{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:38:41Z","timestamp":1777181921508,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Clatterbridge Cancer Charity"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.clon.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T12:59:38Z","timestamp":1475326778000},"page":"6-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Twenty Fraction Prostate Radiotherapy with Intra-prostatic Boost: Results of a Pilot Study"],"prefix":"10.1016","volume":"29","author":[{"given":"E.","family":"Onjukka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Uzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nahum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Syndikus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2016.09.009_bib1","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ijrobp.2008.10.091","article-title":"Higher-than-conventional radiation doses in localized prostate cancer treatment: a meta-analysis of randomized, controlled trials","volume":"74","author":"Viani","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.radonc.2013.09.026","article-title":"Long-term results of the Dutch randomized prostate cancer trial: impact of dose-escalation on local, biochemical, clinical failure, and survival","volume":"110","author":"Heemsbergen","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ijrobp.2014.01.015","article-title":"Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial","volume":"88","author":"Hoffman","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ijrobp.2008.01.040","article-title":"Intensity-modulated radiotherapy as primary therapy for prostate cancer: report on acute toxicity after dose escalation with simultaneous integrated boost to intraprostatic lesion","volume":"72","author":"Fonteyne","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/COC.0b013e318209cd8f","article-title":"Intensity-modulated radiotherapy with simultaneous integrated boost to dominant intraprostatic lesion: preliminary report on toxicity","volume":"35","author":"Ippolito","year":"2012","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ijrobp.2014.12.052","article-title":"Volumetric modulated arc therapy planning for primary prostate cancer with selective intraprostatic boost determined by 18F-choline PET\/CT","volume":"91","author":"Kuang","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijrobp.2009.07.1689","article-title":"Hypofractionated boost to the dominant tumor region with intensity modulated stereotactic radiotherapy for prostate cancer: a sequential dose escalation pilot study","volume":"78","author":"Miralbell","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1748-717X-7-14","article-title":"Dose-escalation using intensity-modulated radiotherapy for prostate cancer \u2013 evaluation of quality of life with and without (18)F-choline PET-CT detected simultaneous integrated boost","volume":"7","author":"Pinkawa","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib9","first-page":"170","article-title":"Early outcome of prostate intensity modulated radiation therapy (IMRT) incorporating a simultaneous intra-prostatic MRI directed boost","volume":"3","author":"Schild","year":"2014","journal-title":"OMICS J Radiol"},{"key":"10.1016\/j.clon.2016.09.009_bib10","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1016\/j.ijrobp.2011.01.048","article-title":"Image-guided radiotherapy for prostate cancer: a prospective trial of concomitant boost using indium-111-capromab pendetide (ProstaScint) imaging","volume":"81","author":"Wong","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1745-6215-12-255","article-title":"Single blind randomized phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial","volume":"12","author":"Lips","year":"2011","journal-title":"Trials"},{"key":"10.1016\/j.clon.2016.09.009_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.clon.2015.06.015","article-title":"Functional radiotherapy targeting using focused dose escalation","volume":"27","author":"Alonzi","year":"2015","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2016.09.009_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.radonc.2013.04.027","article-title":"Boosting imaging defined dominant prostatic tumors: a systematic review","volume":"107","author":"Bauman","year":"2013","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.clon.2016.09.009_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clgc.2015.12.005","article-title":"Radiotherapy boost for the dominant intraprostatic cancer lesion \u2013 a systematic review and meta-analysis","volume":"14","author":"von Eyben","year":"2016","journal-title":"Clin Genitourin Cancer"},{"key":"10.1016\/j.clon.2016.09.009_bib15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ejmp.2012.10.002","article-title":"Biological optimization of simultaneous boost on intra-prostatic lesions (DILs): sensitivity to TCP parameters","volume":"29","author":"Azzeroni","year":"2013","journal-title":"Phys Med"},{"key":"10.1016\/j.clon.2016.09.009_bib16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.radonc.2009.08.010","article-title":"Carbon-11 acetate PET\/CT based dose escalated IMRT in prostate cancer","volume":"93","author":"Seppala","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.clon.2015.09.006","article-title":"Prostate dose-painting radiotherapy and radiobiological guided optimisation enhances the therapeutic ratio","volume":"28","author":"Uzan","year":"2016","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2016.09.009_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1470-2045(11)70293-5","article-title":"Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial","volume":"13","author":"Dearnaley","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.clon.2013.05.003","article-title":"Biological dose escalation and hypofractionation: what is there to be gained and how will it best be done?","volume":"25","author":"Tree","year":"2013","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clon.2016.09.009_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.radonc.2013.08.006","article-title":"Hypofractionated intensity-modulated arc therapy for lymph node metastasized prostate cancer: early late toxicity and 3-year clinical outcome","volume":"109","author":"Fonteyne","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0090-4295(00)00858-X","article-title":"Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer","volume":"56","author":"Wei","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.clon.2016.09.009_bib22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1259\/bjr\/20476567","article-title":"Radiobiologically guided optimisation of the prescription dose and fractionation scheme in radiotherapy using BioSuite","volume":"85","author":"Uzan","year":"2012","journal-title":"Br J Radiol"},{"key":"10.1016\/j.clon.2016.09.009_bib23","doi-asserted-by":"crossref","first-page":"329214","DOI":"10.1155\/2012\/329214","article-title":"(Radio)biological optimization of external-beam radiotherapy","volume":"2012","author":"Nahum","year":"2012","journal-title":"Comput Math Methods Med"},{"key":"10.1016\/j.clon.2016.09.009_bib24","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3109\/0284186X.2010.517782","article-title":"Analytical investigation of the possibility of parameter invariant TCP-based radiation therapy plan ranking","volume":"49","author":"Stavreva","year":"2010","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib25","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1016\/j.ijrobp.2008.06.1026","article-title":"Pre-treatment nomograms predicting severe rectal toxicity after prostate cancer 3D-CRT","volume":"72","author":"Rancati","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijrobp.2006.03.034","article-title":"Rectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modeling","volume":"66","author":"Peeters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ijrobp.2010.06.050","article-title":"Parameters favorable to intraprostatic radiation dose escalation in men with localized prostate cancer","volume":"80","author":"Housri","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ijrobp.2014.01.042","article-title":"Prostate stereotactic ablative radiation therapy using volumetric modulated arc therapy to dominant intraprostatic lesions","volume":"89","author":"Murray","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib29","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/S0360-3016(01)01729-1","article-title":"Field size reduction enables iso-NTCP escalation of tumor control probability for irradiation of lung tumors","volume":"51","author":"Engelsman","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.radonc.2014.10.007","article-title":"Dosimetric analysis of urethral strictures following HDR (192)Ir brachytherapy as monotherapy for intermediate- and high-risk prostate cancer","volume":"113","author":"Diez","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib31","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/S0167-8140(15)40088-X","article-title":"OC-0088: Evaluation of dose-predictors of urethral strictures for prostate patients treated with HDR brachytherapy","volume":"115","author":"Panettieri","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib32","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2214\/AJR.11.7805","article-title":"Diffusion-weighted MRI in the detection of prostate cancer: meta-analysis","volume":"199","author":"Tan","year":"2012","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.clon.2016.09.009_bib33","doi-asserted-by":"crossref","first-page":"e691","DOI":"10.1016\/j.ijrobp.2012.01.087","article-title":"Intensity modulated radiation therapy dose painting for localized prostate cancer using 11C-choline positron emission tomography scans","volume":"83","author":"Chang","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2016.09.009_bib34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1748-717X-4-54","article-title":"Systematisation of spatial uncertainties for comparison between a MR and a CT-based radiotherapy workflow for prostate treatments","volume":"4","author":"Nyholm","year":"2009","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2016.09.009_bib35","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ijrobp.2007.11.054","article-title":"Observations on real-time prostate gland motion using electromagnetic tracking","volume":"71","author":"Langen","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093665551630303X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093665551630303X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:42:37Z","timestamp":1760542957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093665551630303X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S093665551630303X"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2016.09.009","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Twenty Fraction Prostate Radiotherapy with Intra-prostatic Boost: Results of a Pilot Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}