{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:17:29Z","timestamp":1780957049855,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.clon.2006.11.006","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T07:24:59Z","timestamp":1165994699000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adjuvant Hypofractionated Radiation Therapy for Breast Cancer after Conserving Surgery"],"prefix":"10.1016","volume":"19","author":[{"given":"L.","family":"Livi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stefanacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Scoccianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dicosmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Borghesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Simontacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Paiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ponticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chiavacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.P.","family":"Biti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2006.11.006_bib1","first-page":"347","article-title":"Twenty-years follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer","author":"Veronesi","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clon.2006.11.006_bib2","first-page":"347","article-title":"Twenty-years follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer","author":"Fisher","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clon.2006.11.006_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0167-8140(02)00105-6","article-title":"Post-surgery in early breast cancer: survival analysis of registry data","volume":"64","author":"Vinh-Hung","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib4","first-page":"1273","article-title":"Adjuvant radiotherapy for early breast cancer: patterns of practice in Ontario","volume":"149","author":"Whelan","year":"1993","journal-title":"CMAJ"},{"key":"10.1016\/j.clon.2006.11.006_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0936-6555(05)80604-1","article-title":"Non-surgical management of early breast cancer in the United Kingdom: the role and practice of radiotherapy. Clinical Audit Sub-committee of the Faculty of Clinical Oncology, Royal College of Radiologists, and the Joint Council for Clinical Oncology","volume":"7","author":"Yarnold","year":"1995","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2006.11.006_bib6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jnci\/92.3.269","article-title":"Travel distance to radiation therapy and receipt of radiotherapy following breast-conserving surgery","volume":"92","author":"Athas","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clon.2006.11.006_bib7","first-page":"86","article-title":"Radiotherapy to the conserved breast: is it avoidable if the cancer is small?","author":"Gelberd","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clon.2006.11.006_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0167-8140(91)90106-Q","article-title":"Hypofractionation: lessons from complications","volume":"20","author":"Fletcher","year":"1991","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(87)80213-X","article-title":"The value of the NSD formula in the equation of acute and late radiation complications in normal tissue following 2 and 5 fractions per week in breast cancer patients treated with postmastectomy irradiation","volume":"9","author":"Overgaard","year":"1987","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0360-3016(82)90163-8","article-title":"Breast cancer: a 21 year experience with conservative surgery and radiation","volume":"8","author":"Clark","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00000421-198712000-00001","article-title":"Breast cancer. Experiences with conservation therapy","volume":"10","author":"Clark","year":"1987","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib12","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0360-3016(95)00057-6","article-title":"RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system","volume":"31","author":"Rubin","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0360-3016(02)04120-2","article-title":"Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system","volume":"55","author":"Fehlauer","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.clon.2006.11.006_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples","volume":"35","author":"Peto","year":"1977","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2006.11.006_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"334","author":"Cox","year":"1972","journal-title":"J R Stat Soc B"},{"key":"10.1016\/j.clon.2006.11.006_bib17","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1056\/NEJM199306033282202","article-title":"Radiotherapy after breast-preserving surgery in women with localized cancer of the breast","volume":"328","author":"Veronesi","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clon.2006.11.006_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0167-8140(89)90165-5","article-title":"Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer","volume":"14","author":"Sarrazin","year":"1989","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib19","first-page":"6","article-title":"Breast-conserving therapy vs mastectomy in early-stage breast cancer: a meta-analysis of 10-year survival","volume":"3","author":"Morris","year":"1997","journal-title":"Cancer J Sci Am"},{"key":"10.1016\/j.clon.2006.11.006_bib20","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0360-3016(89)90057-6","article-title":"Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up","volume":"17","author":"Fourquet","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(96)91825-3","article-title":"Effect of acetylsalicylic acid on radiation and cosmetic results after conservative surgery for early breast cancer: a randomized trial","volume":"41","author":"Olivotto","year":"1996","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0167-8140(90)90142-J","article-title":"How worthwhile are short schedules in radiotherapy? A series of exploratory calculations","volume":"18","author":"Fowler","year":"1990","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2004.04.059","article-title":"Long-term results of adjuvant hypofractionated radiotherapy for breast cancer in elderly patients","volume":"61","author":"Ortholan","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0167-8140(96)91824-1","article-title":"Late cosmetic results of short fractionation for breast conservation","volume":"41","author":"Olivotto","year":"1996","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0936-6555(05)80808-8","article-title":"Seven-year follow-up on 334 patients treated by breast conserving surgery and short course radical postoperative radiotherapy: a report of the Yorkshire Breast Cancer Group","volume":"7","author":"Ash","year":"1995","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2006.11.006_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0360-3016(00)00567-8","article-title":"A shorter fractionation schedule for post lumpectomy breast cancer patients","volume":"47","author":"Shelley","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0167-8140(88)90016-3","article-title":"Cosmetic results following lumpectomy, axillary dissection and radiotherapy for small breast cancers","volume":"12","author":"Dewar","year":"1988","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2006.11.006_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0360-3016(94)90538-X","article-title":"Waiting for radiotherapy in Ontario","volume":"30","author":"Mackillop","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0360-3016(98)00507-0","article-title":"Does the dose fractionation schedule influence local control of adjuvant radiotherapy for early stage breast cancer?","volume":"44","author":"Yamada","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2006.11.006_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s001740050046","article-title":"Standardization of Breast Radiotherapy (START) Trial","volume":"11","author":"START Trial Management Group","year":"1999","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2006.11.006_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00666003","article-title":"Breast conservation therapy: local tumor control in patients with pathologically clear margins who receive 5000cGy breast irradiation without local boost","volume":"23","author":"Pezner","year":"1994","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clon.2006.11.006_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(87)80016-6","article-title":"Tumor excision and radiotherapy as primary treatment of breast cancer. Analysis of patient and treatment parameters and local control","volume":"8","author":"Van Limbergen","year":"1987","journal-title":"Radiother Oncol"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655506004201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655506004201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:31:54Z","timestamp":1760542314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655506004201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0936655506004201"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2006.11.006","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjuvant Hypofractionated Radiation Therapy for Breast Cancer after Conserving Surgery","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2006.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}