{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:47:47Z","timestamp":1784620067763,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PID2021-122952OB-I00"],"award-info":[{"award-number":["PID2021-122952OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Government of Catalonia Agency for Administration of University and Research Grants","doi-asserted-by":"publisher","award":["2021 SGR 01052"],"award-info":[{"award-number":["2021 SGR 01052"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015439","name":"Centres de Recerca de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015439","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["AC22\/00035"],"award-info":[{"award-number":["AC22\/00035"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PMP22\/00008"],"award-info":[{"award-number":["PMP22\/00008"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005053","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.clnu.2026.106586","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:30:59Z","timestamp":1769355059000},"page":"106586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Proof of concept for an age- and inflammation-adjusted model for the establishment of pediatric serum copper reference intervals"],"prefix":"10.1016","volume":"58","author":[{"given":"Helena","family":"Rodriguez-Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Poyatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela Mercedes","family":"de los Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Minguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Meavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Garcia-Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Loverdos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Molera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Ormazabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Perera-Lluna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-9685","authenticated-orcid":false,"given":"Rafael","family":"Artuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2026.106586_bib1","first-page":"422","article-title":"Copper deficiency and excess in infancy: developing a research agenda","volume":"37","author":"Araya","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib2","first-page":"102","article-title":"Copper homeostasis in infant nutrition: deficit and excess","volume":"31","author":"Olivares","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22043","article-title":"Reference intervals of and relationships among essential trace elements in whole blood of children aged 0\u201314 years","volume":"31","author":"Zhai","year":"2017","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.clnu.2026.106586_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-021-02962-z","article-title":"Determination of 11 minerals in children using inductively coupled plasma mass spectrometry","volume":"21","author":"Li","year":"2021","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.clnu.2026.106586_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2011.12.005","article-title":"Pediatric reference intervals for serum copper and zinc","volume":"413","author":"Lin","year":"2012","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.clnu.2026.106586_bib6","doi-asserted-by":"crossref","DOI":"10.5858\/arpa.2020-0029-OA","article-title":"Total and exchangeable copper assay using inductively coupled plasma mass spectrometry and establishment of a pediatric reference interval","volume":"145","author":"Yim","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.clnu.2026.106586_bib7","doi-asserted-by":"crossref","DOI":"10.1258\/0004563001899429","article-title":"Effect of the inflammatory response on trace element and vitamin status","volume":"37","author":"Galloway","year":"2000","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.clnu.2026.106586_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnu.2007.10.003","article-title":"Acute inflammatory response does not affect erythrocyte concentrations of copper, zinc and selenium","volume":"27","author":"Oakes","year":"2008","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib9","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.111.023812","article-title":"Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements","volume":"95","author":"Duncan","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127155","article-title":"Assessment of trace elements in critically ill patients with systemic inflammatory response syndrome: a systematic review","volume":"78","author":"Silveira","year":"2023","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.clnu.2026.106586_bib11","doi-asserted-by":"crossref","DOI":"10.3945\/jn.114.192336","article-title":"Micronutrient deficiencies are common in 6- to 8-year-old children of rural Nepal, with prevalence estimates modestly affected by inflammation","volume":"144","author":"Schulze","year":"2014","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.clnu.2022.02.021","article-title":"Development of age-dependent micronutrient centile charts and their utility in children with chronic gastrointestinal conditions at risk of deficiencies: a proof-of-concept study","volume":"41","author":"Al Fify","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.clnesp.2025.09.031","article-title":"Serum reference intervals for essential and toxic trace elements in a healthy population: a basis for nutritional monitoring and clinical intervention","volume":"70","author":"Rivas","year":"2025","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clnu.2026.106586_bib14","article-title":"Usefulness of the Acute Phase Reactants (APR) score: early detection of delayed onset of sepsis in extremely low birth weight infants by APR score","volume":"49","author":"Nakamura","year":"2023","journal-title":"Biomed J Sci Tech Res"},{"key":"10.1016\/j.clnu.2026.106586_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-432014-7.50009-7","article-title":"Molecular biology of the acute phase plasma proteins","author":"Gitlin","year":"1987","journal-title":"Lymphokines"},{"key":"10.1016\/j.clnu.2026.106586_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/jalm\/jfad019","article-title":"Pediatric reference value profiling of essential trace and toxic elements in healthy children and adolescents using high-resolution and triple Quadrupole inductively coupled plasma mass spectrometry","volume":"8","author":"Bohn","year":"2023","journal-title":"J Appl Lab Med"},{"key":"10.1016\/j.clnu.2026.106586_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/S0946-672X(97)80032-6","article-title":"Reference values for the trace elements copper, manganese, selenium, and zinc in the serum\/plasma of children, adolescents, and adults","volume":"11","author":"R\u00fckgauer","year":"1997","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.clnu.2026.106586_bib18","doi-asserted-by":"crossref","DOI":"10.1079\/PNS2005468","article-title":"Micronutrients in childhood and the influence of subclinical inflammation","volume":"64","author":"Thurnham","year":"2005","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.clnu.2026.106586_bib19","doi-asserted-by":"crossref","DOI":"10.1097\/MPG.0000000000001334","article-title":"Guideline for the evaluation of cholestatic jaundice in infants","volume":"64","author":"Fawaz","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib20","doi-asserted-by":"crossref","DOI":"10.1177\/030089167806400106","article-title":"The diagnostic value of serum copper levels and other hematochemical parameters in malignancies","volume":"64","author":"Pizzolo","year":"1978","journal-title":"Tumori"},{"key":"10.1016\/j.clnu.2026.106586_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejim.2012.07.009","article-title":"Copper levels in patients with hematological malignancies","volume":"23","author":"Kaiafa","year":"2012","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.clnu.2026.106586_bib22","doi-asserted-by":"crossref","DOI":"10.2741\/1424","article-title":"Copper storage diseases: menkes, Wilsons, and cancer","volume":"9","author":"Daniel","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.clnu.2026.106586_bib23","doi-asserted-by":"crossref","DOI":"10.1007\/s10545-009-9015-8","article-title":"The monitoring of trace elements in blood samples from patients with inborn errors of metabolism","volume":"33","author":"Tondo","year":"2010","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.clnu.2026.106586_bib24","article-title":"Pediatric reference interval verification for 16 biochemical markers on the Alinity ci system in the CALIPER cohort of healthy children and adolescents","volume":"61","author":"Bohn","year":"2023","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.clnu.2026.106586_bib25","doi-asserted-by":"crossref","DOI":"10.1017\/S0007114512005119","article-title":"A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies","volume":"109","author":"Calder","year":"2013","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib26","series-title":"C-reactive protein concentrations as a marker of inflammation or infection for interpreting biomarkers of micronutrient status","year":"2020"},{"key":"10.1016\/j.clnu.2026.106586_bib27","doi-asserted-by":"crossref","DOI":"10.1542\/hpeds.2021-005825","article-title":"Utility of inflammatory markers in hospitalized children with skin erythema","volume":"11","author":"Harper","year":"2021","journal-title":"Hosp Pediatr"},{"key":"10.1016\/j.clnu.2026.106586_bib28","article-title":"From radiocopper to cold copper: mechanistic modeling and simulation to define clinical response criteria and biomarkers for VTX-801 in Wilson disease","author":"Lindauer","year":"2025","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1016\/j.clnu.2026.106586_bib29","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/clinchem\/hvae139","article-title":"Cerebrospinal fluid homovanillic and 5-Hydroxyindoleacetic acids in a large pediatric population; establishment of reference intervals and impact of disease and medication","volume":"70","author":"Rodriguez-Gonzalez","year":"2024","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2026.106586_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.107098","article-title":"Cerebrospinal amino acid profiling in a large cohort of neuropediatric patients with epilepsy","volume":"216","author":"Rodriguez-Gonzalez","year":"2025","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.clnu.2026.106586_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/0009922812446743","article-title":"Three distinct cases of copper deficiency in hospitalized pediatric patients","volume":"51","author":"Dembinski","year":"2012","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.clnu.2026.106586_bib32","doi-asserted-by":"crossref","DOI":"10.3945\/jn.112.167775","volume":"143","author":"Engle-Stone","year":"2013","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib33","doi-asserted-by":"crossref","DOI":"10.3945\/an.115.010215","article-title":"Overview of the biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project","volume":"7","author":"Suchdev","year":"2016","journal-title":"Adv Nutr"},{"key":"10.1016\/j.clnu.2026.106586_bib34","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.2010.29284","article-title":"Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis","volume":"92","author":"Thurnham","year":"2010","journal-title":"Am J Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561426000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561426000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:59:30Z","timestamp":1777532370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561426000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"alternative-id":["S0261561426000130"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2026.106586","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proof of concept for an age- and inflammation-adjusted model for the establishment of pediatric serum copper reference intervals","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2026.106586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106586"}}