{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:58:44Z","timestamp":1791251924359,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.clon.2009.12.005","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T06:11:19Z","timestamp":1264659079000},"page":"208-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":214,"title":["The Effect of Physical Exercise on Cancer-related Fatigue during Cancer Treatment: a Meta-analysis of Randomised Controlled Trials"],"prefix":"10.1016","volume":"22","author":[{"given":"M.J.","family":"Velthuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Agasi-Idenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Aufdemkampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Wittink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2009.12.005_bib1","unstructured":"Signaleringscommissie Kanker van KWF Kankerbestrijding. Kanker in Nederland, Trends prognoses en implicaties voor zorgvraag. Report of the Dutch Cancer Society, 2004."},{"key":"10.1016\/j.clon.2009.12.005_bib2","series-title":"Fatigue in cancer","author":"Armes","year":"2005"},{"key":"10.1016\/j.clon.2009.12.005_bib3","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Cancer-related fatigue. version 1. Fort Washington: National Comprehensive Cancer Network, 2009."},{"key":"10.1016\/j.clon.2009.12.005_bib4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S1470-2045(03)01221-X","article-title":"Cancer-related fatigue: can exercise physiology assist oncologists?","volume":"4","author":"Lucia","year":"2003","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.bjc.6602012","article-title":"Fatigue and cancer: causes, prevalence and treatment approaches","volume":"91","author":"Wagner","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2009.12.005_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1503\/cmaj.051073","article-title":"Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis","volume":"175","author":"McNeely","year":"2006","journal-title":"CMAJ"},{"key":"10.1016\/j.clon.2009.12.005_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005001.pub2","article-title":"Exercise for women receiving adjuvant therapy for breast cancer","author":"Markes","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clon.2009.12.005_bib8","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1200\/JCO.2005.02.148","article-title":"Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials","volume":"23","author":"Knols","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib9","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/ptj\/84.8.736","article-title":"Exercise as an intervention for cancer-related fatigue","volume":"84","author":"Watson","year":"2004","journal-title":"Phys Ther"},{"key":"10.1016\/j.clon.2009.12.005_bib10","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0140-6736(03)14186-4","article-title":"Assessment and management of cancer-related fatigue in adults","volume":"362","author":"Ahlberg","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.clon.2009.12.005_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006145.pub2","article-title":"Exercise for the management of cancer-related fatigue in adults","author":"Cramp","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clon.2009.12.005_bib12","first-page":"1484","article-title":"Physical activity levels among breast cancer survivors","volume":"36","author":"Irwin","year":"2004","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clon.2009.12.005_bib13","series-title":"Textbook of work physiology: physiological basis of exercise","author":"Astrand","year":"2003"},{"key":"10.1016\/j.clon.2009.12.005_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0838.2004.413.x","article-title":"Evidence for exercise therapy in the treatment of chronic disease based on at least three randomized controlled trials \u2014 summary of published systematic reviews","volume":"14","author":"Kujala","year":"2004","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.clon.2009.12.005_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0004-9514(07)70057-0","article-title":"Therapeutic exercise in physiotherapy practice is beneficial: a summary of systematic reviews 2002\u20132005","volume":"53","author":"Taylor","year":"2007","journal-title":"Aust J Physiother"},{"issue":"Suppl. 1","key":"10.1016\/j.clon.2009.12.005_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0838.2006.00520.x","article-title":"Evidence for prescribing exercise as therapy in chronic disease","volume":"16","author":"Pedersen","year":"2006","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.clon.2009.12.005_bib17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jsams.2009.03.002","article-title":"Australian association for exercise and sport science position stand: optimising cancer outcomes through exercise","volume":"12","author":"Hayes","year":"2009","journal-title":"J Sci Med Sport"},{"key":"10.1016\/j.clon.2009.12.005_bib18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/bmj.38446.498542.8F","article-title":"Optimal search strategies for retrieving scientifically strong studies of treatment from medline: analytical survey","volume":"330","author":"Haynes","year":"2005","journal-title":"Br Med J"},{"key":"10.1016\/j.clon.2009.12.005_bib19","first-page":"60","article-title":"Exercise interventions during cancer treatment: biopsychosocial outcomes","volume":"29","author":"Courneya","year":"2001","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.clon.2009.12.005_bib20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ptj\/83.8.713","article-title":"Reliability of the PEDro scale for rating quality of randomized controlled trials","volume":"83","author":"Maher","year":"2003","journal-title":"Phys Ther"},{"key":"10.1016\/j.clon.2009.12.005_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2522\/ptj.20070147","article-title":"Scales to assess the quality of randomized controlled trials: a systematic review","volume":"88","author":"Olivo","year":"2008","journal-title":"Phys Ther"},{"key":"10.1016\/j.clon.2009.12.005_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1191\/0269215504cr843oa","article-title":"The impact of physical therapy on functional outcomes after stroke: what's the evidence?","volume":"18","author":"Van Peppen","year":"2004","journal-title":"Clin Rehabil"},{"key":"10.1016\/j.clon.2009.12.005_bib23","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.clon.2009.12.005_bib24","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1158\/1055-9965.EPI-07-0413","article-title":"Six-month follow-up of patient-rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapy","volume":"16","author":"Courneya","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clon.2009.12.005_bib25","series-title":"The effect of a structured exercise program on fatigue, strength, endurance, physical self-efficacy, and functional wellness in women with early stage breast cancer","author":"Crowley","year":"2003"},{"key":"10.1016\/j.clon.2009.12.005_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01893697-200523010-00004","article-title":"Effects of aerobic exercise training son peak aerobic capacity, fatigue, and psychological factors during radiation for breast cancer","volume":"23","author":"Drouin","year":"2005","journal-title":"Rehabil Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1188\/04.ONF.977-983","article-title":"The effect of seated exercise on fatigue and quality of life in women with advanced breast cancer","volume":"31","author":"Headley","year":"2004","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.clon.2009.12.005_bib28","first-page":"899","article-title":"A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy","volume":"21","author":"Mock","year":"1994","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.clon.2009.12.005_bib29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1523-5394.2001.009003119.x","article-title":"Fatigue and quality of life outcomes of exercise during cancer treatment","volume":"9","author":"Mock","year":"2001","journal-title":"Cancer Pract"},{"key":"10.1016\/j.clon.2009.12.005_bib30","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/pon.863","article-title":"Exercise manages fatigue during breast cancer treatment: a randomized controlled trial","volume":"14","author":"Mock","year":"2005","journal-title":"Psychooncology"},{"key":"10.1016\/j.clon.2009.12.005_bib31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1188\/08.ONF.635-642","article-title":"Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy","volume":"35","author":"Payne","year":"2008","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.clon.2009.12.005_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejon.2004.03.007","article-title":"A pilot study of a supervised group exercise programme as a rehabilitation treatment for women with breast cancer receiving adjuvant treatment","volume":"9","author":"Campbell","year":"2005","journal-title":"Eur J Oncol Nurs"},{"key":"10.1016\/j.clon.2009.12.005_bib33","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1200\/JCO.2006.08.2024","article-title":"Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial","volume":"25","author":"Courneya","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3349\/ymj.2008.49.3.443","article-title":"Effects of supervised exercise therapy in patients receiving radiotherapy for breast cancer","volume":"49","author":"Hwang","year":"2008","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.clon.2009.12.005_bib35","first-page":"517","article-title":"Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial","volume":"334","author":"Mutrie","year":"2007","journal-title":"Br\u00a0Med J"},{"key":"10.1016\/j.clon.2009.12.005_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1590\/S0100-879X2008000800012","article-title":"Effect of exercise on the caloric intake of breast cancer patients undergoing treatment","volume":"41","author":"Battaglini","year":"2008","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.clon.2009.12.005_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00002820-200310000-00012","article-title":"Feasibility of exercise during treatment for multiple myeloma","volume":"26","author":"Coleman","year":"2003","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.clon.2009.12.005_bib38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jpainsymman.2007.06.013","article-title":"Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: a randomized controlled trial","volume":"35","author":"Chang","year":"2008","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.clon.2009.12.005_bib39","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.apmr.2007.08.110","article-title":"Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy","volume":"88","author":"Monga","year":"2007","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.clon.2009.12.005_bib40","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1200\/JCO.2003.09.534","article-title":"Resistance exercise in men receiving androgen deprivation therapy for prostate cancer","volume":"21","author":"Segal","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1200\/JCO.2007.15.4963","article-title":"Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer","volume":"27","author":"Segal","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clon.2009.12.005_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/cncr.20378","article-title":"A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma","volume":"101","author":"Windsor","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2009.12.005_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005263.pub2","article-title":"Supervised exercise therapy versus non-supervised exercise therapy for intermittent claudication","author":"Bendermacher","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clon.2009.12.005_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004017.pub2","article-title":"Home versus center based physical activity programs in older adults","author":"Ashworth","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clon.2009.12.005_bib45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1478951505050443","article-title":"Are palliative cancer patients willing and able to participate in a physical exercise program?","volume":"3","author":"Oldervoll","year":"2005","journal-title":"Palliat Support Care"},{"key":"10.1016\/j.clon.2009.12.005_bib46","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0885-3924(02)00529-8","article-title":"Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales","volume":"24","author":"Cella","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.clon.2009.12.005_bib47","series-title":"International classification of functioning, disability and health: ICF","author":"World Health Organization","year":"2001"},{"key":"10.1016\/j.clon.2009.12.005_bib48","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2522\/ptj.20070309","article-title":"A framework for assessment in oncology rehabilitation","volume":"89","author":"Gilchrist","year":"2009","journal-title":"Phys Ther"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655509004117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655509004117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:35:32Z","timestamp":1760542532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655509004117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0936655509004117"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2009.12.005","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Physical Exercise on Cancer-related Fatigue during Cancer Treatment: a Meta-analysis of Randomised Controlled Trials","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2009.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}