{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:21:46Z","timestamp":1775064106828,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030872","name":"Erasmus MC Sophia Kinderziekenhuis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009480","name":"Friends of the Sophia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clnu.2025.08.030","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:16:25Z","timestamp":1756397785000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Do functional gut parameters predict enteral autonomy and chronic cholestasis in pediatric intestinal failure?"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-7379","authenticated-orcid":false,"given":"Lotte E.","family":"Vlug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Schaap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaatje","family":"Lenaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther G.","family":"Neelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans M.","family":"van Eijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander M.J.","family":"van Kuijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merit M.","family":"Tabbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sjoerd C.J.","family":"Nagelkerke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 M.H.","family":"Wijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond H.H.M.","family":"Rings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie M.","family":"Hulst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.E.","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2 Suppl 1","key":"10.1016\/j.clnu.2025.08.030_bib1","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1053\/j.gastro.2005.12.002","article-title":"Causes and management of intestinal failure in children","volume":"130","author":"Goulet","year":"2006","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.clnu.2025.08.030_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu14091889","article-title":"Chronic intestinal failure in children: an international multicenter cross-sectional survey","volume":"14","author":"Lezo","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.clnu.2025.08.030_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00726-005-0235-4","article-title":"Almost all about citrulline in mammals","volume":"29","author":"Curis","year":"2005","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2050640617737632","article-title":"Citrulline as a marker of intestinal function and absorption in clinical settings: a systematic review and meta-analysis","volume":"6","author":"Fragkos","year":"2018","journal-title":"United European Gastroenterol J"},{"issue":"6","key":"10.1016\/j.clnu.2025.08.030_bib5","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jhep.2015.01.004","article-title":"Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure","volume":"62","author":"Mutanen","year":"2015","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10620-019-05841-x","article-title":"The role of gastrointestinal-related fatty acid-binding proteins as biomarkers in gastrointestinal diseases","volume":"65","author":"Ho","year":"2020","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.clnu.2025.08.030_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu10060664","article-title":"Prevention and treatment of intestinal failure-associated liver disease in children","volume":"10","author":"Norsa","year":"2018","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcn\/nqz110","article-title":"Clinical outcomes in pediatric intestinal failure: a meta-analysis and meta-regression","volume":"110","author":"Pierret","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2025.08.030_bib9","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1093\/ajcn\/nqz036","article-title":"Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a model for end-stage intestinal failure (MESIF risk score)","volume":"109","author":"Koelfat","year":"2019","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2025.08.030_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrgastro.2013.151","article-title":"Bile acid receptors as targets for drug development","volume":"11","author":"Schaap","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2025.08.030_bib11","series-title":"Growth analyser research calculation tool","year":"2011"},{"issue":"Suppl 2","key":"10.1016\/j.clnu.2025.08.030_bib12","first-page":"S1","volume":"41","author":"Koletzko","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2025.08.030_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/MPG.0000000000001722","article-title":"Intestinal rehabilitation programs in the management of pediatric intestinal failure and short bowel syndrome","volume":"65","author":"Merritt","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"10.1016\/j.clnu.2025.08.030_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0148607113496280","article-title":"Incidence, prevention, and treatment of parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease in infants and children: a systematic review","volume":"38","author":"Lauriti","year":"2014","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"12","key":"10.1016\/j.clnu.2025.08.030_bib15","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1249\/MSS.0b013e318265dd3d","article-title":"Aggravation of exercise-induced intestinal injury by ibuprofen in athletes","volume":"44","author":"Van Wijck","year":"2012","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.clnu.2025.08.030_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-4347(93)80062-9","article-title":"Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns spherisorb ODS II column","volume":"620","author":"van Eijk","year":"1993","journal-title":"J Chromatogr"},{"issue":"4","key":"10.1016\/j.clnu.2025.08.030_bib17","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.22771","article-title":"High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis","volume":"49","author":"Schaap","year":"2009","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.clnu.2025.08.030_bib18","first-page":"480","article-title":"Massive small intestinal resection in newborn infants. Hunterian lecture delivered at the royal college of surgeons of England on 13th April 1967","volume":"41","author":"Rickham","year":"1967","journal-title":"Ann R Coll Surg Engl"},{"issue":"5","key":"10.1016\/j.clnu.2025.08.030_bib19","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.jpeds.2013.06.083","article-title":"Serum 7-alpha-hydroxy-4-cholesten-3-one as a marker for bile acid loss in children","volume":"163","author":"Freudenberg","year":"2013","journal-title":"J Pediatr"},{"issue":"Suppl 1","key":"10.1016\/j.clnu.2025.08.030_bib20","first-page":"268","article-title":"Range of serum bile acid concentrations in neonates, infants, older children, and in adults","volume":"7","author":"Polkowska","year":"2001","journal-title":"Med Sci Monit"},{"issue":"7\u20138","key":"10.1016\/j.clnu.2025.08.030_bib21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cca.2010.11.021","article-title":"Citrulline levels in a paediatric age group: does measurement on dried blood spots have additional value?","volume":"412","author":"Goossens","year":"2011","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib22","first-page":"231","article-title":"Enterohepatic circulation of bile acids in infants and children with ileal resection","volume":"95","author":"Heubi","year":"1980","journal-title":"J Lab Clin Med"},{"issue":"1","key":"10.1016\/j.clnu.2025.08.030_bib23","first-page":"127","article-title":"Bile salt metabolism in the first year of life","volume":"100","author":"Heubi","year":"1982","journal-title":"J Lab Clin Med"},{"issue":"6","key":"10.1016\/j.clnu.2025.08.030_bib24","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/14767058.2018.1513483","article-title":"Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates","volume":"33","author":"Memon","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.clnu.2025.08.030_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210797","article-title":"The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis","volume":"14","author":"Kokesova","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.clnu.2025.08.030_bib29","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1016\/j.clnu.2021.07.017","article-title":"Variation of plasma citrulline as a predictive factor for weaning off long-term parenteral nutrition in children with neonatal short bowel syndrome","volume":"40","author":"Proli","year":"2021","journal-title":"Clin Nutr"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.14740\/gr1146","article-title":"Serum citrulline levels exhibit circadian variation and fluctuations in relation to food intake in mice","volume":"12","author":"Park","year":"2019","journal-title":"Gastroenterol Res"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/SLA.0000000000002187","article-title":"Liver inflammation relates to decreased canalicular bile transporter expression in pediatric onset intestinal failure","volume":"268","author":"Mutanen","year":"2018","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.clnu.2025.08.030_bib32","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.32101","article-title":"Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice","volume":"75","author":"El Kasmi","year":"2022","journal-title":"Hepatology"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425002444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561425002444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:47:01Z","timestamp":1758998821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561425002444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":29,"alternative-id":["S0261561425002444"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.08.030","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Do functional gut parameters predict enteral autonomy and chronic cholestasis in pediatric intestinal failure?","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}