{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:54:47Z","timestamp":1789584887559,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaloncologyonline.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Oncology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.clon.2025.104001","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:22:12Z","timestamp":1765473732000},"page":"104001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Role of Post-operative Thyroglobulin in Predicting Disease-recurrence in Differentiated Thyroid Cancer"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-897X","authenticated-orcid":false,"given":"L.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1928-3823","authenticated-orcid":false,"given":"M.","family":"Gajda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-4856","authenticated-orcid":false,"given":"A.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3879-8198","authenticated-orcid":false,"given":"N.","family":"Jones-Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-9128","authenticated-orcid":false,"given":"S.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-1277","authenticated-orcid":false,"given":"J.","family":"Wadsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clon.2025.104001_bib1","first-page":"1","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association","volume":"26","author":"Haugen","year":"2016","journal-title":"LiebertpubCom"},{"key":"10.1016\/j.clon.2025.104001_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4376720","article-title":"Short-term side effects after radioiodine treatment in patients with differentiated thyroid cancer","volume":"2016","author":"Lu","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.clon.2025.104001_bib3","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1089\/thy.2009.1611","article-title":"The benefits and risks of I-131 therapy in patients with well-differentiated thyroid cancer","volume":"19","author":"Van Nostrand","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.clon.2025.104001_bib4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/hed.21214","article-title":"Postsurgery serum thyroglobulin disappearance kinetic in patients with differentiated thyroid carcinoma","volume":"32","author":"Giovanella","year":"2010","journal-title":"Head Neck"},{"key":"10.1016\/j.clon.2025.104001_bib5","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1530\/EJE-14-0148","article-title":"diagnosis of endocrine disease: Thyroglobulin measurement using highly sensitive assays in patients with differentiated thyroid cancer: a clinical position paper","volume":"171","author":"Giovanella","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.clon.2025.104001_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4331\/wjbc.v8.i1.81","article-title":"Use of thyroglobulin as a tumour marker","volume":"8","author":"Indrasena","year":"2017","journal-title":"World J Biol Chem"},{"key":"10.1016\/j.clon.2025.104001_bib7","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad102","article-title":"Thyroglobulin cutoff values for detecting excellent response to therapy in patients with differentiated thyroid cancer","volume":"7","author":"Sipos","year":"2023","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.clon.2025.104001_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cen.12515","article-title":"Guidelines for the management of thyroid cancer","volume":"81","author":"Perros","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.clon.2025.104001_bib9","first-page":"3","article-title":"Laboratory support for the diagnosis and monitoring of thyroid disease","volume":"13","author":"Baloch","year":"2004","journal-title":"Thyroid"},{"key":"10.1016\/j.clon.2025.104001_bib10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/cen.12668","article-title":"A low postoperative nonstimulated serum thyroglobulin level excludes the presence of persistent disease in low-risk papillary thyroid cancer patients: Implication for radioiodine indication","volume":"83","author":"Rosario","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.clon.2025.104001_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(25)00629-4","article-title":"Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial","author":"Mallick","year":"2025","journal-title":"The Lancet"},{"key":"10.1016\/j.clon.2025.104001_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41574-022-00709-z","article-title":"Post-operative radioactive iodine administration in patients with low-risk thyroid cancer","volume":"18","author":"Leboulleux","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.clon.2025.104001_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ando.2022.10.014","article-title":"Prognostic value of postoperative stimulated thyroglobulin in differentiated thyroid cancer","volume":"84","author":"Elmaraghi","year":"2023","journal-title":"Ann Endocrinol (Paris)"},{"key":"10.1016\/j.clon.2025.104001_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.surg.2019.06.048","article-title":"Early postoperative stimulated serum thyroglobulin quantifies risk of recurrence in papillary thyroid cancer","volume":"167","author":"Jayasekara","year":"2020","journal-title":"Surgery"},{"key":"10.1016\/j.clon.2025.104001_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2265.2006.02685.x","article-title":"Serum thyroglobulin concentrations predict disease-free remission and death in differentiated thyroid carcinoma","volume":"66","author":"Heemstra","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.clon.2025.104001_bib16","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1210\/jc.2012-1533","article-title":"The utility of serum thyroglobulin measurement at the time of remnant ablation for predicting disease-free status in patients with differentiated thyroid cancer: a meta-analysis involving 3947 patients","volume":"97","author":"Webb","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clon.2025.104001_bib17","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/sj.bjc.6601319","article-title":"Second primary malignancies in thyroid cancer patients","volume":"89","author":"Rubino","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clon.2025.104001_bib18","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1210\/jc.2005-2009","article-title":"Second primary cancers in thyroid cancer patients: a multinational record linkage study","volume":"91","author":"Sandeep","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clon.2025.104001_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S2213-8587(24)00276-6","article-title":"Thyroidectomy without radioiodine in patients with low-risk thyroid cancer: 5 years of follow-up of the prospective randomised ESTIMABL2 trial","volume":"13","author":"Leboulleux","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.clon.2025.104001_bib20","article-title":"New approach of prediction of recurrence in thyroid cancer patients using machine learning","volume":"100","author":"Kim","year":"2021","journal-title":"Medicine (United States)"},{"key":"10.1016\/j.clon.2025.104001_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/ERC-15-0458","article-title":"Low postoperative nonstimulated thyroglobulin as a criterion to spare radioiodine ablation","volume":"23","author":"Mourao","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.clon.2025.104001_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12020-015-0575-0","article-title":"Post-operative stimulated thyroglobulin and neck ultrasound as personalized criteria for risk stratification and radioactive iodine selection in low- and intermediate-risk papillary thyroid cancer","volume":"50","author":"Orlov","year":"2015","journal-title":"Endocrine"},{"key":"10.1016\/j.clon.2025.104001_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11154-023-09835-z","article-title":"Does it work in childhood and adolescence? The predictive role of postoperative\/preablative stimulated thyroglobulin levels in paediatric thyroid cancer. A systematic review of the literature","volume":"25","author":"Piccardo","year":"2024","journal-title":"Rev Endocr Metab Disord"}],"container-title":["Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655525002560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0936655525002560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T11:40:57Z","timestamp":1770205257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0936655525002560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":23,"alternative-id":["S0936655525002560"],"URL":"https:\/\/doi.org\/10.1016\/j.clon.2025.104001","relation":{},"ISSN":["0936-6555"],"issn-type":[{"value":"0936-6555","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Post-operative Thyroglobulin in Predicting Disease-recurrence in Differentiated Thyroid Cancer","name":"articletitle","label":"Article Title"},{"value":"Clinical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clon.2025.104001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Royal College of Radiologists. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104001"}}