":"2022","journal-title":"N\u00a0Engl J Med"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142500072X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142500072X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T20:46:23Z","timestamp":1745527583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156142500072X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":30,"alternative-id":["S026156142500072X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.03.004","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retrospective real world study on vitamin D supplementation: Looking for the most effective molecule and its frequency of use","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}