{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:43:52Z","timestamp":1789062232030,"version":"build-2803163510"},"reference-count":291,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.clnu.2025.07.002","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:53:11Z","timestamp":1751975591000},"page":"27-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Burden of negative energy balance in anorexia nervosa: Role of circadian rhythm, mitochondrial dynamics, microbiota\u2013gut\u2013brain axis and their interactions"],"prefix":"10.1016","volume":"52","author":[{"given":"L\u00e9na","family":"Rousseau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-335X","authenticated-orcid":false,"given":"Colin","family":"Sala\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najate","family":"Achamrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-2682","authenticated-orcid":false,"given":"Mo\u00efse","family":"Co\u00ebffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2025.07.002_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/YCO.0b013e328365a321","article-title":"From DSM-IV to DSM-5: changes to eating disorder diagnoses","volume":"26","author":"Call","year":"2013","journal-title":"Curr Opin Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/ajcn\/nqy342","article-title":"Prevalence of eating disorders over the 2000\u20132018 period: a systematic literature review","volume":"109","author":"Galmiche","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S2215-0366(15)00356-9","article-title":"Anorexia nervosa: aetiology, assessment, and treatment","volume":"2","author":"Zipfel","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s40519-013-0020-4","article-title":"Prevalence, comorbidities and outpatient treatment of anorexia and bulimia nervosa in German children and adolescents","volume":"18","author":"Jaite","year":"2013","journal-title":"Eat Weight Disord - Stud Anorex Bulim Obes"},{"key":"10.1016\/j.clnu.2025.07.002_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.yco.0000228759.95237.78","article-title":"Incidence, prevalence and mortality of anorexia nervosa and other eating disorders","volume":"19","author":"Hoek","year":"2006","journal-title":"Curr Opin Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104857","article-title":"Treatment of eating disorders: a systematic meta-review of meta-analyses and network meta-analyses","volume":"142","author":"Monteleone","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.clnu.2025.07.002_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41598-020-79410-y","article-title":"Nutritional status and anxious and depressive symptoms in anorexia nervosa: a prospective study","volume":"11","author":"Plepl\u00e9","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib8","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.3390\/nu11123038","article-title":"Eating disorders and gastrointestinal diseases","volume":"11","author":"Santonicola","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib9","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1572-0241.2001.03839.x","article-title":"Frequency of physician visits for GI complaints by anorexic and bulimic patients","volume":"96","author":"Winstead","year":"2001","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"10.1016\/j.clnu.2025.07.002_bib10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/flgastro-2021-101857","article-title":"Anorexia nervosa and the gastrointestinal tract","volume":"13","author":"Jafar","year":"2022","journal-title":"Frontline Gastroenterol"},{"key":"10.1016\/j.clnu.2025.07.002_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12328-015-0611-x","article-title":"Gastrointestinal symptoms and disorders in patients with eating disorders","volume":"8","author":"Sato","year":"2015","journal-title":"Clin J Gastroenterol"},{"key":"10.1016\/j.clnu.2025.07.002_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.autneu.2006.07.023","article-title":"Gastrointestinal disturbances in eating disorders: clinical and neurobiological aspects","volume":"129","author":"Zipfel","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/10640266.2016.1255108","article-title":"Gastrointestinal comorbidities which complicate the treatment of anorexia nervosa","volume":"25","author":"Mascolo","year":"2017","journal-title":"Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.962837","article-title":"Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment","volume":"13","author":"Riedlinger","year":"2022","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.yclnex.2019.05.001","article-title":"Intestinal microbiota and anorexia nervosa","author":"Breton","year":"2019","journal-title":"Clin Nutr Exp"},{"key":"10.1016\/j.clnu.2025.07.002_bib16","first-page":"1","article-title":"The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice","author":"Fan","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib17","article-title":"Gastrointestinal symptoms, gut microbiome, probiotics and prebiotics in anorexia nervosa: a review of mechanistic rationale and clinical evidence","author":"Dhopatkar","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1152\/physiolgenomics.90255.2008","article-title":"Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx\/anx mouse model","volume":"35","author":"Mercader","year":"2008","journal-title":"Physiol Genom"},{"key":"10.1016\/j.clnu.2025.07.002_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-410473-0.00002-7","article-title":"Anorexia and hypothalamic degeneration","volume":"92","author":"Nilsson","year":"2013","journal-title":"Vitam Horm"},{"key":"10.1016\/j.clnu.2025.07.002_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00059","article-title":"The anx\/anx mouse \u2013 a valuable resource in anorexia nervosa research","volume":"13","author":"Nilsson","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib21","article-title":"The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients","volume":"6","author":"M\u00e9quinion","year":"2015","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib22","first-page":"396","article-title":"The role of hypothalamic inflammation, the hypothalamic-pituitary-adrenal axis and serotonin in the cancer anorexia-cachexia syndrome","volume":"20","author":"van Norren","year":"2017","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clnu.2025.07.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112606","article-title":"Anorexia induces a microglial associated pro-inflammatory environment and correlates with neurodegeneration in the prefrontal cortex of young female rats","volume":"392","author":"Reyes-Ortega","year":"2020","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2020.596381","article-title":"Animal models for anorexia nervosa\u2014A systematic review","volume":"14","author":"Scharner","year":"2021","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.regpep.2009.09.011","article-title":"Prepro-orexin and feeding-related peptide receptor expression in dehydration-induced anorexia","volume":"159","author":"Garc\u00eda-Luna","year":"2010","journal-title":"Regul Pept"},{"key":"10.1016\/j.clnu.2025.07.002_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.psyneuen.2008.09.010","article-title":"Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia","volume":"34","author":"de Gortari","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0031-9384(98)00244-3","article-title":"Dehydration-associated anorexia: development and rapid reversal","volume":"65","author":"Watts","year":"1998","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2426413","article-title":"Anorexia reduces GFAP+ cell density in the rat hippocampus","volume":"2016","author":"Reyes-Haro","year":"2016","journal-title":"Neural Plast"},{"key":"10.1016\/j.clnu.2025.07.002_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/474917","article-title":"Dehydration-induced anorexia reduces astrocyte density in the rat corpus callosum","volume":"2015","author":"Reyes-Haro","year":"2015","journal-title":"Neural Plast"},{"key":"10.1016\/j.clnu.2025.07.002_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2019.00069","article-title":"Activity based anorexia as an animal model for anorexia Nervosa\u2013A systematic review","volume":"6","author":"Schalla","year":"2019","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib31","volume":"vol. 15","author":"Spadini","year":"2021"},{"key":"10.1016\/j.clnu.2025.07.002_bib32","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1038\/s41598-018-25548-9","article-title":"Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia","volume":"8","author":"Nobis","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clinthera.2020.12.003","article-title":"A narrative review of sex differences in eating disorders: is there a biological basis?","volume":"43","author":"Culbert","year":"2021","journal-title":"Clin Ther"},{"key":"10.1016\/j.clnu.2025.07.002_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/21662630.2013.839189","article-title":"A comparison of compulsive exercise in Male and female presentations of anorexia nervosa: what is the difference?","volume":"2","author":"Murray","year":"2014","journal-title":"Adv Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2016.12.014","article-title":"Sex differences in response to activity-based anorexia model in C57Bl\/6 mice","volume":"170","author":"Achamrah","year":"2017","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib36","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.clnu.2021.04.014","article-title":"Gut microbiota depletion affects nutritional and behavioral responses to activity-based anorexia model in a sex-dependent manner","volume":"40","author":"Tirelle","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yhbeh.2015.02.004","article-title":"Sex-related difference in food-anticipatory activity of mice","volume":"70","author":"Li","year":"2015","journal-title":"Horm Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pscychresns.2010.12.008","article-title":"In vivo evidence of global and focal brain alterations in anorexia nervosa","volume":"192","author":"Boghi","year":"2011","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-018-0323-3","article-title":"Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa","volume":"8","author":"Zhang","year":"2018","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib40","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.biopsych.2014.09.005","article-title":"Global cortical thinning in acute anorexia nervosa normalizes following long-term weight restoration","volume":"77","author":"King","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106580","article-title":"New perspectives on the role of biological factors in anorexia nervosa: brain volume reduction or oxidative stress, which came first?","volume":"199","author":"Gaiaschi","year":"2024","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.clnu.2025.07.002_bib42","first-page":"283","article-title":"Brain volume loss, astrocyte reduction, and inflammation in anorexia nervosa","volume":"vol. 26","author":"Seitz","year":"2021"},{"key":"10.1016\/j.clnu.2025.07.002_bib43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jneumeth.2017.09.018","article-title":"Establishment of a chronic activity-based anorexia rat model","volume":"293","author":"Frintrop","year":"2018","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.clnu.2025.07.002_bib44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15622975.2016.1273552","article-title":"Reduced astrocyte density underlying brain volume reduction in activity-based anorexia rats","volume":"19","author":"Frintrop","year":"2018","journal-title":"World J Biol Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s40337-023-00948-z","article-title":"Glial cell changes in the corpus callosum in chronically-starved mice","volume":"11","author":"Zimmermann","year":"2023","journal-title":"J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/eat.24423","article-title":"Increased serum neurofilament light chain concentration associated with microglial morphology changes in chronically-starved mice","author":"Zimmermann","year":"2025","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-019-0493-7","article-title":"The reduction of astrocytes and brain volume loss in anorexia Nervosa\u2014The impact of starvation and refeeding in a rodent model","volume":"9","author":"Frintrop","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbr.2012.08.047","article-title":"Activity-based anorexia is associated with reduced hippocampal cell proliferation in adolescent female rats","volume":"236","author":"Barbarich-Marsteller","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/eat.20840","article-title":"Brain tissue volume changes following weight gain in adults with anorexia nervosa","volume":"44","author":"Roberto","year":"2011","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib50","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.biopsych.2011.03.034","article-title":"Changes in gray matter volume with rapid body weight changes in anorexia nervosa: a voxel-based morphometric study","volume":"70","author":"Suda","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib51","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib52","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/brainsci12040431","article-title":"Integrative hedonic and homeostatic food intake regulation by the central nervous system: insights from neuroimaging","volume":"12","author":"Campos","year":"2022","journal-title":"Brain Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib53","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrg862","article-title":"Genetic approaches to studying energy balance: perception and integration","volume":"3","author":"Barsh","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.clnu.2025.07.002_bib54","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrendo.2014.160","article-title":"Mitochondrial dynamics in the central regulation of metabolism","volume":"10","author":"Nasrallah","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib55","first-page":"433","article-title":"Contribution of CNS neuropeptide (NPY, CRH, and beta-endorphin) alterations to psychophysiological abnormalities in anorexia nervosa","volume":"25","author":"Kaye","year":"1989","journal-title":"Psychopharmacol Bull"},{"key":"10.1016\/j.clnu.2025.07.002_bib56","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.mp.4000854","article-title":"Association between an agouti-related protein gene polymorphism and anorexia nervosa","volume":"6","author":"Vink","year":"2001","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.mp.4001206","article-title":"Agouti-related protein prevents self-starvation","volume":"8","author":"Kas","year":"2003","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib58","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1172\/JCI138392","article-title":"Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease\u2013associated cachexia","volume":"130","author":"Zhu","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.clnu.2025.07.002_bib59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1677\/jme.1.01808","article-title":"Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats","volume":"35","author":"Rijke","year":"2005","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib60","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.3390\/nu12113510","article-title":"Influence of glutamine and branched-chain amino acids supplementation during refeeding in activity-based anorectic mice","volume":"12","author":"L'Huillier","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114055","article-title":"Activity-based anorexia alters hypothalamic POMC and orexin populations in Male rats","volume":"436","author":"Pinos","year":"2023","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib62","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.euroneuro.2005.11.004","article-title":"AgRP(83\u2013132) and SHU9119 differently affect activity-based anorexia","volume":"16","author":"Hillebrand","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.clnu.2025.07.002_bib63","article-title":"\u03b2-endorphin differentially contributes to food anticipatory activity in male and female mice undergoing activity-based anorexia","volume":"9","author":"Daimon","year":"2021","journal-title":"Phys Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib64","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.3390\/nu14173607","article-title":"Intestinal epithelial toll-like receptor 4 deficiency modifies the response to the activity-based anorexia model in a sex-dependent manner: a preliminary study","volume":"14","author":"Tirelle","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib65","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-1450669","article-title":"Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa","volume":"145","author":"Otto","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib66","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000346059","article-title":"Des-acyl ghrelin: a metabolically active peptide","volume":"25","author":"Delhanty","year":"2013","journal-title":"Endocr Dev"},{"key":"10.1016\/j.clnu.2025.07.002_bib67","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/EJE-12-0456","article-title":"Mechanisms in endocrinology: ghrelin: the differences between acyl- and des-acyl ghrelin","volume":"167","author":"Delhanty","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib68","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2337\/db13-0414","article-title":"Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors","volume":"63","author":"Heppner","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.clnu.2025.07.002_bib69","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.clnu.2022.06.036","article-title":"Intestinal permeability and appetite regulating peptides-reactive immunoglobulins in severely malnourished women with anorexia nervosa","volume":"41","author":"Grigioni","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib70","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1365-2265.2004.02011.x","article-title":"The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state","volume":"60","author":"Broglio","year":"2004","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib71","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnins.2016.00256","article-title":"New insights in anorexia nervosa","volume":"10","author":"Gorwood","year":"2016","journal-title":"Front Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib72","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2005-2304","article-title":"Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa","volume":"91","author":"Miljic","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib73","first-page":"428","article-title":"The putative role of neuropeptide autoantibodies in anorexia nervosa","volume":"11","author":"Fetissov","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clnu.2025.07.002_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072117","article-title":"The role of ghrelin in anorexia nervosa","volume":"19","author":"Schalla","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib75","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/ncomms3685","article-title":"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in Obese mice and humans","volume":"4","author":"Takagi","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.clnu.2025.07.002_bib76","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.euroneuro.2016.03.010","article-title":"Ghrelin treatment prevents development of activity based anorexia in mice","volume":"26","author":"Legrand","year":"2016","journal-title":"Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol"},{"key":"10.1016\/j.clnu.2025.07.002_bib77","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2009.09.002","article-title":"Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway","volume":"10","author":"Maejima","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib78","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuint.2017.12.006","article-title":"The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa","volume":"113","author":"Pa\u0142asz","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1016\/j.clnu.2025.07.002_bib79","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1210\/jc.2011-3396","article-title":"Orexigenic neuropeptide 26RFa: new evidence for an adaptive profile of appetite regulation in anorexia nervosa","volume":"97","author":"Galusca","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib80","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ajcn\/85.4.967","article-title":"Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin","volume":"85","author":"Germain","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40337-015-0046-2","article-title":"Does anxiety improve during weight restoration in anorexia nervosa? A systematic review","volume":"3","author":"Kezelman","year":"2015","journal-title":"J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib82","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/(SICI)1098-108X(1997)21:4<367::AID-EAT10>3.0.CO;2-W","article-title":"Relationship of depression, anxiety, and obsessionality to state of illness in anorexia nervosa","volume":"21","author":"Pollice","year":"1997","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib83","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.00005.2009","article-title":"Reward processing by the opioid system in the brain","volume":"89","author":"Le Merrer","year":"2009","journal-title":"Physiol Rev"},{"key":"10.1016\/j.clnu.2025.07.002_bib84","first-page":"152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front Neural Circ"},{"key":"10.1016\/j.clnu.2025.07.002_bib85","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cobeha.2021.02.013","article-title":"Positive affect: nature and brain bases of liking and wanting","volume":"39","author":"Nguyen","year":"2021","journal-title":"Curr Opin Behav Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib86","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s11920-013-0396-x","article-title":"Altered brain reward circuits in eating disorders: chicken or egg?","volume":"15","author":"Frank","year":"2013","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib87","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.1074\/jbc.M109.079590","article-title":"Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors","volume":"285","author":"Kim","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clnu.2025.07.002_bib88","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0306-4522(03)00227-6","article-title":"Evidence of increased dopamine receptor signaling in food-restricted rats","volume":"119","author":"Carr","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.clnu.2025.07.002_bib89","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuroscience.2008.08.017","article-title":"Underweight rats have enhanced dopamine release and blunted acetylcholine response in the nucleus accumbens while bingeing on sucrose","volume":"156","author":"Avena","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.clnu.2025.07.002_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.799548","article-title":"The rise and fall of dopamine: a two-stage model of the development and entrenchment of anorexia nervosa","volume":"12","author":"Beeler","year":"2022","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib91","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00213-006-0521-1","article-title":"Opioids for hedonic experience and dopamine to get ready for it","volume":"191","author":"Barbano","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.clnu.2025.07.002_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104711","article-title":"Decreased cerebral opioid receptors availability related to hormonal and psychometric profile in restrictive-type anorexia nervosa","volume":"118","author":"Galusca","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/sj.mp.4001318","article-title":"Candidate genes for anorexia nervosa in the 1p33\u201336 linkage region: Serotonin 1D and Delta opioid receptor loci exhibit significant association to anorexia nervosa","volume":"8","author":"Bergen","year":"2003","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib94","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cmet.2015.07.011","article-title":"Palatability can drive feeding independent of AgRP neurons","volume":"22","author":"Denis","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib95","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nn.3147","article-title":"AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors","volume":"15","author":"Dietrich","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib96","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41593-022-01062-0","article-title":"A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice","volume":"25","author":"Cai","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib97","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41588-019-0439-2","article-title":"Genome-wide association study identifies eight risk loci and implicates Metabo-Psychiatric origins for anorexia nervosa","volume":"51","author":"Watson","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.clnu.2025.07.002_bib98","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/nu13020500","article-title":"The role of the gut microbiome, immunity, and neuroinflammation in the pathophysiology of eating disorders","volume":"13","author":"Butler","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib99","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00508-018-1440-y","article-title":"Body image disturbances, fear and associations with the amygdala in anorexia nervosa","volume":"131","author":"Burkert","year":"2019","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.clnu.2025.07.002_bib100","first-page":"1","article-title":"Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa","author":"Berner","year":"2022","journal-title":"Psychol Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.1087075","article-title":"Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model","volume":"16","author":"Mottarlini","year":"2022","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.717255","article-title":"Effects of transcranial direct current stimulation treatment for anorexia nervosa","volume":"12","author":"Baumann","year":"2021","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib103","doi-asserted-by":"crossref","first-page":"14","DOI":"10.25259\/SNI_1112_2022","article-title":"Refractory anorexia nervosa in adulthood and nucleus accumbens deep brain stimulation","volume":"14","author":"Lara-Almunia","year":"2023","journal-title":"Surg Neurol Int"},{"key":"10.1016\/j.clnu.2025.07.002_bib104","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/2022.11.FOCUS22616","article-title":"Efficacy of deep brain stimulation for the treatment of anorexia nervosa: a systematic review and network meta-analysis of patient-level data","volume":"54","author":"Shaffer","year":"2023","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.clnu.2025.07.002_bib105","first-page":"4094","article-title":"Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity","volume":"130","author":"Simon","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.clnu.2025.07.002_bib106","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.biopsych.2014.09.024","article-title":"Hunger does not motivate reward in women remitted from anorexia nervosa","volume":"77","author":"Wierenga","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib107","article-title":"Horloges circadiennes et nutrition \u2013 circadian clocks and nutrition","volume":"6","author":"Challet","year":"2009","journal-title":"Corresp En M\u00e9tabolismes Horm Diab\u00e8tes Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib108","series-title":"Role of the nuclear receptor Rev-erb alpha in circadian food anticipation and metabolism. phdthesis. Universit\u00e9 de Strasbourg","author":"Delezie","year":"2012"},{"key":"10.1016\/j.clnu.2025.07.002_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-020-00401-5","article-title":"Circadian clocks in the digestive system","author":"Segers","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2025.07.002_bib110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pbb.2017.06.007","article-title":"Contributions of the lateral habenula to circadian timekeeping","volume":"162","author":"Ba\u00f1o-Ot\u00e1lora","year":"2017","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib111","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the Mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.clnu.2025.07.002_bib112","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12557","article-title":"Expression of the clock gene Rev-erb\u03b1 in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism","volume":"30","author":"Sen","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib113","doi-asserted-by":"crossref","first-page":"D1009","DOI":"10.1093\/nar\/gks1161","article-title":"CircaDB: a database of Mammalian circadian gene expression profiles","volume":"41","author":"Pizarro","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib114","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neubiorev.2018.07.003","article-title":"Food intake and addictive-like eating behaviors: time to think about the circadian clock(s)","volume":"106","author":"Mendoza","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.clnu.2025.07.002_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122040","article-title":"Neuropeptide Y and \u03b1-MSH circadian levels in two populations with low body weight: Anorexia nervosa and constitutional thinness","volume":"10","author":"Galusca","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib116","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1530\/eje.0.1420373","article-title":"Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa","volume":"142","author":"Herpertz","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib117","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000023274","article-title":"Circadian plasma leptin levels in patients with anorexia nervosa: relation to insulin and cortisol","volume":"50","author":"Herpertz","year":"1998","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib118","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib119","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41574-019-0210-x","article-title":"The circadian regulation of food intake","volume":"15","author":"Challet","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib120","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.cub.2017.04.059","article-title":"Meal timing regulates the human circadian system","volume":"27","author":"Wehrens","year":"2017","journal-title":"Curr Biol CB"},{"key":"10.1016\/j.clnu.2025.07.002_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110007","article-title":"Circadian influences on feeding behavior","volume":"256","author":"la Fleur","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.clnu.2025.07.002_bib122","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11920-016-0728-8","article-title":"Sleep and eating disorders","volume":"18","author":"Allison","year":"2016","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib123","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.3390\/nu15204488","article-title":"Sleep pathologies and eating disorders: a crossroad for neurology, psychiatry and nutrition","volume":"15","author":"Mutti","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib124","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.50358","article-title":"The role of circadian rhythms and sleep in anorexia nervosa","volume":"7","author":"Wilcox","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.clnu.2025.07.002_bib125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40337-023-00799-8","article-title":"Differences in sleep patterns between patients with anorexia nervosa and healthy controls: a cross-sectional study","volume":"11","author":"Kleppe","year":"2023","journal-title":"J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib126","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s40519-021-01286-2","article-title":"The contribution of sleep to anorexia nervosa severity","volume":"27","author":"Malcolm","year":"2022","journal-title":"Eat Weight Disord - Stud Anorex Bulim Obes"},{"key":"10.1016\/j.clnu.2025.07.002_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.101969","article-title":"Sleep quality in eating disorders: a systematic review and meta-analysis","volume":"77","author":"Degasperi","year":"2024","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.clnu.2025.07.002_bib128","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-244X-13-290","article-title":"Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment","volume":"13","author":"Marzola","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib129","doi-asserted-by":"crossref","first-page":"E584","DOI":"10.1210\/jc.2011-2246","article-title":"Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women","volume":"97","author":"Bredella","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib130","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.clnu.2013.11.006","article-title":"Alteration of intestinal barrier function during activity-based anorexia in mice","volume":"33","author":"J\u00e9sus","year":"2014","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2025.107453","article-title":"Altered circadian pattern of activity in a chronic activity-based anorexia nervosa-like female mouse model deficient for GHSR","volume":"177","author":"Mattioni","year":"2025","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib132","first-page":"497","article-title":"Circadian rhythms disruptions and eating disorders: clinical impact and possible psychopathological correlates","volume":"31","author":"Menculini","year":"2019","journal-title":"Psychiatr Danub"},{"key":"10.1016\/j.clnu.2025.07.002_bib133","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cub.2006.08.053","article-title":"Lack of food anticipation in Per 2 mutant mice","volume":"16","author":"Feillet","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.clnu.2025.07.002_bib134","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1152\/jn.00556.2020","article-title":"Diurnal properties of tonic and synaptic GABAA receptor-mediated currents in suprachiasmatic nucleus neurons","volume":"126","author":"Moldavan","year":"2021","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib135","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1038\/s41467-020-17578-7","article-title":"Paraventricular hypothalamus mediates diurnal rhythm of metabolism","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.clnu.2025.07.002_bib136","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41419-020-2716-5","article-title":"Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)\/Diazepam binding inhibitor (DBI)","volume":"11","author":"Joseph","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clnu.2025.07.002_bib137","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13293-023-00576-x","article-title":"Sex-dependent circadian alterations of both central and peripheral clock genes expression and gut\u2013microbiota composition during activity-based anorexia in mice","volume":"15","author":"Sala\u00fcn","year":"2024","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.clnu.2025.07.002_bib138","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2202-6-30","article-title":"GABAA receptor \u03b32 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines","volume":"6","author":"Chandra","year":"2005","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib139","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1101\/gad.183500","article-title":"Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus","volume":"14","author":"Damiola","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.clnu.2025.07.002_bib140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/nu15020259","article-title":"Gut microbiota and time-restricted feeding\/eating: a targeted biomarker and approach in precision nutrition","volume":"15","author":"Zeb","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib141","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.beproc.2010.02.007","article-title":"The effects of food presentation at regular or irregular times on the development of activity-based anorexia in rats","volume":"84","author":"P\u00e9rez-Padilla","year":"2010","journal-title":"Behav Process"},{"key":"10.1016\/j.clnu.2025.07.002_bib142","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.3390\/nu14245252","article-title":"Food restriction in mice induces food-anticipatory activity and circadian-rhythm-related activity changes","volume":"14","author":"Gabloffsky","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib143","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0010-440X(97)90927-5","article-title":"The prevalence of high-level exercise in the eating disorders: etiological implications","volume":"38","author":"Davis","year":"1997","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib144","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.psyneuen.2012.09.012","article-title":"Food restriction-induced hyperactivity: addiction or adaptation to famine?","volume":"38","author":"Duclos","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib145","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41593-022-01071-z","article-title":"Genetics and neurobiology of eating disorders","volume":"25","author":"Bulik","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib146","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00006842-200007000-00012","article-title":"Tryptophan levels, excessive exercise, and nutritional status in anorexia nervosa","volume":"62","author":"Favaro","year":"2000","journal-title":"Psychosom Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib147","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00005053-199906000-00002","article-title":"Compulsive physical activity in adolescents with anorexia nervosa: a psychobehavioral spiral of pathology","volume":"187","author":"Davis","year":"1999","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.clnu.2025.07.002_bib148","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archpsyc.1972.01750190059011","article-title":"Diagnostic criteria for use in psychiatric research","volume":"26","author":"Feighner","year":"1972","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib149","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1471-0153(01)00026-5","article-title":"Exercise and eating disorders: a 3-year inpatient hospital record analysis","volume":"2","author":"Solenberger","year":"2001","journal-title":"Eat Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/srep21887","article-title":"Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice","volume":"6","author":"Achamrah","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib151","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/nutrit\/nuw001","article-title":"Physical activity in patients with anorexia nervosa","volume":"74","author":"Achamrah","year":"2016","journal-title":"Nutr Rev"},{"key":"10.1016\/j.clnu.2025.07.002_bib152","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.939856","article-title":"Exercise therapy in the treatment of anorexia nervosa: its effects depending on the type of physical exercise\u2014A systematic review","volume":"13","author":"Toutain","year":"2022","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib153","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.clnesp.2018.10.015","article-title":"Body composition and resting energy expenditure in women with anorexia nervosa: is hyperactivity a protecting factor?","volume":"29","author":"Manuelli","year":"2019","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clnu.2025.07.002_bib154","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3390\/nu14142951","article-title":"Inpatient rehabilitation during intensive refeeding in severe anorexia nervosa","volume":"14","author":"Dauty","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib155","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.1705287114","article-title":"Mapping of human brown adipose tissue in lean and Obese young men","volume":"114","author":"Leitner","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib156","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/oby.2010.105","article-title":"Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men","volume":"19","author":"Yoneshiro","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.clnu.2025.07.002_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.700645","article-title":"The central role of hypothermia and hyperactivity in anorexia nervosa: a hypothesis","volume":"15","author":"Smith","year":"2021","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib158","article-title":"Mental disorders in individuals at risk for exercise addiction \u2013 a systematic review","volume":"12","author":"Colledge","year":"2020","journal-title":"Addict Behav Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib159","article-title":"Possible role of exercise therapy on depression: effector neurotransmitters as key players","volume":"459","author":"Alizadeh","year":"2024","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib160","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97440-y","article-title":"Thermoregulatory role of ghrelin in the induction of torpor under a restricted feeding condition","volume":"11","author":"Sato","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib161","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.669980","article-title":"Activity-based anorexia induces browning of adipose tissue independent of hypothalamic AMPK","volume":"12","author":"Fraga","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib162","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib163","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/icb\/icy089","article-title":"The mitochondrial contribution to animal performance, adaptation, and life-history variation","volume":"58","author":"Hood","year":"2018","journal-title":"Integr Comp Biol"},{"key":"10.1016\/j.clnu.2025.07.002_bib164","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106463","article-title":"Altered mitochondrial function and oxidative stress in leukocytes of anorexia nervosa patients","volume":"9","author":"Victor","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/erv.2420","article-title":"Oxidative stress and antioxidant levels in patients with anorexia nervosa after oral Re-alimentation: a systematic review and exploratory meta-analysis","volume":"24","author":"Solmi","year":"2016","journal-title":"Eur Eat Disord Rev J Eat Disord Assoc"},{"key":"10.1016\/j.clnu.2025.07.002_bib166","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3390\/antiox11050842","article-title":"Oxidative status in adult anorexia nervosa patients and healthy controls\u2014results from a cross-sectional pilot study","volume":"11","author":"Wagner-Skacel","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.clnu.2025.07.002_bib167","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/eat.23453","article-title":"Activity-based anorexia disrupts systemic oxidative state and induces cortical mitochondrial fission in adolescent female rats","volume":"54","author":"Hurley","year":"2021","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib168","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/s41366-021-00820-7","article-title":"GHS-R suppression in adipose tissues protects against obesity and insulin resistance by regulating adipose angiogenesis and fibrosis","volume":"45","author":"Lee","year":"2005","journal-title":"Int J Obes"},{"key":"10.1016\/j.clnu.2025.07.002_bib169","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2011.00740.x","article-title":"Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues","volume":"10","author":"Lin","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib170","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/s42255-023-00877-w","article-title":"Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA","volume":"5","author":"Sa","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib171","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fpsyt.2018.00199","article-title":"Metabolic barriers to weight gain in patients with anorexia nervosa: a young adult case report","volume":"9","author":"Haas","year":"2018","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib172","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/66.1.133","article-title":"Increase in diet-induced thermogenesis at the start of refeeding in severely malnourished anorexia nervosa patients","volume":"66","author":"Moukaddem","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib173","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/eat.23301","article-title":"Resting energy expenditure in acutely ill and stabilized patients with anorexia nervosa and bulimia nervosa","volume":"53","author":"Kochavi","year":"2020","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib174","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2050-2974-1-37","article-title":"Impact of exercise on energy metabolism in anorexia nervosa","volume":"1","author":"Zipfel","year":"2013","journal-title":"J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib175","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1007\/s12031-021-01800-2","article-title":"Long-term glucose starvation induces inflammatory responses and phenotype switch in primary cortical rat astrocytes","volume":"71","author":"Kogel","year":"2021","journal-title":"J Mol Neurosci MN"},{"key":"10.1016\/j.clnu.2025.07.002_bib176","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib177","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics \u2014 mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib178","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1210\/en.2018-00667","article-title":"Mitochondrial dynamics and hypothalamic regulation of metabolism","volume":"159","author":"Jin","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib179","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol Metab TEM"},{"key":"10.1016\/j.clnu.2025.07.002_bib180","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology","volume":"103","author":"Yu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2025.07.002_bib181","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/biomedicines11020446","article-title":"The bidirectional relationship of NPY and mitochondria in energy balance regulation","volume":"11","author":"Sousa","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.clnu.2025.07.002_bib182","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cmet.2011.06.008","article-title":"Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance","volume":"14","author":"Kaushik","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib183","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/ars.2011.4254","article-title":"Importance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats","volume":"17","author":"Carneiro","year":"2012","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.clnu.2025.07.002_bib184","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molmet.2018.11.007","article-title":"Mitochondrial dynamin-related protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing","volume":"20","author":"Desmoulins","year":"2019","journal-title":"Mol Metabol"},{"key":"10.1016\/j.clnu.2025.07.002_bib185","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64351","article-title":"Drp 1 is required for AgRP neuronal activity and feeding","volume":"10","author":"Jin","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.clnu.2025.07.002_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.114072","article-title":"Activity-based anorexia in adolescent female rats causes changes in brain mitochondrial dynamics","author":"Bhasin","year":"2023","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clnu.2025.07.002_bib187","doi-asserted-by":"crossref","first-page":"18108","DOI":"10.1073\/pnas.1114863108","article-title":"Hypothalamic mitochondrial dysfunction associated with anorexia in the anx\/anx mouse","volume":"108","author":"Lindfors","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2025.07.002_bib188","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41392-022-01117-5","article-title":"Gut microbes regulate the feeding center: a new discovery of gut brain axis","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.clnu.2025.07.002_bib189","article-title":"Gut microbes and food reward: from the gut to the brain","volume":"16","author":"de Wouters d'Oplinter","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40519-023-01529-4","article-title":"Anorexia nervosa and microbiota: systematic review and critical appraisal","volume":"28","author":"Garcia","year":"2023","journal-title":"Eat Weight Disord - Stud Anorex Bulim Obes"},{"key":"10.1016\/j.clnu.2025.07.002_bib191","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3945\/jn.116.240481","article-title":"Microbiota-gut-brain axis: modulator of host metabolism and appetite","volume":"147","author":"van de Wouw","year":"2017","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib192","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cmet.2015.10.017","article-title":"Gut commensal E. coli proteins activate host satiety pathways following nutrient-induced bacterial growth","volume":"23","author":"Breton","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib193","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3390\/nu11092115","article-title":"Effects of macronutrients on the in vitro production of ClpB, a bacterial mimetic protein of \u03b1-MSH and its possible role in satiety signaling","volume":"11","author":"Dominique","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103908","article-title":"Microbiota and the gut-brain-axis: implications for new therapeutic design in the CNS","volume":"77","author":"Liu","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.clnu.2025.07.002_bib195","first-page":"181","article-title":"Gut microbiota alteration in a mouse model of anorexia nervosa","volume":"40","author":"Breton","year":"2021","journal-title":"Clin Nutr Edinb Scotl"},{"key":"10.1016\/j.clnu.2025.07.002_bib196","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.3390\/ijms24119496","article-title":"Gut microbiota and brain alterations after refeeding in a translational anorexia nervosa rat model","volume":"24","author":"Trinh","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib197","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpsychires.2020.12.030","article-title":"Gut microbiota and brain alterations in a translational anorexia nervosa rat model","volume":"133","author":"Trinh","year":"2021","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib198","doi-asserted-by":"crossref","DOI":"10.1097\/CM9.0000000000002362","article-title":"Features of gut microbiota in patients with anorexia nervosa","author":"Yuan","year":"2022","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.clnu.2025.07.002_bib199","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1902771","article-title":"The intestinal microbiota and metabolites in patients with anorexia nervosa","volume":"13","author":"Prochazkova","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.clnu.2025.07.002_bib200","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.680870","article-title":"Altered serum immunological and biochemical parameters and microbiota composition in patients with AN during realimentation","volume":"8","author":"Roubalova","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib201","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145274","article-title":"Gut dysbiosis in patients with anorexia nervosa","volume":"10","author":"Morita","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib202","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/PSY.0000000000000247","article-title":"The intestinal microbiota in acute anorexia nervosa and during renourishment: relationship to depression, anxiety, and eating disorder psychopathology","volume":"77","author":"Kleiman","year":"2015","journal-title":"Psychosom Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib203","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/eat.23435","article-title":"Gut microbiota alteration in adolescent anorexia nervosa does not normalize with short-term weight restoration","volume":"54","author":"Schulz","year":"2021","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib204","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s41430-022-01116-3","article-title":"Roseburia, a decreased bacterial taxon in the gut microbiota of patients suffering from anorexia nervosa","volume":"76","author":"Mondot","year":"2022","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib205","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1290246","article-title":"The causality between gut microbiome and anorexia nervosa: a Mendelian randomization analysis","volume":"14","author":"Xia","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib206","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2174\/1570159X16666180118101354","article-title":"Is the impact of starvation on the gut microbiota specific or unspecific to anorexia nervosa? A narrative review based on a systematic literature search","volume":"16","author":"Mack","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.clnu.2025.07.002_bib207","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007125","article-title":"Monitoring bacterial community of human gut microbiota reveals an increase in lactobacillus in Obese patients and methanogens in anorexic patients","volume":"4","author":"Armougom","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib208","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179739","article-title":"Microbiota in anorexia nervosa: the triangle between bacterial species, metabolites and psychological tests","volume":"12","author":"Borgo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib209","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.19043.1","article-title":"Probiotics and prebiotics in clinical tests: an update","volume":"8","author":"Br\u00fcssow","year":"2019","journal-title":"F1000Research"},{"key":"10.1016\/j.clnu.2025.07.002_bib210","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1111\/1462-2920.13455","article-title":"Nomadic lifestyle of Lactobacillus plantarum revealed by comparative genomics of 54 strains isolated from different habitats","volume":"18","author":"Martino","year":"2016","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib211","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.micpath.2012.05.007","article-title":"Comparative meta-analysis of the effect of lactobacillus species on weight gain in humans and animals","volume":"53","author":"Million","year":"2012","journal-title":"Microb Pathog"},{"key":"10.1016\/j.clnu.2025.07.002_bib212","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.ade9767","article-title":"Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice","volume":"379","author":"Schwarzer","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.clnu.2025.07.002_bib213","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13099-018-0250-0","article-title":"The role of probiotics, prebiotics and synbiotics in animal nutrition","volume":"10","author":"Markowiak","year":"2018","journal-title":"Gut Pathog"},{"key":"10.1016\/j.clnu.2025.07.002_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106460","article-title":"Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa","volume":"193","author":"Roubalov\u00e1","year":"2024","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.clnu.2025.07.002_bib215","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clnu.2022.10.024","article-title":"Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease","volume":"42","author":"Hodgkinson","year":"2023","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib216","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.611677","article-title":"The gut microbiome in anorexia nervosa: friend or foe?","volume":"11","author":"Ghenciulescu","year":"2021","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib217","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.3390\/nu14245247","article-title":"Plasma concentrations of short-chain fatty acids in active and recovered anorexia nervosa","volume":"14","author":"Xu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.clnu.2025.07.002_bib218","doi-asserted-by":"crossref","DOI":"10.1111\/cns.13953","article-title":"Anorexia nervosa and autoimmune comorbidities: a bidirectional route?","author":"Sirufo","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.clnu.2025.07.002_bib219","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0306-4530(02)00131-2","article-title":"Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa","volume":"29","author":"Kahl","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib220","doi-asserted-by":"crossref","DOI":"10.1038\/srep35813","article-title":"A role for intestinal TLR4-driven inflammatory response during activity-based anorexia","volume":"6","author":"Belmonte","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib221","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","article-title":"Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner","volume":"11","author":"Stephens","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.clnu.2025.07.002_bib222","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.mp.4001374","article-title":"Intestinal permeability is decreased in anorexia nervosa","volume":"9","author":"Monteleone","year":"2004","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.clnu.2025.07.002_bib223","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176290","article-title":"Effects of IL-6 signaling pathway inhibition on weight and BMI: a systematic review and meta-analysis","volume":"21","author":"Patsalos","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnu.2025.07.002_bib224","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2013.10.004","article-title":"Neuroinflammation: the role and consequences","volume":"79","author":"Lyman","year":"2014","journal-title":"Neurosci Res"},{"issue":"Suppl 2","key":"10.1016\/j.clnu.2025.07.002_bib225","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.clnu.2025.07.002_bib226","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1038\/sj.ejcn.1601819","article-title":"Changes in the immune system are conditioned by nutrition","volume":"57","author":"Marcos","year":"2003","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib227","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/568343","article-title":"Role of leptin in the activation of immune cells","volume":"2010","author":"Fern\u00e1ndez-Riejos","year":"2010","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.clnu.2025.07.002_bib228","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.983577","article-title":"Glial cells in anorexia","volume":"16","author":"Reyes-Haro","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib229","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.15252\/embr.201541499","article-title":"Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation","volume":"17","author":"Le Thuc","year":"2016","journal-title":"EMBO Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib230","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrgastro.2016.191","article-title":"The mucosal immune system: master regulator of bidirectional gut-brain communications","volume":"14","author":"Powell","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2025.07.002_bib231","first-page":"248","article-title":"Back to the future: the role of infections in psychopathology. Focus on OCD","volume":"19","author":"Della Vecchia","year":"2022","journal-title":"Clin Neuropsychiatry"},{"key":"10.1016\/j.clnu.2025.07.002_bib232","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/jcm11010186","article-title":"The role of glial cells in regulating feeding behavior: potential relevance to anorexia nervosa","volume":"11","author":"Frintrop","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib233","article-title":"Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis","volume":"6","author":"Jin","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib234","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1210\/en.2014-1849","article-title":"Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior","volume":"156","author":"Reis","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnu.2025.07.002_bib235","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1038\/s41598-019-42728-3","article-title":"Hypoglycemia-activated hypothalamic microglia impairs glucose counterregulatory responses","volume":"9","author":"Winkler","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib236","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144239","article-title":"Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice","volume":"131","author":"Varela","year":"2021","journal-title":"J Clin Investig"},{"key":"10.1016\/j.clnu.2025.07.002_bib237","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.cmet.2022.09.002","article-title":"Hypothalamic astrocytes control systemic glucose metabolism and energy balance","volume":"34","author":"Herrera","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib238","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.peptides.2015.06.011","article-title":"Hypothalamic inflammation and food intake regulation during chronic illness","volume":"77","author":"Dwarkasing","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.clnu.2025.07.002_bib239","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fendo.2017.00197","article-title":"Hypothalamic inflammation and energy balance disruptions: spotlight on chemokines","volume":"8","author":"Le Thuc","year":"2017","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib240","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/eat.24379","article-title":"Changes in circadian rhythm in chronically-starved mice are associated with glial cell density reduction in the suprachiasmatic nucleus","volume":"58","author":"Zimmermann","year":"2025","journal-title":"Int J Eat Disord"},{"key":"10.1016\/j.clnu.2025.07.002_bib241","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbr.2019.01.042","article-title":"Anorexia increases microglial density and cytokine expression in the hippocampus of young female rats","volume":"363","author":"Ragu-Varman","year":"2019","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib242","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.clnu.2025.07.002_bib243","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260077","article-title":"Physical activity and sleep during the first week of anorexia nervosa inpatient care","volume":"16","author":"Langlet","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.clnu.2025.07.002_bib244","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib245","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/19490976.2015.1016690","article-title":"A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host","volume":"6","author":"Thaiss","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.clnu.2025.07.002_bib246","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.1073\/pnas.1501305112","article-title":"Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock","volume":"112","author":"Liang","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2025.07.002_bib247","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3389\/fmicb.2018.00737","article-title":"Circadian disruption changes gut microbiome taxa and functional gene composition","volume":"9","author":"Deaver","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib248","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cell.2014.09.048","article-title":"Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis","volume":"159","author":"Thaiss","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib249","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cell.2013.04.020","article-title":"Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs","volume":"153","author":"Mukherji","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib250","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.chom.2015.03.006","article-title":"Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism","volume":"17","author":"Leone","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.clnu.2025.07.002_bib251","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF00233492","article-title":"Circadian alterations in tubular structures on the outer mitochondrial membrane of rat hepatocytes","volume":"214","author":"Uchiyama","year":"1981","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib252","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fendo.2016.00162","article-title":"The circadian nature of mitochondrial biology","volume":"7","author":"Manella","year":"2016","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnu.2025.07.002_bib253","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/imm.12329","article-title":"Crosstalk between circadian rhythmicity, mitochondrial dynamics and macrophage bactericidal activity","volume":"143","author":"Oliva-Ram\u00edrez","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.clnu.2025.07.002_bib254","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fgene.2018.00452","article-title":"Circadian rhythms and mitochondria: connecting the dots","volume":"9","author":"Sardon Puig","year":"2018","journal-title":"Front Genet"},{"key":"10.1016\/j.clnu.2025.07.002_bib255","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cmet.2015.08.006","article-title":"Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness","volume":"22","author":"Jacobi","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib256","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.cell.2015.04.002","article-title":"The circadian protein BMAL1 regulates translation in response to S6K1-Mediated phosphorylation","volume":"161","author":"Lipton","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib257","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13238-020-00713-x","article-title":"BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy","volume":"11","author":"Li","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib258","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2018.01.011","article-title":"Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics","volume":"27","author":"Schmitt","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib259","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102323","article-title":"Clock-controlled mitochondrial dynamics correlates with cyclic pregnenolone synthesis","volume":"9","author":"Witzig","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.clnu.2025.07.002_bib260","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftv096","article-title":"Microbiota-mitochondria inter-talk: consequence for microbiota-host interaction","volume":"74","author":"Saint-Georges-Chaumet","year":"2016","journal-title":"Pathog Dis"},{"key":"10.1016\/j.clnu.2025.07.002_bib261","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/antiox9090848","article-title":"Microbiota-mitochondria inter-talk: a potential therapeutic strategy in obesity and type 2 diabetes","volume":"9","author":"Vezza","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.clnu.2025.07.002_bib262","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2337\/db16-0924","article-title":"Butyrate regulates liver mitochondrial function, efficiency, and dynamics in insulin-resistant obese mice","volume":"66","author":"Mollica","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.clnu.2025.07.002_bib263","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fphys.2017.00319","article-title":"The crosstalk between the gut microbiota and mitochondria during exercise","volume":"8","author":"Clark","year":"2017","journal-title":"Front Physiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib264","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/febs.14692","article-title":"\u2018inside Out\u2019\u2013 a dialogue between mitochondria and bacteria","volume":"286","author":"Han","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.clnu.2025.07.002_bib265","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.cell.2017.05.048","article-title":"Microbiome and longevity: gut microbes send signals to host mitochondria","volume":"169","author":"Gruber","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib266","doi-asserted-by":"crossref","first-page":"G748","DOI":"10.1152\/ajpgi.00031.2020","article-title":"Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions","volume":"318","author":"McKay","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib267","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13419","article-title":"Altered intestinal microbiota\u2013host mitochondria crosstalk in new onset Crohn's disease","volume":"7","author":"Mottawea","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.clnu.2025.07.002_bib268","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2021.12.004","article-title":"Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction","volume":"178","author":"Yang","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clnu.2025.07.002_bib269","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneurol.2014.228","article-title":"Disturbed mitochondrial dynamics and neurodegenerative disorders","volume":"11","author":"Burt\u00e9","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.clnu.2025.07.002_bib270","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3390\/antiox9101020","article-title":"Mitochondrial dysfunction, oxidative stress and neuroinflammation in neurodegeneration with brain iron accumulation (NBIA)","volume":"9","author":"Hinarejos","year":"2020","journal-title":"Antioxid Basel Switz"},{"key":"10.1016\/j.clnu.2025.07.002_bib271","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.624919","article-title":"Unraveling the link between mitochondrial dynamics and neuroinflammation","volume":"12","author":"de Oliveira","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.clnu.2025.07.002_bib272","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/BST20220014","article-title":"Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?","volume":"51","author":"Afroz","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.clnu.2025.07.002_bib273","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1038\/s41598-017-05232-0","article-title":"Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation","volume":"7","author":"Katoh","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnu.2025.07.002_bib274","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2017.06.050","article-title":"Inflammation and mitochondrial dysfunction: a vicious circle in neurodegenerative disorders?","volume":"710","author":"van Horssen","year":"2019","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.clnu.2025.07.002_bib275","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/jnc.12361","article-title":"Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells","volume":"127","author":"Park","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.clnu.2025.07.002_bib276","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113310","article-title":"Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma","volume":"329","author":"Devanney","year":"2020","journal-title":"Exp Neurol"},{"key":"10.1016\/j.clnu.2025.07.002_bib277","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","article-title":"A breakdown in metabolic reprogramming causes microglia dysfunction in alzheimer's disease","volume":"30","author":"Baik","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.clnu.2025.07.002_bib278","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/glia.23587","article-title":"Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo","volume":"67","author":"Nair","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.clnu.2025.07.002_bib279","doi-asserted-by":"crossref","first-page":"615","DOI":"10.4049\/immunohorizons.2100068","article-title":"Role of mitochondrial dynamics in microglial activation and metabolic switch","volume":"5","author":"Montilla","year":"2021","journal-title":"ImmunoHorizons"},{"key":"10.1016\/j.clnu.2025.07.002_bib280","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2022.03.015","article-title":"Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration","author":"Cheng","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.clnu.2025.07.002_bib281","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.2324-19.2020","article-title":"Neuronal mitochondria modulation of LPS-induced neuroinflammation","volume":"40","author":"Harland","year":"2020","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib282","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.clnu.2019.03.023","article-title":"Anorexia nervosa: gut microbiota-immune-brain interactions","volume":"39","author":"Roubalov\u00e1","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2025.07.002_bib283","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.604179","article-title":"The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology","volume":"11","author":"Rutsch","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.clnu.2025.07.002_bib284","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.clnu.2025.07.002_bib285","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/sj.bjp.0705682","article-title":"Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids","volume":"141","author":"Huuskonen","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.clnu.2025.07.002_bib286","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2006.07.025","article-title":"Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders","volume":"176","author":"MacFabe","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.clnu.2025.07.002_bib287","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5607\/en.2010.19.3.132","article-title":"5-hydroxy-L-tryptophan suppressed food intake in rats despite an increase in the arcuate NPY expression","volume":"19","author":"Moon","year":"2010","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.clnu.2025.07.002_bib288","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan metabolism: a link between the gut microbiota and brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv Nutr Bethesda Md"},{"key":"10.1016\/j.clnu.2025.07.002_bib289","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2020.02.030","article-title":"The link between gut dysbiosis and neuroinflammation in parkinson's disease","volume":"432","author":"Baizabal-Carvallo","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.clnu.2025.07.002_bib290","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/ejn.14631","article-title":"Gut microbiota-brain axis in depression: the role of neuroinflammation","volume":"53","author":"Carlessi","year":"2021","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.clnu.2025.07.002_bib291","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat Neurosci"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425001785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425001785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T02:12:20Z","timestamp":1756174340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561425001785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":291,"alternative-id":["S0261561425001785"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.07.002","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Burden of negative energy balance in anorexia nervosa: Role of circadian rhythm, mitochondrial dynamics, microbiota\u2013gut\u2013brain axis and their interactions","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}