{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:12:44Z","timestamp":1769148764412,"version":"3.49.0"},"reference-count":146,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.clp.2004.07.002","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T07:28:41Z","timestamp":1113982121000},"page":"783-805","source":"Crossref","is-referenced-by-count":40,"title":["Screening and management of inherited thrombophilias in the setting of adverse pregnancy outcome"],"prefix":"10.1016","volume":"31","author":[{"given":"Michael J.","family":"Paidas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Hui W.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yale S.","family":"Arkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib1","first-page":"139","article-title":"Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene","volume":"24","author":"Dahlback","year":"1994","journal-title":"Haemostasis"},{"key":"10.1016\/j.clp.2004.07.002_bib2","first-page":"403","article-title":"Epidemiology, risk factors and prophylaxis of venous thromboembolism in obstetrics and gynecology","volume":"11","author":"Greer","year":"1997","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib3","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0140-6736(98)10265-9","article-title":"Thrombosis in pregnancy: maternal and fetal issues","volume":"353","author":"Greer","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0029-7844(99)00308-7","article-title":"Thrombotic risk during pregnancy: a population study","volume":"94","author":"Lindqvist","year":"1999","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/j.1600-0412.1998.770207.x","article-title":"The cumulative incidence of venous thromboembolism during pregnancy and puerperium","volume":"77","author":"Andersen","year":"1998","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.clp.2004.07.002_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000299596","article-title":"Studies on blood coagulation and fibrinolysis in pregnancy, during delivery and in the puerperium","volume":"12","author":"Hellgren","year":"1981","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.clp.2004.07.002_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1055\/s-0038-1661167","article-title":"Haemostasis in normal pregnancy","volume":"52","author":"Stirling","year":"1984","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1182\/blood.V68.4.881.881","article-title":"Functional and immunologic protein S levels are decreased during pregnancy","volume":"68","author":"Comp","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2141.1995.tb05610.x","article-title":"Development of resistance to activated protein C during pregnancy","volume":"90","author":"Cumming","year":"1995","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1521-6926(03)00021-5","article-title":"Hemostatic changes in pregnancy","volume":"16","author":"Bremme","year":"2003","journal-title":"Best Pract Res Clin Haematol"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib11","first-page":"1074","article-title":"Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies","volume":"90","author":"Ku","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib12","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1001\/jama.1997.03540400055031","article-title":"Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening","volume":"277","author":"Ridker","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.clp.2004.07.002_bib13","first-page":"3","article-title":"Inherited thrombophilias in pregnant patients","volume":"6","author":"Lockwood","year":"2001","journal-title":"Prenat Neonat Med"},{"key":"10.1016\/j.clp.2004.07.002_bib14","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(94)92939-4","article-title":"Association of idiopathic venous thromboembolism with single point\u2013mutation at Arg 506 of factor V","volume":"343","author":"Voorberg","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0029-7844(98)00408-6","article-title":"Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies","volume":"93","author":"Ananth","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.clp.2004.07.002_bib16","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3\u2032-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM200002103420602","article-title":"Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium","volume":"342","author":"Gerhardt","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clp.2004.07.002_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00001703-199804000-00010","article-title":"Inherited thrombophilia and pregnancy","volume":"10","author":"Girling","year":"1998","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-0038-1655930","article-title":"Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"77","author":"Lane","year":"1997","journal-title":"Thromb Haemost"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0029-7844(01)01760-4","article-title":"Inherited thrombophilias in pregnant patients: detection and treatment paradigm","volume":"99","author":"Lockwood","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM199901073400102","article-title":"Increased frequency of genetic thrombophilia in women with complications of pregnancy","volume":"340","author":"Kupferminc","year":"1999","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.clp.2004.07.002_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0301-2115(01)00496-1","article-title":"How strong is the association between maternal thrombophilia and adverse pregnancy outcome? A systematic review","volume":"101","author":"Alfirevic","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.clp.2004.07.002_bib24","series-title":"Hemostasis and thrombosis, basic principles and clinical practice","article-title":"Blood coagulation factors","author":"Greenberg","year":"2001"},{"key":"10.1016\/j.clp.2004.07.002_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0038-1646373","article-title":"Protein S and C4b-binding protein: components involved in the regulation of the protein C anticoagulant pathway","volume":"66","author":"Dahlback","year":"1991","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib26","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1073\/pnas.91.7.2728","article-title":"Protein S binds to and inhibits factor Xa","volume":"91","author":"Heeb","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clp.2004.07.002_bib27","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/S0021-9258(18)53854-0","article-title":"Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of APC","volume":"268","author":"Heeb","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clp.2004.07.002_bib28","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1182\/blood.V86.3.1062.1062","article-title":"Inhibition of intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII","volume":"86","author":"Koppelman","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib29","doi-asserted-by":"crossref","first-page":"21051","DOI":"10.1016\/S0021-9258(17)31928-2","article-title":"Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factor Va and Xa","volume":"269","author":"Hackeng","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clp.2004.07.002_bib30","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood.V85.7.1815.bloodjournal8571815","article-title":"Increased prothrombin activation in protein S\u2013deficient plasma under flow conditions on endothelial cell matrix: an independent anticoagulation function of protein S in plasma","volume":"85","author":"van't Veer","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/s-0037-1614633","article-title":"Regulation of prothrombinase activity by protein S","volume":"82","author":"van't Veer","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib32","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1016\/S0021-9258(18)67196-0","article-title":"Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein","volume":"261","author":"Dahlback","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clp.2004.07.002_bib33","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1055\/s-0037-1615714","article-title":"C4b-binding protein inhibits the factor V\u2013dependent but not the factor FV\u2013independent cofactor activity of protein S in the APC-mediated inactivation of factor VIIIa","volume":"85","author":"van de Poel","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib34","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1055\/s-0037-1616530","article-title":"The role of protein S in the activation of TAFI and regulation of fibrinolysis","volume":"86","author":"Mosnier","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib35","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.1365-2141.2001.02813.x","article-title":"A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state","volume":"113","author":"Dykes","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clp.2004.07.002_bib36","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1182\/blood.V68.4.881.881","article-title":"Functional and immunologic protein S levels are decreased during pregnancy","volume":"68","author":"Comp","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2141.1995.tb05610.x","article-title":"Development of resistance to activated protein C during pregnancy","volume":"90","author":"Cumming","year":"1995","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.clp.2004.07.002_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-2007-994957","article-title":"Detection of decreased response to activated protein C during pregnancy by an endogenous thrombin potential-based assay","volume":"25","author":"Sugimura","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.clp.2004.07.002_bib39","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/01.CIR.92.4.962","article-title":"Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots","volume":"92","author":"Prager","year":"1995","journal-title":"Circulation"},{"issue":"Suppl 1","key":"10.1016\/j.clp.2004.07.002_bib40","doi-asserted-by":"crossref","first-page":"P0879","DOI":"10.1111\/j.1538-7836.2003.tb04394.x","article-title":"Patients with adverse pregnancy outcome have lower levels of protein Z and protein S compared to patients with normal pregnancy outcome","volume":"1","author":"Paidas","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1055\/s-2001-17966","article-title":"Protein Z","volume":"5","author":"Kemkes-Matthes","year":"2001","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.clp.2004.07.002_bib42","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1182\/blood.V96.9.3049","article-title":"Characterization of the protein Z\u2013dependent protease inhibitor","volume":"96","author":"Han","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0037-1616195","article-title":"Protein Z\u2013dependent regulation of coagulation","volume":"86","author":"Broze","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib44","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(00)04229-X","article-title":"Protein-Z and thrombosis","volume":"357","author":"Broze","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib45","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1021\/bi990641a","article-title":"The protein Z\u2013dependent protease inhibitor is a serpin","volume":"38","author":"Han","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.clp.2004.07.002_bib46","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ajh.2830480315","article-title":"Plasma protein Z levels in healthy newborn infants","volume":"48","author":"Yurdakok","year":"1995","journal-title":"Am J Hematol"},{"key":"10.1016\/j.clp.2004.07.002_bib47","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood.V69.6.1580.1580","article-title":"Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy","volume":"69","author":"Miletich","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0049-3848(02)00181-0","article-title":"Protein Z influences the prothrombotic phenotype in factor V Leiden patients","volume":"106","author":"Kemkes-Matthes","year":"2002","journal-title":"Thromb Res"},{"key":"10.1016\/j.clp.2004.07.002_bib49","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1046\/j.1365-2141.2003.04151_5.x","article-title":"Plasma protein Z deficiency is common in women with antiphospholipid antibodies","volume":"120","author":"McColl","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clp.2004.07.002_bib50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00001721-200107000-00012","article-title":"Low plasma protein Z levels in patients with antiphospholipid antibodies","volume":"12","author":"Steffano","year":"2001","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.clp.2004.07.002_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/bcmd.2002.0549","article-title":"Low protein Z levels and the risk of ischemic stroke: differences by diabetic status and gender","volume":"2","author":"Heeb","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.clp.2004.07.002_bib52","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(01)05983-9","article-title":"Frequency of PZ deficiency in patients with ischemic stroke","volume":"358","author":"Wuillemin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib53","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1182\/blood.V99.7.2606","article-title":"High frequency of protein Z deficiency in patients with unexplained early fetal loss","volume":"99","author":"Gris","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0049-3848(98)00036-X","article-title":"Bleeding tendency of unknown origin and protein Z levels","volume":"90","author":"Gamba","year":"1998","journal-title":"Thromb Res"},{"issue":"Suppl 1","key":"10.1016\/j.clp.2004.07.002_bib55","first-page":"P0878","article-title":"Normal pregnancy is associated with decreased protein Z levels in the second and third trimesters compared to early pregnancy","volume":"1","author":"Paidas","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib56","unstructured":"Paidas M.J., Ku D.H.W., Arkel Y.S., Rebarber A., Lee M.J., Roshan D., et al. First trimester maternal protein Z levels are lower in patients with complicated pregnancies and patients with thrombophilia and subsequent adverse pregnancy outcomes. Presented at the 44th ASH Annual Meeting. Philadelphia, December 4\u20138, 2002 [poster presentation]"},{"issue":"10","key":"10.1016\/j.clp.2004.07.002_bib57","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1182\/blood-2003-12-4250","article-title":"Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder","volume":"103","author":"Gris","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.clp.2004.07.002_bib58","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.5858\/2002-126-1401-PAILAP","article-title":"Plasminogen activator inhibitor-1 levels and polymorphisms","volume":"126","author":"Francis","year":"2002","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"10.1016\/j.clp.2004.07.002_bib59","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsgi.2003.07.008","article-title":"Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study","volume":"11","author":"Hefler","year":"2004","journal-title":"J Soc Gynecol Invest"},{"issue":"7","key":"10.1016\/j.clp.2004.07.002_bib60","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1538-7836.2003.00306.x","article-title":"Thrombomodulin","volume":"1","author":"Weiler","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1016\/j.clp.2004.07.002_bib61","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1538-7836.2004.00680.x","article-title":"Patients with thrombophilia and subsequent adverse pregnancy outcomes have a decreased first trimester response to thrombomodulin in an activated partial thromboplastin time (APTT) system","volume":"2","author":"Paidas","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib62","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/aje\/153.4.332","article-title":"Placental abruption and perinatal mortality in the United States","volume":"153","author":"Ananth","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"8850","key":"10.1016\/j.clp.2004.07.002_bib63","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"Barker","year":"1993","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clp.2004.07.002_bib64","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/oxfordjournals.bmb.a011609","article-title":"Fetal nutrition and cardiovascular disease in later life","volume":"53","author":"Barker","year":"1997","journal-title":"Br Med Bull"},{"issue":"1 pt 1","key":"10.1016\/j.clp.2004.07.002_bib65","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0002-9378(00)70513-8","article-title":"Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network","volume":"182","author":"Bernstein","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib66","series-title":"National vital statistics reports; vol 49, no. 4","first-page":"1","article-title":"Trends in pregnancy rates for the United States, 1976\u201397: an update","author":"Ventura","year":"2001"},{"issue":"11","key":"10.1016\/j.clp.2004.07.002_bib67","first-page":"883","article-title":"Recurrent stillbirth. Significance and characteristics","volume":"38","author":"Samueloff","year":"1993","journal-title":"J Reprod Med"},{"issue":"9032","key":"10.1016\/j.clp.2004.07.002_bib68","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston","year":"1993","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib69","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1055\/s-0037-1614594","article-title":"Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent\u2014the Nimes Obstetricians and Haematologists Study 5 (NOHA5)","volume":"81","author":"Gris","year":"1999","journal-title":"Thromb Haemost"},{"issue":"14","key":"10.1016\/j.clp.2004.07.002_bib70","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJM200010053431405","article-title":"Mutations in coagulation factors in women with unexplained late fetal loss","volume":"343","author":"Martinelli","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clp.2004.07.002_bib71","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0037-1613008","article-title":"Recurrent late fetal death in women with and without thrombophilia","volume":"87","author":"Martinelli","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib72","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1471-0528.1997.tb10977.x","article-title":"The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence","volume":"104","author":"Rasmussen","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.clp.2004.07.002_bib73","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0029-7844(96)00088-9","article-title":"Placental abruption and its association with hypertension and prolonged rupture of membranes: a methodologic review and meta-analysis","volume":"88","author":"Ananth","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib74","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1034\/j.1600-0412.2001.080008708.x","article-title":"Women with a history of placental abruption: when in a subsequent pregnancy should special surveillance for a recurrent placental abruption be initiated?","volume":"80","author":"Rasmussen","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.clp.2004.07.002_bib75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s004040100227","article-title":"Pregnancy following placental abruption","volume":"267","author":"Furuhashi","year":"2002","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.clp.2004.07.002_bib76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/jmf.11.1.34.39","article-title":"Incidence, obstetric risk factors and pregnancy outcome of preterm placental abruption: a retrospective analysis","volume":"11","author":"Sheiner","year":"2002","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.clp.2004.07.002_bib77","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0029-7844(02)01938-5","article-title":"Third trimester unexplained intrauterine fetal death is associated with inherited thrombophilia","volume":"99","author":"Many","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib78","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/0002-9378(91)90379-6","article-title":"Severe preeclampsia in the second trimester: recurrence risk and long-term prognosis","volume":"165","author":"Sibai","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib79","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/0002-9378(86)90336-4","article-title":"Severe preeclampsia-eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis","volume":"155","author":"Sibai","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib80","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S0002-9378(94)70063-X","article-title":"The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) in subsequent gestations","volume":"171","author":"Sullivan","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib81","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1067\/mob.2002.120280","article-title":"National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine-Units. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas","volume":"186","author":"Hnat","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib82","series-title":"Hypertensive disorders in pregnancy","author":"Chesley","year":"1978"},{"key":"10.1016\/j.clp.2004.07.002_bib83","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1471-0528.1985.tb01064.x","article-title":"Pre-eclampsia in second pregnancy","volume":"92","author":"Campbell","year":"1985","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.clp.2004.07.002_bib84","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9378(95)90099-3","article-title":"Pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): subsequent pregnancy outcome and long-term prognosis","volume":"172","author":"Sibai","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib85","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1365-3016.2001.00347.x","article-title":"Risks of hypertensive disorders in the second pregnancy","volume":"15","author":"Zhang","year":"2001","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.clp.2004.07.002_bib86","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0029-7844(01)01780-X","article-title":"Intrauterine growth restriction","volume":"99","author":"Resnik","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib87","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0029-7844(00)01008-5","article-title":"Predicting preeclampsia in the second pregnancy from low birth weight in the first pregnancy","volume":"96","author":"Rasmussen","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib88","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1471-0528.2000.tb11657.x","article-title":"Risk factors and clinical manifestations of preeclampsia","volume":"107","author":"Odegard","year":"2000","journal-title":"Br J Obstet Gynaecol"},{"issue":"8","key":"10.1016\/j.clp.2004.07.002_bib89","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa031587","article-title":"Previous preterm and small-for-gestational-age births and the subsequent risk of stillbirth","volume":"350","author":"Surkan","year":"2004","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.clp.2004.07.002_bib90","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1056\/NEJMp038245","article-title":"Small-for-gestational-age infants and risk of fetal death in subsequent pregnancies","volume":"350","author":"Zhang","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clp.2004.07.002_bib91","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/0140-6736(91)93124-R","article-title":"Prevention of fetal growth retardation with low-dose aspirin: findings of the Epreda trial","volume":"337","author":"Uzan","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib92","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0301-2115(98)00083-9","article-title":"Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study","volume":"80","author":"Riyazi","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.clp.2004.07.002_bib93","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/s-0037-1613894","article-title":"Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin","volume":"83","author":"Brenner","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib94","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0020-7292(01)00447-7","article-title":"Outcome of pregnancy in women with hereditary thrombophilia","volume":"74","author":"Ogueh","year":"2001","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.clp.2004.07.002_bib95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/10641950109152640","article-title":"Low molecular weight heparin for the prevention of obstetric complications in women with thrombophilia","volume":"20","author":"Kupferminc","year":"2001","journal-title":"Hypertens Pregnancy"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib96","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0015-0282(02)03222-3","article-title":"Preventing adverse obstetric outcomes in women with genetic thrombophilia","volume":"78","author":"Grandone","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.clp.2004.07.002_bib97","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","article-title":"Thrombophilic disorders and fetal loss: a meta-analysis","volume":"361","author":"Rey","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib98","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3109\/00016340009169243","article-title":"High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss","volume":"79","author":"Kupferminc","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib99","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/0002-9378(95)91324-6","article-title":"Underlying disorders associated with severe early-onset preeclampsia","volume":"173","author":"Dekker","year":"1995","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib100","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9378(96)80022-6","article-title":"The factor V Leiden mutation may predispose women to severe preeclampsia","volume":"175","author":"Dizon-Townson","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib101","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1399-0004.1998.tb02599.x","article-title":"Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women","volume":"53","author":"Nagy","year":"1998","journal-title":"Clin Genet"},{"issue":"3","key":"10.1016\/j.clp.2004.07.002_bib102","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0029-7844(98)00208-7","article-title":"Activated protein C resistance and factor V Leiden in patients with hemolysis, elevated liver enzymes, low platelets syndrome","volume":"92","author":"Krauss","year":"1998","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.clp.2004.07.002_bib103","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0002-9378(99)70608-3","article-title":"High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia","volume":"180","author":"van Pampus","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib104","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-9378(99)70335-2","article-title":"Preeclampsia and genetic risk factors for thrombosis: a case-control study","volume":"181","author":"DeGroot","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib105","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0049-3848(00)00312-1","article-title":"Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome (hemolysis, elevated liver-enzymes, low platelets)","volume":"100","author":"von Tempelhoff","year":"2000","journal-title":"Thromb Res"},{"issue":"5","key":"10.1016\/j.clp.2004.07.002_bib106","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0037-1613083","article-title":"Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review","volume":"87","author":"Morrison","year":"2002","journal-title":"Thromb Haemost"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib107","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0890-6238(01)00136-8","article-title":"Fetal effects of cocaine: an updated meta-analysis","volume":"15","author":"Addis","year":"2001","journal-title":"Reprod Toxicol"},{"issue":"11","key":"10.1016\/j.clp.2004.07.002_bib108","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1471-0528.1997.tb10970.x","article-title":"Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies","volume":"104","author":"deVries","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.clp.2004.07.002_bib109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1056\/NEJM200207043470105","article-title":"Absence of association of thrombophilia polymorphisms with intrauterine growth restriction","volume":"347","author":"Infante-Rivard","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1160\/TH03-09-0596","article-title":"Maternal thrombophilias are not associated with early pregnancy loss","volume":"91","author":"Roque","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib111","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1538-7836.2004.00784.x","article-title":"Does heparin therapy improve pregnancy outcome in patients with thrombophilias?","volume":"2","author":"Paidas","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"11","key":"10.1016\/j.clp.2004.07.002_bib112","first-page":"43","article-title":"Enoxaparin treatment improves the gestational outcome of pregnant women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study","volume":"102","author":"Brenner","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib113","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/bmj.322.7282.329","article-title":"Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review","volume":"322","author":"Duley","year":"2001","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib114","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0029-7844(03)00169-8","article-title":"Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review","volume":"101","author":"Coomarasamy","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib115","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1055\/s-0037-1614550","article-title":"Safety of low-molecular-weight heparin in pregnancy: a systematic review","volume":"81","author":"Sanson","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib116","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0306-5456(01)00272-8","article-title":"Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies","volume":"108","author":"Lepercq","year":"2001","journal-title":"BJOG"},{"key":"10.1016\/j.clp.2004.07.002_bib117","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1046\/j.1538-7836.2003.00270.x","article-title":"Heparin-induced thrombocytopenia","volume":"1","author":"Chong","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib118","series-title":"Hematology","first-page":"503","article-title":"Heparin-induced thrombocytopenia","author":"Warkentin","year":"2003"},{"key":"10.1016\/j.clp.2004.07.002_bib119","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood.V96.5.1703","article-title":"Impact of the patient population on the risk for heparin-induced thrombocytopenia","volume":"96","author":"Warkentin","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.clp.2004.07.002_bib120","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM200104263441704","article-title":"Temporal aspects of heparin-induced thrombocytopenia","volume":"344","author":"Warkentin","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clp.2004.07.002_bib121","series-title":"Heparin-induced thrombocytopenia","first-page":"87","article-title":"Frequency of heparin-induced thrombocytopenia","author":"Lee","year":"2001"},{"key":"10.1016\/j.clp.2004.07.002_bib122","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199505183322003","article-title":"Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin","volume":"332","author":"Warkentin","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clp.2004.07.002_bib123","unstructured":"Warkentin T.E., Greinacher A. Heparin-induced thrombocytopenia. Chest, in press"},{"key":"10.1016\/j.clp.2004.07.002_bib124","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1055\/s-0037-1613092","article-title":"Absence of placental transfer of pentasaccharide (Fondaparinux, Arixtra) in the dually perfused human cotyledon in vitro","volume":"87","author":"Lagrange","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2004.07.002_bib125","first-page":"202","article-title":"Pharmacological survey recombinant hirudin","volume":"43","author":"Markwardt","year":"1988","journal-title":"Pharmazie"},{"key":"10.1016\/j.clp.2004.07.002_bib126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00063030-200014020-00005","article-title":"Heparin-induced thrombocytopenia. Recommendations for optimal use of recombinant hirudin","volume":"14","author":"Lubenow","year":"2000","journal-title":"BioDrugs"},{"key":"10.1016\/j.clp.2004.07.002_bib127","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1006\/bcmd.1997.0158","article-title":"Effects of hirudin (thrombin specific inhibitor) in zebrafish embryos: a developmental role for thrombin","volume":"23","author":"Jagadeeswaran","year":"1997","journal-title":"Blood Cells Mol Dis"},{"issue":"8716","key":"10.1016\/j.clp.2004.07.002_bib128","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0140-6736(90)92159-F","article-title":"Recurrent miscarriage","volume":"336","author":"Stirrat","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2004.07.002_bib129","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0029-7844(00)00861-9","article-title":"Severe preeclampsia: high frequency of genetic thrombophilic mutations","volume":"96","author":"Kupferminc","year":"2000","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1081\/PRG-100100132","article-title":"Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutations and 5, 10 methylenetetrahydrofolate reductase","volume":"19","author":"Rigo","year":"2000","journal-title":"Hypertens Pregnancy"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib131","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1067\/mob.2001.110411","volume":"184","author":"Kim","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib132","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mob.2001.114691","article-title":"Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia","volume":"185","author":"Livingston","year":"2001","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2004.07.002_bib133","first-page":"191","article-title":"Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia?","volume":"109","author":"Currie","year":"2002","journal-title":"BJOG"},{"issue":"12","key":"10.1016\/j.clp.2004.07.002_bib134","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1034\/j.1600-0412.2002.811201.x","article-title":"Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome","volume":"81","author":"Benedetto","year":"2002","journal-title":"Acta Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib135","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1042\/CS20030073","article-title":"Association of maternal and\/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction","volume":"105","author":"Schlembach","year":"2003","journal-title":"Clin Sci"},{"issue":"6 Pt 1","key":"10.1016\/j.clp.2004.07.002_bib136","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0002-9378(98)70025-0","article-title":"Resistance to activated protein C and the Leiden mutation: high prevalence in patients with abruptio placentae","volume":"179","author":"Wiener-Megnagi","year":"1998","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.clp.2004.07.002_bib137","first-page":"785","article-title":"Thrombophilic mutations are a main risk factor for placental abruption","volume":"88","author":"Faccinetti","year":"2003","journal-title":"Haemotologica"},{"issue":"5 Pt 1","key":"10.1016\/j.clp.2004.07.002_bib138","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0029-7844(01)01190-5","article-title":"Postnatal screening for thrombophilia in women with severe pregnancy complications","volume":"97","author":"Alfirevic","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib139","first-page":"428","article-title":"Familial thrombophilia and the occurrence of fetal growth restriction","volume":"86","author":"Martinelli","year":"2001","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.clp.2004.07.002_bib140","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1046\/j.1471-0528.2002.02194.x","article-title":"Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia","volume":"109","author":"Kupferminc","year":"2002","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.clp.2004.07.002_bib141","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1471-0528.2002.00411.x","article-title":"Thrombophilia and immunological disorders in pregnancies as risk factors for small for gestational age infants","volume":"109","author":"Verspyck","year":"2002","journal-title":"BJOG"},{"issue":"6","key":"10.1016\/j.clp.2004.07.002_bib142","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/humrep\/14.6.1624","article-title":"A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure","volume":"14","author":"Tal","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.clp.2004.07.002_bib143","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0037-1613984","article-title":"Bleeding complications associated with low molecular weight heparin prophylaxis during pregnancy","volume":"84","author":"Lindqvist","year":"2000","journal-title":"Thromb Haemost"},{"issue":"4","key":"10.1016\/j.clp.2004.07.002_bib144","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0002-9378(97)70615-X","article-title":"The incidence of the factor V Leiden mutation in an obstetric population and its relationship to deep vein thrombosis","volume":"176","author":"Dizon-Townson","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2004.07.002_bib145","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.ATV.20.1.266","article-title":"Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy","volume":"20","author":"Murphy","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1016\/j.clp.2004.07.002_bib146","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1067\/mob.2002.126849","article-title":"Acquired and inherited thrombophilia in women with unexplained fetal losses","volume":"187","author":"Alonso","year":"2002","journal-title":"Am J Obstet Gynecol"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510804000909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510804000909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T05:46:27Z","timestamp":1625809587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510804000909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":146,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0095510804000909"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2004.07.002","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}