{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:10:31Z","timestamp":1793711431582,"version":"4.6.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009491","name":"St Mark&apos;s Hospital Foundation","doi-asserted-by":"publisher","award":["1140930"],"award-info":[{"award-number":["1140930"]}],"id":[{"id":"10.13039\/501100009491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.clon.2021.05.011","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T06:25:49Z","timestamp":1623911149000},"page":"e540-e552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Body Composition and Dose-limiting Toxicity in Colorectal Cancer Chemotherapy Treatment; a Systematic Review of the Literature. Could Muscle Mass be the New Body Surface Area in Chemotherapy Dosing?"],"prefix":"10.1016","volume":"33","author":[{"given":"I.","family":"Drami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-9762","authenticated-orcid":false,"given":"E.T.","family":"Pring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8014-3762","authenticated-orcid":false,"given":"L.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Malietzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Naghibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Athanasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Glynne-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-9409","authenticated-orcid":false,"given":"J.T.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2021.05.011_bib1","series-title":"Incidence","year":"2018"},{"key":"10.1016\/j.clon.2021.05.011_bib2","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/annonc\/mdx271","article-title":"Forcing the vicious circle: sarcopenia increases toxicity, decreases response to chemotherapy and worsens with chemotherapy","volume":"28","author":"Bozzetti","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.clon.2021.05.011_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-014-0135-0","article-title":"Muscle wasting disease: a proposal for a new disease classification","volume":"5","author":"Anker","year":"2014","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jcsm.12483","article-title":"Sarcopenia: a time for action. An SCWD Position Paper","volume":"10","author":"Bauer","year":"2019","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/bjs.10075","article-title":"Influence of body composition profile on outcomes following colorectal cancer surgery","volume":"103","author":"Malietzis","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2021.05.011_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jcsm.12529","article-title":"Low skeletal muscle mass and postoperative morbidity in surgical oncology: a systematic review and meta-analysis","volume":"11","author":"Weerink","year":"2020","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib8","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1245\/s10434-016-5188-1","article-title":"Skeletal muscle changes after elective colorectal cancer resection: a longitudinal study","volume":"23","author":"Malietzis","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/archinte.1916.00080130010002","article-title":"A\u00a0formula to estimate the surface area if height and weight are known","author":"du bois","year":"1916","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clon.2021.05.011_bib10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1056\/NEJM198804283181717","article-title":"More on simplified calculation of body-surface area","volume":"318","author":"Lam","year":"1988","journal-title":"New Engl J Med"},{"key":"10.1016\/j.clon.2021.05.011_bib11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-nutr-082117-051723","article-title":"The obesity paradox in cancer: how important is muscle?","volume":"38","author":"Cespedes Feliciano","year":"2018","journal-title":"Ann Rev Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/11598930-000000000-00000","article-title":"The relationship between drug clearance and body size: systematic review and meta-analysis of the literature published from 2000 to 2007","volume":"51","author":"McLeay","year":"2012","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.clon.2021.05.011_bib14","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/annonc\/mdp605","article-title":"Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma","volume":"21","author":"Antoun","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib15","series-title":"Common terminology criteria for adverse events (CTCAE).v.5.0","first-page":"183","year":"1999"},{"key":"10.1016\/j.clon.2021.05.011_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejso.2014.11.040","article-title":"Sarcopenia is associated with toxicity in patients undergoing neo-adjuvant chemotherapy for oesophago-gastric cancer","volume":"41","author":"Tan","year":"2015","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib17","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","article-title":"Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment","volume":"15","author":"Prado","year":"2009","journal-title":"Clin Canc Res"},{"key":"10.1016\/j.clon.2021.05.011_bib18","first-page":"e129","article-title":"Drug dose per kilogram lean body mass predicts hematologic toxicity from carboplatin-doublet chemotherapy in advanced non-small-cell lung cancer","volume":"18","author":"Sj\u00f8blom","year":"2017","journal-title":"Clin Lung Canc"},{"key":"10.1016\/j.clon.2021.05.011_bib19","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.clnesp.2016.04.001","article-title":"Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel","volume":"13","author":"Cushen","year":"2016","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clon.2021.05.011_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037563","article-title":"Sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinoma","volume":"7","author":"Mir","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clon.2021.05.011_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLOS Med"},{"key":"10.1016\/j.clon.2021.05.011_bib22","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/bmj.323.7308.334","article-title":"A\u00a0new system for grading recommendations in evidence based guidelines","volume":"323","author":"Harbour","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.clon.2021.05.011_bib23","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1245\/s10434-016-5360-7","article-title":"Sarcopenia is associated with chemotherapy toxicity in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer","volume":"23","author":"Chemama","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib24","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1245\/s10434-015-4429-z","article-title":"Skeletal muscle depletion is associated with severe postoperative complications in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer","volume":"22","author":"van Vugt","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib25","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1158\/1078-0432.CCR-06-3067","article-title":"Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity","volume":"13","author":"Prado","year":"2007","journal-title":"Clin Canc Res"},{"key":"10.1016\/j.clon.2021.05.011_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/01635581.2014.894103","article-title":"Sarcopenia is linked to treatment toxicity in patients with metastatic colorectal cancer","volume":"66","author":"Barret","year":"2014","journal-title":"Nutr Canc"},{"key":"10.1016\/j.clon.2021.05.011_bib27","first-page":"687","article-title":"Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy","volume":"23","author":"Jung","year":"2014","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/cam4.621","article-title":"Lean body mass as an independent determinant of dose-limiting toxicity and neuropathy in patients with colon cancer treated with FOLFOX regimens","volume":"5","author":"Ali","year":"2016","journal-title":"Canc Med"},{"key":"10.1016\/j.clon.2021.05.011_bib29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1200\/JCO.2015.63.6043","article-title":"Loss of muscle mass during chemotherapy is predictive for poor survival of patients with metastatic colorectal cancer","volume":"34","author":"Blauwhoff-Buskermolen","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib30","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1002\/cncr.30950","article-title":"Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: the C-SCANS study","volume":"123","author":"Cespedes Feliciano","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-018-4860-1","article-title":"Dynapenia could predict chemotherapy-induced dose-limiting neurotoxicity in digestive cancer patients","volume":"18","author":"Botsen","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00280-017-3487-2","article-title":"The impact of skeletal muscle on the pharmacokinetics and toxicity of 5-fluorouracil in colorectal cancer","volume":"81","author":"Williams","year":"2018","journal-title":"Canc Chemother Pharmacol"},{"key":"10.1016\/j.clon.2021.05.011_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jcsm.12391","article-title":"Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? A prospective study","volume":"10","author":"da Rocha","year":"2019","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/jcsm.12436","article-title":"Skeletal muscle mass loss and dose-limiting toxicities in metastatic colorectal cancer patients","volume":"10","author":"Kurk","year":"2019","journal-title":"J\u00a0Cachexia, Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jamcollsurg.2010.03.039","article-title":"Sarcopenia and mortality after liver transplantation","volume":"211","author":"Englesbe","year":"2010","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.clon.2021.05.011_bib36","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A\u00a0practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care","volume":"33","author":"Mourtzakis","year":"2008","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.clon.2021.05.011_bib37","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2021.05.011_bib38","first-page":"78","article-title":"Low muscle attenuation is a prognostic factor for survival in metastatic breast cancer patients treated with first line palliative chemotherapy","volume":"32","author":"Rier","year":"2017","journal-title":"Breast"},{"key":"10.1016\/j.clon.2021.05.011_bib39","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jcsm.12575","article-title":"Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta-analysis","volume":"11","author":"Lee","year":"2020","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib40","doi-asserted-by":"crossref","first-page":"102839","DOI":"10.1016\/j.critrevonc.2019.102839","article-title":"Myosteatosis and prognosis in cancer: systematic review and meta-analysis","volume":"145","author":"Aleixo","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.clon.2021.05.011_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0129742","article-title":"Negative impact of skeletal muscle loss after systemic chemotherapy in patients with unresectable colorectal cancer","volume":"10","author":"Miyamoto","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clon.2021.05.011_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","article-title":"Epidemiology of sarcopenia among the elderly in New Mexico","volume":"147","author":"Baumgartner","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clon.2021.05.011_bib43","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41430-017-0034-5","article-title":"Percentiles for skeletal muscle index, area and radiation attenuation based on computed tomography imaging in a healthy Caucasian population","volume":"72","author":"van der Werf","year":"2018","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00774-013-0468-3","article-title":"A\u00a0cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: reference values, prevalence, and association with bone mass","volume":"32","author":"Cheng","year":"2014","journal-title":"J\u00a0Bone Mineral Metab"},{"key":"10.1016\/j.clon.2021.05.011_bib45","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.nut.2016.04.003","article-title":"Proposal for new diagnostic criteria for low skeletal muscle mass based on computed tomography imaging in Asian adults","volume":"32","author":"Hamaguchi","year":"2016","journal-title":"Nutrition"},{"key":"10.1016\/j.clon.2021.05.011_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-011-0025-7","article-title":"Myopenia \u2013 a new universal term for muscle wasting","volume":"2","author":"Fearon","year":"2011","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/jappl.2000.89.1.81","article-title":"Skeletal muscle mass and distribution in 468 men and women aged 18\u201388 yr","volume":"89","author":"Janssen","year":"2000","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clon.2021.05.011_bib48","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/jcsm.12337","article-title":"Impact of different palliative systemic treatments on skeletal muscle mass in metastatic colorectal cancer patients","volume":"9","author":"Kurk","year":"2018","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib49","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jcsm.12267","article-title":"Loss of skeletal muscle during systemic chemotherapy is prognostic of poor survival in patients with foregut cancer","volume":"9","author":"Daly","year":"2018","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib50","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.biocel.2013.05.032","article-title":"Muscle wasting in cancer","volume":"45","author":"Johns","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.clon.2021.05.011_bib51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1152\/jappl.2000.89.1.104","article-title":"Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content","volume":"89","author":"Goodpaster","year":"2000","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clon.2021.05.011_bib52","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1152\/jappl.2001.90.6.2157","article-title":"Attenuation of skeletal muscle and strength in the elderly: the health ABC study","volume":"90","author":"Goodpaster","year":"2001","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clon.2021.05.011_bib53","doi-asserted-by":"crossref","first-page":"327167","DOI":"10.1155\/2013\/327167","article-title":"Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress","volume":"2013","author":"Lee","year":"2013","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.clon.2021.05.011_bib54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13539-011-0030-x","article-title":"Intramyocellular lipid droplets increase with progression of cachexia in cancer patients","volume":"2","author":"Stephens","year":"2011","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clon.2021.05.011_bib55","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.clnu.2017.07.007","article-title":"Contrast-enhancement influences skeletal muscle density, but not skeletal muscle mass, measurements on computed tomography","volume":"37","author":"van Vugt","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib56","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00256-004-0825-3","article-title":"Compositional analysis of muscle in boys with Duchenne muscular dystrophy using MR imaging","volume":"34","author":"Marden","year":"2005","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.clon.2021.05.011_bib57","first-page":"e1106","article-title":"Chemotherapy dosing and toxicity in a patient with muscular dystrophy","volume":"1","author":"Lomma","year":"2018","journal-title":"Canc Rep"},{"key":"10.1016\/j.clon.2021.05.011_bib58","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<796::AID-CNCR10>3.0.CO;2-P","article-title":"The predictive value of body protein for chemotherapy-induced toxicity","volume":"88","author":"Aslani","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib59","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2165\/00003088-199426040-00005","article-title":"Lean body mass as a predictor of drug dosage: implications for drug therapy","volume":"26","author":"Morgan","year":"1994","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.clon.2021.05.011_bib60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2125.2002.01598.x","article-title":"Relationships between body composition parameters and fluorouracil pharmacokinetics","volume":"54","author":"Gusella","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.clon.2021.05.011_bib61","first-page":"1257","article-title":"Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study","volume":"25","author":"Crosby","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib62","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2133\/dmpk.21.357","article-title":"Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes","volume":"21","author":"Nishimura","year":"2006","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1016\/j.clon.2021.05.011_bib63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/pharmaceutics11050199","article-title":"DPYD and fluorouracil-based chemotherapy: mini review and case report","volume":"11","author":"Wigle","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.clon.2021.05.011_bib64","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/sj.bjc.6690098","article-title":"Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity","volume":"79","author":"Milano","year":"1999","journal-title":"Br J Canc"},{"key":"10.1016\/j.clon.2021.05.011_bib65","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/bjc.2013.262","article-title":"Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity","volume":"108","author":"Loganayagam","year":"2013","journal-title":"Br J Canc"},{"key":"10.1016\/j.clon.2021.05.011_bib66","article-title":"DPYD variants as predictors of 5-fluorouracil toxicity in adjuvant colon cancer treatment (NCCTG N0147)","volume":"106","author":"Lee","year":"2014","journal-title":"J\u00a0Natl Canc Inst"},{"key":"10.1016\/j.clon.2021.05.011_bib67","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/jnci\/djaa124","article-title":"Sex and adverse events of adjuvant chemotherapy in colon cancer: an analysis of 34,640 patients in the ACCENT database","volume":"113","author":"Wagner","year":"2020","journal-title":"J\u00a0Natl Canc Inst"},{"key":"10.1016\/j.clon.2021.05.011_bib68","first-page":"183","article-title":"Skeletal muscle: a brief review of structure and function","volume":"45","author":"Frontera","year":"2015","journal-title":"Behav Genet"},{"key":"10.1016\/j.clon.2021.05.011_bib69","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3945\/ajcn.2008.27273","article-title":"A\u00a0viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands","volume":"89","author":"Lieffers","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib70","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.clnu.2020.01.009","article-title":"The effect of nutritional counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy: a randomized controlled trial","volume":"39","author":"van der Werf","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib71","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.clnu.2014.11.005","article-title":"Omega-3 supplements for patients in chemotherapy and\/or radiotherapy: a systematic review","volume":"34","author":"de Aguiar Pastore Silva","year":"2015","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clon.2021.05.011_bib72","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00384-008-0593-y","article-title":"Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer","volume":"24","author":"Fakih","year":"2009","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.clon.2021.05.011_bib73","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1210\/jc.2014-1742","article-title":"The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials","volume":"99","author":"Beaudart","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clon.2021.05.011_bib74","first-page":"2159","article-title":"Exercise improves functional capacity and lean body mass in patients with gastrointestinal cancer during chemotherapy: a single-blind RCT","volume":"27","author":"Stuecher","year":"2019","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clon.2021.05.011_bib75","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10151-020-02262-1","article-title":"Does prehabilitation modify muscle mass in patients with rectal cancer undergoing neoadjuvant therapy? A subanalysis from the REx randomised controlled trial","volume":"24","author":"Moug","year":"2020","journal-title":"Techn Coloproctol"},{"key":"10.1016\/j.clon.2021.05.011_bib76","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jcsm.12268","article-title":"Pitfalls in the measurement of muscle mass: a need for a reference standard","volume":"9","author":"Buckinx","year":"2018","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655521001886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655521001886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:07:58Z","timestamp":1778558878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655521001886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0936655521001886"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2021.05.011","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Body Composition and Dose-limiting Toxicity in Colorectal Cancer Chemotherapy Treatment; a Systematic Review of the Literature. Could Muscle Mass be the New Body Surface Area in Chemotherapy Dosing?","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2021.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}