{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:23:24Z","timestamp":1774293804695,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017857","name":"Soci\u00e9t\u00e9 Francophone Nutrition Clinique et M\u00e9tabolisme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.clnu.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T18:35:02Z","timestamp":1747247702000},"page":"128-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Identification of Pappalysin-2 (PAPP-A2), a modulator of Insulin-like Growth Factor-1 pathway, as a potential marker of teduglutide efficacy in patients with short bowel syndrome"],"prefix":"10.1016","volume":"50","author":[{"given":"Brune","family":"de Dreuille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9my","family":"Nicolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Cros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Cazals-Hatem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u00efs","family":"Chassac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Pot\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Le Beyec-Le Bihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Bado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clnu.2025.05.006_bib1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.clnu.2018.07.036","article-title":"Intestinal failure in adults: recommendations from the ESPEN expert groups","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2025.05.006_bib2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0261-5614(03)00042-6","article-title":"Quality of life and concerns in patients with short bowel syndrome","volume":"22","author":"Carlsson","year":"2003","journal-title":"Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2025.05.006_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/j.2040-4603.2018.tb00039.x","article-title":"Glucagon-like peptide-2 and the regulation of intestinal growth and function","volume":"8","author":"Brubaker","year":"2018","journal-title":"Compr Physiol"},{"issue":"5","key":"10.1016\/j.clnu.2025.05.006_bib4","first-page":"344","article-title":"The new place of enterohormones in intestinal failure","volume":"23","author":"Daoud","year":"2020","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"10.1016\/j.clnu.2025.05.006_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1210\/en.2014-1710","article-title":"An analysis of cosecretion and coexpression of gut hormones from Male rat proximal and distal small intestine","volume":"156","author":"Svendsen","year":"2015","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.clnu.2025.05.006_bib6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.soard.2015.02.011","article-title":"Detailed characterization of incretin cell distribution along the human small intestine","volume":"11","author":"Guedes","year":"2015","journal-title":"Surg Obes Relat Dis"},{"issue":"8","key":"10.1016\/j.clnu.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1210\/en.2019-00398","article-title":"Localization of glucagon-like Peptide-2 receptor expression in the mouse","volume":"160","author":"Yusta","year":"2019","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.clnu.2025.05.006_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/j.gastro.2005.11.005","article-title":"GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow","volume":"130","author":"Guan","year":"2006","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.clnu.2025.05.006_bib9","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/en.2006-1232","article-title":"Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat","volume":"148","author":"Nelson","year":"2007","journal-title":"Endocrinology"},{"issue":"1\u20133","key":"10.1016\/j.clnu.2025.05.006_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.regpep.2004.07.009","article-title":"GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors","volume":"124","author":"\u00d8rskov","year":"2005","journal-title":"Regul Pept"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1073\/pnas.96.4.1569","article-title":"Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2","volume":"96","author":"Munroe","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.clnu.2025.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2011.09.014","article-title":"Loss of glucagon-like peptide-2-induced proliferation following intestinal epithelial insulin-like growth factor-1-receptor deletion","volume":"141","author":"Rowland","year":"2011","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.clnu.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1210\/en.2007-0561","article-title":"Glucagon-like peptide-2 activates \u03b2-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I","volume":"149","author":"Dub\u00e9","year":"2008","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.clnu.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/j.gastro.2009.05.057","article-title":"ErbB signaling is required for the proliferative actions of GLP-2 in the Murine gut","volume":"137","author":"Yusta","year":"2009","journal-title":"Gastroenterology [Internet]"},{"issue":"APR","key":"10.1016\/j.clnu.2025.05.006_bib15","article-title":"Microbiota is involved in post-resection adaptation in humans with short bowel syndrome","volume":"8","author":"Gillard","year":"2017","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.clnu.2025.05.006_bib16","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.90657.2008","article-title":"Morphological adaptation with preserved proliferation\/transporter content in the colon of patients with short bowel syndrome","volume":"297","author":"Joly","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"11","key":"10.1016\/j.clnu.2025.05.006_bib17","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.clnu.2023.09.003","article-title":"Hyperphagia is prominent in adult patients with short bowel syndrome: a role for the colon?","volume":"42","author":"Fourati","year":"2023","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.05.006_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep28345","article-title":"Enhanced ghrelin levels and hypothalamic orexigenic AgRP and NPY neuropeptide expression in models of Jejuno-Colonic short bowel syndrome","volume":"6","author":"Gillard","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.clnu.2025.05.006_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.clnu.2025.05.006_bib20","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.clnu.2019.12.019","article-title":"Six-month outcomes of teduglutide treatment in adult patients with short bowel syndrome with chronic intestinal failure: a real-world French observational cohort study","volume":"39","author":"Joly","year":"2020","journal-title":"Clinical Nutrition [Internet]"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ncp.10092","article-title":"Reduction of parenteral nutrition and hydration support and safety with long-term teduglutide treatment in patients with short bowel syndrome\u2212associated intestinal failure: STEPS-3 study","volume":"33","author":"Seidner","year":"2018","journal-title":"Nutr Clin Pract"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/nu14040796","article-title":"Efficacy of teduglutide for parenteral support reduction in patients with short bowel syndrome: a systematic review and meta-analysis","volume":"14","author":"Bioletto","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1053\/j.gastro.2017.11.023","article-title":"Factors associated with response to teduglutide in patients with short-bowel syndrome and intestinal failure","volume":"154","author":"Jeppesen","year":"2018","journal-title":"Gastroenterology [Internet]"},{"issue":"1","key":"10.1016\/j.clnu.2025.05.006_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jpen.1011","article-title":"Single-center experience with the use of teduglutide in adult patients with short bowel syndrome","volume":"42","author":"Lam","year":"2018","journal-title":"J Parenter Enteral Nutr"},{"issue":"7799","key":"10.1016\/j.clnu.2025.05.006_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(73)90131-1","article-title":"Role of the Colon in ileal-resection diarrh\u0153a","volume":"301","author":"Cummings","year":"1973","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.clnu.2025.05.006_bib26","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M102191200","article-title":"Pregnancy-associated Plasma Protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding Protein-5 proteinase","volume":"276","author":"Overgaard","year":"2001","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.clnu.2025.05.006_bib27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.15252\/emmm.201707950","article-title":"One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology","volume":"9","author":"Argente","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"12","key":"10.1016\/j.clnu.2025.05.006_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123576","article-title":"Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease","volume":"10","author":"Barrios","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.clnu.2025.05.006_bib29","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2006.05.055","article-title":"The essential role of insulin-like growth Factor-1 in the intestinal tropic effects of glucagon-like Peptide-2 in mice","volume":"131","author":"Dub\u00e9","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.clnu.2025.05.006_bib30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1210\/en.2010-0822","article-title":"Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts","volume":"152","author":"Leen","year":"2011","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.clnu.2025.05.006_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/2211-5463.12330","article-title":"Matrix metalloproteinase-1 facilitates MSC migration via cleavage of IGF-2\/IGFBP2 complex","volume":"8","author":"Guan","year":"2018","journal-title":"FEBS Open Bio"},{"issue":"2","key":"10.1016\/j.clnu.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1210\/en.2014-1829","article-title":"IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine","volume":"156","author":"Austin","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnu.2025.05.006_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.peptides.2017.03.008","article-title":"Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway","volume":"91","author":"Shawe-Taylor","year":"2017","journal-title":"Peptides (NY) [Internet]"},{"issue":"8","key":"10.1016\/j.clnu.2025.05.006_bib34","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1152\/ajpgi.00372.2011","article-title":"Exogenous GLP-2 and IGF-I induce a differential intestinal response in IGF binding protein-3 and - 5 double knockout mice","volume":"302","author":"Murali","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib35","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201506106","article-title":"Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF -I availability","volume":"8","author":"Dauber","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.clnu.2025.05.006_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00614","article-title":"Pregnancy-Associated plasma Protein-A2 is associated with mortality in patients with lung cancer","volume":"11","author":"Hjortebjerg","year":"2020","journal-title":"Front Endocrinol"},{"issue":"June","key":"10.1016\/j.clnu.2025.05.006_bib37","first-page":"1","article-title":"Novel prognostic biomarkers in gastric cancer: CGB5, MKNK2, and PAPPA2","volume":"11","author":"Qin","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clnu.2025.05.006_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnesp.2021.09.364","article-title":"Early development of small-intestinal polyps in patients with short bowel syndrome treated with teduglutide","volume":"46","author":"De Dreuille","year":"2021","journal-title":"Clin Nutr ESPEN"},{"issue":"7","key":"10.1016\/j.clnu.2025.05.006_bib39","doi-asserted-by":"crossref","DOI":"10.1210\/en.2011-2170","article-title":"Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry","volume":"153","author":"Habib","year":"2012","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.clnu.2025.05.006_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1152\/ajpendo.00326.2004","article-title":"Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP","volume":"290","author":"Theodorakis","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clnu.2025.05.006_bib41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/gut.45.4.559","article-title":"Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure","volume":"45","author":"Jeppesen","year":"1999","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.clnu.2025.05.006_bib42","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/gut.47.3.370","article-title":"Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved Colon","volume":"47","author":"Jeppesen","year":"2000","journal-title":"Gut"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425001347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425001347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:57:49Z","timestamp":1762275469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561425001347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"alternative-id":["S0261561425001347"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.05.006","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Pappalysin-2 (PAPP-A2), a modulator of Insulin-like Growth Factor-1 pathway, as a potential marker of teduglutide efficacy in patients with short bowel syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}