{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:51:59Z","timestamp":1767675119990,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.clon.2006.10.008","type":"journal-article","created":{"date-parts":[[2006,11,21]],"date-time":"2006-11-21T14:53:44Z","timestamp":1164120824000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vascular Endothelial Growth Factor Expression Predicts Outcome after Primary Radiotherapy for Head and Neck Squamous Cell Cancer"],"prefix":"10.1016","volume":"19","author":[{"given":"S.G.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Orridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.L.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2006.10.008_bib1","first-page":"65","article-title":"The role of angiogenesis in tumour growth","volume":"3","author":"Folkman","year":"1992","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.clon.2006.10.008_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/84643","article-title":"Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis","volume":"7","author":"Skobe","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.clon.2006.10.008_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/84635","article-title":"VEGF-D promotes the metastatic spread of tumor cells via lymphatics","volume":"7","author":"Stacker","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.clon.2006.10.008_bib4","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/emboj\/20.4.672","article-title":"Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis","volume":"20","author":"Mandriota","year":"2001","journal-title":"EMBO J"},{"issue":"Suppl 3","key":"10.1016\/j.clon.2006.10.008_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000088479","article-title":"VEGF as a therapeutic target in cancer","volume":"69","author":"Ferrara","year":"2005","journal-title":"Oncology"},{"key":"10.1016\/j.clon.2006.10.008_bib6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1084\/jem.20041896","article-title":"VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis","volume":"201","author":"Hirakawa","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.clon.2006.10.008_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cardiores.2004.12.002","article-title":"The biology of vascular endothelial growth factors","volume":"65","author":"Tammela","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.clon.2006.10.008_bib8","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1073\/pnas.92.8.3566","article-title":"Expression of the FMS-like kinase-4 gene becomes restricted to lymphatic endothelium during development","volume":"92","author":"Kaipainen","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clon.2006.10.008_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1520-6823(1999)7:3<125::AID-ROI1>3.0.CO;2-W","article-title":"Molecular markers as prognostic factors for local recurrence and radioresistance in head and neck squamous cell carcinoma","volume":"7","author":"Smith","year":"1999","journal-title":"Radiat Oncol Invest"},{"key":"10.1016\/j.clon.2006.10.008_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0360-3016(00)00573-3","article-title":"Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx","volume":"48","author":"Aebersold","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.10.008_bib11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0360-3016(00)00677-5","article-title":"Cancer vascularization: implication in radiotherapy","volume":"48","author":"Koukourakis","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.10.008_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1054\/bjoc.2000.1357","article-title":"Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas","volume":"83","author":"Mineta","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2006.10.008_bib13","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1200\/JCO.2000.18.10.2046","article-title":"Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma","volume":"18","author":"Smith","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2006.10.008_bib14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1046\/j.1365-2273.2001.00512.x","article-title":"The expression of vascular endothelial growth factor (VEGF) and VEGF-C in early laryngeal cancer: relationship with radioresistance","volume":"26","author":"Homer","year":"2001","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.clon.2006.10.008_bib15","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1158\/1078-0432.CCR-04-1870","article-title":"Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis","volume":"11","author":"Kyzas","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clon.2006.10.008_bib16","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00432-005-0003-6","article-title":"Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma","volume":"131","author":"Kyzas","year":"2005","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.clon.2006.10.008_bib17","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archotol.131.12.1065","article-title":"Lymphatic vessel density, nodal metastases and prognosis in patients with head and neck cancer","volume":"131","author":"Audet","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.clon.2006.10.008_bib18","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/bjc.1996.276","article-title":"Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small-cell lung cancer: an interim report","volume":"73","author":"Saunders","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2006.10.008_bib19","first-page":"1669","article-title":"Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma","volume":"62","author":"White","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.clon.2006.10.008_bib20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00005537-200205000-00013","article-title":"Tumor angiogenesis as a predictive marker for organ preservation in patients with advanced laryngeal carcinoma","volume":"112","author":"Teknos","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.clon.2006.10.008_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1023\/A:1011083121295","article-title":"Tumor specific activation of the VEGF\/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas","volume":"18","author":"Giatromanolaki","year":"2000","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.clon.2006.10.008_bib22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2005.09.013","article-title":"Lymphatic vessel density in vocal cord carcinomas assessed with lyve-1 receptor expression","volume":"77","author":"Koskinen","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.10.008_bib23","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/1097-0142(20010801)92:3<556::AID-CNCR1355>3.0.CO;2-Q","article-title":"Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis","volume":"92","author":"O-charoenrat","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2006.10.008_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1034\/j.1600-0714.2003.00168.x","article-title":"Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer","volume":"32","author":"Sedivy","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.clon.2006.10.008_bib25","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1007\/s00268-005-0076-z","article-title":"Prognostic significance of vascular endothelial growth factor D in gastric carcinoma","volume":"29","author":"Shida","year":"2005","journal-title":"World J Surg"},{"key":"10.1016\/j.clon.2006.10.008_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1200\/JCO.2004.00.3467","article-title":"Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma","volume":"24","author":"Juttner","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2006.10.008_bib27","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ijc.21420","article-title":"Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells","volume":"118","author":"Akahane","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clon.2006.10.008_bib28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/PL00002428","article-title":"Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancers","volume":"177","author":"Dunst","year":"2001","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.clon.2006.10.008_bib29","first-page":"BR280","article-title":"Dual role of VEGF family members in the pathogenesis of head and neck cancer (HNSCC): possible link between angiogenesis and immune tolerance","volume":"11","author":"Strauss","year":"2005","journal-title":"Med Sci Monitor"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655506004092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655506004092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:31:54Z","timestamp":1760542314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655506004092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0936655506004092"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2006.10.008","relation":{},"ISSN":["0936-6555"],"issn-type":[{"type":"print","value":"0936-6555"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vascular Endothelial Growth Factor Expression Predicts Outcome after Primary Radiotherapy for Head and Neck Squamous Cell Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2006.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}