{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:07:04Z","timestamp":1737349624231,"version":"3.33.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.clon.2024.103692","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:32:08Z","timestamp":1731573128000},"page":"103692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Neoadjuvant Chemoradiotherapy in Locally Advanced and Locally Recurrent Colon Cancer"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-1962","authenticated-orcid":false,"given":"R.A.F.","family":"Agas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-8624","authenticated-orcid":false,"given":"R.R.","family":"Gosavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.H.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Leong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Heriot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Ngan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2024.103692_bib1","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1200\/JCO.2004.01.029","article-title":"Phase III Study of Adjuvant Chemotherapy and Radiation Therapy Compared With Chemotherapy Alone in the Surgical Adjuvant Treatment of Colon Cancer: Results of Intergroup Protocol 0130","volume":"22","author":"Martenson","year":"2004","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1148\/radiol.2016142043","article-title":"Practical PERCIST: A Simplified Guide to PET Response Criteria in Solid Tumors 1.0","volume":"280","author":"O","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.clon.2024.103692_bib3","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1200\/JCO.2011.34.9068","article-title":"Magnetic Resonance Imaging\u2013Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience","volume":"29","author":"Patel","year":"2011","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.clcc.2023.03.002","article-title":"Intensification of Local Therapy With High Dose Rate, Intraoperative Radiation Therapy (HDR-IORT) and Extended Resection for Locally Advanced and Recurrent Colorectal Cancer","volume":"22","author":"Agas","year":"2023","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.clon.2024.103692_bib5","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5. Published: November 27. US Department Health Hum Serv Natl Institutes Health Natl Cancer Inst https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf (accessed October 15, 2024). pp. 4-155"},{"key":"10.1016\/j.clon.2024.103692_bib6","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1053\/j.gastro.2008.02.098","article-title":"Systemic treatment of colorectal cancer","volume":"134","author":"Wolpin","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clon.2024.103692_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13014-022-02064-9","article-title":"Postoperative locoregional recurrence pattern and treatment management of stage pT4 sigmoid colon cancer: a retrospective cohort study","volume":"17","author":"Lin","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clon.2024.103692_bib8","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1200\/JCO.2004.08.173","volume":"22","author":"Gunderson","year":"2004","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.amjsurg.2010.03.003","article-title":"Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer","volume":"201","author":"Akiyoshi","year":"2011","journal-title":"Am J Surg"},{"key":"10.1016\/j.clon.2024.103692_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7326\/0003-4819-129-1-199807010-00007","article-title":"Surgery for Recurrent Colon Cancer: Strategies for Identifying Resectable Recurrence and Success Rates after Resection","volume":"129","author":"Goldberg","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clon.2024.103692_bib11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/DCR.0b013e31820b36f0","article-title":"Metabolic Response of Rectal Cancer Assessed by 18-FDG PET Following Chemoradiotherapy is Prognostic for Patient Outcome","volume":"54","author":"Yeung","year":"2011","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.clon.2024.103692_bib12","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clon.2024.103692_bib13","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00384-022-04174-y","article-title":"Factors influencing downstaging after neoadjuvant long-course chemoradiotherapy in rectal carcinoma","volume":"37","author":"Kohl","year":"2022","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.clon.2024.103692_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1477-7819-5-73","article-title":"Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients","volume":"5","author":"Andreoni","year":"2007","journal-title":"World J Surg Onc"},{"key":"10.1016\/j.clon.2024.103692_bib15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF02148847","article-title":"Postoperative morbidity and mortality following resection of the colon and rectum for cancer","volume":"38","author":"Bokey","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.clon.2024.103692_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.surg.2018.06.015","article-title":"Neoadjuvant radiation for clinical T4 colon cancer: A potential improvement to overall survival","volume":"165","author":"Hawkins","year":"2019","journal-title":"Surgery"},{"key":"10.1016\/j.clon.2024.103692_bib17","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejso.2012.05.001","article-title":"Neoadjuvant chemoradiotherapy and multivisceral resection for primary locally advanced adherent colon cancer: A single institution experience","volume":"38","author":"Cukier","year":"2012","journal-title":"Eur J Surg Oncol (EJSO)"},{"key":"10.1016\/j.clon.2024.103692_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12885-021-07894-6","article-title":"Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection","volume":"21","author":"Yuan","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clon.2024.103692_bib19","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1111\/codi.15868","article-title":"Is neoadjuvant therapy an alternative strategy to immediate surgery in locally perforated colon cancer?","volume":"23","author":"Kong","year":"2021","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.clon.2024.103692_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12029-019-00300-2","article-title":"Assessing the Effect of Radiotherapy in Addition to Surgery in Colon Adenocarcinomas: a Systematic Review and Meta-analysis of Contemporary Evidence","volume":"51","author":"Agas","year":"2020","journal-title":"J\u00a0Gastrointest Canc"},{"key":"10.1016\/j.clon.2024.103692_bib21","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1200\/JCO.2007.15.8261","article-title":"Survival Following Recurrence in Stage II and III Colon Cancer: Findings From the ACCENT Data Set","volume":"26","author":"O\u2019Connell","year":"2008","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.21037\/jgo-2019-ccm-09","article-title":"Surgical management of recurrent colon cancer","volume":"11","author":"Brown","year":"2020","journal-title":"J\u00a0Gastrointest Oncol"},{"key":"10.1016\/j.clon.2024.103692_bib23","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/ags3.12483","article-title":"Overall survival after recurrence in stage I\u2013III colorectal cancer patients in accordance with the recurrence organ site and pattern","volume":"5","author":"Sawayama","year":"2021","journal-title":"Ann Gastroent Surg"},{"key":"10.1016\/j.clon.2024.103692_bib24","first-page":"605","article-title":"Impact of age and comorbidity on survival in colorectal cancer","volume":"6","author":"van Eeghen","year":"2015","journal-title":"J\u00a0Gastrointest Oncol"},{"key":"10.1016\/j.clon.2024.103692_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1463-1318.2008.01556.x","article-title":"Prognostic factors in survival of colorectal cancer patients after surgery","volume":"11","author":"Mehrkhani","year":"2009","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.clon.2024.103692_bib26","first-page":"139","article-title":"Prognostic Factors of Disease Recurrence and Overall Survival Following Curative Resection of Colon Cancer: A 10-year Cohort from a Referral Center","volume":"36","author":"Keramati","year":"2022","journal-title":"Med J Islam Repub Iran"},{"key":"10.1016\/j.clon.2024.103692_bib27","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1200\/JCO.22.00046","article-title":"Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial","volume":"41","author":"Morton","year":"2023","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib28","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2023.41.17_suppl.LBA3503","article-title":"Phase III randomized clinical trial comparing the efficacy of neoadjuvant chemotherapy and standard treatment in patients with locally advanced colon cancer: The NeoCol trial","volume":"41","author":"Jensen","year":"2023","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102836","article-title":"Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for initially unresectable locally advanced colon cancer: short-term outcomes of an open-label, single-centre, randomised, controlled, phase 3 trial","volume":"76","author":"Zhang","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.clon.2024.103692_bib30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.annonc.2024.06.019","article-title":"Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial","volume":"35","author":"Conroy","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clon.2024.103692_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1470-2045(20)30555-6","article-title":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial","volume":"22","author":"Bahadoer","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clon.2024.103692_bib32","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1200\/JCO.21.01667","article-title":"Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR)","volume":"40","author":"Jin","year":"2022","journal-title":"JCO"},{"key":"10.1016\/j.clon.2024.103692_bib33","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0302-2838(02)00062-3","article-title":"Long-Term Follow-up after Surgery for Advanced Colorectal Carcinoma Involving the Urogenital Tract","volume":"41","author":"Stief","year":"2002","journal-title":"Eur Urol"},{"key":"10.1016\/j.clon.2024.103692_bib34","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1177\/000313480507101101","article-title":"T4 rectal cancer: analysis of patient outcome after surgical excision","volume":"71","author":"Amshel","year":"2005","journal-title":"Am Surg"},{"key":"10.1016\/j.clon.2024.103692_bib35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000276974","article-title":"Multivisceral Resection for Colon Cancer: Analysis of Prognostic Factors","volume":"27","author":"L\u00f3pez-Cano","year":"2010","journal-title":"Dig Surg"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655524004886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655524004886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T20:36:48Z","timestamp":1737319008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655524004886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":35,"alternative-id":["S0936655524004886"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2024.103692","relation":{},"ISSN":["0936-6555"],"issn-type":[{"type":"print","value":"0936-6555"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neoadjuvant Chemoradiotherapy in Locally Advanced and Locally Recurrent Colon Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2024.103692","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Royal College of Radiologists. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103692"}}