{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:52:44Z","timestamp":1775811164093,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.clon.2016.04.039","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T11:31:11Z","timestamp":1462447871000},"page":"604-610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intensity-modulated Radiotherapy and Anal Cancer: Clinical Outcome and Late Toxicity Assessment"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-0366","authenticated-orcid":false,"given":"I.","family":"De Francesco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wedlake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.clon.2016.04.039_bib1","first-page":"1082","article-title":"Intensity-modulated radiation therapy for anal cancer","volume":"23","author":"Czito","year":"2009","journal-title":"Oncology"},{"issue":"2","key":"10.1016\/j.clon.2016.04.039_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.radonc.2009.07.006","article-title":"A\u00a0multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy","volume":"93","author":"Devisetty","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1748-717X-2-41","article-title":"Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal carcinoma: a comparison of conventional and IMRT plans","volume":"2","author":"Menkarios","year":"2007","journal-title":"Radiat Oncol"},{"issue":"5","key":"10.1016\/j.clon.2016.04.039_bib4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ijrobp.2009.09.046","article-title":"Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis","volume":"78","author":"Pepek","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.clon.2016.04.039_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijrobp.2010.09.030","article-title":"Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy","volume":"82","author":"Kachnic","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.04.039_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijrobp.2012.09.023","article-title":"RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal","volume":"86","author":"Kachnic","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.04.039_bib7","first-page":"815","article-title":"Intensity-modulated radiation therapy for anal cancer: toxicity versus outcomes","volume":"9","author":"Zagar","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.clon.2016.04.039_bib8","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ijrobp.2013.07.041","article-title":"Preliminary toxicity analysis of 3-dimensional conformal radiation therapy versus intensity modulated radiation therapy on the high-dose arm of the Radiation Therapy Oncology Group 0126 prostate cancer trial","volume":"87","author":"Michalski","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.clon.2016.04.039_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"PARSPORT trial management group. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cncr.11489","article-title":"A\u00a0survey of intensity-modulated radiation therapy use in the United States","volume":"98","author":"Mell","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2016.04.039_bib11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s00268-003-7105-6","article-title":"Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer","volume":"27","author":"Eisbruch","year":"2003","journal-title":"World J Surg"},{"key":"10.1016\/j.clon.2016.04.039_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1053\/srao.2002.00000","article-title":"Intensity-modulated radiation therapy for prostate cancer","volume":"12","author":"Zelefsky","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib13","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/S0360-3016(01)02785-7","article-title":"Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies","volume":"52","author":"Mundt","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.04.039_bib14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clon.2011.09.014","article-title":"Concurrent chemotherapy and intensity-modulated radiation therapy for anal carcinoma \u2013 clinical outcomes in a large National Cancer Institute-designated integrated cancer centre network","volume":"6","author":"DeFoe","year":"2012","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib15","first-page":"39","article-title":"Intensity-modulated radiation therapy vs. 3D conformal radiation therapy for squamous cell carcinoma of the anal canal","volume":"2","author":"Chuong","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"10.1016\/j.clon.2016.04.039_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.radonc.2008.04.011","article-title":"The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer","volume":"87","author":"Saarilahti","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib17","first-page":"4581","article-title":"Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience","volume":"29","author":"Salama","year":"2007","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1748-717X-7-45","article-title":"IMRT for locally advanced anal cancer: clinical experience of the Montpellier Cancer Center","volume":"7","author":"Vieillot","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S1470-2045(13)70086-X","article-title":"Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT 11): a randomised, phase 3, open-label, 2 x 2 factorial trial","volume":"6","author":"James","year":"2013","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.clon.2016.04.039_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0895-4356(99)00152-3","article-title":"The UK IBDQ \u2013 a British version of the Inflammatory Bowel Disease questionnaire: development and validation","volume":"53","author":"Cheung","year":"2000","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"9","key":"10.1016\/j.clon.2016.04.039_bib21","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/sj.bjc.6602552","article-title":"A\u00a0modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence Questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy","volume":"92","author":"Olopade","year":"2005","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.clon.2016.04.039_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0167-8140(03)00190-7","article-title":"The impact of radiotherapy for carcinoma of the cervix on sexual function assessed using the LENT SOMA scales","volume":"68","author":"Davidson","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clon.2013.08.003","article-title":"The effects of pelvic radiotherapy on cancer survivors: symptom profile, psychological morbidity and quality of life","volume":"26","author":"Adams","year":"2014","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clon.2012.08.008","article-title":"Organ-sparing intensity-modulated radiotherapy for anal cancer using the ACTII schedule: a comparison of conventional and intensity-modulated radiotherapy plans","volume":"25","author":"Brooks","year":"2013","journal-title":"Clin Oncol"},{"key":"10.1016\/j.clon.2016.04.039_bib25","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1056\/NEJMoa067423","article-title":"A\u00a0study of sexuality and health among older adults in the United States","volume":"357","author":"Lindau","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.clon.2016.04.039_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.clon.2015.06.018","article-title":"Sexual difficulties after pelvic radiotherapy: improving clinical management","volume":"27","author":"White","year":"2015","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655516300668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655516300668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:42:59Z","timestamp":1760542979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655516300668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0936655516300668"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2016.04.039","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intensity-modulated Radiotherapy and Anal Cancer: Clinical Outcome and Late Toxicity Assessment","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2016.04.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}