{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:15:54Z","timestamp":1786986954289,"version":"build-2736575974"},"reference-count":182,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.clp.2011.12.002","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T20:29:39Z","timestamp":1326486579000},"page":"111-136","source":"Crossref","is-referenced-by-count":42,"title":["Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit"],"prefix":"10.1016","volume":"39","author":[{"given":"Palmer G.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gillam-Krakauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Paige","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1067\/mpd.2000.106569","article-title":"Ductal shunting, high pulmonary blood flow, and pulmonary hemorrhage","volume":"137","author":"Kluckow","year":"2000","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0022-3476(78)80451-X","article-title":"Medical management of small preterm\u00a0infants with symptomatic patent ductus arteriosus","volume":"92","author":"Cotton","year":"1978","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1542\/peds.71.3.364","article-title":"Evaluation of the preterm infant for patent ductus arteriosus","volume":"71","author":"Ellison","year":"1983","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1542\/peds.2005-1528","article-title":"Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less","volume":"117","author":"Koch","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3476(69)80103-4","article-title":"Congestive heart failure from suspected ductal closure in utero","volume":"75","author":"Arcilla","year":"1969","journal-title":"J\u00a0Pediatr"},{"issue":"10","key":"10.1016\/j.clp.2011.12.002_bib6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1056\/NEJM197609022951003","article-title":"Pharmacologic closure of patent ductus arteriosus in the premature infant","volume":"295","author":"Friedman","year":"1976","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.clp.2011.12.002_bib7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1056\/NEJM197609022951004","article-title":"Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis","volume":"295","author":"Heymann","year":"1976","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clp.2011.12.002_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-4615-9035-4_10","article-title":"Prostaglandins and the control of muscle tone in the ductus arteriosus","volume":"78","author":"Coceani","year":"1977","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"10.1016\/j.clp.2011.12.002_bib9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1139\/y79-126","article-title":"Age-dependent changes in the response of the lamb ductus arteriosus to oxygen and ibuprofen","volume":"57","author":"Coceani","year":"1979","journal-title":"Can J Physiol Pharmacol"},{"issue":"8969","key":"10.1016\/j.clp.2011.12.002_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(95)91304-1","article-title":"Ibuprofen treatment of patent ductus arteriosus","volume":"346","author":"Patel","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib11","doi-asserted-by":"crossref","first-page":"F179","DOI":"10.1136\/fn.76.3.F179","article-title":"Treatment of patent ductus arteriosus with ibuprofen","volume":"76","author":"Van Overmeire","year":"1997","journal-title":"Arch Dis Child"},{"issue":"7","key":"10.1016\/j.clp.2011.12.002_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1001\/jama.1996.03530310045031","article-title":"Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants","volume":"275","author":"Varvarigou","year":"1996","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.clp.2011.12.002_bib13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","article-title":"Cyclooxygenase in biology and disease","volume":"12","author":"Dubois","year":"1998","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0095-5108(18)30293-8","article-title":"Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment","volume":"22","author":"Hammerman","year":"1995","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clp.2011.12.002_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.clp.2011.12.002_bib16","series-title":"Encyclopedia of molecular medicine","first-page":"961","article-title":"Cyclooxygenases","author":"Reese","year":"2002"},{"key":"10.1016\/j.clp.2011.12.002_bib17","series-title":"Goodman & Gilmans's The pharmacological basis of therapeutics","first-page":"959","article-title":"Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout","author":"Grosser","year":"2011"},{"issue":"Suppl 3","key":"10.1016\/j.clp.2011.12.002_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/14767058.2011.604987","article-title":"Current evidence on the safety profile of NSAIDs for the treatment of PDA","volume":"24","author":"Romagnoli","year":"2011","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"12","key":"10.1016\/j.clp.2011.12.002_bib19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI13271","article-title":"Why there are two cyclooxygenase isozymes","volume":"107","author":"Smith","year":"2001","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1073\/pnas.031573498","article-title":"Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2","volume":"98","author":"Loftin","year":"2001","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1203\/01.pdr.0000246480.13170.c0","article-title":"Attenuated cyclooxygenase-2 expression contributes to patent ductus arteriosus in preterm mice","volume":"60","author":"Trivedi","year":"2006","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib22","doi-asserted-by":"crossref","first-page":"R1717","DOI":"10.1152\/ajpregu.00259.2006","article-title":"Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice","volume":"291","author":"Reese","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1203\/01.pdr.0000233066.28496.7c","article-title":"Changing expression of cyclooxygenases and prostaglandin receptor EP4 during development of the human ductus arteriosus","volume":"60","author":"Rheinlaender","year":"2006","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1471-0528.2005.00539.x","article-title":"TOCOX\u2013a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk","volume":"112","author":"Groom","year":"2005","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1172\/JCI27291","article-title":"Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities","volume":"116","author":"Grosser","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib26","first-page":"393","article-title":"The pharmacology of selective inhibition of COX-2","volume":"96","author":"Grosser","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clp.2011.12.002_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1172-4-17","article-title":"Patent arterial duct","volume":"4","author":"Forsey","year":"2009","journal-title":"Orphanet J Rare Dis"},{"issue":"7","key":"10.1016\/j.clp.2011.12.002_bib28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1096\/fj.03-0645rev","article-title":"Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic","volume":"18","author":"Warner","year":"2004","journal-title":"FASEB J"},{"issue":"7","key":"10.1016\/j.clp.2011.12.002_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5694\/j.1326-5377.1997.tb123171.x","article-title":"Toxicity of antirheumatic drugs","volume":"166","author":"Lehmann","year":"1997","journal-title":"Med J Aust"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib30","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1152\/jappl.1993.74.4.1672","article-title":"Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids","volume":"74","author":"Malcolm","year":"1993","journal-title":"J\u00a0Appl Physiol"},{"issue":"34","key":"10.1016\/j.clp.2011.12.002_bib31","doi-asserted-by":"crossref","first-page":"31825","DOI":"10.1074\/jbc.M303588200","article-title":"The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production","volume":"278","author":"Sagi","year":"2003","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"10.1016\/j.clp.2011.12.002_bib32","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","article-title":"Cyclooxygenase-independent actions of cyclooxygenase inhibitors","volume":"15","author":"Tegeder","year":"2001","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib33","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0022-3476(83)80022-5","article-title":"Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study","volume":"102","author":"Gersony","year":"1983","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib34","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00431-002-0915-y","article-title":"Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: a randomised controlled trial","volume":"161","author":"Lago","year":"2002","journal-title":"Eur J Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-0029-1243315","article-title":"Treatment of patent ductus arteriosus: indomethacin or ibuprofen?","volume":"27","author":"Linder","year":"2010","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0022-3476(78)80909-3","article-title":"Closure of the patent ductus arteriosus with ligation and indomethacin: a consecutive experience","volume":"93","author":"Merritt","year":"1978","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-3476(81)80479-9","article-title":"Early closure of the patent ductus arteriosus in very low-birth-weight infants: a controlled trial","volume":"99","author":"Merritt","year":"1981","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/adc.58.4.267","article-title":"Indomethacin treatment for patent ductus arteriosus in very low birthweight infants: double blind trial","volume":"58","author":"Rudd","year":"1983","journal-title":"Arch Dis Child"},{"issue":"10","key":"10.1016\/j.clp.2011.12.002_bib39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM200009073431001","article-title":"A\u00a0comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus","volume":"343","author":"Van Overmeire","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.clp.2011.12.002_bib40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1055\/s-0028-1090594","article-title":"The ductus arteriosus rarely requires treatment in infants\u00a0> 1000 grams","volume":"25","author":"Nemerofsky","year":"2008","journal-title":"Am J Perinatol"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib41","doi-asserted-by":"crossref","first-page":"F94","DOI":"10.1136\/adc.2007.120584","article-title":"Comparison of ibuprofen and indomethacin for early-targeted treatment of patent ductus arteriosus in extremely premature infants: a randomised controlled trial","volume":"93","author":"Su","year":"2008","journal-title":"Arch Dis Child"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib42","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-3476(95)70084-6","article-title":"Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin","volume":"127","author":"Weiss","year":"1995","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jpeds.2007.05.007","article-title":"Risk factors for persistent ductus arteriosus patency during indomethacin treatment","volume":"151","author":"Chorne","year":"2007","journal-title":"J\u00a0Pediatr"},{"issue":"Suppl 1","key":"10.1016\/j.clp.2011.12.002_bib44","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/sj.jp.7211465","article-title":"Patent ductus arteriosus: pathophysiology and management","volume":"26","author":"Hermes-DeSantis","year":"2006","journal-title":"J\u00a0Perinatol"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jpeds.2010.05.020","article-title":"Intrauterine inflammation as a risk factor for persistent ductus arteriosus patency after cyclooxygenase inhibition in extremely low birth weight infants","volume":"157","author":"Kim","year":"2010","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib46","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1067\/mpd.2000.103414","article-title":"Prophylactic indomethacin: factors determining permanent ductus arteriosus closure","volume":"136","author":"Narayanan","year":"2000","journal-title":"J\u00a0Pediatr"},{"issue":"22","key":"10.1016\/j.clp.2011.12.002_bib47","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1056\/NEJM199311253292202","article-title":"Neonatal complications after the administration of indomethacin for preterm labor","volume":"329","author":"Norton","year":"1993","journal-title":"N\u00a0Engl J Med"},{"issue":"1 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib48","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1542\/peds.110.1.e10","article-title":"Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy","volume":"110","author":"Quinn","year":"2002","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1442-200X.2010.03251.x","article-title":"Clinical aspects of very-low-birthweight infants showing reopening of ductus arteriosus","volume":"53","author":"Uchiyama","year":"2011","journal-title":"Pediatr Int"},{"issue":"9","key":"10.1016\/j.clp.2011.12.002_bib50","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJM198203043060903","article-title":"Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants","volume":"306","author":"Mahony","year":"1982","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib51","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-0028-1103515","article-title":"A\u00a0randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants","volume":"26","author":"Aranda","year":"2009","journal-title":"Am J Perinatol"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib52","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1442-200X.2003.01797.x","article-title":"Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants","volume":"45","author":"Su","year":"2003","journal-title":"Pediatr Int"},{"key":"10.1016\/j.clp.2011.12.002_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003481.pub4","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants","volume":"4","author":"Ohlsson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clp.2011.12.002_bib54","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1542\/neo.4-8-e215","article-title":"Pharmacology review: pharmacological closure of patent ductus arteriosus in the neonate","volume":"4","author":"Narayanan-Sankar","year":"2003","journal-title":"NeoReviews"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib55","first-page":"250","article-title":"Indomethacin therapy in infants with advanced postnatal age and patent ductus arteriosus","volume":"9","author":"Achanti","year":"1986","journal-title":"Clin Invest Med"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib56","first-page":"127","article-title":"Recovery of prostaglandin production associated with reopening of the ductus arteriosus after indomethacin treatment in preterm infants with respiratory distress syndrome","volume":"2","author":"Seyberth","year":"1982","journal-title":"Pediatr Pharmacol (New York)"},{"key":"10.1016\/j.clp.2011.12.002_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003480.pub3","article-title":"Prolonged versus short course of indomethacin for the treatment of patent ductus arteriosus in preterm infants","volume":"2","author":"Herrera","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib58","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1542\/peds.95.2.244","article-title":"Continuous versus multiple rapid infusions of indomethacin: effects on cerebral blood flow velocity","volume":"95","author":"Hammerman","year":"1995","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib59","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1651-2227.2002.tb01668.x","article-title":"Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin","volume":"91","author":"Christmann","year":"2002","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0022-3476(86)81017-4","article-title":"Intestinal perforations after enteral administration of indomethacin in premature infants","volume":"108","author":"Kuhl","year":"1986","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib61","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0022-3468(81)80865-2","article-title":"Gastrointestinal perforation following indomethacin therapy in very low birth weight infants","volume":"16","author":"Nagaraj","year":"1981","journal-title":"J\u00a0Pediatr Surg"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/hrt.41.3.301","article-title":"Poor response to oral indomethacin therapy for persistent ductus arteriosus in very low birthweight infants","volume":"41","author":"Cooke","year":"1979","journal-title":"Br Heart J"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib63","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0022-3476(85)80305-X","article-title":"Localized intestinal perforations after enteral administration of indomethacin in premature infants","volume":"106","author":"Alpan","year":"1985","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib64","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0022-3476(85)80541-2","article-title":"Intestinal perforation following enteral administration of indomethacin","volume":"107","author":"Marshall","year":"1985","journal-title":"J\u00a0Pediatr"},{"issue":"2-3","key":"10.1016\/j.clp.2011.12.002_bib65","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000455528","article-title":"Pharmacokinetics of oral and intravenous indomethacin in preterm infants","volume":"1","author":"Bhat","year":"1980","journal-title":"Dev Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib66","first-page":"251","article-title":"A\u00a0comparison of oral and intravenous indomethacin dispositions in the premature infant with patent ductus arteriosus","volume":"1","author":"Evans","year":"1981","journal-title":"Pediatr Pharmacol (New York)"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib67","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/FTD.0b013e31815b3e13","article-title":"Orogastric and intravenous indomethacin administration to very premature neonates with patent ductus arteriosus: population pharmacokinetics, absolute bioavailability, and treatment outcome","volume":"29","author":"Al Za\u2019abi","year":"2007","journal-title":"Ther Drug Monit"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib68","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1651-2227.1997.tb08892.x","article-title":"Pharmacokinetics and protein binding of intravenous ibuprofen in the premature newborn infant","volume":"86","author":"Aranda","year":"1997","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib69","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2710.2005.00630.x","article-title":"Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method","volume":"30","author":"Desfrere","year":"2005","journal-title":"J\u00a0Clin Pharm Ther"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib70","doi-asserted-by":"crossref","first-page":"e1256","DOI":"10.1542\/peds.2008-1780","article-title":"Randomized pilot study comparing oral ibuprofen with intravenous ibuprofen in very low birth weight infants with patent ductus arteriosus","volume":"122","author":"Cherif","year":"2008","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib71","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jpeds.2010.10.008","article-title":"Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus","volume":"158","author":"Gokmen","year":"2011","journal-title":"J\u00a0Pediatr"},{"issue":"9","key":"10.1016\/j.clp.2011.12.002_bib72","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/0091270003254635","article-title":"Pharmacokinetics of oral ibuprofen in premature infants","volume":"43","author":"Sharma","year":"2003","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.clp.2011.12.002_bib73","article-title":"Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants","author":"Barzilay","year":"2011","journal-title":"Arch Dis Child"},{"issue":"10","key":"10.1016\/j.clp.2011.12.002_bib74","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.clinthera.2010.08.011","article-title":"Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants","volume":"32","author":"Gouyon","year":"2010","journal-title":"Clin Ther"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib75","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1542\/peds.2008-2418","article-title":"Failure of ductus arteriosus closure is associated with increased mortality in preterm infants","volume":"123","author":"Noori","year":"2009","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJM200101113440203","article-title":"Adverse effects of early dexamethasone in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network","volume":"344","author":"Stark","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib77","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1542\/peds.2004-1159","article-title":"Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial","volume":"114","author":"Watterberg","year":"2004","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib78","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jpeds.2004.12.040","article-title":"Pretreatment cortisol values may predict responses to hydrocortisone administration for the prevention of bronchopulmonary dysplasia in high-risk infants","volume":"146","author":"Peltoniemi","year":"2005","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/sj.jp.7211429","article-title":"New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure","volume":"26","author":"Attridge","year":"2006","journal-title":"J\u00a0Perinatol"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00442142","article-title":"Intestinal perforation associated with indomethacin treatment in premature infants","volume":"143","author":"Kuhl","year":"1985","journal-title":"Eur J Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib81","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/00005176-198809000-00026","article-title":"Localized intestinal perforation following intravenous indomethacin for patent ductus arteriosus","volume":"7","author":"Scholz","year":"1988","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"12","key":"10.1016\/j.clp.2011.12.002_bib82","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/jp.2010.59","article-title":"Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis","volume":"30","author":"Sharma","year":"2010","journal-title":"J\u00a0Perinatol"},{"issue":"1 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib83","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9378(94)70392-2","article-title":"Tocolysis with indomethacin increases the incidence of necrotizing enterocolitis in the low-birth-weight neonate","volume":"170","author":"Major","year":"1994","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib84","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0022-3476(88)80392-5","article-title":"Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin","volume":"113","author":"Vanhaesebrouck","year":"1988","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib85","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ajog.2008.01.026","article-title":"Antenatal indomethacin is more likely associated with spontaneous intestinal perforation rather than NEC","volume":"198","author":"Gordon","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2011.12.002_bib86","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000174.pub2","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","volume":"7","author":"Fowlie","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"23","key":"10.1016\/j.clp.2011.12.002_bib87","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJM198906083202302","article-title":"A\u00a0randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth","volume":"320","author":"Cassady","year":"1989","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib88","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00005176-200502000-00019","article-title":"Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study","volume":"40","author":"Dollberg","year":"2005","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib89","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005176-198605000-00004","article-title":"Risk factors for developing and dying from necrotizing enterocolitis","volume":"5","author":"Milner","year":"1986","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib90","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0022-3468(88)80439-1","article-title":"Association of closure of patent ductus arteriosus and development of necrotizing enterocolitis","volume":"23","author":"Palder","year":"1988","journal-title":"J\u00a0Pediatr Surg"},{"issue":"10 Spec No","key":"10.1016\/j.clp.2011.12.002_bib91","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/adc.65.10_Spec_No.1067","article-title":"Gut blood flow velocities in the newborn: effects of patent ductus arteriosus and parenteral indomethacin","volume":"65","author":"Coombs","year":"1990","journal-title":"Arch Dis Child"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib92","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0022-3476(99)70093-4","article-title":"Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus","volume":"135","author":"Pezzati","year":"1999","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib93","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0022-3476(94)70210-1","article-title":"Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant","volume":"125","author":"Shimada","year":"1994","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib94","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0022-3476(05)80662-6","article-title":"Effect of indomethacin on superior mesenteric artery blood flow velocity in preterm infants","volume":"116","author":"Van Bel","year":"1990","journal-title":"J\u00a0Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib95","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0022-3476(98)70480-9","article-title":"Effects of prophylactic low-dose indomethacin on hemodynamics in very low birth weight infants","volume":"132","author":"Yanowitz","year":"1998","journal-title":"J\u00a0Pediatr"},{"issue":"7","key":"10.1016\/j.clp.2011.12.002_bib96","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.jp.7210795","article-title":"Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus","volume":"22","author":"Fujii","year":"2002","journal-title":"J\u00a0Perinatol"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib97","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00000658-199609000-00011","article-title":"Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin","volume":"224","author":"Grosfeld","year":"1996","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib98","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1440-1754.1991.tb00422.x","article-title":"Intravenous indomethacin therapy in preterm neonates with patent ductus arteriosus","volume":"27","author":"Rajadurai","year":"1991","journal-title":"J\u00a0Paediatr Child Health"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib99","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/oxfordjournals.aje.a112960","article-title":"Necrotizing enterocolitis: a prospective multicenter investigation","volume":"112","author":"Ryder","year":"1980","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib100","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00005176-200410000-00012","article-title":"Variations in incidence of necrotizing enterocolitis in Canadian neonatal intensive care units","volume":"39","author":"Sankaran","year":"2004","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"26","key":"10.1016\/j.clp.2011.12.002_bib101","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","article-title":"Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants","volume":"344","author":"Schmidt","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib102","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/jp.2010.3","article-title":"Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?","volume":"30","author":"Benitz","year":"2010","journal-title":"J\u00a0Perinatol"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib103","doi-asserted-by":"crossref","first-page":"F498","DOI":"10.1136\/adc.2005.092734","article-title":"Patent ductus arteriosus: lack of evidence for common treatments","volume":"92","author":"Bose","year":"2007","journal-title":"Arch Dis Child"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib104","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jpeds.2006.12.048","article-title":"Patent ductus arteriosus: evidence for and against treatment","volume":"150","author":"Clyman","year":"2007","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2011.12.002_bib105","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004213.pub3","article-title":"Ibuprofen for the prevention of patent ductus arteriosus in\u00a0preterm and\/or low birth weight infants","volume":"7","author":"Ohlsson","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 3","key":"10.1016\/j.clp.2011.12.002_bib106","first-page":"S28","article-title":"Prophylaxis of symptomatic patent ductus arteriosus with oral ibuprofen in very low birth weight infants","volume":"91","author":"Sangtawesin","year":"2008","journal-title":"J\u00a0Med Assoc Thai"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib107","first-page":"314","article-title":"Oral ibuprofen prophylaxis for symptomatic patent ductus arteriosus of prematurity","volume":"89","author":"Sangtawesin","year":"2006","journal-title":"J\u00a0Med Assoc Thai"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib108","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0009-9236(97)90066-7","article-title":"Furosemide does not prevent indomethacin-induced renal side effects in preterm infants","volume":"62","author":"Romagnoli","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clp.2011.12.002_bib109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1472-6904-11-8","article-title":"Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts","volume":"11","author":"Kushnir","year":"2011","journal-title":"BMC Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib110","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0029-1243371","article-title":"Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus","volume":"27","author":"Katakam","year":"2010","journal-title":"Am J Perinatol"},{"issue":"9449","key":"10.1016\/j.clp.2011.12.002_bib111","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0140-6736(04)17477-1","article-title":"Prophylactic ibuprofen in premature infants: a multicentre, randomised, double-blind, placebo-controlled trial","volume":"364","author":"Van Overmeire","year":"2004","journal-title":"Lancet"},{"issue":"9449","key":"10.1016\/j.clp.2011.12.002_bib112","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0140-6736(04)17476-X","article-title":"Prophylactic ibuprofen versus placebo in very premature infants: a randomised, double-blind, placebo-controlled trial","volume":"364","author":"Gournay","year":"2004","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib113","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1542\/peds.82.4.533","article-title":"Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants","volume":"82","author":"Bandstra","year":"1988","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib114","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00467-009-1349-9","article-title":"Ibuprofen in very preterm infants impairs renal function for the first month of life","volume":"25","author":"Vieux","year":"2010","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib115","doi-asserted-by":"crossref","first-page":"F514","DOI":"10.1136\/adc.2004.060434","article-title":"Potential risk factors for the development of acute renal failure in preterm newborn infants: a case-control study","volume":"90","author":"Cataldi","year":"2005","journal-title":"Arch Dis Child"},{"issue":"7","key":"10.1016\/j.clp.2011.12.002_bib116","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00467-006-0118-2","article-title":"Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions","volume":"21","author":"Cuzzolin","year":"2006","journal-title":"Pediatr Nephrol"},{"issue":"9","key":"10.1016\/j.clp.2011.12.002_bib117","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00467-008-0835-9","article-title":"Oral-ibuprofen-induced acute renal failure in a preterm infant","volume":"23","author":"Erdeve","year":"2008","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib118","first-page":"231","article-title":"Ibuprofen and acute kidney injury in the newborn","volume":"52","author":"Fanos","year":"2010","journal-title":"Turk J Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib119","first-page":"54","article-title":"Acute renal impairment after oral ibuprofen for medical closure of patent ductus arteriosus","volume":"44","author":"Tiker","year":"2007","journal-title":"Indian Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib120","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1055\/s-2008-1043829","article-title":"Can dopamine prevent the renal side effects of indomethacin? A prospective randomized clinical study","volume":"211","author":"Baenziger","year":"1999","journal-title":"Klin Padiatr"},{"issue":"5 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib121","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3476(05)81914-6","article-title":"Effect of dopamine on failure of indomethacin to close the patent ductus arteriosus","volume":"121","author":"Fajardo","year":"1992","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2011.12.002_bib122","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003213","article-title":"Dopamine versus no treatment to prevent renal dysfunction in indomethacin-treated preterm newborn infants","volume":"3","author":"Barrington","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib123","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jpeds.2003.11.027","article-title":"Effect of ibuprofen on bilirubin-albumin binding","volume":"144","author":"Ahlfors","year":"2004","journal-title":"J\u00a0Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib124","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1651-2227.2008.01007.x","article-title":"Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants","volume":"98","author":"Rheinlaender","year":"2009","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib125","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.2008-2433","article-title":"Does ibuprofen increase neonatal hyperbilirubinemia?","volume":"124","author":"Zecca","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib126","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/jpm.2010.113","article-title":"Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants","volume":"39","author":"Amin","year":"2011","journal-title":"J\u00a0Perinat Med"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib127","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.semperi.2006.04.003","article-title":"Systematic review: intravenous ibuprofen in preterm newborns","volume":"30","author":"Aranda","year":"2006","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.clp.2011.12.002_bib128","article-title":"Unbound bilirubin does not increase during ibuprofen treatment of patent ductus arteriosus in preterm infants","author":"Desfrere","year":"2011","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib129","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-3476(97)70060-X","article-title":"Comparative evaluation of the effects of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus","volume":"131","author":"Mosca","year":"1997","journal-title":"J\u00a0Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1203\/00006450-200001000-00009","article-title":"Randomized double-blind controlled trial\u00a0comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus","volume":"47","author":"Patel","year":"2000","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib131","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mcp.2000.107048","article-title":"Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates","volume":"67","author":"Romagnoli","year":"2000","journal-title":"Clin Pharmacol Ther"},{"issue":"7 Spec No","key":"10.1016\/j.clp.2011.12.002_bib132","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/adc.67.7_Spec_No.851","article-title":"Regional cerebral blood flow velocity changes after indomethacin infusion in preterm infants","volume":"67","author":"Austin","year":"1992","journal-title":"Arch Dis Child"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib133","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000244223","article-title":"Acute effects of indomethacin on cerebral hemodynamics and oxygenation","volume":"68","author":"Benders","year":"1995","journal-title":"Biol Neonate"},{"issue":"8704","key":"10.1016\/j.clp.2011.12.002_bib134","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(90)93030-S","article-title":"Effects of indomethacin on cerebral haemodynamics in very preterm infants","volume":"335","author":"Edwards","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib135","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000242860","article-title":"Effect of indomethacin on cerebral blood flow velocity of premature newborns","volume":"54","author":"Laudignon","year":"1988","journal-title":"Biol Neonate"},{"issue":"1-2","key":"10.1016\/j.clp.2011.12.002_bib136","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000457546","article-title":"Effect of indomethacin on cerebral blood flow velocities in very low birth weight neonates with a patent ductus arteriosus","volume":"20","author":"Ohlsson","year":"1993","journal-title":"Dev Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib137","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00442705","article-title":"Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus","volume":"147","author":"Pryds","year":"1988","journal-title":"Eur J Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib138","first-page":"29","article-title":"Effects on cerebral blood flow velocities of slow and rapid infusion of indomethacin","volume":"14","author":"Simko","year":"1994","journal-title":"J\u00a0Perinatol"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib139","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1542\/peds.84.5.802","article-title":"Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: duration of its effect","volume":"84","author":"Van Bel","year":"1989","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib140","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1542\/peds.2007-0925","article-title":"Impact of patent ductus arteriosus and subsequent therapy with indomethacin on cerebral oxygenation in preterm infants","volume":"121","author":"Lemmers","year":"2008","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib141","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1203\/00006450-199306000-00015","article-title":"Effect of indomethacin on cerebral oxidized cytochrome oxidase in preterm infants","volume":"33","author":"McCormick","year":"1993","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib142","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archpedi.154.6.598","article-title":"Neurodevelopmental follow-up at 36 months\u2019 corrected age of preterm infants treated with prophylactic indomethacin","volume":"154","author":"Couser","year":"2000","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib143","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1542\/peds.98.4.714","article-title":"Neurodevelopmental outcome at 36 months\u2019 corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial","volume":"98","author":"Ment","year":"1996","journal-title":"Pediatrics"},{"issue":"3 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib144","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1542\/peds.105.3.485","article-title":"Outcome of children in the Indomethacin Intraventricular Hemorrhage Prevention Trial","volume":"105","author":"Ment","year":"2000","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib145","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jpeds.2004.07.035","article-title":"Prevention of intraventricular hemorrhage by indomethacin in male preterm infants","volume":"145","author":"Ment","year":"2004","journal-title":"J\u00a0Pediatr"},{"issue":"4 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib146","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1542\/peds.111.4.e340","article-title":"School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial","volume":"111","author":"Vohr","year":"2003","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib147","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jpeds.2006.09.001","article-title":"Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice","volume":"150","author":"Clyman","year":"2007","journal-title":"J\u00a0Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib148","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1651-2227.2011.02189.x","article-title":"Indomethacin prophylaxis revisited: changing practice and supportive evidence","volume":"100","author":"AlFaleh","year":"2011","journal-title":"Acta Paediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib149","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1542\/peds.69.6.778","article-title":"Abnormal cerebral hemodynamics in preterm infants with patent ductus arteriosus","volume":"69","author":"Lipman","year":"1982","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1212\/WNL.33.2.179","article-title":"Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial","volume":"33","author":"Ment","year":"1983","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib151","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0022-3476(85)80197-9","article-title":"Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants","volume":"107","author":"Ment","year":"1985","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib152","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0022-3476(88)80225-7","article-title":"Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates","volume":"112","author":"Ment","year":"1988","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib153","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0022-3476(89)80300-2","article-title":"Indomethacin reduces the risks of severe intraventricular hemorrhage","volume":"115","author":"Bada","year":"1989","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib154","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0022-3476(88)80224-5","article-title":"Administration of indomethacin for the prevention of periventricular-intraventricular hemorrhage in high-risk neonates","volume":"112","author":"Hanigan","year":"1988","journal-title":"J\u00a0Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib155","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0022-3476(87)80262-7","article-title":"Prevention of symptomatic patent ductus arteriosus with a single dose of indomethacin","volume":"111","author":"Krueger","year":"1987","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib156","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1542\/peds.93.4.543","article-title":"Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial","volume":"93","author":"Ment","year":"1994","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib157","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1651-2227.2011.02216.x","article-title":"Why would a sane clinician not prescribe prophylactic indomethacin?","volume":"100","author":"DeMauro","year":"2011","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.clp.2011.12.002_bib158","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004213","article-title":"Ibuprofen for the prevention of patent ductus arteriosus in\u00a0preterm and\/or low birth weight infants","volume":"2","author":"Shah","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib159","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1542\/peds.2004-1178","article-title":"Prophylactic ibuprofen for the prevention of intraventricular hemorrhage among preterm infants: a multicenter, randomized study","volume":"115","author":"Dani","year":"2005","journal-title":"Pediatrics"},{"issue":"5 Pt 1","key":"10.1016\/j.clp.2011.12.002_bib160","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0022-3476(96)80127-2","article-title":"Prophylactic indomethacin therapy in the first twenty-four hours of life for the prevention of patent ductus arteriosus in preterm infants treated prophylactically with surfactant in the delivery room","volume":"128","author":"Couser","year":"1996","journal-title":"J\u00a0Pediatr"},{"issue":"11","key":"10.1016\/j.clp.2011.12.002_bib161","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1651-2227.2000.tb00767.x","article-title":"Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants","volume":"89","author":"Dani","year":"2000","journal-title":"Acta Paediatr"},{"issue":"5","key":"10.1016\/j.clp.2011.12.002_bib162","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s004310051288","article-title":"Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants","volume":"159","author":"De Carolis","year":"2000","journal-title":"Eur J Pediatr"},{"issue":"13","key":"10.1016\/j.clp.2011.12.002_bib163","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1503\/cmaj.051446","article-title":"Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus","volume":"174","author":"Bellini","year":"2006","journal-title":"CMAJ"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib164","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-0029-1239492","article-title":"The impact of an early ibuprofen treatment protocol on the incidence of surgical ligation of the ductus arteriosus","volume":"27","author":"Tefft","year":"2010","journal-title":"Am J Perinatol"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1056\/NEJM198107093050203","article-title":"Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus","volume":"305","author":"Brash","year":"1981","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib166","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2125.2004.02139.x","article-title":"Intravenous indomethacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study","volume":"58","author":"Smyth","year":"2004","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib167","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000480944","article-title":"Indomethacin therapy in premature infants with patent ductus arteriosus\u2013determination of therapeutic plasma levels","volume":"12","author":"Yeh","year":"1989","journal-title":"Dev Pharmacol Ther"},{"issue":"1\u20133","key":"10.1016\/j.clp.2011.12.002_bib168","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0378-3782(92)90179-K","article-title":"Patent ductus arteriosus: how important to which babies?","volume":"29","author":"Knight","year":"1992","journal-title":"Early Hum Dev"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib169","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/siny.2000.0036","article-title":"The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials","volume":"6","author":"Knight","year":"2001","journal-title":"Semin Neonatol"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib170","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00008480-200404000-00005","article-title":"Patency of the ductus arteriosus in the premature infant: is it pathologic? Should it be treated?","volume":"16","author":"Laughon","year":"2004","journal-title":"Curr Opin Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib171","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/hrt.30.1.4","article-title":"Natural history of persistent ductus arteriosus","volume":"30","author":"Campbell","year":"1968","journal-title":"Br Heart J"},{"issue":"6","key":"10.1016\/j.clp.2011.12.002_bib172","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-3476(84)80499-0","article-title":"Patent ductus arteriosus in neonates with severe respiratory disease","volume":"104","author":"Dudell","year":"1984","journal-title":"J\u00a0Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib173","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0022-3476(80)80336-2","article-title":"The contribution of PDA in the neonate with severe RDS","volume":"96","author":"Jacob","year":"1980","journal-title":"J\u00a0Pediatr"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib174","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-3476(75)80722-0","article-title":"Patent ductus arteriosus complicating the respiratory distress syndrome in preterm infants","volume":"86","author":"Thibeault","year":"1975","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2011.12.002_bib175","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0022-3476(78)80910-X","article-title":"Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants","volume":"93","author":"Cotton","year":"1978","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2011.12.002_bib176","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1651-2227.1983.tb09693.x","article-title":"Early closure of patent ductus arteriosus with indomethacin in preterm infants with idiopathic respiratory distress syndrome","volume":"72","author":"Kaapa","year":"1983","journal-title":"Acta Paediatr Scand"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib177","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jpedsurg.2008.10.019","article-title":"Analysis of outcome in 298 extremely low-birth-weight infants with patent ductus arteriosus","volume":"44","author":"Alexander","year":"2009","journal-title":"J\u00a0Pediatr Surg"},{"issue":"3","key":"10.1016\/j.clp.2011.12.002_bib178","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1136\/adc.2004.057638","article-title":"Is surgical ligation of patent ductus arteriosus necessary? The Western Australian experience of conservative management","volume":"90","author":"Brooks","year":"2005","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clp.2011.12.002_bib179","first-page":"1","article-title":"What happens when the patent ductus arteriosus is treated less aggressively in very low birth weight infants?","author":"Kaempf","year":"2011","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib180","doi-asserted-by":"crossref","first-page":"F48","DOI":"10.1136\/adc.2007.129270","article-title":"Spontaneous closure of the patent ductus arteriosus in very low birth weight infants following discharge from the neonatal unit","volume":"94","author":"Herrman","year":"2009","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.clp.2011.12.002_bib181","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1136\/adc.2009.168682","article-title":"Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants","volume":"96","author":"Jones","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clp.2011.12.002_bib182","first-page":"e1","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","author":"Hammerman","year":"2011","journal-title":"Pediatrics"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510811001291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510811001291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T19:03:52Z","timestamp":1640459032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510811001291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":182,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0095510811001291"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2011.12.002","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}