{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:02:40Z","timestamp":1788609760122,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["126"],"award-info":[{"award-number":["126"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019229","name":"ViewRay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.clon.2023.04.003","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T12:10:14Z","timestamp":1681819814000},"page":"e434-e444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prediction of Radiation-induced Lymphopenia following Exposure of the Thoracic Region and Associated Risk of Infections and Mortality"],"prefix":"10.1016","volume":"35","author":[{"given":"C.","family":"Terrones-Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ledergerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Helleberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Specht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Vogelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2023.04.003_bib1","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa1809697","article-title":"Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC","volume":"379","author":"Antonia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"21","key":"10.1016\/j.clon.2023.04.003_bib2","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1056\/NEJMoa1501824","article-title":"Pembrolizumab for the treatment of non-small-cell lung cancer","volume":"372","author":"Garon","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.clon.2023.04.003_bib3","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jamaoncol.2015.2756","article-title":"Role of local radiation therapy in cancer immunotherapy","volume":"1","author":"Demaria","year":"2015","journal-title":"JAMA Oncol"},{"issue":"4","key":"10.1016\/j.clon.2023.04.003_bib4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.adro.2018.08.014","article-title":"Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors","volume":"3","author":"Ellsworth","year":"2018","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.clon.2023.04.003_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.radonc.2021.02.029","article-title":"Hematological toxicity in patients with solid malignant tumors treated with radiation \u2013 temporal analysis, dose response and impact on survival","volume":"158","author":"Terrones-Campos","year":"2021","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.clon.2023.04.003_bib6","doi-asserted-by":"crossref","first-page":"pky053","DOI":"10.1093\/jncics\/pky053","article-title":"Development and validation of a risk score for febrile neutropenia after chemotherapy in patients with cancer: the FENCE score","volume":"2","author":"Aagaard","year":"2018","journal-title":"JNCI Cancer Spectr"},{"issue":"1","key":"10.1016\/j.clon.2023.04.003_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/mp.15353","article-title":"RootPainter3D: Interactive-machine-learning enables rapid and accurate contouring for radiotherapy","volume":"49","author":"Smith","year":"2022","journal-title":"Med Phys"},{"key":"10.1016\/j.clon.2023.04.003_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.radonc.2020.06.015","article-title":"Delineation of whole heart and substructures in thoracic radiation therapy: national guidelines and contouring atlas by the Danish Multidisciplinary Cancer Groups","volume":"150","author":"Milo","year":"2020","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.clon.2023.04.003_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1667\/RR15367.1","article-title":"Comprehensive analysis of the kinetics of radiation-induced lymphocyte loss in patients treated with external beam radiation therapy","volume":"193","author":"Ellsworth","year":"2020","journal-title":"Radiat Res"},{"key":"10.1016\/j.clon.2023.04.003_bib10","series-title":"Common Terminology Criteria for Adverse events (CTCAE)","year":"2020"},{"key":"10.1016\/j.clon.2023.04.003_bib11","series-title":"International language for drug utilization research","year":"2020"},{"issue":"2","key":"10.1016\/j.clon.2023.04.003_bib12","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijrobp.2019.05.064","article-title":"Impact of radiation dose to the host immune system on tumor control and survival for stage III non-small cell lung cancer treated with definitive radiation therapy","volume":"105","author":"Ladbury","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.clon.2023.04.003_bib13","article-title":"Risk of bacterial, viral, and fungal infections in patients with solid malignant tumors treated with curative intent radiation therapy","volume":"7","author":"Terrones-Campos","year":"2022","journal-title":"Adv Radiat Oncol"},{"issue":"11","key":"10.1016\/j.clon.2023.04.003_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225253","article-title":"Visualising statistical models using dynamic nomograms","volume":"14","author":"Jalali","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.clon.2023.04.003_bib15","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/bmj.311.7019.1539","article-title":"Commentary: Prognostic models: clinically useful or quickly forgotten?","volume":"311","author":"Wyatt","year":"1995","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.clon.2023.04.003_bib16","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.jtho.2020.06.008","article-title":"Radiotherapy-related lymphopenia affects overall survival in patients with lung cancer","volume":"15","author":"Abravan","year":"2020","journal-title":"J\u00a0Thorac Oncol"},{"issue":"11","key":"10.1016\/j.clon.2023.04.003_bib17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.clon.2023.04.003_bib18","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1182\/blood-2006-07-034405","article-title":"Late cardiotoxicity after treatment for Hodgkin lymphoma","volume":"109","author":"Aleman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clon.2023.04.003_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2019.07.016","article-title":"Are unsatisfactory outcomes after concurrent chemoradiotherapy for locally advanced non-small cell lung cancer due to treatment-related immunosuppression?","volume":"143","author":"Thor","year":"2020","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.clon.2023.04.003_bib20","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.radonc.2018.05.017","article-title":"Cardiac dose is associated with immunosuppression and poor survival in locally advanced non-small cell lung cancer","volume":"128","author":"Contreras","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clon.2023.04.003_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.radonc.2020.02.015","article-title":"The impact of the effective dose to immune cells on lymphopenia and survival of esophageal cancer after chemoradiotherapy","volume":"146","author":"Xu","year":"2020","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.clon.2023.04.003_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jrr\/rrz006","article-title":"Impact of radiotherapy on immunological parameters, levels of inflammatory factors, and clinical prognosis in patients with esophageal cancer","volume":"60","author":"Wang","year":"2019","journal-title":"J\u00a0Radiat Res"},{"issue":"36","key":"10.1016\/j.clon.2023.04.003_bib23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000020993","article-title":"Impact of radiotherapy on circulating lymphocyte subsets in patients with esophageal cancer","volume":"99","author":"Lv","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"10.1016\/j.clon.2023.04.003_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/cid\/ciq147","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America","volume":"52","author":"Freifeld","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"RR-4","key":"10.1016\/j.clon.2023.04.003_bib25","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America","volume":"58","author":"Kaplan","year":"2009","journal-title":"MMWR Recomm Rep"},{"issue":"16","key":"10.1016\/j.clon.2023.04.003_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.21037\/atm.2019.07.58","article-title":"Lymphopenia association with accelerated hyperfractionation and its effects on limited-stage small cell lung cancer patients' clinical outcomes","volume":"7","author":"Wang","year":"2019","journal-title":"Ann Transl Med"},{"issue":"2","key":"10.1016\/j.clon.2023.04.003_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.semradonc.2019.12.003","article-title":"Lymphocyte-sparing radiotherapy: the rationale for protecting lymphocyte-rich organs when combining radiotherapy with immunotherapy","volume":"30","author":"Lambin","year":"2020","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.clon.2023.04.003_bib28","article-title":"Potential determinants for radiation-induced lymphopenia in patients with breast cancer using interpretable machine learning approach","volume":"13","author":"Yu","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.clon.2023.04.003_bib29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijrobp.2015.04.027","article-title":"Distribution atlas of proliferating bone marrow in non-small cell lung cancer patients measured by FLT-PET\/CT imaging, with potential applicability in radiation therapy planning","volume":"92","author":"Campbell","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clon.2023.04.003_bib30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fonc.2019.00147","article-title":"Increasing radiation dose to the thoracic marrow is associated with acute hematologic toxicities in patients receiving chemoradiation for esophageal cancer","volume":"9","author":"Fabian","year":"2019","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.clon.2023.04.003_bib31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ijrobp.2017.11.025","article-title":"Radiation dose to the thoracic vertebral bodies is associated with acute hematologic toxicities in patients receiving concurrent chemoradiation for lung cancer: results of a single-center retrospective analysis","volume":"100","author":"Barney","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3 Suppl","key":"10.1016\/j.clon.2023.04.003_bib32","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","article-title":"Use of normal tissue complication probability models in the clinic","volume":"76","author":"Marks","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.clon.2023.04.003_bib33","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/1878-0261.12685","article-title":"Harnessing data science to advance radiation oncology","volume":"14","author":"Vogelius","year":"2020","journal-title":"Mol Oncol"},{"issue":"5","key":"10.1016\/j.clon.2023.04.003_bib34","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ijrobp.2014.04.025","article-title":"Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes","volume":"89","author":"Tang","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.clon.2023.04.003_bib35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijrobp.2018.01.069","article-title":"Effect of radiation treatment volume reduction on lymphopenia in patients receiving chemoradiotherapy for glioblastoma","volume":"101","author":"Rudra","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.clon.2023.04.003_bib36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaccao.2021.06.007","article-title":"Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification","volume":"3","author":"Bergom","year":"2021","journal-title":"JACC CardioOncol"},{"issue":"9","key":"10.1016\/j.clon.2023.04.003_bib38","first-page":"100391","article-title":"Severe radiation-induced lymphopenia attenuates the benefit of durvalumab after concurrent chemoradiotherapy for NSCLC","volume":"3","author":"Jing","year":"2022","journal-title":"JTO Clin Res Rep"},{"key":"10.1016\/j.clon.2023.04.003_bib39","article-title":"Impact of radiation dose to circulating immune cells on tumor control and survival in esophageal cancer","author":"Cai","year":"2021","journal-title":"Cancer Biother Radiopharm"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655523001504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655523001504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:52:06Z","timestamp":1760543526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655523001504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0936655523001504"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2023.04.003","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of Radiation-induced Lymphopenia following Exposure of the Thoracic Region and Associated Risk of Infections and Mortality","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2023.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists.","name":"copyright","label":"Copyright"}]}}