{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:23:51Z","timestamp":1792452231441,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","perinatology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.clp.2016.04.011","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T01:10:32Z","timestamp":1470964232000},"page":"547-557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy"],"prefix":"10.1016","volume":"43","author":[{"given":"Hannah C.","family":"Glass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Rowitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.clp.2016.04.011_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clp.2016.04.011_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jcrc.2015.11.008","article-title":"Impact of neurointensivist-managed intensive care unit implementation on patient outcomes after aneurysmal subarachnoid hemorrhage","volume":"32","author":"Egawa","year":"2015","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.clp.2016.04.011_bib3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3171\/2009.8.JNS09441","article-title":"Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management","volume":"112","author":"Josephson","year":"2010","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.clp.2016.04.011_bib4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s11940-011-0144-7","article-title":"Neurocritical care for neonates","volume":"13","author":"Glass","year":"2011","journal-title":"Curr Treat Options Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/0883073812469051","article-title":"Advancing neurologic care in the neonatal intensive care unit with a neonatal neurologist","volume":"29","author":"Mulkey","year":"2014","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MCC.0b013e32808255c6","article-title":"Neurocritical care: a distinct discipline?","volume":"13","author":"Rincon","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.clp.2016.04.011_bib7","series-title":"Cerebral palsy in infancy","author":"Shepherd","year":"2014"},{"key":"10.1016\/j.clp.2016.04.011_bib8","doi-asserted-by":"crossref","first-page":"e735","DOI":"10.1542\/peds.2012-3985","article-title":"Enriched environments and motor outcomes in cerebral palsy: systematic review and meta-analysis","volume":"132","author":"Morgan","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2016.04.011_bib9","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0883073814535503","article-title":"Evidence-based diagnosis, health care, and rehabilitation for children with cerebral palsy","volume":"29","author":"Novak","year":"2014","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fnhum.2014.00377","article-title":"Harnessing the power of neuroplasticity for intervention","volume":"8","author":"Kolb","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.clp.2016.04.011_bib11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2012-0498","article-title":"Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics","volume":"130","author":"Wu","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2016.04.011_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.pediatrneurol.2014.08.010","article-title":"Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy","volume":"51","author":"Rogers","year":"2014","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib13","article-title":"Moderate hypothermia within 6\u00a0h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial","author":"Azzopardi","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib14","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy","volume":"164","author":"Cotten","year":"2014","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2016.04.011_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.spen.2014.10.003","article-title":"Interdisciplinary approach to neurocritical care in the intensive care nursery","volume":"21","author":"Glass","year":"2014","journal-title":"Semin Pediatr Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib16","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1542\/peds.2006-2839","article-title":"Determinants of outcomes after head cooling for neonatal encephalopathy","volume":"119","author":"Wyatt","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2016.04.011_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.siny.2013.08.004","article-title":"Strategies to prevent reperfusion injury to the brain following intrapartum hypoxia-ischemia","volume":"18","author":"Kasdorf","year":"2013","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.clp.2016.04.011_bib18","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3174\/ajnr.A3423","article-title":"Brain injury patterns in hypoglycemia in neonatal encephalopathy","volume":"34","author":"Wong","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.clp.2016.04.011_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpeds.2011.12.047","article-title":"Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy","volume":"161","author":"Tam","year":"2012","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2016.04.011_bib20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jpeds.2005.11.015","article-title":"Neonatal hypoglycemia and occipital cerebral injury","volume":"148","author":"Filan","year":"2006","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2016.04.011_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12028-009-9324-7","article-title":"Neurocritical care for neonates","volume":"12","author":"Glass","year":"2010","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1016\/j.clp.2016.04.011_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003311.pub3","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clp.2016.04.011_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clp.2016.04.011_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.clp.2013.10.008","article-title":"Outcomes of hypoxic-ischemic encephalopathy in neonates treated with hypothermia","volume":"41","author":"Shankaran","year":"2014","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clp.2016.04.011_bib25","unstructured":"California Perinatal Quality Care Collaborative, 2015. Early screening and identification of candidates for neonatal therapeutic hypothermia toolkit. 2015. Available at: https:\/\/www.cpqcc.org\/qi-tool-kits\/early-screening-and-identification-candidates-neonatal-therapeutic-hypothermia-toolkit. Accessed January 13, 2016."},{"key":"10.1016\/j.clp.2016.04.011_bib26","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clp.2016.04.011_bib27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000353948","article-title":"Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns","volume":"104","author":"Thoresen","year":"2013","journal-title":"Neonatology"},{"key":"10.1016\/j.clp.2016.04.011_bib28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nurx.2006.01.007","article-title":"Hypothermic neuroprotection","volume":"3","author":"Gunn","year":"2006","journal-title":"NeuroRx"},{"issue":"4","key":"10.1016\/j.clp.2016.04.011_bib29","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jpeds.2014.12.061","article-title":"A\u00a0randomized clinical trial of therapeutic hypothermia mode during transport for neonatal encephalopathy","volume":"166","author":"Akula","year":"2015","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2016.04.011_bib30","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1212\/WNL.0000000000000282","article-title":"Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study","volume":"82","author":"Glass","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.clp.2016.04.011_bib31","doi-asserted-by":"crossref","first-page":"F267","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: an observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clp.2016.04.011_bib32","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/0883073810390036","article-title":"Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"26","author":"Wusthoff","year":"2011","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e31820af91a","article-title":"Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"76","author":"Nash","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.clp.2016.04.011_bib34","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2016.04.011_bib35","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1177\/0883073813488663","article-title":"Amplitude-integrated electro-encephalography: the child neurologist's perspective","volume":"28","author":"Glass","year":"2013","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib36","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1177\/0883073815569307","article-title":"Outcome after therapeutic hypothermia in term neonates with encephalopathy and a syndromic diagnosis","volume":"30","author":"Mrelashvili","year":"2015","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1017\/S0012162200001493","article-title":"Birth defects in children with newborn encephalopathy","volume":"42","author":"Felix","year":"2000","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib39","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"2","key":"10.1016\/j.clp.2016.04.011_bib40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.siny.2014.12.011","article-title":"Impact of hypothermia on predictors of poor outcome: how do we decide to redirect care?","volume":"20","author":"Bonifacio","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.clp.2016.04.011_bib41","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.2522\/ptj.20050397","article-title":"Activity, activity, activity: rethinking our physical therapy approach to cerebral palsy","volume":"86","author":"Damiano","year":"2006","journal-title":"Phys Ther"},{"key":"10.1016\/j.clp.2016.04.011_bib42","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/dmcn.12246","article-title":"A\u00a0systematic review of interventions for children with cerebral palsy: state of the evidence","volume":"55","author":"Novak","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.clp.2016.04.011_bib43","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2014-0899","article-title":"Hypothermia and encephalopathy","volume":"133","author":"Committee on Fetus and Newborn","year":"2014","journal-title":"Pediatrics"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816300367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816300367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T04:20:54Z","timestamp":1536466854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510816300367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0095510816300367"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2016.04.011","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2016.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}