{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:04:26Z","timestamp":1789830266872,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.clnu.2026.106764","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:06:25Z","timestamp":1787209585000},"page":"106764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of a multidimensional body composition grading system for cancer prognosis"],"prefix":"10.1016","volume":"65","author":[{"given":"Lishuang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1770-5651","authenticated-orcid":false,"given":"Hailun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.clnu.2026.106764_bib1","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/cncr.33587","article-title":"The ever-increasing importance of cancer as a leading cause of premature death worldwide","volume":"127","author":"Bray","year":"2021","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.clnu.2026.106764_bib2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/ijc.33826","article-title":"Paid and unpaid productivity losses due to premature mortality from cancer in Europe in 2018","volume":"150","author":"Ortega-Ortega","year":"2022","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib3","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib4","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clnu.2026.106764_bib5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.clnesp.2025.03.027","article-title":"The Global Leadership Initiative on Malnutrition (GLIM) inflammation criteria to predict survival in patients with advanced cancer: a prospective cohort study","volume":"67","author":"Pumtako","year":"2025","journal-title":"Clin Nutr ESPEN"},{"issue":"8","key":"10.1016\/j.clnu.2026.106764_bib6","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ejca.2008.02.033","article-title":"Cancer cachexia: developing multimodal therapy for a multidimensional problem","volume":"44","author":"Fearon","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.clnu.2026.106764_bib7","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer cachexia: definition, staging, and emerging treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag Res"},{"issue":"7","key":"10.1016\/j.clnu.2026.106764_bib8","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41416-023-02175-4","article-title":"Tumour-derived small extracellular vesicles contribute to the tumour progression through reshaping the systemic immune macroenvironment","volume":"128","author":"Du","year":"2023","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.clnu.2026.106764_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"issue":"7678","key":"10.1016\/j.clnu.2026.106764_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.clnu.2026.106764_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate metabolism in human lung tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.clnu.2026.106764_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/nu13061980","article-title":"The spectrum of Malnutrition\/Cachexia\/Sarcopenia in oncology according to different cancer types and settings: a narrative review","volume":"13","author":"Bossi","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.clnu.2026.106764_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chest.2019.04.115","article-title":"Prognostic value of Sarcopenia in lung cancer: a systematic review and meta-analysis","volume":"156","author":"Yang","year":"2019","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.clnu.2026.106764_bib14","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/jgh.16681","article-title":"Sarcopenia and survival in colorectal cancer without distant metastasis: a systematic review and meta-analysis","volume":"39","author":"Lin","year":"2024","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.clnu.2026.106764_bib15","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00423-021-02274-x","article-title":"Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis","volume":"406","author":"Xie","year":"2021","journal-title":"Langenbecks Arch Surg"},{"issue":"1","key":"10.1016\/j.clnu.2026.106764_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcsm.13126","article-title":"The prognostic value of sarcopenia in oesophageal cancer: a systematic review and meta-analysis","volume":"14","author":"Fang","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"13","key":"10.1016\/j.clnu.2026.106764_bib17","doi-asserted-by":"crossref","first-page":"e3164","DOI":"10.1097\/MD.0000000000003164","article-title":"Sarcopenia is an independent predictor of severe postoperative complications and long-term survival after radical gastrectomy for gastric cancer: analysis from a large-scale cohort","volume":"95","author":"Zhuang","year":"2016","journal-title":"Medicine (Baltim)"},{"issue":"11","key":"10.1016\/j.clnu.2026.106764_bib18","doi-asserted-by":"crossref","first-page":"9501","DOI":"10.3390\/curroncol30110688","article-title":"Re-Evaluating chemotherapy dosing strategies for ovarian cancer: impact of Sarcopenia","volume":"30","author":"Shah","year":"2023","journal-title":"Curr Oncol"},{"key":"10.1016\/j.clnu.2026.106764_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fphys.2013.00275","article-title":"Adipose tissue immunity and cancer","volume":"4","author":"Catal\u00e1n","year":"2013","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.clnu.2026.106764_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.smhs.2024.03.006","article-title":"Exploring the role of adipokines in exercise-induced inhibition of tumor growth","volume":"7","author":"Qian","year":"2025","journal-title":"Sports Med Health Sci"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/adip.24472","article-title":"Loss of adipocyte specification and necrosis augment tumor-associated inflammation","volume":"2","author":"Wagner","year":"2013","journal-title":"Adipocyte"},{"issue":"1","key":"10.1016\/j.clnu.2026.106764_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70030","article-title":"Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions","volume":"6","author":"Wang","year":"2025","journal-title":"MedComm"},{"issue":"9","key":"10.1016\/j.clnu.2026.106764_bib23","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s41366-022-01165-5","article-title":"Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies","volume":"46","author":"Jayedi","year":"2022","journal-title":"Int J Obes"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib24","doi-asserted-by":"crossref","first-page":"102241","DOI":"10.1016\/j.esmoop.2024.102241","article-title":"Body mass index, weight change, and cancer prognosis: a meta-analysis and systematic review of 73 cohort studies","volume":"9","author":"Wen","year":"2024","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.clnu.2026.106764_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00011-023-01832-x","article-title":"Association of systemic inflammation with the obesity paradox in cancer: results from multi-cohort studies","volume":"73","author":"Xie","year":"2024","journal-title":"Inflamm Res"},{"key":"10.1016\/j.clnu.2026.106764_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-nutr-082117-051723","article-title":"The obesity paradox in cancer: how important is muscle?","volume":"38","author":"Cespedes Feliciano","year":"2018","journal-title":"Annu Rev Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s13668-019-00280-6","article-title":"The obesity paradox in cancer: Epidemiologic insights and perspectives","volume":"8","author":"Lee","year":"2019","journal-title":"Curr Nutr Rep"},{"key":"10.1016\/j.clnu.2026.106764_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155577","article-title":"Interplay of skeletal muscle and adipose tissue: sarcopenic obesity","volume":"144","author":"Park","year":"2023","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.clnu.2026.106764_bib29","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.clnu.2026.106764_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/320724","article-title":"Adipo-myokines: two sides of the same coin--mediators of inflammation and mediators of exercise","volume":"2013","author":"Raschke","year":"2013","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.clnu.2026.106764_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doaa002","article-title":"The impact of preoperative sarcopenia on postoperative complications following esophagectomy for esophageal neoplasia: a systematic review and meta-analysis","author":"Papaconstantinou","year":"2020","journal-title":"Dis Esophagus"},{"issue":"3","key":"10.1016\/j.clnu.2026.106764_bib32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s43587-024-00797-8","article-title":"Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target","volume":"5","author":"Zuo","year":"2025","journal-title":"Nat Aging"},{"issue":"10046","key":"10.1016\/j.clnu.2026.106764_bib33","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0140-6736(16)30175-1","article-title":"Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents","volume":"388","author":"Global BMI Mortality Collaboration","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2026.106764_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/ggi.70222","article-title":"Inflammatory and nutrition-glucose metabolic factors in relation to Sarcopenia prevalence among US adults: evidence from NHANES 2015-2018","author":"Wei","year":"2025","journal-title":"Geriatr Gerontol Int"},{"issue":"7203","key":"10.1016\/j.clnu.2026.106764_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.clnu.2026.106764_bib36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/jcsm.12261","article-title":"Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017","volume":"8","author":"von Haehling","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561426001913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561426001913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:35:08Z","timestamp":1789828508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561426001913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"alternative-id":["S0261561426001913"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2026.106764","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a multidimensional body composition grading system for cancer prognosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2026.106764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106764"}}