{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:18:19Z","timestamp":1762543099958,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.clon.2019.08.003","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:50:58Z","timestamp":1567705858000},"page":"e53-e59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Retrospective Study of the Dosimetric Parameters and Duodenal Toxicity in Patients With Upper Gastrointestinal and Gynaecological Cancers Treated With Radiation Therapy"],"prefix":"10.1016","volume":"32","author":[{"given":"G.","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Phurailatpam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Engineer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2019.08.003_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"Cancer J Clin"},{"issue":"3","key":"10.1016\/j.clon.2019.08.003_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/2278-330X.187585","article-title":"Gastrointestinal cancers in India: treatment perspective","volume":"5","author":"Ghadyalpatil","year":"2016","journal-title":"South Asian J Cancer"},{"key":"10.1016\/j.clon.2019.08.003_bib3","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1200\/JCO.2010.33.8038","article-title":"Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression","volume":"29","author":"Crane","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"10.1016\/j.clon.2019.08.003_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1200\/JCO.2015.61.3778","article-title":"Ablative radiotherapy doses lead to substantial prolongation of survival in patients with inoperable intrahepatic cholangiocarcinoma: a retrospective dose response analysis","volume":"34","author":"Tao","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2019.08.003_bib5","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.ijrobp.2012.02.051","article-title":"A\u00a0phase I\/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer","volume":"84","author":"Ben-Josef","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2019.08.003_bib6","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.ejso.2011.08.128","article-title":"Metastasis to deep obturator and paraaortic lymph nodes in 649 patients with cervical carcinoma","volume":"37","author":"Huang","year":"2011","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2019.08.003_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0360-3016(01)01628-5","article-title":"Isolated paraaortic lymph node recurrence after definitive irradiation for cervical carcinoma","volume":"51","author":"Chou","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.clon.2019.08.003_bib8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijrobp.2004.03.035","article-title":"IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk","volume":"60","author":"Ahmed","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2019.08.003_bib9","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1016\/j.ijrobp.2012.09.035","article-title":"Duodenal toxicity after fractionated chemoradiation for unresectable pancreatic cancer","volume":"85","author":"Kelly","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.clon.2019.08.003_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijrobp.2013.09.053","article-title":"Dosimetric predictors of duodenal toxicity after intensity modulated radiation therapy for treatment of the para-aortic nodes in gynecologic cancer","volume":"88","author":"Verma","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2019.08.003_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00066-013-0343-0","article-title":"Predictive factors for gastroduodenal toxicity based on endoscopy following radiotherapy in patients with hepatocellular carcinoma","volume":"189","author":"Yoon","year":"2013","journal-title":"Strahlenther Onkol"},{"issue":"2","key":"10.1016\/j.clon.2019.08.003_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.prro.2013.06.004","article-title":"Upper abdominal normal organ contouring guidelines and atlas: a Radiation Therapy Oncology Group consensus","volume":"4","author":"Jabbour","year":"2014","journal-title":"Pract Radiat Oncol"},{"year":"2009","series-title":"Common terminology criteria for adverse events v4.0","key":"10.1016\/j.clon.2019.08.003_bib13"},{"key":"10.1016\/j.clon.2019.08.003_bib14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.radonc.2009.05.017","article-title":"Predictive factors of gastroduodenal toxicity in cirrhotic patients after three-dimensional conformal radiotherapy for hepatocellular carcinoma","volume":"93","author":"Kim","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2019.08.003_bib15","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijrobp.2011.09.022","article-title":"Dose-volume analysis of predictors for gastrointestinal toxicity after concurrent full-dose gemcitabine and radiotherapy for locally advanced pancreatic adenocarcinoma","volume":"83","author":"Huang","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2019.08.003_bib16","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijrobp.2011.12.026","article-title":"Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy","volume":"84","author":"Nakamura","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2019.08.003_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.radonc.2013.05.011","article-title":"Dosimetric and clinical predictors of toxicity following combined chemotherapy and moderately hypofractionated rotational radiotherapy of locally advanced pancreatic adenocarcinoma","volume":"108","author":"Cattaneo","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2019.08.003_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.radonc.2017.04.024","article-title":"Modelling duodenum radiotherapy toxicity using cohort dose-volume-histogram data","volume":"123","author":"Holyoake","year":"2017","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.clon.2019.08.003_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.clon.2018.02.067","article-title":"Stomach dose-volume predicts acute gastrointestinal toxicity in chemoradiotherapy for locally advanced pancreatic cancer","volume":"30","author":"Holyoake","year":"2018","journal-title":"Clin Oncol"},{"issue":"3","key":"10.1016\/j.clon.2019.08.003_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.12998\/wjcc.v3.i3.231","article-title":"Gall bladder carcinoma: aggressive malignancy with protean loco-regional and distant spread","volume":"3","author":"Nandan","year":"2015","journal-title":"World J Clin Cases"},{"issue":"3","key":"10.1016\/j.clon.2019.08.003_bib21","first-page":"157","article-title":"The role of radiotherapy in management of pancreatic cancer","volume":"2","author":"Wang","year":"2011","journal-title":"J\u00a0Gastrointest Oncol"},{"issue":"9","key":"10.1016\/j.clon.2019.08.003_bib22","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1245\/s10434-016-5197-0","article-title":"Neoadjuvant chemoradiation followed by surgery for locally advanced gallbladder cancers: a new paradigm","volume":"23","author":"Engineer","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.clon.2019.08.003_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.21037\/jgo.2017.01.20","article-title":"High dose chemoradiation for unresectable hilar cholangiocarcinomas using intensity modulated external beam radiotherapy: a single tertiary care centre experience","volume":"8","author":"Engineer","year":"2017","journal-title":"J\u00a0Gastrointest Oncol"},{"issue":"5","key":"10.1016\/j.clon.2019.08.003_bib24","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ijrobp.2009.09.075","article-title":"A\u00a0dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer","volume":"78","author":"Murphy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655519303395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655519303395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:46:40Z","timestamp":1760543200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655519303395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0936655519303395"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2019.08.003","relation":{},"ISSN":["0936-6555"],"issn-type":[{"type":"print","value":"0936-6555"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Retrospective Study of the Dosimetric Parameters and Duodenal Toxicity in Patients With Upper Gastrointestinal and Gynaecological Cancers Treated With Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2019.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}