{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:53:11Z","timestamp":1792601591801,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2021"],"award-info":[{"award-number":["IG 2021"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["26201"],"award-info":[{"award-number":["26201"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.clnu.2025.106573","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:41:47Z","timestamp":1767372107000},"page":"106573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Impact of nutritional status on chemotherapy delivery and outcomes in advanced pancreatic cancer: A prospective multicenter study"],"prefix":"10.1016","volume":"57","author":[{"given":"Maria","family":"Kiriukova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Sandru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"de la Iglesia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Panic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryana","family":"Bozhychko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartu","family":"Avci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Burini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cardellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Loliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Archibugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Macchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrodita","family":"Panaitescu-Damian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Bordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Giorgio","family":"Arcidiacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Maisonneuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"de-Madaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Reni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-8753","authenticated-orcid":false,"given":"Gabriele","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.clnu.2025.106573_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clnu.2025.106573_bib2","first-page":"10","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"10.1016\/j.clnu.2025.106573_bib3","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ueg2.12123","article-title":"UEG position paper on pancreatic cancer. Bringing pancreatic cancer to the 21st century: prevent, detect, and treat the disease earlier and better","volume":"9","author":"Michl","year":"2021","journal-title":"Uni Eur Gastroenterol J"},{"issue":"4","key":"10.1016\/j.clnu.2025.106573_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2025.104528","article-title":"ESMO Clinical Practice Guideline Express update on the management of metastatic pancreatic cancer","volume":"10","author":"Conroy","year":"2025","journal-title":"ESMO Open"},{"issue":"24","key":"10.1016\/j.clnu.2025.106573_bib5","first-page":"2545","article-title":"Metastatic pancreatic Cancer: ASCO Clinical Practice Guideline update","volume":"36","author":"Sohal","year":"2018"},{"issue":"1","key":"10.1016\/j.clnu.2025.106573_bib6","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1186\/s12885-025-14558-2","article-title":"Global epidemiological characteristics of malnutrition in cancer patients: a comprehensive meta-analysis and systematic review","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.clnu.2025.106573_bib7","first-page":"1093","article-title":"Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus","volume":"45","author":"Hart","year":"2016","journal-title":"Pancreas"},{"issue":"2","key":"10.1016\/j.clnu.2025.106573_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/14737140.2022.2026771","article-title":"The impact of nutritional status on pancreatic cancer therapy","volume":"22","author":"Capurso","year":"2022","journal-title":"Expert Rev Anticancer Ther"},{"issue":"9","key":"10.1016\/j.clnu.2025.106573_bib9","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1177\/2050640620938987","article-title":"Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: a systematic review and meta-analysis","volume":"8","author":"Iglesia","year":"2020","journal-title":"Uni Eur Gastroenterol J"},{"key":"10.1016\/j.clnu.2025.106573_bib10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12885-018-4439-x","article-title":"Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis","volume":"18","author":"Dom\u00ednguez-Mu\u00f1oz","year":"2018","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.clnu.2025.106573_bib11","first-page":"1001","article-title":"Effect of cancer cachexia on first-line chemotherapy in patients with advanced pancreatic cancer: a claims database study in Japan","volume":"115","author":"Furuse","year":"2024","journal-title":"Cancer Sci"},{"issue":"4","key":"10.1016\/j.clnu.2025.106573_bib12","first-page":"1234","article-title":"Impact of malnutrition as defined by the GLIM criteria on postoperative complications and survival in patients with cancer","volume":"42","author":"Matsui","year":"2023","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.clnu.2025.106573_bib13","doi-asserted-by":"crossref","first-page":"e1609","DOI":"10.1002\/onco.13822","article-title":"Relative dose intensity of chemotherapy and survival in patients with advanced stage solid tumor cancer: a systematic review and meta-analysis","volume":"26","author":"Nielson","year":"2021","journal-title":"Oncologist"},{"issue":"7","key":"10.1016\/j.clnu.2025.106573_bib14","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.21037\/tcr-22-1604","article-title":"Efficacy of relative dose intensity of nab-paclitaxel for the short-term survival of patients with advanced pancreatic cancer","volume":"11","author":"Lian","year":"2022","journal-title":"Transl Cancer Res"},{"issue":"495","key":"10.1016\/j.clnu.2025.106573_bib15","article-title":"Pancreatic cancer malnutrition and pancreatic exocrine insufficiency in the course of chemotherapy in unresectable pancreatic cancer","volume":"7","author":"Kiriukova","year":"2020","journal-title":"Front Med"},{"key":"10.1016\/j.clnu.2025.106573_bib16","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical","year":"2013","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.clnu.2025.106573_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040297","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration","volume":"4","author":"Vandenbroucke","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.clnu.2025.106573_bib18","first-page":"15","article-title":"Mini nutritional assessment: a practical assessment tool for grading the nutritional state of elderly patients","author":"Guigoz","year":"1997","journal-title":"Facts Res Interv Geriatr"},{"issue":"6","key":"10.1016\/j.clnu.2025.106573_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0959-8049(99)00047-7","article-title":"Development of a disease specific quality of life (QoL) questionnaire module to supplement the EORTC core cancer QoL questionnaire, the QLQ-C30 in patients with pancreatic cancer","volume":"35","author":"Fitzsimmons","year":"1999","journal-title":"Eur J Cancer"},{"issue":"11","key":"10.1016\/j.clnu.2025.106573_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224540","article-title":"Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer","volume":"14","author":"Abraham","year":"2019","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.clnu.2025.106573_bib21","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.clnu.2025.106573_bib22","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.clnu.2025.106573_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2468-1253(18)30196-1","article-title":"Nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in metastatic pancreatic adenocarcinoma (PACT-19)","volume":"3","author":"Reni","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.clnu.2025.106573_bib24","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1200\/JCO.1997.15.6.2403","article-title":"Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial","volume":"15","author":"Burris","year":"1997","journal-title":"J Clin Oncol"},{"issue":"15","key":"10.1016\/j.clnu.2025.106573_bib25","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1200\/JCO.2005.06.023","article-title":"Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial","volume":"23","author":"Louvet","year":"2005","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.clnu.2025.106573_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends","year":"2017","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2025.106573_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/jnci\/djr556","article-title":"Oral nutritional interventions in malnourished patients with cancer: a systematic review and meta-analysis","volume":"104","author":"Baldwin","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.clnu.2025.106573_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/jhn.12811","article-title":"Cancer cachexia: an overview of diagnostic criteria and therapeutic approaches for the accredited practicing dietitian","volume":"34","author":"van der Meij","year":"2021","journal-title":"J Hum Nutr Diet"},{"issue":"3","key":"10.1016\/j.clnu.2025.106573_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13871","article-title":"A randomized trial of nutrition and exercise treatment in patients with pancreatic and non-small cell lung cancer (NEXTAC-TWO)","volume":"16","author":"Mitsunaga","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"8","key":"10.1016\/j.clnu.2025.106573_bib30","doi-asserted-by":"crossref","DOI":"10.2196\/21088","article-title":"Usefulness of smartphone apps for improving nutritional status of pancreatic cancer patients: randomized controlled trial","volume":"9","author":"Keum","year":"2021","journal-title":"JMIR mHealth uHealth"},{"key":"10.1016\/j.clnu.2025.106573_bib31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.clnesp.2019.06.003","article-title":"The utility of nutritional supportive care with an eicosapentaenoic acid\u2013enriched nutrition agent during pre-operative chemoradiotherapy for pancreatic cancer: prospective randomized control study","volume":"33","author":"Akita","year":"2019","journal-title":"Clin Nutr ESPEN"},{"issue":"11","key":"10.1016\/j.clnu.2025.106573_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166513","article-title":"Early parenteral nutrition in patients with biliopancreatic mass lesions: a prospective, randomized intervention trial","volume":"11","author":"Kr\u00fcger","year":"2016","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.clnu.2025.106573_bib33","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1056\/NEJMoa2409515","article-title":"Ponsegromab for the treatment of cancer cachexia","volume":"391","author":"Groarke","year":"2024","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.clnu.2025.106573_bib34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.nut.2014.12.001","article-title":"Nutritional approaches in cancer: relevance of individualized counseling and supplementation","volume":"31","author":"Ravasco","year":"2015","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.clnu.2025.106573_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/bmjspcare-2017-001440","article-title":"Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and anti-inflammatory medication for Cachexia) trial","volume":"8","author":"Solheim","year":"2018","journal-title":"BMJ Support Palliat Care"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142500353X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S026156142500353X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:57:40Z","timestamp":1777532260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S026156142500353X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"alternative-id":["S026156142500353X"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2025.106573","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of nutritional status on chemotherapy delivery and outcomes in advanced pancreatic cancer: A prospective multicenter study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2025.106573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106573"}}