{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:08:25Z","timestamp":1770836905711,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.clon.2022.09.055","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T01:34:54Z","timestamp":1665797694000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Organ Preservation in Rectal Cancer: An Overview of the Dutch Perspective and Recent Developments"],"prefix":"10.1016","volume":"35","author":[{"given":"A.E.","family":"Verrijssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.J.","family":"Ketelaers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.T.","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Theuws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.A.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Cnossen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2022.09.055_bib1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1470-2045(08)70129-3","article-title":"Controversies of total mesorectal excision for rectal cancer in elderly patients","volume":"9","author":"Rutten","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib2","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.ejso.2019.06.017","article-title":"Significant improvement in postoperative and 1-year mortality after colorectal cancer surgery in recent years","volume":"45","author":"Ketelaers","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib3","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/codi.15542","article-title":"Age-related differences in morbidity and mortality after surgery for primary clinical T4 and locally recurrent rectal cancer","volume":"23","author":"Ketelaers","year":"2021","journal-title":"Color Dis"},{"key":"10.1016\/j.clon.2022.09.055_bib4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/bjs.10163","article-title":"Meta-analysis of oncological outcomes after local excision of pT1-2 rectal cancer requiring adjuvant (chemo)radiotherapy or completion surgery","volume":"103","author":"Borstlap","year":"2016","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1463-1318.2008.01711.x","article-title":"Anastomotic leakage after anterior resection for rectal cancer: risk factors","volume":"12","author":"Bertelsen","year":"2010","journal-title":"Color Dis"},{"key":"10.1016\/j.clon.2022.09.055_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/bjs5.50106","article-title":"Population-based cohort study of the impact on postoperative mortality of anastomotic leakage after anterior resection for rectal cancer","volume":"3","author":"Bostr\u00f6m","year":"2018","journal-title":"BJS Open"},{"key":"10.1016\/j.clon.2022.09.055_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/bjs.9395","article-title":"Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit","volume":"101","author":"Bakker","year":"2014","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijsu.2018.06.031","article-title":"A\u00a0meta-analysis of the prevalence of low anterior resection syndrome and systematic review of risk factors","volume":"56","author":"Croese","year":"2018","journal-title":"Int J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib9","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/bjs.6126","article-title":"Urinary dysfunction after rectal cancer treatment is mainly caused by surgery","volume":"95","author":"Lange","year":"2008","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/annonc\/mdr133","article-title":"Sexual (dys)function and the quality of sexual life in patients with colorectal cancer: a systematic review","volume":"23","author":"Traa","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib11","article-title":"Functional bowel complaints and the impact on quality of life after colorectal cancer surgery in the elderly","volume":"12","author":"Ketelaers","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib12","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ejso.2021.12.020","article-title":"Outcomes on diverting ostomy formation and reversal after low anterior resection in the older rectal cancer patient","volume":"48","author":"Ketelaers","year":"2022","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1470-2045(07)70047-5","article-title":"A\u00a0multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study","volume":"8","author":"den Dulk","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib15","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0140-6736(18)31078-X","article-title":"Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study","volume":"391","author":"van der Valk","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.clon.2022.09.055_bib16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ejso.2020.01.005","article-title":"Is watch and wait a safe and effective way to treat rectal cancer in older patients?","volume":"46","author":"Haak","year":"2020","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/annonc\/mdu253","article-title":"Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013","volume":"26","author":"Papamichael","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study","volume":"380","author":"Barnett","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.clon.2022.09.055_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s00268-005-0711-8","article-title":"Which comorbid conditions predict complications after surgery for colorectal cancer?","volume":"31","author":"Lemmens","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib21","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.ijrobp.2017.12.261","article-title":"Decision-making strategy for rectal cancer management using radiation therapy for elderly or comorbid patients","volume":"100","author":"Wang","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2022.09.055_bib22","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.ejso.2018.08.003","article-title":"Personalized management of elderly patients with rectal cancer: expert recommendations of the European Society of Surgical Oncology, European Society of Coloproctology, International Society of Geriatric Oncology, and American College of Surgeons Commissi","volume":"44","author":"Montroni","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib23","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jgo.2018.08.001","article-title":"Optimal management of localized rectal cancer in older patients","volume":"9","author":"Bujko","year":"2018","journal-title":"J\u00a0Geriatr Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib24","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/S1470-2045(14)70398-5","article-title":"Organ preservation in rectal cancer: have all questions been answered?","volume":"16","author":"Marijnen","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/SLA.0000000000002761","article-title":"Oncological and survival outcomes in Watch and Wait patients with a clinical complete response after neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and pooled analysis","volume":"268","author":"Dattani","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib27","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/bjs.9811","article-title":"Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer","volume":"102","author":"Pettersson","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib28","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.ejso.2018.03.017","article-title":"Tumor response after long interval comparing 5x5Gy radiation therapy with chemoradiation therapy in rectal cancer patients","volume":"44","author":"Rombouts","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ejso.2018.03.014","article-title":"Comparison of pathological complete response rates after neoadjuvant short-course radiotherapy or chemoradiation followed by delayed surgery in locally advanced rectal cancer","volume":"44","author":"Hoendervangers","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13014-020-01695-0","article-title":"Recent advances in (chemo-)radiation therapy for rectal cancer: a comprehensive review","volume":"15","author":"Roeder","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib31","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/bjs.9809","article-title":"Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study)","volume":"102","author":"Verseveld","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jamasurg.2018.3752","article-title":"Long-term oncological and functional outcomes of chemoradiotherapy followed by organ-sparing transanal endoscopic microsurgery for distal rectal cancer: the CARTS Study","volume":"154","author":"Stijns","year":"2019","journal-title":"JAMA Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s12885-016-2557-x","article-title":"A\u00a0multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer","volume":"16","author":"Borstlap","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clon.2022.09.055_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-019474","article-title":"Can we Save the rectum by watchful waiting or Trans Anal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: Protocol for a multicentre, randomised feasibility study","volume":"7","author":"Rombouts","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.clon.2022.09.055_bib35","author":"Grotenhuis"},{"key":"10.1016\/j.clon.2022.09.055_bib36","author":"Herbert"},{"key":"10.1016\/j.clon.2022.09.055_bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0140-6736(17)31056-5","article-title":"Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial","volume":"390","author":"Rullier","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.clon.2022.09.055_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S2468-1253(19)30410-8","article-title":"Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial","volume":"5","author":"Rullier","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.clon.2022.09.055_bib39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S2468-1253(20)30333-2","article-title":"Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study","volume":"6","author":"Bach","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.clon.2022.09.055_bib40","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1200\/JCO.2022.40.16_suppl.3502","article-title":"STAR-TREC phase II: can we save the rectum by watchful waiting or transanal surgery following (chemo)radiotherapy versus total mesorectal excision for early rectal cancer?","volume":"40","author":"Bach","year":"2022","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib41","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1200\/JCO.2022.40.16_suppl.3512","article-title":"Contact x-ray brachytherapy (Papillon) in addition to chemoradiotherapy to improve organ preservation in early cT2-T3 rectal adenocarcinoma: the 3-year results of OPERA randomized trial (NCT02505750)","volume":"40","author":"Gerard","year":"2022","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib42","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ijrobp.2017.01.033","article-title":"Endorectal brachytherapy boost after external beam radiation therapy in elderly or medically inoperable patients with rectal cancer: primary outcomes of the phase 1 HERBERT Study","volume":"98","author":"Rijkmans","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2022.09.055_bib43","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1245\/s10434-021-11121-8","article-title":"Rectal sparing approach after neoadjuvant therapy in patients with rectal cancer: the preliminary results of the ReSARCh trial","volume":"29","author":"Marchegiani","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib44","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S1470-2045(15)00215-6","article-title":"Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial","volume":"16","author":"Garcia-Aguilar","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib45","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/bjs.6456","article-title":"A\u00a0predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer","volume":"96","author":"Bach","year":"2009","journal-title":"Br J Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00000658-200003000-00007","article-title":"Local excision of rectal cancer without adjuvant therapy: a word of caution","volume":"231","author":"Garcia-Aguilar","year":"2000","journal-title":"Ann Surg"},{"key":"10.1016\/j.clon.2022.09.055_bib47","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/annonc\/mdl085","article-title":"Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation","volume":"17","author":"Calvo","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib48","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0071","article-title":"Adoption of total neoadjuvant therapy for locally advanced rectal cancer","volume":"4","author":"Cercek","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib49","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/annonc\/mdv223","article-title":"Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial","volume":"26","author":"Fern\u00e1ndez-Martos","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib50","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2478\/raon-2018-0028","article-title":"Induction chemotherapy, chemoradiotherapy and consolidation chemotherapy in preoperative treatment of rectal cancer \u2013 long-term results of phase II OIGIT-01 Trial","volume":"52","author":"Golo","year":"2018","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijrobp.2017.05.048","article-title":"Improved metastasis- and disease-free survival with preoperative sequential short-course radiation therapy and FOLFOX chemotherapy for rectal cancer compared with neoadjuvant long-course chemoradiotherapy: results of a matched pair analysis","volume":"99","author":"Markovina","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2022.09.055_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1470-2045(20)30555-6","article-title":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial","volume":"22","author":"Bahadoer","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib53","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1470-2045(21)00079-6","article-title":"Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Conroy","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib54","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1470-2045(15)00120-5","article-title":"High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study","volume":"16","author":"Appelt","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib55","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ejso.2019.12.017","article-title":"Role of radiotherapy in the treatment of rectal cancer in older patients","volume":"46","author":"Myint","year":"2020","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib56","first-page":"15","article-title":"GEC ESTRO ACROP consensus recommendations for contact brachytherapy for rectal cancer","volume":"33","author":"Stewart","year":"2022","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brachy.2018.10.001","article-title":"A\u00a0systematic review comparing radiation toxicity after various endorectal techniques","volume":"18","author":"Verrijssen","year":"2019","journal-title":"Brachytherapy"},{"key":"10.1016\/j.clon.2022.09.055_bib58","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1200\/JCO.2004.08.170","article-title":"Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the Lyon R96-02 randomized trial","volume":"22","author":"Gerard","year":"2004","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clon.2022.09.055_bib59","doi-asserted-by":"crossref","first-page":"E165","DOI":"10.1016\/j.ijrobp.2011.12.002","article-title":"Correlation in rectal cancer between clinical tumor response after neoadjuvant radiotherapy and sphincter or organ preservation: 10-year results of the Lyon R 96-02 randomized trial","volume":"83","author":"Ortholan","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2022.09.055_bib60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S2468-1253(20)30390-3","article-title":"Moving forward with organ preservation in rectal cancer","volume":"6","author":"Beets","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655522004642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655522004642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:51:42Z","timestamp":1760543502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655522004642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0936655522004642"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2022.09.055","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organ Preservation in Rectal Cancer: An Overview of the Dutch Perspective and Recent Developments","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2022.09.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}