{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:45:03Z","timestamp":1791081903607,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000301","name":"Breast Cancer Campaign","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000301","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU FP7 Cooperation programme"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.clon.2014.02.001","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T08:15:40Z","timestamp":1396340140000},"page":"301-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Finding the Genetic Determinants of Adverse Reactions to\u00a0Radiotherapy"],"prefix":"10.1016","volume":"26","author":[{"given":"T.","family":"Rattay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.J.","family":"Talbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2014.02.001_bib1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cncr.21324","article-title":"The role of radiotherapy in the treatment of cancer: estimating the optimal utilization from a review of evidence-based clinical guidelines","volume":"104","author":"Delaney","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib2","series-title":"Radiobiology of normal tissues","first-page":"99","article-title":"Arnold","author":"van der Kogel","year":"1993"},{"key":"10.1016\/j.clon.2014.02.001_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/gm268","article-title":"Genetics and genomics of radiotherapy toxicity: towards prediction","volume":"3","author":"West","year":"2011","journal-title":"Genome Med"},{"key":"10.1016\/j.clon.2014.02.001_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1053-4296(05)80034-7","article-title":"Patient to patient variability in the expression of radiation-induced normal tissue injury","volume":"4","author":"Bentzen","year":"1994","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-8140(02)00154-8","article-title":"Does variability in normal tissue reactions after radiotherapy have a genetic basis \u2013 where and how to look for it?","volume":"64","author":"Andreassen","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-8140(01)00491-1","article-title":"Studies on radiosensitivity from an epidemiological point of view - overview of methods and results","volume":"62","author":"Twardella","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/095530098141915","article-title":"Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer","volume":"73","author":"Russell","year":"1998","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.clon.2014.02.001_bib8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.clon.2011.04.011","article-title":"The Cambridge Breast Intensity-modulated Radiotherapy Trial: patient- and treatment-related factors that influence late toxicity","volume":"23","author":"Barnett","year":"2011","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib9","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/02841860152619115","article-title":"The inherited basis of human radiosensitivity","volume":"40","author":"Gatti","year":"2001","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0167-8140(98)00014-0","article-title":"Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients","volume":"47","author":"Ramsay","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0360-3016(01)02690-6","article-title":"Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy","volume":"52","author":"Safwat","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00439-008-0500-1","article-title":"Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation","volume":"123","author":"Finnon","year":"2008","journal-title":"Hum Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/mutage\/geq059","article-title":"Heritability of baseline and induced micronucleus frequencies","volume":"26","author":"Surowy","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.clon.2014.02.001_bib14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1086\/302544","article-title":"Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?","volume":"65","author":"Roberts","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3109\/09553002.2010.496027","article-title":"The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring","volume":"86","author":"Curwen","year":"2010","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.clon.2014.02.001_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0360-3016(01)01575-9","article-title":"Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix","volume":"51","author":"West","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg1746","article-title":"The role of double-strand break repair \u2013 insights from human genetics","volume":"7","author":"O'Driscoll","year":"2006","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/258427a0","article-title":"Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity","volume":"258","author":"Taylor","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.clon.2014.02.001_bib19","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1038\/sj.onc.1210872","article-title":"Activation and regulation of ATM kinase activity in response to DNA double-strand breaks","volume":"26","author":"Lee","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.clon.2014.02.001_bib20","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.281.5383.1677","article-title":"Activation of the ATM kinase by ionizing radiation and phosphorylation of p53","volume":"281","author":"Canman","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.clon.2014.02.001_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.dnarep.2010.12.002","article-title":"Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly","volume":"10","author":"Matsumoto","year":"2011","journal-title":"DNA Repair"},{"key":"10.1016\/j.clon.2014.02.001_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ajhg.2009.04.010","article-title":"Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder","volume":"84","author":"Waltes","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrm2851","article-title":"Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis","volume":"11","author":"Moynahan","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.clon.2014.02.001_bib24","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1038\/sj.onc.1206679","article-title":"Regulation and mechanisms of mammalian double-strand break repair","volume":"22","author":"Valerie","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.clon.2014.02.001_bib25","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1007\/s00018-010-0485-5","article-title":"Functions of disordered regions in mammalian early base excision repair proteins","volume":"67","author":"Hedge","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.clon.2014.02.001_bib26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1667\/RR2220.1","article-title":"Sensitivity to low-dose\/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species","volume":"175","author":"Aykin-Burns","year":"2011","journal-title":"Radiat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nrc1950","article-title":"Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology","volume":"6","author":"Bentzen","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1634\/theoncologist.2009-S101","article-title":"Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy","volume":"15","author":"Anscher","year":"2010","journal-title":"Oncologist"},{"key":"10.1016\/j.clon.2014.02.001_bib29","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0360-3016(00)00728-8","article-title":"Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients","volume":"48","author":"Leong","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-8140(02)00167-6","article-title":"Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations","volume":"64","author":"Borgmann","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.radonc.2009.06.015","article-title":"Genetic variants and normal tissue toxicity after radiotherapy: a systematic review","volume":"92","author":"Andreassen","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mrfmmm.2008.10.014","article-title":"Genetic variation in normal tissue toxicity induced by ionizing radiation","volume":"667","author":"Popanda","year":"2009","journal-title":"Mutat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib33","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1158\/1078-0432.CCR-04-2657","article-title":"Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients","volume":"11","author":"Chang-Claude","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clon.2014.02.001_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1748-717X-7-65","article-title":"Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy","volume":"7","author":"Raabe","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mrfmmm.2009.11.009","article-title":"DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients","volume":"684","author":"Sterpone","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijrobp.2007.06.021","article-title":"Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients","volume":"69","author":"Suga","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-8-31","article-title":"XRCC1 codon 399Gln polymorphism is associated with radiotherapy-induced acute dermatitis and mucositis in nasopharyngeal carcinoma patients","volume":"8","author":"Li","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.radonc.2011.05.062","article-title":"Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer","volume":"99","author":"Pratesi","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/09553000600876637","article-title":"Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM\u2013a study based on DNA from formalin fixed paraffin embedded tissue samples","volume":"82","author":"Andreassen","year":"2006","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.clon.2014.02.001_bib40","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/sj.bjc.6605036","article-title":"Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer","volume":"100","author":"Chang-Claude","year":"2009","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2010.01.016","article-title":"Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity","volume":"97","author":"Zschenker","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib42","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/sj.bjc.6603637","article-title":"The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes","volume":"96","author":"Giotopoulos","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib43","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1667\/RR1769.1","article-title":"Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes","volume":"173","author":"Alsbeih","year":"2010","journal-title":"Radiat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib44","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/1471-2407-11-291","article-title":"Dose and polymorphic genes XRCC1, XRCC3, GST play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery","volume":"11","author":"Falvo","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib45","first-page":"1168","article-title":"Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy","volume":"12","author":"Moullan","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.clon.2014.02.001_bib46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1667\/RR1219.1","article-title":"Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer","volume":"170","author":"Burri","year":"2008","journal-title":"Radiat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.radonc.2011.01.021","article-title":"Association between single nucleotide polymorphisms in the gene for XRCC1 and radiation-induced late toxicity in prostate cancer patients","volume":"98","author":"Langsenlehner","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib48","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1158\/1078-0432.CCR-08-0700","article-title":"Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy","volume":"14","author":"Azria","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clon.2014.02.001_bib49","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ijrobp.2012.02.018","article-title":"Variation in telangiectasia predisposing genes is associated with overall radiation toxicity","volume":"84","author":"Tanteles","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib50","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.ijrobp.2007.02.052","article-title":"A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy","volume":"68","author":"Cesaretti","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib51","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ijrobp.2007.07.2240","article-title":"A validation study to examine the correlation between possession of variants in the ATM gene with the development of erectile dysfunction in prostate cancer patients treated with radiotherapy","volume":"69","author":"Rosenstein","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib52","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/bcr1526","article-title":"Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study","volume":"8","author":"Ambrosone","year":"2006","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.clon.2014.02.001_bib53","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/ijc.23138","article-title":"Genetic predictors of long-term toxicities after radiation therapy for breast cancer","volume":"122","author":"Kuptsova","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib54","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/ijc.23854","article-title":"Refining the evidence for GSTA1 and eNOS genetic effects on risk of radiotherapy-induced telangiectasia","volume":"123","author":"Giotopoulos","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib55","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2004.12.012","article-title":"TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer","volume":"75","author":"Andreassen","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.radonc.2003.09.010","article-title":"Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes","volume":"69","author":"Andreassen","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib57","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/0955300021000045673","article-title":"Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients","volume":"79","author":"Quarmby","year":"2003","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.clon.2014.02.001_bib58","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radonc.2009.12.006","article-title":"No association between SNPs regulating TGF-\u03b21 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study","volume":"97","author":"Barnett","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib59","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.radonc.2012.01.015","article-title":"TGF\u03b21 SNPs and radio-induced toxicity in prostate cancer patients","volume":"103","author":"Fachal","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib60","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.radonc.2012.10.017","article-title":"Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity","volume":"105","author":"Barnett","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1470-2045(11)70302-3","article-title":"Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study","volume":"13","author":"Barnett","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib62","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.radonc.2009.12.007","article-title":"Establishment of a radiogenomics consortium","volume":"94","author":"West","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib63","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/bjc.2012.290","article-title":"A replicated association between polymorphisms near TNF-alpha and risk for adverse reactions to radiotherapy","volume":"107","author":"Talbot","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib64","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature09298","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.clon.2014.02.001_bib65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng.1049","article-title":"Genome-wide association analysis identifies three new breast cancer susceptibility loci","volume":"44","author":"Ghoussaini","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib66","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/bjc.2011.118","article-title":"Polygenic susceptibility to prostate and breast cancer: implications for personalised screening","volume":"104","author":"Pashayan","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2014.02.001_bib67","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrg3046","article-title":"Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data","volume":"12","author":"Cooper","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.clon.2014.02.001_bib68","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.ijrobp.2012.08.003","article-title":"A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiation therapy for prostate cancer","volume":"85","author":"Kerns","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2014.02.012","article-title":"A Genome Wide Association Study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity","author":"Barnett","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib70","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0360-3016(95)00059-8","article-title":"Late Effects Working Group: late effects toxicity scoring: the SOMA scale","volume":"31","author":"Pavy","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1015296607061","article-title":"Breast cancer acute radiotherapy morbidity evaluated by different scoring systems","volume":"73","author":"L\u00f3pez","year":"2002","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clon.2014.02.001_bib72","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.radonc.2011.05.007","article-title":"Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy","volume":"99","author":"Murray","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2014.02.001_bib73","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ijrobp.2011.03.015","article-title":"Standardized Total Average Toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies","volume":"82","author":"Barnett","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2014.02.001_bib74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygeno.2011.11.001","article-title":"Common copy number variations in fifty radiosensitive cell lines","volume":"99","author":"Li","year":"2012","journal-title":"Genomics"},{"key":"10.1016\/j.clon.2014.02.001_bib75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1667\/RR2524.1","article-title":"Transcriptional response of ex vivo human skin to ionizing radiation: comparison between low- and high-dose effects","volume":"177","author":"Albrecht","year":"2012","journal-title":"Radiat Res"},{"key":"10.1016\/j.clon.2014.02.001_bib76","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2010.12.006","article-title":"A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects","volume":"302","author":"Mayer","year":"2011","journal-title":"Cancer Lett"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655514000685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655514000685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:41:02Z","timestamp":1760542862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655514000685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0936655514000685"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2014.02.001","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Finding the Genetic Determinants of Adverse Reactions to\u00a0Radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2014.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}